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Volumn 5, Issue 3, 2011, Pages 251-257

Bone effects of cancer therapies: Pros and cons

Author keywords

Bone; Chemotherapy; Osteoblast; Osteoclast; Remodeling

Indexed keywords

ANTINEOPLASTIC AGENT; AROMATASE INHIBITOR; GLUCOCORTICOID; RETINOIC ACID; SELECTIVE ESTROGEN RECEPTOR MODULATOR;

EID: 80052766482     PISSN: 17514258     EISSN: 17514266     Source Type: Journal    
DOI: 10.1097/SPC.0b013e328349c524     Document Type: Review
Times cited : (24)

References (82)
  • 1
    • 0030879065 scopus 로고    scopus 로고
    • Mechanisms of bone metastasis
    • Mundy GR. Mechanisms of bone metastasis. Cancer 1997; 80:1546-1556. (Pubitemid 27444026)
    • (1997) Cancer , vol.80 , Issue.SUPPL. 8 , pp. 1546-1556
    • Mundy, G.R.1
  • 2
    • 0031853806 scopus 로고    scopus 로고
    • The deleterious effects of low-dose corticosteroids on bone density in patients with polymyalgia rheumatica
    • Pearce G, Ryan PF, Delmas PD, et al. The deleterious effects of low-dose corticosteroids on bone density in patients with polymyalgia rheumatica. Br J Rheumatol 1998; 37:292-299.
    • (1998) Br J Rheumatol , vol.37 , pp. 292-299
    • Pearce, G.1    Ryan, P.F.2    Delmas, P.D.3
  • 3
    • 76649116231 scopus 로고    scopus 로고
    • Management of glucocorticoid-induced osteoporosis
    • An excellent summary of the pathophysiology of glucocorticoid-induced osteoporosis, including management guidelines
    • Compston J. Management of glucocorticoid-induced osteoporosis. Nat Rev Rheumatol 2010; 6:82-88. An excellent summary of the pathophysiology of glucocorticoid-induced osteoporosis, including management guidelines.
    • (2010) Nat Rev Rheumatol , vol.6 , pp. 82-88
    • Compston, J.1
  • 5
    • 77954505723 scopus 로고    scopus 로고
    • Intermittent parathyroid hormone administration counteracts the adverse effects of glucocorticoids on osteoblast and osteocyte viability, bone formation, and strength in mice
    • Weinstein RS, Jilka RL, Almeida M, et al. Intermittent parathyroid hormone administration counteracts the adverse effects of glucocorticoids on osteoblast and osteocyte viability, bone formation, and strength in mice. Endocrinology 2010; 151:2641-2649.
    • (2010) Endocrinology , vol.151 , pp. 2641-2649
    • Weinstein, R.S.1    Jilka, R.L.2    Almeida, M.3
  • 6
    • 28844483810 scopus 로고    scopus 로고
    • Evaluation of bone mineral density at different phases of therapy of childhood all
    • DOI 10.1080/08880010500313272
    • Maniadaki I, Stiakaki E, Germanakis I, Kalmanti M. Evaluation of bone mineral density at different phases of therapy of childhood all. Pediatr Hematol Oncol 2006; 23:11-18. (Pubitemid 41769968)
    • (2006) Pediatric Hematology and Oncology , vol.23 , Issue.1 , pp. 11-18
    • Maniadaki, I.1    Stiakaki, E.2    Germanakis, I.3    Kalmanti, M.4
  • 7
    • 0034502338 scopus 로고    scopus 로고
    • Oral corticosteroids and fracture risk: Relationship to daily and cumulative doses
    • van Staa TP, Leufkens HG, Abenhaim L, et al. Oral corticosteroids and fracture risk: relationship to daily and cumulative doses. Rheumatology (Oxford) 2000; 39:1383-1389. (Pubitemid 32045866)
    • (2000) Rheumatology , vol.39 , Issue.12 , pp. 1383-1389
    • Van Staa, T.P.1    Leufkens, H.G.M.2    Abenhaim, L.3    Zhang, B.4    Cooper, C.5
  • 10
    • 43049143010 scopus 로고    scopus 로고
    • Fracture risk associated with different types of oral corticosteroids and effect of termination of corticosteroids on the risk of fractures
    • Vestergaard P, Rejnmark L, Mosekilde L. Fracture risk associated with different types of oral corticosteroids and effect of termination of corticosteroids on the risk of fractures. Calcif Tissue Int 2008; 82:249-257.
    • (2008) Calcif Tissue Int , vol.82 , pp. 249-257
    • Vestergaard, P.1    Rejnmark, L.2    Mosekilde, L.3
  • 12
    • 0034944221 scopus 로고    scopus 로고
    • American college of rheumatology ad hoc committee on glucocorticoid- induced osteoporosis
    • Recommendations for the prevention and treatment of glucocorticoid- induced osteoporosis: 2001 update
    • Recommendations for the prevention and treatment of glucocorticoid- induced osteoporosis: 2001 update. American College of Rheumatology Ad Hoc Committee on Glucocorticoid-Induced Osteoporosis. Arthritis Rheum 2001; 44:1496-1503.
