The associations of adiposity, physical activity and inflammation with fatigue in older adults

Brain, Behavior, and Immunity

Volumn 25, Issue 7, 2011, Pages 1482-1490

  Valentine, Rudy J ^a   Woods, Jeffrey A ^a   McAuley, Edward ^a   Dantzer, Robert ^a   Evans, Ellen M ^b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

Author keywords

Adiposity; Depression; Fatigue; Inflammation; Physical activity

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 6;

AGE DISTRIBUTION; AGED; AGING; ARTICLE; BODY WEIGHT; DEPRESSION; DISEASE ASSOCIATION; DUAL ENERGY X RAY ABSORPTIOMETRY; DYSTHYMIA; FATIGUE; FEMALE; GERIATRIC DEPRESSION SCALE; HUMAN; INFLAMMATION; LEUKOCYTE; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; OBESITY; PHYSICAL ACTIVITY; PITTSBURGH SLEEP QUALITY INDEX; PRIORITY JOURNAL; QUALITY OF LIFE; REGRESSION ANALYSIS; SEX DIFFERENCE; SLEEP QUALITY;

ADIPOSITY; AGED; AGED, 80 AND OVER; C-REACTIVE PROTEIN; FATIGUE; FEMALE; HUMANS; INFLAMMATION; INTERLEUKIN-6; MALE; MENTAL FATIGUE; MIDDLE AGED; MOTOR ACTIVITY; QUALITY OF LIFE; SEX FACTORS; SLEEP;

EID: 80052783039     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2011.06.002     Document Type: Article

References (48)

