Protective effect of thymic humoral factor on porcine serum-induced hepatic fibrosis and liver damage in wistar rats

Annals of Hepatology

Volumn 10, Issue 4, 2011, Pages 540-551

  Osuna Martínez, Ulises ^a   Reyes Esparza, Jorge Alberto ^a   Petricevich, Vera L ^a   Hernández Pando, Rogelio ^b   Rodríguez Fragoso, Lourdes ^a  

^a UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MORELOS   (Mexico)

^b INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

Author keywords

Autoimmune; Fibrosis; Hepatitis; IL 10; IL 6; THF

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE; HUMORAL THYMUS FACTOR; INTERLEUKIN 10; INTERLEUKIN 6;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFICACY; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; LIVER FIBROSIS; LIVER INJURY; LIVER PROTECTION; MALE; NONHUMAN; PROTEIN BLOOD LEVEL; RAT; TREATMENT DURATION; WISTAR RAT;

EID: 80052722520     PISSN: 16652681     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1665-2681(19)31523-6     Document Type: Article

References (51)

1. Parsons CJ, Takashima M, Rippe RA. Molecular mechanisms of hepatic fibrogenesis. J Gastroenterol Hepatol 2007; 22(Suppl. 1): S79-S84.
2. Dang SS, Wang BF, Cheng YA, Song P, Liu ZG, Li ZF. Inhibitory effects of saikosaponin-d on CCl4-induced hepatic fibrogenesis in rats. World J Gastroenterol 2007; 13(4): 557-63.
3. Liu H, Wei W, Sun WY, Li X. Protective effects of astragaloside IV on porcine-serum-induced hepatic fibrosis in rats and in vitro effects on hepatic stellate cells. J Ethnopharmacol 2009; 122(3): 502-8.
4. Friedman SL. Evolving challenges in hepatic fibrosis. Nat Rev Gastroenterol Hepatol 2010; 7(8): 425-36.
5. Ramadori G, Moriconi F, Malik I, Dudas J. Physiology and pathophysiology of liver inflammation, damage and repair. J Physiol Pharmacol 2008; 59(Suppl. 1): 107-17.
6. Tiggelman Anke MBC, Boers W, Linthorst C, Brand HS, Sala M, Chamuleau Robert AFM. Interleukin-6 production by human liver (myo) fibroblasts in culture. Evidence for a regulatory role of LPS, IL-1β and TNFa. J Hepatol 1995; 23: 295-306.
7. Toda K, Kumagai N, Kaneko F, Tsunematsu S, Tsuchimoto K, Saito H, Hibi T. Pentoxifylline prevents pig serum-induced rat liver fibrosis by inhibiting interleukin-6 produc tion. J Gastroenterol Hepatol 2009; 24(5): 860-5.
8. Gressner AM, Gao CF, Gressner OA. Non-invasive biomarkers for monitoring the fibrogenic process in liver: a short survey. World J Gastroenterol 2009; 15(20): 2433-40.
9. Gressner AM, Weiskirchen R. Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets. J Cell Mol Med 2006; 10(1): 76-99.
10. Peng XD, Dai LL, Huang CQ, He CM, Chen LJ. Correlation between anti-fibrotic effect of baicalin and serum cytokines in rat hepatic fibrosis. World J Gastroenterol 2009; 15(37): 4720-5.
11. Hasegawa-Baba Y, Doi K. Changes in TIMP-1 and -2 expression in the early stage of porcine serum-induced liver fibrosis in rats. Exp Toxicol Pathol 2010; 10 [In press].
12. Albillos A, Nieto M, Ubeda M, Muñoz L, Fraile B, Reyes E, Lledó L, et al. The biological response modifier AM3 attenuates the inflammatory cell response and hepatic fibrosis in rats with biliary cirrhosis. Gut 2010; 59(7): 943-52.
13. Wang ZL, Wu XH, Song LF, Wang YS, Hu XH, Luo YF, Chen ZZ, et al. Phosphoinositide 3-kinase gamma inhibitor ameliorates concanavalin A-induced hepatic injury in mice. Biochem Biophys Res Commun 2009; 386(4): 569-74.
14. Goso C, Frasca D, Doria G. Effect of synthetic thymic humoral factor (THF-gamma 2) on T cell activities in immunodeficient ageing mice. Clin Exp Immunol 1992; 87(3): 346-51.