    • (2001) Arthritis Rheum , vol.44 , pp. 1496-1503
  • 13
    • 2142657293 scopus 로고    scopus 로고
    • Skeletal morbidity in childhood acute lymphoblastic leukemia
    • DOI 10.1200/JCO.2004.04.199
    • Mandel K, Atkinson S, Barr RD, Pencharz P. Skeletal morbidity in childhood acute lymphoblastic leukemia. J Clin Oncol 2004; 22:1215-1221. (Pubitemid 41079834)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.7 , pp. 1215-1221
    • Mandel, K.1    Atkinson, S.2    Barr, R.D.3    Pencharz, P.4
  • 14
    • 0034037097 scopus 로고    scopus 로고
    • Osteoporosis due to cancer treatment: Pathogenesis and management
    • Pfeilschifter J, Diel IJ. Osteoporosis due to cancer treatment: pathogenesis and management. J Clin Oncol 2000; 18:1570-1593. (Pubitemid 30205404)
    • (2000) Journal of Clinical Oncology , vol.18 , Issue.7 , pp. 1570-1593
    • Pfeilschifter, J.1    Diel, I.J.2
  • 15
    • 57449112967 scopus 로고    scopus 로고
    • Damaging effects of chronic low-dose methotrexate usage on primary bone formation in young rats and potential protective effects of folinic acid supplementary treatment
    • Fan C, Cool JC, Scherer MA, et al. Damaging effects of chronic low-dose methotrexate usage on primary bone formation in young rats and potential protective effects of folinic acid supplementary treatment. Bone 2009; 44:61-70.
    • (2009) Bone , vol.44 , pp. 61-70
    • Fan, C.1    Cool, J.C.2    Scherer, M.A.3
  • 16
    • 0036312301 scopus 로고    scopus 로고
    • Methotrexate in the treatment of rheumatoid arthritis. II. In vivo effects on bone mineral density
    • Minaur NJ, Kounali D, Vedi S, et al. Methotrexate in the treatment of rheumatoid arthritis. II. In vivo effects on bone mineral density. Rheumatology (Oxford) 2002; 41:741-749. (Pubitemid 34822955)
    • (2002) Rheumatology , vol.41 , Issue.7 , pp. 741-749
    • Minaur, N.J.1    Kounali, D.2    Vedi, S.3    Compston, J.E.4    Beresford, J.N.5    Bhalla, A.K.6
  • 17
    • 0033022533 scopus 로고    scopus 로고
    • A case of growth failure caused by 13-cis-retinoic acid administration after bone marrow transplantation for neuroblasoma
    • Inamo Y, Suzuki T, Mugishima H. A case of growth failure caused by 13-cisretinoic acid administration after bone marrow transplantation for neuroblastoma. Endocr J 1999; 46 (Suppl):S113-S115. (Pubitemid 29254498)
    • (1999) Endocrine Journal , vol.46 , Issue.SUPPL.
    • Inamo, Y.1    Suzuki, T.2    Mugishima, H.3
  • 18
  • 19
    • 78651102286 scopus 로고    scopus 로고
    • Prevalence of advanced bone age in a cohort of patients who received cis-retinoic acid for high-risk neuroblastoma
    • A small, single-institution review of existing data on bone age in a cohort of patients who received cis-retinoic acid for high-risk neuroblastoma
    • Hobbie WL, Moab SM, Carlson CA, et al. Prevalence of advanced bone age in a cohort of patients who received cis-retinoic acid for high-risk neuroblastoma. Pediatr Blood Cancer 2011; 56:474-476. A small, single-institution review of existing data on bone age in a cohort of patients who received cis-retinoic acid for high-risk neuroblastoma.
    • (2011) Pediatr Blood Cancer , vol.56 , pp. 474-476
    • Hobbie, W.L.1    Moab, S.M.2    Carlson, C.A.3
  • 20
    • 83055179820 scopus 로고    scopus 로고
    • Retinoic acid inhibits NFATc1 expression and osteoclast differentiation
    • An in-vitro analysis of the impact of retinoic acid and isoform-specific retinoic acid receptor antagonists on osteoclastogenesis
    • Balkan W, Rodriguez-Gonzalez M, Pang M, et al. Retinoic acid inhibits NFATc1 expression and osteoclast differentiation. J Bone Miner Metab 2011. An in-vitro analysis of the impact of retinoic acid and isoform-specific retinoic acid receptor antagonists on osteoclastogenesis.
    • (2011) J Bone Miner Metab
    • Balkan, W.1    Rodriguez-Gonzalez, M.2    Pang, M.3
  • 21
    • 0034033954 scopus 로고    scopus 로고
    • Recent advances in cancer chemoprevention, with emphasis on breast and colorectal cancer
    • DOI 10.1016/S0959-8049(00)00040-X, PII S095980490000040X
    • Decensi A, Costa A. Recent advances in cancer chemoprevention, with emphasis on breast and colorectal cancer. Eur J Cancer 2000; 36:694-709. (Pubitemid 30179740)
    • (2000) European Journal of Cancer , vol.36 , Issue.6 , pp. 694-709
    • Decensi, A.1    Costa, A.2
  • 22
    • 69549103081 scopus 로고    scopus 로고
    • Fenretinide inhibits myeloma cell growth, osteoclastogenesis and osteoclast viability
    • Li X, Ling W, Pennisi A, et al. Fenretinide inhibits myeloma cell growth, osteoclastogenesis and osteoclast viability. Cancer Lett 2009; 284:175- 181.
