Discovery of a clinical stage multi-kinase inhibitor sodium (E)-2-{2-methoxy-5-[(2′,4′,6′-trimethoxystyrylsulfonyl)methyl] phenylamino}acetate (ON 01910.Na): Synthesis, structure-activity relationship, and biological activity

Journal of Medicinal Chemistry

Volumn 54, Issue 18, 2011, Pages 6254-6276

  Reddy, M V Ramana ^a   Venkatapuram, Padmavathi ^a   Mallireddigari, Muralidhar R ^b   Pallela, Venkat R ^b   Cosenza, Stephen C ^a   Robell, Kimberly A ^a   Akula, Balaiah ^b   Hoffman, Benjamin S ^a   Reddy, E Premkumar ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b Onconova Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN D; SODIUM 2 [2 METHOXY 5 [(2',4',6' TRIMETHOXYSTYRYLSULFONYL)METHYL]PHENYLAMINO]ACETATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; MALE; MOUSE; MYELODYSPLASTIC SYNDROME; NONHUMAN; PHASE 3 CLINICAL TRIAL (TOPIC); PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOLOGICAL AVAILABILITY; CELL LINE, TUMOR; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; GLYCINE; HUMANS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PROTEIN KINASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES; TRANSPLANTATION, HETEROLOGOUS;

EID: 80052785631     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200570p     Document Type: Article

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