Nell-1, an osteoinductive factor, is a direct transcriptional target of Osterix

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Chen, Feng ^a,d   Zhang, Xinli ^a   Sun, Shan ^a   Zara, Janette N ^b   Zou, Xuan ^a   Chiu, Robert ^a   Culiat, Cymbelin T ^c   Ting, Kang ^a   Soo, Chia ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of California   (United States)

^c OAK RIDGE NATIONAL LABORATORY   (United States)

^d PEKING UNIVERSITY SCHOOL AND HOSPITAL OF STOMATOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

NEL LIKE MOLECULE 1; PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; NELL1 PROTEIN, HUMAN; NERVE PROTEIN; SMALL INTERFERING RNA; SP7 PROTEIN, HUMAN; TRANSCRIPTION FACTOR SP1;

ARTICLE; BINDING SITE; BIOMINERALIZATION; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA FLANKING REGION; DOWN REGULATION; GEL MOBILITY SHIFT ASSAY; GENE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NELL 1 GENE; NUCLEOTIDE SEQUENCE; OSTEOBLAST; OSTEOSARCOMA CELL; PROMOTER REGION; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION; CELL CULTURE; CELL LINE; GENETICS; METABOLISM; PROTEIN BINDING; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BINDING SITES; CELL LINE; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HUMANS; NERVE TISSUE PROTEINS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS;

EID: 80052710271     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024638     Document Type: Article

References (28)

1. Matsuhashi S, Noji S, Koyama E, Myokai F, Ohuchi H, et al. (1995) New gene, nel, encoding a M(r) 93 K protein with EGF-like repeats is strongly expressed in neural tissues of early stage chick embryos. Dev Dyn 203: 212-222.
2. Watanabe TK, Katagiri T, Suzuki M, Shimizu F, Fujiwara T, et al. (1996) Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats. Genomics 38: 273-276.
3. Truong T, Zhang X, Pathmanathan D, Soo C, Ting K, (2007) Craniosynostosis-associated gene nell-1 is regulated by runx2. J Bone Miner Res 22: 7-18.
4. Ting K, Vastardis H, Mulliken JB, Soo C, Tieu A, et al. (1999) Human NELL-1 expressed in unilateral coronal synostosis. J Bone Miner Res 14: 80-89.
5. Zhang X, Kuroda S, Carpenter D, Nishimura I, Soo C, et al. (2002) Craniosynostosis in transgenic mice overexpressing Nell-1. J Clin Invest 110: 861-870.
6. Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, et al. (2006) Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Hum Mol Genet 15: 1329-1341.
7. Zhang X, Ko T, Pathmanathan D, Lee H, Chen F, et al. (2008) Craniofacial Bone Defect in Nell-1 Mutant Mice Associated with Disregulated Runx2 and Osx Expression. J Bone Miner Res 23: S99.
8. Zhang X, Ting K, Bessette CM, Culiat CT, Sung SJ, et al. (2010) Nell-1, a key functional mediator of Runx2, partially rescues calvarial defects in Runx2(+/-) mice. J Bone Miner Res 26: 777-791.
9. Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, et al. (2002) The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108: 17-29.
10. Koga T, Matsui Y, Asagiri M, Kodama T, de Crombrugghe B, et al. (2005) NFAT and Osterix cooperatively regulate bone formation. Nat Med 11: 880-885.
11. Karsenty G, (2008) Transcriptional control of skeletogenesis. Annu Rev Genomics Hum Genet 9: 183-196.
12. Nishio Y, Dong Y, Paris M, O'Keefe RJ, Schwarz EM, et al. (2006) Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene. Gene 372: 62-70.
13. Ulsamer A, Ortuno MJ, Ruiz S, Susperregui AR, Osses N, et al. (2008) BMP-2 induces Osterix expression through up-regulation of Dlx5 and its phosphorylation by p38. J Biol Chem 283: 3816-3826.
14. Nakashima K, de Crombrugghe B, (2003) Transcriptional mechanisms in osteoblast differentiation and bone formation. Trends Genet 19: 458-466.
15. Kaback LA, Soung do Y, Naik A, Smith N, Schwarz EM, et al. (2008) Osterix/Sp7 regulates mesenchymal stem cell mediated endochondral ossification. J Cell Physiol 214: 173-182.
16. Aghaloo T, Cowan CM, Chou YF, Zhang X, Lee H, et al. (2006) Nell-1-induced bone regeneration in calvarial defects. Am J Pathol 169: 903-915.
17. Goto T, Matsui Y, Fernandes RJ, Hanson DA, Kubo T, et al. (2006) Sp1 family of transcription factors regulates the human alpha2 (XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells. J Bone Miner Res 21: 661-673.
18. McQuillan DJ, Richardson MD, Bateman JF, (1995) Matrix deposition by a calcifying human osteogenic sarcoma cell line (SAOS-2). Bone 16: 415-426.
19. Rao LG, Liu LJ, Murray TM, McDermott E, Zhang X, (2003) Estrogen added intermittently, but not continuously, stimulates differentiation and bone formation in SaOS-2 cells. Biol Pharm Bull 26: 936-945.
20. Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, et al. (1997) Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89: 755-764.
21. Cowan CM, Cheng S, Ting K, Soo C, Walder B, et al. (2006) Nell-1 induced bone formation within the distracted intermaxillary suture. Bone 38: 48-58.
22. Zhang C, Cho K, Huang Y, Lyons JP, Zhou X, et al. (2008) Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix. Proc Natl Acad Sci U S A 105: 6936-6941.
23. Cao Y, Jia SF, Chakravarty G, de Crombrugghe B, Kleinerman ES, (2008) The osterix transcription factor down-regulates interleukin-1 alpha expression in mouse osteosarcoma cells. Mol Cancer Res 6: 119-126.
24. Cook T, Gebelein B, Urrutia R, (1999) Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors. Ann N Y Acad Sci 880: 94-102.
25. Sinha KM, Yasuda H, Coombes MM, Dent SY, de Crombrugghe B, (2010) Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase. EMBO J 29: 68-79.
26. Komori T, (2006) Regulation of osteoblast differentiation by transcription factors. J Cell Biochem 99: 1233-1239.
27. Deng ZL, Sharff KA, Tang N, Song WX, Luo J, et al. (2008) Regulation of osteogenic differentiation during skeletal development. Front Biosci 13: 2001-2021.
28. Lemon B, Tjian R, (2000) Orchestrated response: a symphony of transcription factors for gene control. Genes Dev 14: 2551-2569.