Design and development of solid self-micro-emulsifying drug delivery system (SMEDDS) of fenofibrate

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 3, Issue SUPPL. 4, 2011, Pages 163-166

  Mahajan Harshal, D ^a   Tanvir, Shaikh ^a   Dheeraj, Baviskar ^b   Rajendra Wagh, D ^a  

^a A R A College of Pharmacy Nagaon   (India)

^b Institute of Pharmaceutical Education   (India)

Author keywords

Adsorbent; Fenofibrate; Magnesium alminometa silicate; Microporous calcium silicate; Self microemulsifying; Silicon dioxide and microcrystalline cellulose

Indexed keywords

CALCIUM SILICATE; CREMOPHOR; FENOFIBRATE; FLORITE; MICROCRYSTALLINE CELLULOSE; NEUSILIN; POLYSORBATE 20; SYLYSIS; UNCLASSIFIED DRUG;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SOLUBILITY; FREEZE THAWING; MICROEMULSION; PARTICLE SIZE; SELF MICRO EMULSIFYING DRUG DELIVERY SYSTEM; ULTRAVIOLET SPECTROPHOTOMETRY;

EID: 80052657806     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Pouton CW. Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems. Eur J Pharm Sci. 2000; 11: S93-S98.
2. Constantinides PP. Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharm Res. 1995; 12: 1561-1572.
3. Kim HJ, Yoon KA, Hahn M, Park ES, Chi SC. Preparation and in vitro evaluation of self-microemulsifying drug delivery systems containing idebenone. Drug Dev Ind Pharm. 2000; 26: 523-529.
4. Kang BK, Lee JS, Chona SK, et al. Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs. Int J Pharm. 2004; 274: 65-73.
5. Kasim NA, Whitehouse M, Ramachandran C, et al. Molecular properties of WHO essential drugs and provisional biopharmaceutical classification. Mol Pharm. 2004; 1: 85-96.
6. Shah NH, Carvajal MT, Patel CI, Infeld MH, Malick AW. Self-emulsifying drug delivery systems (SEDDS) with polyglycolysed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs. Int J Pharm. 1994; 106: 15-23.
7. Charman SA, Charman WN, Rogge MC, Wilson TD, Dutko FJ, Pouton CW. Self emulsifying drug delivery systems: formulation and biopharmaceutical evaluation of an investigational lipophilic compound. Pharm Res. 1992; 9: 87-93.
8. Kommuru TR, Gurley B, Khan MA, Reddy IK. Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment. Int J Pharm. 2001; 212: 233-246.
9. Kasim NA, Whitehouse M, Ramachandran C, et al. Molecular properties of WHO essential drugs and provisional biopharmaceutical classification. Mol Pharm. 2004; 1: 85-96.
10. Patel AR, Vavia PR. Effect of hydrophilic polymer on solubilization of fenofibrate by cyclodextrin complexation. J Incl Phenom Macrocycl Chem. 2006; 56: 247-251.
11. Law D, Wang W, Schmitt E, Qiu Y, Krill SK, Fort JJ. Properties of rapidly dissolving eutectic mixtures of poly(ethylene glycol) and fenofibrate: the eutectic microstructure. J Pharm Sci. 2003; 92: 505-515.
12. Laruelle C.P. Harmaceitical dosage formulation of Fenofibrate & their application. US Patent 58,27,536 (1998)
13. Ashok R. Patel, Pradeep R. Vavia. Preparation and In Vivo Evaluation of SMDDS (Self-Microemulsifing Drug Delivery System) Containing Fenofibrate. AAPS 2007; 9(3) Articles 41.
14. Patil P, Joshi P, Paradkar A. Effect of formulation variables on preparation and evaluation of self emulsifying drug delivery system (SMEDDS) of detoprofen. AAPS SciTech. 2004; 5: 321-329.
15. Gursoy RN, Benita S. Self emulsifying drug delivery system (SMEDDS) for improved drug delivery of lipophillic drug. Biomed. Pharmaco. 2004; 58: 173-182.
16. Gershanik T, Benita S. Self dispersing lipid formulations for improving oral absorption of lipophillic drugs. Eur J Pharm. Biopharm. 2000; 50: 173-182.
17. Woo JS, Song YK, and Ji-Yeon Hong. Reduced food-effect and enhanced bioavailability of a self-microemulsifying formulation of itraconazole in healthy volunteers. Euro J Pharma Scis 2008; 33: 159-165.
18. Constantinides PP, Scalart JP. Formulation and physical characterization of water-in-oil microemulsions containing long versus medium chain length glycerides. Int. J Pharm 1997; 158:57-68.
19. Pouton C. Self emulsifying drug delivery. Adv. Drug Deliv. Rev 1996; 19: 154-159.
20. M. Nagaraju Patro, Adhikrao V. Yadav. Formulation Design and Evaluation of Self Micro Emulsifying Drug Delivery System (SMEDDS) of Valproic acid. Jordan Journal of Pharmaceutical Sciences, Volume 3, No. 2, 2010.