Pharmacokinetics, tissue distribution and magnetic resonance's response characterstics of folic acid-O-carboxymethyl chitosan ultrasmall superparamagnetic iron oxide nanoparticles in mice and rats

Yaoxue Xuebao

Volumn 46, Issue 7, 2011, Pages 845-851

  Gao, Wen Hui ^a,b   Liu, Shi Ting ^a   Fan, Cai Xia ^c   Qi, Lin Yan ^a   Chen, Zhi Liang ^a  

^a FIRST MILITARY MEDICAL UNIVERSITY   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

^c YUEBEI PEOPLE S HOSPITAL   (China)

Author keywords

In vivo distribution; Magnetic resonance imaging; Magnetite nanoparticle; Pharmacokinetics

Indexed keywords

1,10 PHENANTHROLINE; CHITOSAN; FOLIC ACID DERIVATIVE; NANOPARTICLE; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE;

ARTICLE; DRUG DISTRIBUTION; DRUG HALF LIFE; HEART; IRON BLOOD LEVEL; KIDNEY; LIVER; LUNG; MOLECULARLY TARGETED THERAPY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHAGOCYTOSIS; PLASMA CONCENTRATION-TIME CURVE; RAT; SIGNAL NOISE RATIO; SPLEEN; TISSUE DISTRIBUTION; URINARY EXCRETION;

ANIMALS; AREA UNDER CURVE; CHITOSAN; CONTRAST MEDIA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; FERRIC COMPOUNDS; FOLIC ACID; INJECTIONS, INTRAVENOUS; MAGNETIC RESONANCE IMAGING; MAGNETITE NANOPARTICLES; MALE; MICE; NANOPARTICLES; PARTICLE SIZE; PHAGOCYTOSIS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 80052637896     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Harada T, Tanigawa N, Matsuki M, et al. Evaluation of lymph node metastases of breast cancer using ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging [J]. Eur J Radiol, 2007, 63: 401-407. (Pubitemid 47321038)
2. Corot C, Robert P, Idee JM, et al. Recent advances in iron oxide nanocrystal technology for medical imaging [J]. Adv Drug Deliv Dev, 2006, 58: 1471-1504. (Pubitemid 44820503)
3. Liu XQ, Zheng CL, Zhu JB. Preparation of polyelectrolyte microcapsules containing ferrosoferric oxide nanoparticles [J]. Acta Pharm Sin, 2011, 46: 115-120.
4. Fan CX, Gao WH, Chen ZL, et al. Tumor selectivity of stealth multi-functionalized superparamagnetic iron oxide nanoparticles [J]. Int J Pharm, 2011, 404: 180-190.
5. Fan CX, Gao WH, Chen ZL. The synthesis and characterizations of carboxymethyl-chitosan ultra-small superparamagnetic iron oxide nanoparticle [J]. Chin J Mod Appl Pharm, 2010, 27: 825-831.
6. Molday RS, MacKenzie D. Immunospecific ferromagnetic iron-dextran reagents for the labeling and magnetic separation of cells [J]. J Immunol Methods, 1982, 52: 353-367. (Pubitemid 12044733)
7. Ma HL, Xu YF, Qi XR, et al. Superparamagnetic iron oxide nanoparticles stabilized by alginate: pharmacokinetics, tissue distribution, and applications in detecting liver cancers [J]. Int J Pharm, 2008, 354: 217-266.
8. Tanimoto A, Kuribayashi S. Hepatocyte-targeted MR contrast agents: contrast enhanced detection of liver cancer in diffusely damaged liver [J]. Magn Reson Med Sci, 2005, 4: 53-60.
9. Akihiro T, Makio M, Sachio K. Evaluation of superparamagnetic iron oxide for MR imaging of liver injury: proton relaxation mechanisms and optimal MR imaging parameters [J]. Magn Reson Med Sci, 2006, 5: 89-98.
10. Sun JF. Animal Experiments Methodology [M]. Beijing: People's Medical Publishing Press, 2001: 357.
11. Plassat V, Martina MS, Barratt G, et al. Sterically stabilized superparamagnetic liposomes for MR imaging and cancer therapy: pharmacokinetics and biodistribution [J]. Int J Pharm, 2007, 344: 118-127. (Pubitemid 47464819)
12. Kai C, Jin X, Hengyi X, et al. Triblock copolymer coated iron oxide nanoparticle conjugate for tumor integrin targeting [J]. Biomaterials, 2009, 30: 6912-6919.
13. Peter AJ, Torjus S, Anita G, et al. Iron oxide core oil-in-water emulsions as a multifunctional nanoparticle platform for tumor targeting and imaging [J]. Biomaterials, 2009, 30: 6947-6954.
14. Hamm B, Taupitz M, Hussmann P, et al. MR lymphography with iron oxide particles: dose-response studies and pulse sequence optimization in rabbits [J]. AJR Am J Roentgenol 1992, 158: 183-190.
15. Wang CX, Li CL, Zhao X, et al. Pharmacodynamics, pharmacokinetics and tissue distribution of liposomal mitoxantrone hydrochloride [J]. Acta Pharm Sin, 2010, 45: 1565-1569.
16. Wu Y, Zhang FC, Wu C, et al. Pharmacokinetics of epirubicin hydrochloride long-circulating thermosensitive liposomes in rat plasma [J]. Acta Pharm Sin, 2010, 45: 365-370.
17. Feng L, Hu CJ, Yu LY. Pharmacokinetics of ginsenosides Rg1 and its metabolites in rats [J]. Acta Pharm Sin, 2010, 45: 636-640.
18. Xu R, Shi SJ, Zhou SC, et al. Pharmacokinetics and distribution of 5-Fu magnetic album in deuto-microsphere in normal and tumor-bearing mice [J]. Acta Pharm Sin, 2007, 42: 66-70.