    • (2009) Cancer Lett , vol.284 , pp. 175-181
    • Li, X.1    Ling, W.2    Pennisi, A.3
  • 23
    • 27144477320 scopus 로고    scopus 로고
    • N-(4-hydroxyphenyl)retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of IB kinase and nuclear factor-B-regulated gene products
    • DOI 10.1158/0008-5472.CAN-05-1585
    • Shishodia S, Gutierrez AM, Lotan R, Aggarwal BB. N-(4-hydroxyphenyl) retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of IkB(alpha) kinase and nuclear factorkB- regulated gene products. Cancer Res 2005; 65:9555-9565. (Pubitemid 41508026)
    • (2005) Cancer Research , vol.65 , Issue.20 , pp. 9555-9565
    • Shishodia, S.1    Gutierrez, A.M.2    Lotan, R.3    Aggarwal, B.B.4
  • 24
    • 77958081869 scopus 로고    scopus 로고
    • Effects of suppression of folliclestimulating hormone secretion on bone resorption markers in postmenopausal women
    • A prospective clinical trial comparing serum FSH levels in postmenopausal women treated with a GnRH agonist or placebo in addition to aromatase inhibitors
    • Drake MT, McCready LK, Hoey KA, et al. Effects of suppression of folliclestimulating hormone secretion on bone resorption markers in postmenopausal women. J Clin Endocrinol Metab 2010; 95:5063-5068. A prospective clinical trial comparing serum FSH levels in postmenopausal women treated with a GnRH agonist or placebo in addition to aromatase inhibitors.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 5063-5068
    • Drake, M.T.1    McCready, L.K.2    Hoey, K.A.3
  • 25
    • 77953625420 scopus 로고    scopus 로고
    • Regulation of adult bone turnover by sex steroids
    • A comprehensive review of mechanisms by which sex steroids effect adult bone turnover and the regulation of bone mass
    • Frenkel B, Hong A, Baniwal SK, et al. Regulation of adult bone turnover by sex steroids. J Cell Physiol 2010; 224:305-310. A comprehensive review of mechanisms by which sex steroids effect adult bone turnover and the regulation of bone mass.
    • (2010) J Cell Physiol , vol.224 , pp. 305-310
    • Frenkel, B.1    Hong, A.2    Baniwal, S.K.3
  • 26
    • 55449096689 scopus 로고    scopus 로고
    • Skeletal effects of drugs to treat cancer
    • Vestergaard P. Skeletal effects of drugs to treat cancer. Curr Drug Saf 2008; 3:173-177.
    • (2008) Curr Drug Saf , vol.3 , pp. 173-177
    • Vestergaard, P.1
  • 27
    • 33745249570 scopus 로고    scopus 로고
    • Effects of tamoxifen vs. Raloxifene on the risk of developing invasive breast cancer and other disease outcomes: The NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial
    • Vogel VG, Costantino JP, Wickerham DL, et al. Effects of tamoxifen vs. raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial. J Am Med Assoc 2006; 295:2727-2741.
    • (2006) J Am Med Assoc , vol.295 , pp. 2727-2741
    • Vogel, V.G.1    Costantino, J.P.2    Wickerham, D.L.3
  • 29
    • 33746455931 scopus 로고    scopus 로고
    • Effect of an aromatase inhibitor on BMD and bone turnover markers: 2-Year results of the anastrozole, tamoxifen, alone or in combination (ATAC) trial (18233230)
    • DOI 10.1359/jbmr.060508
    • Eastell R, Hannon RA, Cuzick J, et al. Effect of an aromatase inhibitor on bmd and bone turnover markers: 2-year results of the Anastrozole, Tamoxifen, Alone or in Combination (ATAC) trial (18233230). J Bone Miner Res 2006;21:1215-1223. (Pubitemid 44128334)
    • (2006) Journal of Bone and Mineral Research , vol.21 , Issue.8 , pp. 1215-1223
    • Eastell, R.1    Hannon, R.A.2    Cuzick, J.3    Dowsett, M.4    Clack, G.5    Adams, J.E.6
  • 30
    • 79960491885 scopus 로고    scopus 로고
    • Aromatase inhibitor-associated bone and musculoskeletal effects: New evidence defining etiology and strategies for management
    • A thorough review of management strategies for patients on aromatase inhibitor therapy, including discussion of recent clinical data on survival outcomes of patients treated with aromatase inhibitors compared with those receiving tamoxifen alone
    • Gaillard S, Stearns V. Aromatase inhibitor-associated bone and musculoskeletal effects: new evidence defining etiology and strategies for management. Breast Cancer Res 2011; 13:205. A thorough review of management strategies for patients on aromatase inhibitor therapy, including discussion of recent clinical data on survival outcomes of patients treated with aromatase inhibitors compared with those receiving tamoxifen alone.
    • (2011) Breast Cancer Res , vol.13 , pp. 205
    • Gaillard, S.1    Stearns, V.2
  • 31
    • 37449028688 scopus 로고    scopus 로고
    • Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial
    • Forbes JF, Cuzick J, Buzdar A, et al. Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial. Lancet Oncol 2008; 9:45-53.
