Formulation and evaluation of sustained release implantable microspheres of temozolomide for brain targeting prepared by a novel technique

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 3, Issue SUPPL. 4, 2011, Pages 187-194

  Thirupathy, Archana ^a   Srinivas, Prathima ^a   Ravindhra Babu, D S ^b   Mamidi, Sadanandhan ^a  

^a Sri Venkateshwara College of Pharmacy   (India)

^b Celon Laboratories PvtLtd   (India)

Author keywords

Microspheres; PLGA; Solvent evaporation; Solvent extraction

Indexed keywords

MICROSPHERE; POLYGLACTIN; TEMOZOLOMIDE;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG HALF LIFE; DRUG RELEASE; DRUG SYNTHESIS; DRUG TARGETING; ENCAPSULATION; FEASIBILITY STUDY; IN VITRO STUDY; MULTIPLE CYCLE TREATMENT; PARTICLE SIZE; SCANNING ELECTRON MICROSCOPY; SUSTAINED RELEASE FORMULATION;

EID: 80052655542     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Madan madhu, Lewis shaila, Baig jamal anwar. Biodegradable injectable implant systems for sustained delivery using poly (lactide-co-glycolide) copolymers. International Journal of Pharmacy and Pharmaceutical Sciences 2009; Vol. 1, Suppl: 103-107.
2. Alekha K. Dash, Greggrey C. Cudworth II. Therapeutic Applications of Implantable Drug, Delivery Systems. Journal of Pharmacological and Toxicological Methods 1998; (40): 1-12.
3. M.J. Payne, S.E. Pratap, M.R. Middleton. Temozolomide in the treatment of solid tumours: current results and rationale for dosing/scheduling. Critical Reviews in Oncology/Hematology 2005; (53): 241-252.
4. Grace H. Huynh, Dennis F. Deen, Francis C. Szoka JR. Barriers to carrier mediated drug and gene delivery to brain tumors. Journal of Controlled Release 2006; (110): 236-259.
5. Maddalena Lino, Adrian Merlo. Translating biology into clinic: the case of Glioblastoma. Current Opinion in Cell Biology 2009; (21): 311-316.
6. E. Fournier, C. Passirani, C.N. Montero-Menei, J.P. Benoit. Biocompatibility of implantable synthetic polymeric drug carriers: focus on brain biocompatibility. Biomaterials 2003; (24): 3311-3331.
7. H. Brem, P. Gabikian. Biodegradable polymer implants to treat brain tumors. Journal of Controlled Release 2001; (74): 63-67.
8. Hajime Katoua, Anne JuliaWandrey, Bruno Ganderb. Kinetics of solvent extraction/evaporation process for PLGA microparticle fabrication. International Journal of Pharmaceutics 2008; (364): 45-53.
9. Sergio Freitas, Hans P. Merkle, Bruno Gander. Micro encapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology. Journal of Controlled Release 2005; (102): 313-332.
10. Patrick B, O'Donnell, James W, MC Ginity. Preparation of microspheres by the solvent evaporation technique. Advanced Drug Delivery Reviews 1997; (28): 25-42.
11. Y. Phalguna, B.S. Venkateshwarlu, Ganesh kumar gudas, Subal Debnath. Hpmc microspheres of zidovudine for sustained release. International Journal of Pharmacy and Pharmaceutical Sciences 2010; vol 2, suppl 4: 41-43.
12. Guihua Huang, Na Zhang, Xiuli Bi, Mingjin Dou. Solid lipid nanoparticles of temozolomide: Potential reduction of cardial and nephric toxicity. International Journal of Pharmaceutics 2008; (355): 314-320.
13. Melgardt M. de Villiers, Pornanong Aramwit, Glen S. Kwon. Nanotechnology in Drug Delivery. Pg- 129.
14. He Zhang, Shen Gao. Temozolomide/PLGA microparticles and antitumor activity against Glioma C6 cancer cells in vitro. International Journal of Pharmaceutics 2007; (329): 122-128.
15. S. Govender, V. Pillay, D.J. Chetty, S.Y. Essack, C.M. Dangor, T. Govender. Optimisation and characterisation of bioadhesive controlled release tetracycline microspheres. International Journal of Pharmaceutics 2005; (306): 24-40.
16. Paulo Costa, Jose Manuel Sousa Lobo. Modeling and comparison of dissolution prfioles. European Journal of Pharmaceutical Sciences 2001; (13): 123-133.