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Haissaguerre M, Shoda M, Jais P, et al. Mapping and ablation of idiopathic ventricular fibrillation. Circulation 2002;106:962-7. This study demonstrates the feasibility of eliminating or decreasing the incidence of idiopathic VF by catheter ablation of the sources, dominantly originating from the specialised intraventricular conducting system. (Pubitemid 34925331)
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Moss AJ, Hall WJ, Cannom DS, et al. Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia. Multicenter Automatic Defibrillator Implantation Trial Investigators. N Engl J Med 1996;335:1933-40. The first randomised study demonstrating that the implantation of an ICD provided effective protection against death in high risk patients with coronary heart disease and left ventricular dysfunction. (Pubitemid 26428217)
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Multicenter Unsustained Tachycardia Trial Investigators
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Factors influencing appropriate firing of the implanted defibrillator for ventricular tachycardia/fibrillation: Findings from the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II)
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Singh JP, Hall WJ, McNitt S, et al. Factors influencing appropriate firing of the implanted defibrillator for ventricular tachycardia/fibrillation: findings from the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II). J Am Coll Cardiol 2005;46:1712-20. A prospective analysis of the role of clinical, laboratory, echocardiographic, and electrophysiological variables as predictors of appropriate initial ICD therapy for malignant ventricular arrhythmias or death in the MADIT II population. (Pubitemid 41531628)
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Bardy GH, Lee KL, Mark DB, et al. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med 2005;352:225-37. This study raised the standard of care for patients with ischaemic cardiac heart failure (CHF) by substantiating evidence from earlier trials in favour of ICD therapy in those patients and by providing evidence of a survival benefit associated with such therapy in patients with non-ischaemic CHF. (Pubitemid 40110811)
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Systematic assessment of patients with unexplained cardiac arrest: Cardiac Arrest Survivors with Preserved Ejection Fraction Registry (CASPER)
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A prospective multicentre experience demonstrating that systematic, rigorous clinical testing can determine the cause of unexplained cardiac arrest in more than half of all patients
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A comparison of antiarrhythmic-drug therapy with implantable defibrillators in patients resuscitated from near-fatal ventricular arrhythmias
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AVID Investigators. The Antiarrhythmics versus Implantable Defibrillators (AVID) Investigators. The largest trial comparing ICD vs antiarrhythmic drugs in secondary prevention, which concluded that overall survival was greater with the ICD
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AVID Investigators. A comparison of antiarrhythmic-drug therapy with implantable defibrillators in patients resuscitated from near-fatal ventricular arrhythmias. The Antiarrhythmics versus Implantable Defibrillators (AVID) Investigators. N Engl J Med 1997;337:1576-83. The largest trial comparing ICD vs antiarrhythmic drugs in secondary prevention, which concluded that overall survival was greater with the ICD.
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Kuck KH, Cappato R, Siebels J, et al. Randomized comparison of antiarrhythmic drug therapy with implantable defibrillators in patients resuscitated from cardiac arrest: the Cardiac Arrest Study Hamburg (CASH). Circulation 2000;102:748-54. (Pubitemid 30648765)
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Meta-analysis of the implantable cardioverter defibrillator secondary prevention trials. AVID, CASH and CIDS studies. Antiarrhythmics vs Implantable Defibrillator Study. Cardiac Arrest Study Hamburg. Canadian Implantable Defibrillator Study
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An important meta-analysis of the three main randomised trials of ICD therapy versus medical treatment for the prevention of death in survivors of VF or sustained VT
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Conolly SJ, Hallstrom AP, Cappato R, et al. Meta-analysis of the implantable cardioverter defibrillator secondary prevention trials. AVID, CASH and CIDS studies. Antiarrhythmics vs Implantable Defibrillator Study. Cardiac Arrest Study Hamburg. Canadian Implantable Defibrillator Study. Eur Heart J 2000;21:2071-8. An important meta-analysis of the three main randomised trials of ICD therapy versus medical treatment for the prevention of death in survivors of VF or sustained VT.
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Comparison of beta-blockers, amiodarone plus beta-blockers, or sotalol for prevention of shocks from implantable cardioverter defibrillators - The OPTIC study: A randomized trial
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Catheter ablation for the treatment of electrical storm in patients with implantable cardioverter defibrillators: Short- and long-term outcomes in a prospective single-center study
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A prospective study of patients with either coronary artery disease, idiopathic dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy suggesting that early catheter ablation may benefit patients with electrical storm
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Carbucicchio C, Santamaria M, Trevisi N, et al. Catheter ablation for the treatment of electrical storm in patients with implantable cardioverter defibrillators: short- and long-term outcomes in a prospective single-center study. Circulation 2008;117:462-9. A prospective study of patients with either coronary artery disease, idiopathic dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy suggesting that early catheter ablation may benefit patients with electrical storm.
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A randomised trial in which prophylactic catheter ablation of arrhythmogenic ventricular tissue reduced the incidence of ICD therapy in patients with a history of myocardial infarction who received ICDs for secondary prevention of sudden death
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Reddy VY, Reynolds MR, Neuzil P, et al. Prophylactic catheter ablation for the prevention of defibrillator therapy. N Engl J Med 2007;357:2657-65. A randomised trial in which prophylactic catheter ablation of arrhythmogenic ventricular tissue reduced the incidence of ICD therapy in patients with a history of myocardial infarction who received ICDs for secondary prevention of sudden death.
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