Does glucagon like peptide-2 receptor expression have any effect on the development of human colorectal cancer?

Turkish Journal of Gastroenterology

Volumn 22, Issue 4, 2011, Pages 388-394

  Bengi, Göksel ^a   Kayahan, Hasan ^a   Akarsu, Mesut ^a   Aysal, Anil ^a   Saǧol, Özgül ^a   Meral, Murat ^a   Akpinar, Hale ^a  

^a DOKUZ EYLUL UNIVERSITY   (Turkey)

Author keywords

Colon polyp; Colorectal cancer; Glucagon like peptide 2

Indexed keywords

GLUCAGON LIKE PEPTIDE 2; GLUCAGON LIKE PEPTIDE 2 RECEPTOR; HORMONE RECEPTOR; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER LOCALIZATION; CANCER PATIENT; CANCER TISSUE; CLINICAL ARTICLE; COLON ADENOMA; COLON BIOPSY; COLON CARCINOGENESIS; COLON MUCOSA; COLON POLYP; COLORECTAL CANCER; CONTROLLED STUDY; ENDOSCOPY; ENTEROENDOCRINE CELL; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; OUTCOME ASSESSMENT; PROTEIN EXPRESSION;

ADENOCARCINOMA; ADENOMA; ADULT; AGED; AGED, 80 AND OVER; COLONIC POLYPS; COLORECTAL NEOPLASMS; FEMALE; GLUCAGON-LIKE PEPTIDE 2; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; RECEPTORS, GLUCAGON;

EID: 80052692323     PISSN: 13004948     EISSN: None     Source Type: Journal    
DOI: 10.4318/tjg.2011.0243     Document Type: Article

References (18)

1. Ries LA, Wingo PA, Miller DS, et al. The annual report to the nation on the status of cancer, 1973-1997, with a special section on colorectal cancer. Cancer 2000; 88: 2398-424.
2. Edwards BK, Howe HL, Ries LA, et al. Annual report to the nation on the status of cancer, 1973-1999, featuring implications of age and aging on U.S. cancer burden. Cancer 2002; 94: 2766-92.
3. Damholt AB, Buchan AM, Holst JJ, et al. Proglucagon processing profile in canine L cells expressing endogenous prohormone convertase 1/3 and prohormone convertase 2. Endocrinology 1999; 140: 4800-8. (Pubitemid 30666150)
4. Jeppesen PB, Hartmann B, Thulesen J, et al. Glucagon-like peptide 2 improves nutrient absorption and nutritional status in short-bowel patients with no colon. Gastroenterology 2001; 120: 806-15. (Pubitemid 32193176)
5. Hartmann B, Harr MB, Jeppesen PB, et al. In vivo and in vitro degradation of glucagon-like peptide-2 in humans. J Clin Endocrinol Metab 2000; 85: 2884-8.
6. Xiao Q, Boushey RP, Cino M, et al. Circulating levels of glucagon-like peptide-2 in human subjects with inflammatory bowel disease. Am J Physiol Regul Integr Comp Physiol 2000; 278: R1057-63.
7. Brubaker PL, Drucker DJ. Minireview: glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system. Endocrinology 2004; 145: 2653-9. (Pubitemid 38686211)
8. Gleeson MH, Bloom SR, Polak JM, et al. Endocrine tumour in kidney affecting small bowel structure, motility and absorptive function. Gut. 1971; 12: 773-82.
9. Chance WT, Foley-Nelson T, Thomas I, et al. Prevention of parenteral nutrition-induced gut hypoplasia by coinfusion of glucagon-like peptide-2. Am J Physiol 1997; 273: G559-63.
10. Boushey RP, Yusta B, Drucker DJ. Glucagon-like peptide 2 decreases mortality and reduces the severity of indomethacin-induced murine enteritis. Am J Physiol 1999; 277: E937-47.
11. Prasad R, Alavi K, Schwartz MZ. Glucagonlike peptide-2 analogue enhances intestinal mucosal mass after ischemia and reperfusion. J Pediatr Surg 2000; 35: 357-9. (Pubitemid 30082600)
12. Drucker DJ, Yusta B, Boushey RP, et al. Human [Gly2]GLP-2 reduces the severity of colonic injury in a murine model of experimental colitis. Am J Physiol 1999; 276: G79-91.
13. Tavakkolizadeh A, Shen R, Abraham P, et al. Glucagon-like peptide 2: a new treatment for chemotherapy-induced enteritis. J Surg Res 2000; 99(1): 77-82. (Pubitemid 30340900)
14. Boushey RP, Yusta B, Drucker DJ. Glucagon-like peptide (GLP)-2 reduces chemotherapy-associated mortality and enhances cell survival in cells expressing a transfected GLP-2 receptor. Cancer Res 2001; 61: 687-93. (Pubitemid 32128634)
15. Thulesen J, Hartmann B, Hare KJ, et al. Glucagon-like peptide 2 (GLP-2) accelerates the growth of colonic neoplasms in mice. Gut 2004; 53: 1145-50. (Pubitemid 38961969)
16. Bulut K, Meier JJ, Ansorge N, et al. Glucagon-like peptide 2 improves intestinal wound healing through induction of epithelial cell migration in vitro-evidence for a TGF-beta-mediated effect. Regul Pept 2004; 121: 137-43. (Pubitemid 38901072)
17. Masur K, Schwartz F, Entschladen F, et al. DPPIV inhibitors extend GLP-2 mediated tumour promoting effects on intestinal cancer cells. Regul Pept 2006; 137: 147-55. (Pubitemid 44841989)
18. Yusta B, Huang L, Munroe D, et al. Enteroendocrine localization of GLP-2 receptor expression in humans and rodents. Gastroenterology 2000; 119: 744-55.