    • (2008) Lancet Oncol , vol.9 , pp. 45-53
    • Forbes, J.F.1    Cuzick, J.2    Buzdar, A.3
  • 33
    • 33846545851 scopus 로고    scopus 로고
    • Survival and safety of exemestane versus tamoxifen after 2-3 years' tamoxifen treatment (Intergroup Exemestane Study): A randomised controlled trial
    • Coombes RC, Kilburn LS, Snowdon CF, et al. Survival and safety of exemestane versus tamoxifen after 2-3 years' tamoxifen treatment (Intergroup Exemestane Study): a randomised controlled trial. Lancet 2007; 369:559-570.
    • (2007) Lancet , vol.369 , pp. 559-570
    • Coombes, R.C.1    Kilburn, L.S.2    Snowdon, C.F.3
  • 35
    • 50649113295 scopus 로고    scopus 로고
    • Aromatase inhibitors: Are there differences between steroidal and nonsteroidal aromatase inhibitors and do they matter?
    • Miller WR, Bartlett J, Brodie AM, et al. Aromatase inhibitors: are there differences between steroidal and nonsteroidal aromatase inhibitors and do they matter? Oncologist 2008; 13:829-837.
    • (2008) Oncologist , vol.13 , pp. 829-837
    • Miller, W.R.1    Bartlett, J.2    Brodie, A.M.3
  • 36
    • 66149083574 scopus 로고    scopus 로고
    • Exemestane: A review of its use in postmenopausal women with breast cancer
    • Deeks ED, Scott LJ. Exemestane: a review of its use in postmenopausal women with breast cancer. Drugs 2009; 69:889-918.
    • (2009) Drugs , vol.69 , pp. 889-918
    • Deeks, E.D.1    Scott, L.J.2
  • 37
    • 79952841608 scopus 로고    scopus 로고
    • Effects of exemestane, anastrozole and tamoxifen on bone mineral density and bone turnover markers in postmenopausal early breast cancer patients: Results of N-SAS BC 04, the TEAM Japan Substudy
    • A substudy of the TEAM Japan data on aromatase inhibitor-induced skeletal changes. Provides data on the differential effects of steroidal and nonsteroidal aromatase inhibitor skeletal effects
    • Aihara T, Suemasu K, Takei H, et al. Effects of exemestane, anastrozole and tamoxifen on bone mineral density and bone turnover markers in postmenopausal early breast cancer patients: results of N-SAS BC 04, the TEAM Japan Substudy. Oncology 2011; 79:376-381. A substudy of the TEAM Japan data on aromatase inhibitor-induced skeletal changes. Provides data on the differential effects of steroidal and nonsteroidal aromatase inhibitor skeletal effects.
    • (2011) Oncology , vol.79 , pp. 376-381
    • Aihara, T.1    Suemasu, K.2    Takei, H.3
  • 39
    • 33645987269 scopus 로고    scopus 로고
    • Bone mineral density changes in patients with prostate cancer during the first 2 years of androgen suppression
    • discussion 1683
    • Morote J, Orsola A, Abascal JM, et al. Bone mineral density changes in patients with prostate cancer during the first 2 years of androgen suppression. J Urol 2006; 175:1679-1683; discussion 1683.
    • (2006) J Urol , vol.175 , pp. 1679-1683
    • Morote, J.1    Orsola, A.2    Abascal, J.M.3
  • 40
    • 0345689611 scopus 로고    scopus 로고
    • Immediate dual energy X-ray absorptiometry reveals a high incidence of osteoporosis in patients with advanced prostate cancer before hormonal manipulation
    • DOI 10.1046/j.1464-410X.2003.04471.x
    • Hussain SA, Weston R, Stephenson RN, et al. Immediate dual energy X-ray absorptiometry reveals a high incidence of osteoporosis in patients with advanced prostate cancer before hormonal manipulation. BJU Int 2003; 92:690-694. (Pubitemid 37475806)
    • (2003) BJU International , vol.92 , Issue.7 , pp. 690-694
    • Hussain, S.A.1    Weston, R.2    Stephenson, R.N.3    George, E.4    Parr, N.J.5
  • 42
    • 61349083540 scopus 로고    scopus 로고
    • Management of decreased bone mineral density in men starting androgen-deprivation therapy for prostate cancer
    • Panju AH, Breunis H, Cheung AM, et al. Management of decreased bone mineral density in men starting androgen-deprivation therapy for prostate cancer. BJU Int 2009; 103:753-757.
    • (2009) BJU Int , vol.103 , pp. 753-757
    • Panju, A.H.1    Breunis, H.2    Cheung, A.M.3
  • 43
    • 69249090994 scopus 로고    scopus 로고
    • Long-term changes in bone mineral density and predicted fracture risk in patients receiving androgen-deprivation therapy for prostate cancer, with stratification of treatment based on presenting values
    • Wadhwa VK, Weston R, Mistry R, Parr NJ. Long-term changes in bone mineral density and predicted fracture risk in patients receiving androgen-deprivation therapy for prostate cancer, with stratification of treatment based on presenting values. BJU Int 2009; 104:800-805.
