Use of risedronate to prevent bone loss following a single course of glucocorticoids: Findings from a proof-of-concept study in inflammatory bowel disease

Osteoporosis International

Volumn 21, Issue 3, 2010, Pages 507-513

  Kriel, M H ^a   Tobias, J H ^b   Creed, T J ^c   Lockett, M ^d   Linehan, J ^e   Bell, A ^f   Przemioslo, R ^d   Smithson, J E ^c   Brooklyn, T N ^g   Fraser, W D ^h   Probert, C S J ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b SOUTHMEAD HOSPITAL   (United Kingdom)

^c UNIVERSITY HOSPITALS BRISTOL NHS FOUNDATION TRUST   (United Kingdom)

^d FRENCHAY HOSPITAL   (United Kingdom)

^e ROYAL UNITED HOSPITAL   (United Kingdom)

^f WESTON GENERAL HOSPITAL   (United Kingdom)

^g CHELTENHAM GENERAL HOSPITAL   (United Kingdom)

^h UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Bisphosphonate; Crohn's disease; Inflammatory bowel disease; Osteoporosis; Ulcerative colitis; Ward's triangle

Indexed keywords

CALCIUM; INFLIXIMAB; PLACEBO; PREDNISOLONE; PROTON PUMP INHIBITOR; RISEDRONIC ACID; SALAZOSULFAPYRIDINE; VITAMIN D;

ADULT; ARTICLE; BONE DENSITY; CHEMOPROPHYLAXIS; CLINICAL TRIAL; COLON RESECTION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CROHN DISEASE; DEEP VEIN THROMBOSIS; DISEASE EXACERBATION; DRUG DOSE REDUCTION; DRUG HYPERSENSITIVITY; DRUG INTERMITTENT THERAPY; DRUG WITHDRAWAL; DUAL ENERGY X RAY ABSORPTIOMETRY; ENTERITIS; FEMALE; GASTROESOPHAGEAL REFLUX; HIP; HUMAN; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; OSTEOLYSIS; PHARYNGITIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RELAPSE; SIDE EFFECT; TREATMENT DURATION; TREATMENT OUTCOME; ULCERATIVE COLITIS;

ABSORPTIOMETRY, PHOTON; ADULT; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; DRUG ADMINISTRATION SCHEDULE; ETIDRONIC ACID; FEMALE; GLUCOCORTICOIDS; HIP JOINT; HUMANS; INFLAMMATORY BOWEL DISEASES; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; OSTEOPOROSIS; PREDNISOLONE;

EID: 76549099415     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-009-0960-8     Document Type: Article

References (22)