1. Alexander N.B., Taffet G.E., Horne F.M., Eldadah B.A., Ferrucci L., Nayfield S., Studenski S. Bedside-to-bench conference. Research agenda for idiopathic fatigue and aging. J. Am. Geriatr. Soc. 2010, 58:967-975.
2. Bixler E.O., Vgontzas A.N., Lin H.M., Calhoun S.L., Vela-Bueno A., Kales A. Excessive daytime sleepiness in a general population sample: the role of sleep apnea, age, obesity, diabetes, and depression. J. Clin. Endocrinol. Metab. 2005, 90:4510-4515.
3. Buysse D.J., Reynolds C.F., Monk T.H., Berman S.R., Kupfer D.J. The Pittsburgh Sleep Quality index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989, 28:193-213.
4. Castanon-Cervantes O., Wu M., Ehlen J.C., Paul K., Gamble K.L., Johnson R.L., Besing R.C., Menaker M., Gewirtz A.T., Davidson A.J. Dysregulation of inflammatory responses by chronic circadian disruption. J. Immunol. 2010, 185:5796-5805.
5. Chen M.K. The epidemiology of self-perceived fatigue among adults. Prev. Med. 1986, 15:74-81.
6. Cho H.J., Seeman T.E., Bower J.E., Kiefe C.I., Irwin M.R. Prospective association between C-reactive protein and fatigue in the coronary artery risk development in young adults study. Biol. Psychiatry 2009, 66:871-878.
7. Collado-Hidalgo A., Bower J.E., Ganz P.A., Cole S.W., Irwin M.R. Inflammatory biomarkers for persistent fatigue in breast cancer survivors. Clin. Cancer Res. 2006, 12:2759-2766.
8. Corwin E.J., Klein L.C., Rickelman K. Predictors of fatigue in healthy young adults: moderating effects of cigarette smoking and gender. Biol. Res. Nurs. 2002, 3:222-233.
9. Dantzer R., O'Connor J.C., Freund G.G., Johnson R.W., Kelley K.W. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat. Rev. Neurosci. 2008, 9:46-56.
10. Dantzer R., Capuron L., Irwin M.R., Miller A.H., Ollat H., Hugh Perry V., Rousey S., Yirmiya R. Identification and treatment of symptoms associated with inflammation in medically ill patients. Psychoneuroendocrinology 2008, 33:18-29.
11. Davis M.C., Zautra A.J., Younger J., Motivala S.J., Attrep J., Irwin M.R. Chronic stress and regulation of cellular markers of inflammation in rheumatoid arthritis: implications for fatigue. Brain Behav. Immun. 2008, 22:24-32.
12. Florez H., Troen B.R. Fat and inflammaging: a dual path to unfitness in elderly people?. J. Am. Geriatr. Soc. 2008, 56:558-560.
13. Gill T.M., Desai M.M., Gahbauer E.A., Holford T.R., Williams C.S. Restricted activity among community-living older persons: incidence, precipitants, and health care utilization. Ann. Intern. Med. 2001, 135:313-321.
14. Glaser R., Kiecolt-Glaser J.K. Stress-induced immune dysfunction: implications for health. Nat. Rev. Immunol. 2005, 5:243-251.
15. Hojlund K., Mogensen M., Sahlin K., Beck-Nielsen H. Mitochondrial dysfunction in type 2 diabetes and obesity. Endocrinol. Metab. Clin. North Am. 2008, 37:713-731.
16. Hyyppa M.T., Lindholm T., Lehtinen V., Puukka P. Self-perceived fatigue and cortisol secretion in a community sample. J. Psychosom. Res. 1993, 37:589-594.
17. Irwin M.R., Wang M., Ribeiro D., Cho H.J., Olmstead R., Breen E.C., Martinez-Maza O., Cole S. Sleep loss activates cellular inflammatory signaling. Biol. Psychiatry 2008, 64:538-540.
18. Keaney J.F., Larson M.G., Vasan R.S., Wilson P.W.F., Lipinska I., Corey D., Massaro J.M., Sutherland P., Vita J.A., Benjamin E.J. Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham study. Arterioscler. Thromb. Vasc. Biol. 2003, 23:434-439.
19. Ko S.u., Stenholm S., Ferrucci L. Characteristic gait patterns in older adults with obesity - results from the Baltimore longitudinal study of aging. J. Biomech. 2010, 43:1104-1110.
20. Kohut M.L., McCann D.A., Russell D.W., Konopka D.N., Cunnick J.E., Franke W.D., Castillo M.C., Reighard A.E., Vanderah E. Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of [beta]-blockers, BMI, and psychosocial factors in older adults. Brain Behav. Immun. 2006, 20:201-209.
21. Kyle U.G., Genton L., Hans D., Karsegard L., Slosman D.O., Pichard C. Age-related differences in fat-free mass, skeletal muscle, body cell mass and fat mass between 18 and 94years. Eur. J. Clin. Nutr. 2001, 55:663-672.
22. Lee D.C., Sui X., Blair S.N. Does physical activity ameliorate the health hazards of obesity?. Br. J. Sports Med. 2009, 43:49-51.
23. Liao S., Ferrell B.A. Fatigue in an older population. J. Am. Geriatr. Soc. 2000, 48:426-430.
24. Lim W., Hong S., Nelesen R., Dimsdale J.E. The association of obesity, cytokine levels, and depressive symptoms with diverse measures of fatigue in healthy subjects. Arch. Intern. Med. 2005, 165:910-915.
25. Luctkar-Flude M.F., Groll D.L., Tranmer J.E., Woodend K. Fatigue and physical activity in older adults with cancer: a systematic review of the literature. Cancer Nurs. 2007, 30:E35-E45.