    • (2009) BJU Int , vol.104 , pp. 800-805
    • Wadhwa, V.K.1    Weston, R.2    Mistry, R.3    Parr, N.J.4
  • 44
    • 66649136169 scopus 로고    scopus 로고
    • Review of major adverse effects of androgendeprivation therapy in men with prostate cancer
    • Taylor LG, Canfield SE, Du XL. Review of major adverse effects of androgendeprivation therapy in men with prostate cancer. Cancer 2009; 115:2388- 2399.
    • (2009) Cancer , vol.115 , pp. 2388-2399
    • Taylor, L.G.1    Canfield, S.E.2    Du, X.L.3
  • 46
    • 48949107708 scopus 로고    scopus 로고
    • Pulse treatment with the proteasome inhibitor bortezomib inhibits osteoclast resorptive activity in clinically relevant conditions
    • Boissy P, Andersen TL, Lund T, et al. Pulse treatment with the proteasome inhibitor bortezomib inhibits osteoclast resorptive activity in clinically relevant conditions. Leuk Res 2008; 32:1661-1668.
    • (2008) Leuk Res , vol.32 , pp. 1661-1668
    • Boissy, P.1    Andersen, T.L.2    Lund, T.3
  • 48
    • 57849161431 scopus 로고    scopus 로고
    • The combination of bortezomib, melphalan, dexamethasone and intermittent thalidomide is an effective regimen for relapsed/refractory myeloma and is associated with improvement of abnormal bone metabolism and angiogenesis
    • Terpos E, Kastritis E, Roussou M, et al. The combination of bortezomib, melphalan, dexamethasone and intermittent thalidomide is an effective regimen for relapsed/refractory myeloma and is associated with improvement of abnormal bone metabolism and angiogenesis. Leukemia 2008; 22:2247- 2256.
    • (2008) Leukemia , vol.22 , pp. 2247-2256
    • Terpos, E.1    Kastritis, E.2    Roussou, M.3
  • 51
    • 77956966765 scopus 로고    scopus 로고
    • First-line treatment with bortezomib rapidly stimulates both osteoblast activity and bone matrix deposition in patients with multiple myeloma, and stimulates osteoblast proliferation and differentiation in vitro
    • This prospective study evaluated the effect of bortezomib on osteoblast differentiation and proliferation as well as bone matrix deposition in bisphosphonate- naïve myeloma patients
    • Lund T, Soe K, Abildgaard N, et al. First-line treatment with bortezomib rapidly stimulates both osteoblast activity and bone matrix deposition in patients with multiple myeloma, and stimulates osteoblast proliferation and differentiation in vitro. Eur J Haematol 2010; 85:290-299. This prospective study evaluated the effect of bortezomib on osteoblast differentiation and proliferation as well as bone matrix deposition in bisphosphonate- naïve myeloma patients.
    • (2010) Eur J Haematol , vol.85 , pp. 290-299
    • Lund, T.1    Soe, K.2    Abildgaard, N.3
  • 52
    • 50449086728 scopus 로고    scopus 로고
    • Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma
    • San Miguel JF, Schlag R, Khuageva NK, et al. Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma. N Engl J Med 2008; 359:906-917.
    • (2008) N Engl J Med , vol.359 , pp. 906-917
    • San Miguel, J.F.1    Schlag, R.2    Khuageva, N.K.3
  • 53
    • 77952310929 scopus 로고    scopus 로고
    • Bortezomib plus melphalan and prednisone compared with melphalan and prednisone in previously untreated multiple myeloma: Updated follow-up and impact of subsequent therapy in the phase III VISTA trial
    • Long-term survival follow-up of the phase III VISTA trial, (bortezomib, melphalan, prednisone versus melphalan and prednisone in patients with previously untreated myeloma ineligible for high-dose therapy)
    • Mateos MV, Richardson PG, Schlag R, et al. Bortezomib plus melphalan and prednisone compared with melphalan and prednisone in previously untreated multiple myeloma: updated follow-up and impact of subsequent therapy in the phase III VISTA trial. J Clin Oncol 2010; 28:2259-2266. Long-term survival follow-up of the phase III VISTA trial, (bortezomib, melphalan, prednisone versus melphalan and prednisone in patients with previously untreated myeloma ineligible for high-dose therapy).
    • (2010) J Clin Oncol , vol.28 , pp. 2259-2266
    • Mateos, M.V.1    Richardson, P.G.2    Schlag, R.3
  • 54
    • 79954426340 scopus 로고    scopus 로고
    • Fewer bone disease events, improvement in bone remodeling, and evidence of bone healing with bortezomib plus melphalan-prednisone vs. Melphalan-prednisone in the phase III VISTA trial in multiple myeloma
    • An update of survival data (median follow-up of 36.7 months) from the landmark VISTA (Velcade as Initial Standard Therapy in Multiple Myeloma) trial, confirming the significant prolongation of OS seen with VMP treatment as compared with melphalan and prednisone
    • Delforge M, Terpos E, Richardson PG, et al. Fewer bone disease events, improvement in bone remodeling, and evidence of bone healing with bortezomib plus melphalan-prednisone vs. melphalan-prednisone in the phase III VISTA trial in multiple myeloma. Eur J Haematol 2011; 86:372-384. An update of survival data (median follow-up of 36.7 months) from the landmark VISTA (Velcade as Initial Standard Therapy in Multiple Myeloma) trial, confirming the significant prolongation of OS seen with VMP treatment as compared with melphalan and prednisone.