1. JD Adachi EJ Sargeant MA Sagle D Lamont PD Fawcett WG Bensen M McQueen DJ Nazir CH Goldsmith 1997 A double-blind randomised controlled trial of the effects of medroxyprogesterone on bone density of women taking oestrogen replacement therapy Brit J Obstet Gynaecol 104 64 70
2. Saaq K, Emkey R, Gruber B, Tesser J, Lane N, Yanover M 1997 Alendronate for the management of glucocorticoid-induced osteoporosis: results of the multicenter US study. Arthritis Rheum ACR abstract 630
3. A Struys AA Snelder H Mulder 1995 Cyclical etidronate reverses bone loss of the spine and proximal femur in patients with established corticosteroid-induced osteoporosis Am J Med 99 235 242 10.1016/S0002-9343(99) 80154-5 7653482
4. S Wallach S Cohen DM Reid RA Hughes DJ Hosking RF Laan SM Doherty M Maricic C Rosen J Brown I Barton AA Chines 2000 Effects of risedronate treatment on bone density and vertebral fracture in patients on corticosteroid therapy Calcif Tissue Int 67 277 285 10.1007/s002230001146 11000340 (Pubitemid 30736856)
5. JH Tobias M Sasi R Greenwood CSJ Probert 2004 Rapid hip bone loss in Crohn's disease patients receiving corticosteroid therapy Aliment Pharmacol Ther 20 951 958 10.1111/j.1365-2036.2004.02207.x 15521842 (Pubitemid 39593276)
6. F De Vries M Bracke HG Leufkens JW Lammers C Cooper TP Van Staa 2007 Fracture risk with intermittent high-dose oral glucocorticoid therapy Arthritis Rheum 56 208 214 10.1002/art.22294 17195223 (Pubitemid 46106193)
7. TP van Staa C Cooper LS Brusse H Leufkens MK Javaid NK Arden 2003 Inflammatory bowel disease and the risk of fracture Gastroenterology 125 1591 1597 10.1053/j.gastro.2003.09.027 14724810 (Pubitemid 37500422)
8. SR Schwid AD Goodman JE Puzas MP McDermott DH Mattson 1996 Sporadic corticosteroid pulses and osteoporosis in multiple sclerosis Arch Neurol 53 753 757 8759981
9. B Frediani P Falsetti S Bisogno F Baldi C Acciai G Filippou MR Bacarelli P Filipponi M Galeazzi R Marcolongo 2004 Effects of high dose methylprednisolone pulse therapy on bone mass and biochemical markers of bone metabolism in patients with active rheumatoid arthritis: a 12-month randomized prospective controlled study J Rheumatol 31 1083 1087 15170918
10. A Dovio L Perazzolo G Osella M Ventura A Termine E Milano A Bertolotto A Angeli 2004 Immediate fall of bone formation and transient increase of bone resorption in the course of high-dose, short-term glucocorticoid therapy in young patients with multiple sclerosis J Clin Endocrinol Metab 89 4923 4928 10.1210/jc.2004-0164 15472186 (Pubitemid 39391429)
11. V Abitbol K Briot C Roux C Roy P Seksik A Charachon Y Bouhnik B Coffin M Allez D Lamarque S Chaussade 2007 A double-blind placebo-controlled study of intravenous clodronate for prevention of steroid-induced bone loss in inflammatory bowel disease Clin Gastroenterol Hepatol 5 1184 1189 10.1016/j.cgh.2007.05.016 17683996 (Pubitemid 47496232)
12. S Henderson N Hoffman R Prince 2006 A double-blind placebo-controlled study of the effects of the bisphosphonate risedronate on bone mass in patients with inflammatory bowel disease Am J Gastroenterol 101 119 123 10.1111/j.1572-0241.2006.00372.x 16405543 (Pubitemid 43381718)
13. KV Haderslev L Tjellesen HA Sorensen M Staun 2000 Alendronate increases lumbar spine bone mineral density in patients with Crohn's disease Gastroenterology 119 639 646 10.1053/gast.2000.16518 10982756
14. S Ghosh S Cowen WJ Hannan A Ferguson 1994 Low bone mineral density in Crohn's disease, but not in ulcerative colitis, at diagnosis Gastroenterology 107 1031 1039 7926456
15. EJ Lamb T Wong DJ Smith DE Simpson AJ Coakley C Moniz AF Muller 2002 Metabolic bone disease is present at diagnosis in patients with inflammatory bowel disease Aliment Pharmacol Ther 16 1895 1902 10.1046/j.1365-2036.2002. 01363.x 12390098 (Pubitemid 35253005)
16. SR Cummings DM Black MC Nevitt W Browner J Cauley K Ensrud HK Genant L Palermo J Scott TM Vogt 1993 Bone density at various sites for prediction of hip fractures Lancet 341 72 75 10.1016/0140-6736(93)92555-8 8093403 (Pubitemid 23028113)
17. DW Dempster 1989 Bone histomorphometry in glucocorticoid-induced osteoporosis J Bone Miner Res 4 137 141 10.1002/jbmr.5650040202 2658477
18. WF Lems MI Gerrits JW Jacobs RM van Vugt HJ van Rijn JW Bijlsma 1996 Changes in (markers of) bone metabolism during high dose corticosteroid pulse treatment in patients with rheumatoid arthritis Ann Rheum Dis 55 288 293 10.1136/ard.55.5.288 8660101
19. SC Manolagas SC Weinstein 1999 New developments in the pathogenesis and treatment of steroid-induced osteoporosis J Bone Miner Res 14 1061 1066 10.1359/jbmr.1999.14.7.1061 10404005 (Pubitemid 29314048)
20. JE Compston SJ Ryde RJ Motley EO Crawley WD Evans WD Morgan 1990 Longitudinal study of total body calcium measurements in patients with inflammatory bowel disease: correlations with quantitative CT and single photon absorptiometry Basic Life Sci 55 75 78 2088310
21. J Silvennoinen 1996 Relationships between vitamin D, parathyroid hormone and bone mineral density in inflammatory bowel disease J Intern Med 239 131 137 10.1046/j.1365-2796.1996.420765000.x 8568480 (Pubitemid 26043148)
22. H Vogelsang P Ferenci W Woloszczuk H Resch C Herold S Frotz A Gangl 1989 Bone disease in vitamin D-deficient patients with Crohn's disease Dig Dis Sci 34 1094 1099 10.1007/BF01536381 2743850