Fusion between cancer cells and myofibroblasts is involved in osteosarcoma

Oncology Letters

Volumn 2, Issue 6, 2011, Pages 1083-1087

  Yu, Ling ^a   Guo, Weichun ^a   Zhao, Shenghao ^a   Wang, Fuan ^a   Xu, Yong ^a  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

smooth muscle actin; Cell fusion; Myofibroblast; Osteosarcoma

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN;

ADULT; ANIMAL CELL; ARTICLE; CANCER CELL; CANCER GROWTH; CELL COMMUNICATION; CELL FUSION; CHILD; COCULTURE; CONTROLLED STUDY; EMBRYO; FEMALE; GIANT CELL; HUMAN; MALE; MOUSE; MYOFIBROBLAST; NONHUMAN; OSTEOSARCOMA; PROTEIN EXPRESSION; SCHOOL CHILD;

EID: 80052723991     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2011.363     Document Type: Article

References (28)

1. Ottaviani G and Jaffe N: The epidemiology of osteosarcoma. Cancer Treat Res 152: 3-13, 2009.
2. Hansen MF, Koufos A, Gallie BL, et al: Osteosarcoma and retinoblastoma: a shared chromosomal mechanism revealing recessive predisposition. Proc Natl Acad Sci USA 82: 6216-6120, 1985.
3. Porter DE, Holden ST, Steel CM, Cohen BB, Wallace MR and Reid R: A significant proportion of patients with osteosarcoma may belong to Li-Fraumeni cancer families. J Bone Joint Surg Br 74: 883-886, 1992.
4. Selvarajah S, Yoshimoto M, Ludkovski O, et al: Genomic signatures of chromosomal instability and osteosarcoma progression detected by high resolution array CGH and interphase FISH. Cytogenet Genome Res 122: 5-15, 2008.
5. Bayani J, Zielenska M, Pandita A, et al: Spectral karyotyping identifies recurrent complex rearrangements of chromosomes 8, 17, and 20 in osteosarcomas. Genes Chromosomes Cancer 36: 7-16, 2003.
6. Ogle BM, Cascalho M and Platt JL: Biological implications of cell fusion. Nat Rev Mol Cell Biol 6: 567-575, 2005.
7. Lu X and Kang Y: Cell fusion as a hidden force in tumor progression. Cancer Res 69: 8536-8539, 2009.
8. Orimo A, Tomioka Y, Shimizu Y, et al: Cancer-associated myofibroblasts possess various factors to promote endometrial tumor progression. Clin Cancer Res 7: 3097-3105, 2001.
9. Garfield AS: Derivation of primary mouse embryonic fibroblast (PMEF) cultures. Methods Mol Biol 633: 19-27, 2010.
10. Meister P, Konrad E, Lob G, Janka G, Keyl W and Stürz H: Osteosarcoma: histological evaluation and grading. Arch Orthop Trauma Surg 94: 91-98, 1979.
11. Tsujino T, Seshimo I, Yamamoto H, et al: Stromal myofibroblasts predict disease recurrence for colorectal cancer. Clin Cancer Res 13: 2082-2090, 2007.
12. Henry LR, Lee HO, Lee JS, et al: Clinical implications of fibroblast activation protein in patients with colon cancer. Clin Cancer Res 13: 1736-1741, 2007.
13. Cohen SJ, Alpaugh RK, Palazzo I, et al: Fibroblast activation protein and its relationship to clinical outcome in pancreatic adenocarcinoma. Pancreas 37: 154-158, 2008.
14. Infante JR, Matsubayashi H, Sato N, et al: Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma. J Clin Oncol 25: 319-325, 2007.
15. Sasaki T, Nakamura T, Rebhun RB, et al: Modification of the primary tumor microenvironment by transforming growth factor alpha-epidermal growth factor receptor signaling promotes metastasis in an orthotopic colon cancer model. Am J Pathol 173: 205-16, 2008.
16. Kalluri R and Zeisberg M: Fibroblasts in cancer. Nat Rev Cancer 6: 392-401, 2006.
17. Shekhar MP, Santner S, Carolin KA and Tait L: Direct involvement of breast tumor fibroblasts in the modulation of tamoxifen sensitivity. Am J Pathol 170: 1546-1560, 2007.
18. Koukourakis MI, Giatromanolaki A, Harris AL and Sivridis E: Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma. Cancer Res 66: 632-637, 2006.
19. Karnoub AE, Dash AB, Vo AP, et al: Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449: 557-563, 2007.
20. Ishii G, Sangai T, Oda T, et al: Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction. Biochem Biophys Res Commun 309: 232-240, 2003.
21. Direkze NC, Hodivala-Dilke K, Jeffery R, et al: Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts. Cancer Res 64: 8492-8495, 2004.
22. Radisky DC, Kenny PA and Bissell MJ: Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT? J Cell Biochem 101: 830-839, 2007.
23. Zeisberg EM, Potenta S, Xie L, Zeisberg M and Kalluri R: Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res 67: 10123-10128, 2007.
24. Mishra PJ, Mishra PJ, Humeniuk R, et al: Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells. Cancer Res 68: 4331-4339, 2008.
25. Miller FR, McInerney D, Rogers C and Miller BE: Spontaneous fusion between metastatic mammary tumor subpopulations. J Cell Biochem 36: 129-136, 1988.
26. Duelli D and Lazebnik Y: Cell fusion: a hidden enemy? Cancer Cell 3: 445-448, 2003.
27. Andersen TL, Boissy P, Sondergaard TE, et al: Osteoclast nuclei of myeloma patients show chromosome translocations specific for the myeloma cell clone: a new type of cancer-host partnership? J Pathol 211: 10-17, 2007.
28. Mortensen K, Lichtenberg J, Thomsen PD and Larsson LI: Spontaneous fusion between cancer cells and endothelial cells. Cell Mol Life Sci 61: 2125-2131, 2004.