    • (2011) Eur J Haematol , vol.86 , pp. 372-384
    • Delforge, M.1    Terpos, E.2    Richardson, P.G.3
  • 55
    • 79551627290 scopus 로고    scopus 로고
    • A prospective evaluation of the biochemical, metabolic, hormonal and structural bone changes associated with bortezomib response in multiple myeloma patients
    • This study evaluated bone changes (bone architecture and metabolism changes) associated with proteasome inhibitor treatment in relapsed or refractory myeloma patients
    • Zangari M, Yaccoby S, Pappas L, et al. A prospective evaluation of the biochemical, metabolic, hormonal and structural bone changes associated with bortezomib response in multiple myeloma patients. Haematologica 2011; 96:333-336. This study evaluated bone changes (bone architecture and metabolism changes) associated with proteasome inhibitor treatment in relapsed or refractory myeloma patients.
    • (2011) Haematologica , vol.96 , pp. 333-336
    • Zangari, M.1    Yaccoby, S.2    Pappas, L.3
  • 56
    • 79952003783 scopus 로고    scopus 로고
    • Histone deacetylases in skeletal development and bone mass maintenance
    • A thorough review of HDAC biology and summary of current understanding of how HDACs contribute to bone development and maintenance
    • McGee-Lawrence ME, Westendorf JJ. Histone deacetylases in skeletal development and bone mass maintenance. Gene 2011; 474:1-11. A thorough review of HDAC biology and summary of current understanding of how HDACs contribute to bone development and maintenance.
    • (2011) Gene , vol.474 , pp. 1-11
    • McGee-Lawrence, M.E.1    Westendorf, J.J.2
  • 57
    • 28044471827 scopus 로고    scopus 로고
    • Acetylation and deacetylation of nonhistone proteins
    • Glozak MA, Sengupta N, Zhang X, Seto E. Acetylation and deacetylation of nonhistone proteins. Gene 2005; 363:15-23.
    • (2005) Gene , vol.363 , pp. 15-23
    • Glozak, M.A.1    Sengupta, N.2    Zhang, X.3    Seto, E.4
  • 58
    • 68949212379 scopus 로고    scopus 로고
    • Lysine acetylation targets protein complexes and co-regulates major cellular functions
    • Choudhary C, Kumar C, Gnad F, et al. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 2009; 325: 834-840.
    • (2009) Science , vol.325 , pp. 834-840
    • Choudhary, C.1    Kumar, C.2    Gnad, F.3
  • 59
    • 33745196250 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 stimulates Runx2 acetylation
    • Jeon EJ, Lee KY, Choi NS, et al. Bone morphogenetic protein-2 stimulates Runx2 acetylation. J Biol Chem 2006; 281:16502-16511.
    • (2006) J Biol Chem , vol.281 , pp. 16502-16511
    • Jeon, E.J.1    Lee, K.Y.2    Choi, N.S.3
  • 60
    • 28144448363 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors promote osteoblast maturation
    • DOI 10.1359/JBMR.050813
    • Schroeder TM, Westendorf JJ. Histone deacetylase inhibitors promote osteoblast maturation. J Bone Miner Res 2005; 20:2254-2263. (Pubitemid 41698788)
    • (2005) Journal of Bone and Mineral Research , vol.20 , Issue.12 , pp. 2254-2263
    • Schroeder, T.M.1    Westendorf, J.J.2
  • 61
    • 4744349390 scopus 로고    scopus 로고
    • Histone deacetylase 3 interacts with Runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation
    • DOI 10.1074/jbc.M403702200
    • Schroeder TM, Kahler RA, Li X, Westendorf JJ. Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation. J Biol Chem 2004; 279:41998-42007. (Pubitemid 39313651)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.40 , pp. 41998-42007
    • Schroeder, T.M.1    Kahler, R.A.2    Li, X.3    Westendorf, J.J.4
  • 62
    • 78650749107 scopus 로고    scopus 로고
    • Zfp521 controls bone mass by HDAC3- dependent attenuation of Runx2 activity
    • Hesse E, Saito H, Kiviranta R, et al. Zfp521 controls bone mass by HDAC3- dependent attenuation of Runx2 activity. J Cell Biol 2010; 191:1271-1283.
    • (2010) J Cell Biol , vol.191 , pp. 1271-1283
    • Hesse, E.1    Saito, H.2    Kiviranta, R.3
  • 63
    • 77955349977 scopus 로고    scopus 로고
    • Histone deacetylase 3 depletion in osteo/chondroprogenitor cells decreases bone density and increases marrow fat
    • Razidlo DF, Whitney TJ, Casper ME, et al. Histone deacetylase 3 depletion in osteo/chondroprogenitor cells decreases bone density and increases marrow fat. PLoS One 2010; 5:e11492.