15. Ben-Hur H, Pecht M, Netzer L, Borenstein R, Blickstein I, Burstein Y, Trainin N. Immune modulation exerted by thymic humoral factor (THF-gamma 2), on T-cell subsets and IL-2 production of umbilical cord blood lymphocytes. Immunopharmacol Immunotoxicol 1990; 12(1): 123-33.
16. Farhat BA, Marinos G, Daniels HM, Naoumov NV, Williams R. Evaluation of efficacy and safety of thymus humoral factor-gamma 2 in the management of chronic hepatitis B. J Hepatol 1995; 23(1): 21-7.
17. Daniels HM, O'Toole A, Hussein MJ, Corridori S, Alexander GJ, Williams R. THF gamma 2 stimulates cytokine release by peripheral blood mononuclear cells of patients with chronic hepatitis B virus infection. J Hepatol 1994; 20(3): 370-5.
18. Rosina F, Conoscitore P, Smedile A, Mangia A, Borghesio E, Martinotti R, Andriulli A, et al. Treatment of chronic hepatitis D with thymus-derived polypeptide thymic humoral factor-gamma 2: a pilot study. Dig Liver Dis 2002; 34(4): 285-9.
19. Rager-Zisman B, Zuckerman F, Benharroch D, Pecht M, Burstein Y, Trainin N. Therapy of a fatal murine cytomegalovirus infection with thymic humoral factor (THF-gamma 2) treated immune spleen cells. Clin Exp Immunol 1990; 79(2): 246-52.
20. Revised guide for the care and use of laboratory animals. NIH guide 1996; 25(28).
21. Paronetto F, Popper H., Chronic liver injury induced by immunologic reactions. Cirrhosis following immunization with heterologous sera. Am J Pathol 1966; 49(6): 1087-101.
22. Li C, Luo J, Li L, Cheng M, Huang N, Liu J, Waalkes MP. The collagenolytic effects of the traditional Chinese medicine preparation, Han-Dan-Gan-Le, contribute to reversal of chemical-induced liver fibrosis in rats. Life Sci 2003; 72(14): 1563-71.
23. Baba Y, Saeki K, Onodera T, Doi K. Serological and immunohistochemical studies on porcine-serum-induced hepatic fibrosis in rats. Exp Mol Pathol 2005; 79(3): 229-35.
24. Liu H, Wei W, Li X. Celecoxib exacerbates hepatic fibrosis and induces hepatocellular necrosis in rats treated with porcine serum. Prostaglandins Other Lipid Mediat 2009; 88(3-4): 63-7.
25. Young-Gyu, Mi-La, So-Youn, Ho-Youn. Type II collagen autoimmunity in a mouse model of human rheumatoid arthritis. Autoimmun Rev 2007: (7): 65-77.
26. Baba Y, Doi K. MHC class II-related genes expression in porcine-serum-induced rat hepatic fibrosis. Exp Mol Pathol 2004; 77(3): 214-21.
27. Minz RW, Chhabra S, Aggarwal R, Das A, Saikia B, Chawla YK. Incipient primary biliary cirrhosis/autoimmune hepatitis overlap or hepatitic form of primary biliary cirrhosis: a case report. Cases J 2009; 2: 7491.
28. Gupta P, Hart J, Millis JM, Cronin D, Brady L. De novo hepatitis with autoimmune antibodies and atypical histology: a rare cause of late graft dysfunction after pediatric liver transplantation. Transplantation 2001; 71(5): 664-8.
29. Maggiore G, Riva S, Sciveres M. Autoimmune diseases of the liver and biliary tract and overlap syndromes in childhood. Minerva Gastroenterol Dietol 2009; 55(1): 53-70.
30. Ejilemele AA, Orluwene CG. Biochemical changes in chronic alcoholics in port harcourt: the report of a pilot survey. Niger Postgrad Med J 2010; 17(2): 154-9.
31. Verweij CL, Bayley JP, Bakker A, Kaijzel EL. Allele specific regulation of cytokine genes: monoallelic expression of the IL-1A gene. Adv Exp Med Biol 2001; 495: 129-39.
32. Malhi H, Gores GJ. Cellular and molecular mechanisms of liver injury. Gastroenterology 2008; 134(6): 1641-54.
33. Vergani D, Mieli-Vergani G. Aetiopathogenesis of autoimmune hepatitis. World J Gastroenterol 2008; 14(21): 3306-12.