26. Masse L.C., Fuemmeler B.F., Anderson C.B., Matthews C.E., Trost S.G., Catellier D.J., Treuth M. Accelerometer data reduction: a comparison of four reduction algorithms on selected outcome variables. Med. Sci. Sports Exerc. 2005, 37:S544-S554.
27. McAuley E., White S.M., Rogers L.Q., Motl R.W., Courneya K.S. Physical activity and fatigue in breast cancer and multiple sclerosis: psychosocial mechanisms. Psychosom. Med. 2010, 72:88-96.
28. National Institute on Aging. Unexplained fatigue in the elderly: an exploratory workshop sponsored by the National Institute on Aging. NIH. 2008.
29. Patel S.R., Zhu X., Storfer-Isser A., Mehra R., Jenny N.S., Tracy R., Redline S. Sleep duration and biomarkers of inflammation. Sleep 2009, 32:200-204.
30. Pearson T.A., Mensah G.A., Alexander R.W., Anderson J.L., Cannon R.O., Criqui M., Fadl Y.Y., Fortmann S.P., Hong Y., Myers G.L., Rifai N., Smith S.C., Taubert K., Tracy R.P., Vinicor F. Markers of inflammation and cardiovascular disease: application to clinical and public health practice. a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 2003, 107:499-511.
31. Poluri A., Mores J., Cook D.B., Findley T.W., Cristian A. Fatigue in the elderly population. Phys. Med. Rehabil. Clin. N. Am. 2005, 16:91-108.
32. Puetz T.W., Flowers S.S., O'Connor P.J. A randomized controlled trial of the effect of aerobic exercise training on feelings of energy and fatigue in sedentary young adults with persistent fatigue. Psychother. Psychosom. 2008, 77:167-174.
33. Reichert F.F., Barros A.J.D., Domingues M.R., Hallal P.C. The role of perceived personal barriers to engagement in leisure-time physical activity. Am. J. Public Health 2007, 97:515-519.
34. Resnick H.E., Carter E.A., Aloia M., Phillips B. Cross-sectional relationship of reported fatigue to obesity, diet, and physical activity: results from the third national health and nutrition examination survey. J. Clin. Sleep Med. 2006, 2:163-169.
35. Rockwood K., Davis H.S., Merry H.R., MacKnight C., McDowell I. Sleep disturbances and mortality: results from the Canadian study of health and aging. J. Am. Geriatr. Soc. 2001, 49:639-641.
36. Shelton R.C., Miller A.H. Eating ourselves to death (and despair): the contribution of adiposity and inflammation to depression. Prog. Neurobiol. 2010, 91:275-299.
37. Smets E.M.A., Garssen B., Bonke B., Haes de J.C.J.M. The Multidimensional Fatigue Inventory (MFI); psychometric qualities of an instrument to assess fatigue. J. Psychosom. Res. 1995, 39:315-325.
38. Sorensen B., Streib J.E., Strand M., Make B., Giclas P.C., Fleshner M., Jones J.F. Complement activation in a model of chronic fatigue syndrome. J. Allergy Clin. Immunol. 2003, 112:397-403.
39. Stewart J.C., Rand K.L., Muldoon M.F., Kamarck T.W. A prospective evaluation of the directionality of the depression-inflammation relationship. Brain Behav. Immun. 2009, 23:936-944.
40. Tak L.M., Bakker S.J.L., Slaets J.P.J., Rosmalen J.G.M. Is high-sensitive C-reactive protein a biomarker for functional somatic symptoms? A population-based study. Brain Behav. Immun. 2009, 23:1014-1019.
41. Tilg H., Moschen A.R. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat. Rev. Immunol. 2006, 6:772-783.
42. Valentine R.J., McAuley E., Vieira V.J., Baynard T., Hu L., Evans E.M., Woods J.A. Sex differences in the relationship between obesity, C-reactive protein, physical activity, depression, sleep quality and fatigue in older adults. Brain Behav. Immun. 2009, 23:643-648.
43. van Mens-Verhulst J., Bensing J.M. Sex differences in persistent fatigue. Women Health 1997, 26:51-70.
44. Vestergaard S., Nayfield S.G., Patel K.V., Eldadah B., Cesari M., Ferrucci L., Ceresini G., Guralnik J.M. Fatigue in a representative population of older persons and its association with functional impairment, functional limitation, and disability. J. Gerontol. A Biol. Sci. Med. Sci. 2009, 64:76-82.
45. Vgontzas A.N., Bixler E.O., Chrousos G.P. Obesity-related sleepiness and fatigue: the role of the stress system and cytokines. Ann. N. Y. Acad. Sci. 2006, 1083:329-344.
46. Vgontzas A.N., Papanicolaou D.A., Bixler E.O., Kales A., Tyson K., Chrousos G.P. Elevation of plasma cytokines in disorders of excessive daytime sleepiness: role of sleep disturbance and obesity. J. Clin. Endocrinol. Metab. 1997, 82:1313-1316.
47. Vieira V.J., Hu L., Valentine R.J., McAuley E., Evans E.M., Baynard T., Woods J.A. Reduction in trunk fat predicts cardiovascular exercise training-related reductions in C-reactive protein. Brain Behav. Immun. 2009, 23:485-491.
48. Washburn R.A., McAuley E., Katula J., Mihalko S.L., Boileau R.A. The physical activity scale for the elderly (PASE): evidence for validity. J. Clin. Epidemiol. 1999, 52:643-651.