    • (2010) PLoS One , vol.5
    • Razidlo, D.F.1    Whitney, T.J.2    Casper, M.E.3
  • 64
    • 79953330801 scopus 로고    scopus 로고
    • HDAC3 and HDAC7 have opposite effects on osteoclast differentiation
    • A concise summary of HDAC3 and HDAC7 effects on osteoclast differentiation
    • Pham L, Kaiser B, Romsa A, et al. HDAC3 and HDAC7 have opposite effects on osteoclast differentiation. J Biol Chem 2011; 286:12056-12065. A concise summary of HDAC3 and HDAC7 effects on osteoclast differentiation.
    • (2011) J Biol Chem , vol.286 , pp. 12056-12065
    • Pham, L.1    Kaiser, B.2    Romsa, A.3
  • 65
    • 59049104478 scopus 로고    scopus 로고
    • Bone morphogenic protein 2 activates protein kinase D to regulate histone deacetylase 7 localization and repression of Runx2
    • Jensen ED, Gopalakrishnan R, Westendorf JJ. Bone morphogenic protein 2 activates protein kinase D to regulate histone deacetylase 7 localization and repression of Runx2. J Biol Chem 2009; 284:2225-2234.
    • (2009) J Biol Chem , vol.284 , pp. 2225-2234
    • Jensen, E.D.1    Gopalakrishnan, R.2    Westendorf, J.J.3
  • 66
    • 39749130325 scopus 로고    scopus 로고
    • Histone deacetylase 7 associates with Runx2 and represses its activity during osteoblast maturation in a deacetylation-independent manner
    • DOI 10.1359/jbmr.071104
    • Jensen ED, Schroeder TM, Bailey J, et al. Histone deacetylase 7 associates with Runx2 and represses its activity during osteoblast maturation in a deacetylation-independent manner. J Bone Miner Res 2008; 23:361-372. (Pubitemid 351304666)
    • (2008) Journal of Bone and Mineral Research , vol.23 , Issue.3 , pp. 361-372
    • Jensen, E.D.1    Schroeder, T.M.2    Bailey, J.3    Gopalakrishnan, R.4    Westendorf, J.J.5
  • 67
    • 71349086901 scopus 로고    scopus 로고
    • Effect of estrogens on bone marrow adipogenesis and Sirt1 in aging C57BL/6J mice
    • Elbaz A, Rivas D, Duque G. Effect of estrogens on bone marrow adipogenesis and Sirt1 in aging C57BL/6J mice. Biogerontology 2009; 10:747-755.
    • (2009) Biogerontology , vol.10 , pp. 747-755
    • Elbaz, A.1    Rivas, D.2    Duque, G.3
  • 68
    • 79953191835 scopus 로고    scopus 로고
    • Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kB ligand (RANKL) activation of NF-kB signaling and inhibit osteoclastogenesis in bone-derived cells
    • An in-vitro study of the effects of resveratrol on RANKL during bone morphogenesis. Findings demonstrated that resveratrol-activated Sirt-1 is important for the regulation of osteoclast-osteoblast activity in bone formation
    • Shakibaei M, Buhrmann C, Mobasheri A. Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kB ligand (RANKL) activation of NF-kB signaling and inhibit osteoclastogenesis in bone-derived cells. J Biol Chem 2011; 286:11492-11505. An in-vitro study of the effects of resveratrol on RANKL during bone morphogenesis. Findings demonstrated that resveratrol-activated Sirt-1 is important for the regulation of osteoclast-osteoblast activity in bone formation.
    • (2011) J Biol Chem , vol.286 , pp. 11492-11505
    • Shakibaei, M.1    Buhrmann, C.2    Mobasheri, A.3
  • 69
    • 80052751218 scopus 로고    scopus 로고
    • Compounds that inhibit histone deacetylases in class I and class II effectively suppress human osteoclasts in vitro
    • An in-vitro evaluation of the effects of HDAC classes on human osteoclast activity. Results suggest that inhibition of both HDAC classes I and II may be required for suppression of human osteoclasts
    • Cantley M, Fairlie D, Bartold P, et al. Compounds that inhibit histone deacetylases in class I and class II effectively suppress human osteoclasts in vitro. J Cell Physiol 2011. An in-vitro evaluation of the effects of HDAC classes on human osteoclast activity. Results suggest that inhibition of both HDAC classes I and II may be required for suppression of human osteoclasts.
    • (2011) J Cell Physiol
    • Cantley, M.1    Fairlie, D.2    Bartold, P.3
  • 70
    • 33748451151 scopus 로고    scopus 로고
    • Anticancer activities of histone deacetylase inhibitors
    • DOI 10.1038/nrd2133, PII NRD2133
    • Bolden JE, Peart MJ, Johnstone RW. Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov 2006; 5:769-784. (Pubitemid 44348499)
    • (2006) Nature Reviews Drug Discovery , vol.5 , Issue.9 , pp. 769-784
    • Bolden, J.E.1    Peart, M.J.2    Johnstone, R.W.3
  • 71
    • 33646851955 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing nuclear factor-B activation
    • DOI 10.1074/jbc.M507213200
    • Takada Y, Gillenwater A, Ichikawa H, Aggarwal BB. Suberoylanilide hydroxamic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing nuclear factor-kB activation. J Biol Chem 2006; 281:5612-5622. (Pubitemid 43847658)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.9 , pp. 5612-5622
    • Takada, Y.1    Gillenwater, A.2    Ichikawa, H.3    Aggarwal, B.B.4
  • 72
    • 79954548904 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid (SAHA; vorinostat) causes bone loss by inhibiting immature osteoblasts
    • An in-vivo study of SAHA's effects on bone remodeling and bone mass that includes a thorough review of preclinical literature on SAHA's other skeletal effects
    • McGee-Lawrence ME, McCleary-Wheeler AL, Secreto FJ, et al. Suberoylanilide hydroxamic acid (SAHA; vorinostat) causes bone loss by inhibiting immature osteoblasts. Bone 2011; 48:1117-1126. An in-vivo study of SAHA's effects on bone remodeling and bone mass that includes a thorough review of preclinical literature on SAHA's other skeletal effects.
