Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia

New England Journal of Medicine

Volumn 335, Issue 26, 1996, Pages 1933-1940

  Moss, Arthur J ^a   Jackson Hall, W ^b   Cannom, David S ^c   Daubert, James P ^a   Higgins, Steven L ^d   Klein, Helmut ^e   Levine, Joseph H ^f   Saksena, Sanjeev ^g   Waldo, Albert L ^h   Wilber, David ⁱ   Brown, Mary W ^b   Heo, Moonseong ^b  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^c GOOD SAMARITAN HOSPITAL   (United States)

^d SCRIPPS MEMORIAL HOSPITAL   (United States)

^e UNIVERSITY HOSPITAL MAGDEBURG   (Germany)

^f ST FRANCIS HOSPITAL   (United States)

^g Eastern Heart Institute   (United States)

^h UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

ⁱ UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIARRHYTHMIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIGITALIS; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; SOTALOL;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DEFIBRILLATOR; ELECTROPHYSIOLOGY; FEMALE; HEART ELECTROPHYSIOLOGY; HEART VENTRICLE ARRHYTHMIA; HIGH RISK POPULATION; HUMAN; HYPOTENSION; IMPLANT; LUNG EMBOLISM; LUNG FIBROSIS; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINUS BRADYCARDIA; SURVIVAL; SYNCOPE;

ADULT; AGED; ANTI-ARRHYTHMIA AGENTS; CORONARY DISEASE; DEFIBRILLATORS, IMPLANTABLE; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PROPORTIONAL HAZARDS MODELS; RISK FACTORS; SURVIVAL ANALYSIS; TACHYCARDIA, VENTRICULAR; VENTRICULAR DYSFUNCTION, LEFT;

EID: 0006918490     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199612263352601     Document Type: Article

References (28)

1. Anderson KP, DeCamilla J, Moss AJ. Clinical significance of ventricular tachycardia (3 beats or longer) detected during ambulatory monitoring after myocardial infarction. Circulation 1978;57:890-7.
2. Bigger IT Jr, Fleiss JL, Kleiger R, Miller JP, Rolnitzky LM, Multicenter Post-Infarction Research Group. The relationships among ventricular arrhythmias, left ventricular dysfunction, and mortality in the 2 years after myocardial infarction. Circulation 1984;69:250-8.
3. Buxton AE, Marchlinski FE, Waxman HL, Flores BT, Cassidy DM, Josephson ME. Prognostic factors in nonsustained ventricular tachycardia. Am J Cardiol 1984;53:1275-9.
4. Ruskin JN, McGovern B, Garan H, DiMarco JP, Kelly K. Antiarrhythmic drugs: a possible cause of out-of-hospital cardiac arrest. N Engl J Med 1983;309:1302-6.
5. Echt DS, Liebson PR, Mitchell LB, et al. Mortality and morbidity in patients receiving encainide, flecainide, or placebo: the Cardiac Arrhythmia Suppression Trial. N Engl J Med 1991;324:781-8.
6. Mason JW. A comparison of seven antiarrhythmic drugs in patients with ventricular tachyarrhythmias. N Engl J Med 1993;329:452-8.
7. Spielman SR, Greenspan AM, Kay HR, et al. Electrophysiologic testing in patients at high risk for sudden cardiac death. I. Nonsustained ventricular tachycardia and abnormal ventricular function. J Am Coll Cardiol 1985;6:31-40.
8. Wilber DI, Olshansky B, Moran IF, Scanlon PJ. Electrophysiological testing and nonsustained ventricular tachycardia: use and limitation in patients with coronary artery disease and impaired ventricular function. Circulation 1990;82:350-8.
9. Healy B, Campeau L, Gray R, et al. Conflict-of-interest guidelines for a multicenter clinical trial of treatment after coronary-artery bypass-graft surgery. N Engl J Med 1989;320:949-51.
10. Morady F, Kou WH, Schmaitz S, et al. Pharmacodynamics of intravenous procainamide as used during acute electropharmacologic testing. Am J Cardiol 1988;61:93-8.
11. MADIT Executive Committee. Multicenter Automatic Defibrillator Implantation Trial (MADIT): design and clinical protocol. Pacing Clin Electrophysiol 1991;14:920-7.
12. Greenberg H, Gillespie J, Dwyer EM Jr, Multicenter Post-Infarction Research Group. A new electrocardiographic classification for post-myocardial infarction clinical trials. Am J Cardiol 1987;59:1057-63.
13. Hinkle LE Jr, Thaler HT. Clinical classification of cardiac deaths. Circulation 1982;65:457-64.
14. Whitehead J. The design and analysis of sequential clinical trials. 2nd ed. Chichester. England: Ellis Horwood, 1992.
15. Brunier H, Whitehead J. PEST: planning and evaluation of sequential trials, version 3.0: operating manual. Reading, England: PEST Project, University of Reading, 1993 (and software).
16. Cox DR. Regression models and life-tables. J R Stat Soc [B] 1972;34: 187-220.
17. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-81.
18. Mirowski M, Reid PR, Mower MM, et al. Termination of malignant ventricular arrhythmias with an implanted automatic defibrillator in human beings. N Engl J Med 1980;303:322-4.
19. Echt DS, Armstrong K, Schmidt P, Over PE, Stinson EB, Winkle RA. Clinical experience, complications, and survival in 70 patients with the automatic implantable cardioverter/defibrillator. Circulation 1985;71:289-96.
20. Kelly PA, Cannom DS, Garan H, et al. The automatic implantable cardioverter-defibrillator: efficacy, complications and survival in patients with malignant ventricular arrhythmias. J Am Coll Cardiol 1988;11:1278-86.
21. Lehmann MH, Steinman RT, Schuger CD, Jackson K. The automatic implantabie cardioverter defibrillator as antiarrhythmic treatment modality of choice for survivors of cardiac arrest unrelated to acute myocardial infarction. Am J Cardiol 1988;62:803-5.
22. Winkle RA, Mead RH, Ruder MA, et al. Long-term outcome with the automatic implantable cardioverter-defibrillator. J Am Coll Cardiol 1989; 13:1353-61
23. Fogoros RN, Elson JJ, Bonnet CA. Actuarial incidence and pattern of occurrence of shocks following implantation of the automatic implantable cardioverter defibrillator. Pacing Clin Electrophysiol 1989;12:1465-73.
24. Levine JH, Mcllits ED, Baumgardner RA, et al. Predictors of first discharge and subsequent survival in patients with automatic implantable cardioverter-defibrillators. Circulation 1991;84:558-66.
25. Singh SN, Fletcher RD, Fisher SG, et al. Amiodarone in patients with congestive heart failure and asymptomatic ventricular arrhythmia. N Engl J Med 1995;333:77-82.
26. Task Force of the Working Group on Arrhythmias of the European Society of Cardiology. The early termination of clinical trials: causes, consequences, and control: with special reference to trials in the field of arrhythmias and sudden death. Circulation 1994;89:2892-907.
27. Bigger JT Jr. Should deflbrillators be implanted in high-risk patients without a previous sustained ventricular tachyarrhythmia? In: Naccarelli GV, Veltri EP, eds. Implantable cardioverter-defibrillators. Boston: Blackwell Scientific, 1993:284-317.
28. Greene HL. Antiarrhythmic drugs versus implantable deflbrillators: the need for a randomized controlled study. Am Heart J 1994;127:1171-8.