34. Kremer AE, Rust C, Eichhorn P, Beuers U, Holdenrieder S. Immune-mediated liver diseases: programmed cell death ligands and circulating apoptotic markers. Expert Rev Mol Diagn 2009; 9(2): 139-56.
35. Kahraman A, Gerken G, Canbay A. Apoptosis in immunemediated liver diseases. Dig Dis 2010; 28(1): 144-9.
36. Hofer H, Oesterreicher C, Wrba F, Ferenci P, Penner E. Centrilobular necrosis in autoimmune hepatitis: a histological feature associated with acute clinical presentation. J Clin Pathol 2006; 59(3): 246-9.
37. Muriel P. NF-kappaB in liver diseases: a target for drug therapy. J Appl Toxicol 2009; 29(2): 91-100.
38. Solís Herruzo JA, de la Torre P, Díaz Sanjuán T, García Ruiz I, Muñoz Yagüe T. IL-6 and extracellular matrix remodeling. Rev Esp Enferm Dig 2005; 97(8): 575-95.
39. Greenwel P, Iraburu MJ, Reyes-Romero M, Meraz-Cruz N, Casado E, Solis-Herruzo JA, Rojkind M. Induction of an acute phase response in rats stimulates the expression of alpha 1(I) procollagen messenger ribonucleic acid in their livers. Possible role of interleukin-6. Lab Invest 1995; 72(1): 83-91.
40. Tiggelman AM, Boers W, Linthorst C, Brand HS, Sala M, Chamuleau RA. Interleukin-6 production by human liver (myo)fibroblasts in culture. Evidence for a regulatory role of LPS, IL-1 beta and TNF alpha. J Hepatol 1995; 23(3): 295-306.
41. Toda K, Kumagai N, Tsuchimoto K, Inagaki H, Suzuki T, Oishi T, Atsukawa K, et al. Induction of hepatic stellate cell proliferation by LPS-stimulated peripheral blood mononuclear cells from patients with liver cirrhosis. J Gastroenterol 2000; 35(3): 214-20.
42. Dinant S, Veteläinen RL, Florquin S, van Vliet AK, van Gulik TM. IL-10 attenuates hepatic I/R injury and promotes hepatocyte proliferation. J Surg Res 2007; 141(2): 176-82.
43. Rabelo F, Oliveira CP, Faintuch J, Mazo DF, Lima VM, Stefano JT, Barbeiro HV, et al. Pro- and anti-inflammatory cytokines in steatosis and steatohepatitis. Obes Surg 2010; 20(7): 906-12.
44. Diveu C, McGeachy MJ, Cua DJ. Cytokines that regulate autoimmunity. Curr Opin Immunol 2008; 20(6): 663-8.
45. Cintra DE, Pauli JR, Araújo EP, Moraes JC, de Souza CT, Milanski M, Morari J, et al. Interleukin-10 is a protective factor against diet-induced insulin resistance in liver. J Hepatol 2008; 48(4): 628-37.
46. Kaplan DE, Ikeda F, Li Y, Nakamoto N, Ganesan S, Valiga ME, Nunes FA, et al. Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis. J Hepatol 2008; 48(6): 903-13.
47. den Boer MA, Voshol PJ, Schröder-van der Elst JP, Korsheninnikova E, Ouwens DM, Kuipers F, Havekes LM, et al. Endogenous interleukin-10 protects against hepatic steatosis but does not improve insulin sensitivity during high-fat feeding in mice. Endocrinology 2006; 147(10): 4553-8.
48. Hanabuchi S, Ito T, Park WR, Watanabe N, Shaw JL, Roman E, Arima K, et al. Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of FOXP3+ regulatory T cells in human thymus. J Immunol 2010; 184(6): 2999-3007.
49. Saraiva M, Christensen JR, Veldhoen M, Murphy TL, Murphy KM, O'Garra A. Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose. Immunity 2009; 31(2): 209-19.
50. Braga M, Gianotti L, Gentilini O, Fortis C, Consogno G, Di Carlo V. Thymopentin modulates Th1 and Th2 cytokine response and host survival in experimental injury. J Surg Res. 1996; 62(2): 197-200.
51. Colic M, Popovic R, Mrdakovic D, Radeta M, Novakovic J, Pavlovic B, Vucevic D. Evaluation of the immunomodulatory properties of a calf lipid thymus extract and standardization of a method for quantification of its biological activity. Am J Immunol 2008; 3(2): 35-44.