    • (2011) Bone , vol.48 , pp. 1117-1126
    • McGee-Lawrence, M.E.1    McCleary-Wheeler, A.L.2    Secreto, F.J.3
  • 74
    • 73949149251 scopus 로고    scopus 로고
    • Phase II multiinstitutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma
    • Piekarz RL, Frye R, Turner M, et al. Phase II multiinstitutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma. J Clin Oncol 2009; 27:5410-5417.
    • (2009) J Clin Oncol , vol.27 , pp. 5410-5417
    • Piekarz, R.L.1    Frye, R.2    Turner, M.3
  • 75
    • 78650992102 scopus 로고    scopus 로고
    • Phase 2 trial of the histone deacetylase inhibitor romidepsin for the treatment of refractory multiple myeloma
    • Niesvizky R, Ely S, Mark T, et al. Phase 2 trial of the histone deacetylase inhibitor romidepsin for the treatment of refractory multiple myeloma. Cancer 2011; 117:336-342.
    • (2011) Cancer , vol.117 , pp. 336-342
    • Niesvizky, R.1    Ely, S.2    Mark, T.3
  • 77
    • 78650594649 scopus 로고    scopus 로고
    • Early decrements in bone density after completion of neoadjuvant chemotherapy in pediatric bone sarcoma patients
    • An evaluation of BMD decrements in pediatric and adolescent Ewing's and osteosarcoma patients following completion of neoadjuvant therapy. BMD decrements were compared at the affected and nonaffected femoral neck in patients with lower extremity tumors, as well as in the lumbar spine and calcaneus
    • Muller C, Winter CC, Rosenbaum D, et al. Early decrements in bone density after completion of neoadjuvant chemotherapy in pediatric bone sarcoma patients. BMC Musculoskelet Disord 2010; 11:287. An evaluation of BMD decrements in pediatric and adolescent Ewing's and osteosarcoma patients following completion of neoadjuvant therapy. BMD decrements were compared at the affected and nonaffected femoral neck in patients with lower extremity tumors, as well as in the lumbar spine and calcaneus.
    • (2010) BMC Musculoskelet Disord , vol.11 , pp. 287
    • Muller, C.1    Winter, C.C.2    Rosenbaum, D.3
  • 78
    • 33746520783 scopus 로고    scopus 로고
    • Bone mineral density and bone metabolism in children treated for bone sarcomas
    • DOI 10.1203/01.pdr.0000219129.12960.c2, PII 0000645020060600000022
    • Ruza E, Sierrasesumaga L, Azcona C, Patino-Garcia A. Bone mineral density and bone metabolism in children treated for bone sarcomas. Pediatr Res 2006; 59:866-871. (Pubitemid 44297644)
    • (2006) Pediatric Research , vol.59 , Issue.6 , pp. 866-871
    • Ruza, E.1    Sierrasesumaga, L.2    Azcona, C.3    Patino-Garcia, A.4
  • 80
    • 0037396164 scopus 로고    scopus 로고
    • Reduced bone mineralization in adolescent survivors of malignant bone tumors: Comparison of quantitative ultrasound and dual-energy x-ray absorptiometry
    • DOI 10.1097/00043426-200304000-00006
    • Azcona C, Burghard E, Ruza E, et al. Reduced bone mineralization in adolescent survivors of malignant bone tumors: comparison of quantitative ultrasound and dual-energy x-ray absorptiometry. J Pediatr Hematol Oncol 2003; 25:297-302. (Pubitemid 36506216)
    • (2003) Journal of Pediatric Hematology/Oncology , vol.25 , Issue.4 , pp. 297-302
    • Azcona, C.1    Burghard, E.2    Ruza, E.3    Gimeno, J.4    Sierrasesumaga, L.5
  • 82
    • 79952743744 scopus 로고    scopus 로고
    • American society of clinical oncology executive summary of the clinical practice guideline update on the role of bone-modifying agents in metastatic breast cancer
    • A comprehensive summary by ASCO on the management of bone health in patients with metastatic breast cancer
    • Van Poznak CH, Temin S, Yee GC, et al. American society of clinical oncology executive summary of the clinical practice guideline update on the role of bone-modifying agents in metastatic breast cancer. J Clin Oncol 2011; 29:1221-1227. A comprehensive summary by ASCO on the management of bone health in patients with metastatic breast cancer.
    • (2011) J Clin Oncol , vol.29 , pp. 1221-1227
    • Van Poznak, C.H.1    Temin, S.2    Yee, G.C.3


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