Patients with acute coronary syndrome and nonobstructive coronary artery disease in the real world are markedly undertreated

Journal of Cardiovascular Medicine

Volumn 12, Issue 10, 2011, Pages 700-708

  De Ferrari, Gaetano M ^a   Leonardi, Sergio ^a,b   Baduena, Lara ^c   Chieffo, Enrico ^a,d   Lesce, Angela ^a,d   Repetto, Alessandra ^a   Previtali, Mario ^a,d  

^a FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^d UNIVERSITY OF PAVIA   (Italy)

Author keywords

acute coronary syndrome; cardiovascular pharmacology; coronary angiography; coronary artery disease

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; THIENOPYRIDINE DERIVATIVE;

ACUTE CORONARY SYNDROME; ADULT; ANGIOCARDIOGRAPHY; ARTICLE; CORONARY ARTERY DISEASE; FEMALE; HEART DEATH; HEART INFARCTION; HUMAN; MAJOR CLINICAL STUDY; MALE; PATIENT CARE; PROGNOSIS; UNSTABLE ANGINA PECTORIS;

ACUTE CORONARY SYNDROME; AGED; CARDIOVASCULAR AGENTS; CHI-SQUARE DISTRIBUTION; CORONARY ANGIOGRAPHY; CORONARY OCCLUSION; CORONARY STENOSIS; DISEASE-FREE SURVIVAL; DRUG THERAPY, COMBINATION; DRUG UTILIZATION; FEMALE; GUIDELINE ADHERENCE; HOSPITAL MORTALITY; HUMANS; ITALY; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; PATIENT DISCHARGE; PHYSICIAN'S PRACTICE PATTERNS; PRACTICE GUIDELINES AS TOPIC; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; SEVERITY OF ILLNESS INDEX; TIME FACTORS;

EID: 80052616941     PISSN: 15582027     EISSN: 15582035     Source Type: Journal    
DOI: 10.2459/JCM.0b013e328348e575     Document Type: Article

References (23)

1. Ryan TJ, Anderson JL, Antman EM, et al. ACC/AHA guidelines for the management of patients with acute myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Acute Myocardial Infarction). J Am Coll Cardiol 1996; 28:1328-1428. (Pubitemid 26377013)
2. Bugiardini R, Bairey Merz CN. Angina with 'normal' coronary arteries: a changing philosophy. JAMA 2005; 293:477-484.
3. Bugiardini R, Manfrini O, De Ferrari GM. Unanswered questions for management of acute coronary syndrome. Risk stratification of patients with minimal disease or normal findings on coronary angiography. Arch Intern Med 2006; 166:1391-1395. (Pubitemid 44036351)
4. Roe MT, Harrington RA, Prosper DM, et al. Clinical and therapeutic profile of patients presenting with acute coronary syndromes who do not have significant coronary artery disease. The platelet glycoprotein IIb/IIIa in unstable angina: Receptor Suppression Using Integrilin Therapy (PURSUIT) Trial Investigators. Circulation 2000; 102:1101-1106.
5. Hochman JS, Tamis JE, Thompson TD, et al. Sex, clinical presentation, and outcome in patients with acute coronary syndromes. Global use of strategies to open occluded coronary arteries in acute coronary syndromes IIb investigators. N Engl J Med 1999; 341:226-232.
6. Diver DJ, Bier JD, Ferreira PE, et al. Clinical and arteriographic characterization of patients with unstable angina without critical coronary arterial narrowing (from the TIMI-IIIA Trial). Am J Cardiol 1994; 74:531-537. (Pubitemid 24279931)
7. Patel MR, Chen AY, Peterson ED, et al. Prevalence, predictors, and outcomes of patients with non-ST-segment elevation myocardial infarction and insignificant coronary artery disease: results from the Can Rapid risk stratification of Unstable angina patients Suppress Adverse outcomes with Early implementation of the ACC/AHA Guidelines (CRUSADE) initiative. Am Heart J 2006; 152:641-647. (Pubitemid 44396875)
8. Ramanath VS, Armstrong DF, Grzybowski M, et al. Receipt of cardiac medications upon discharge among men and women with acute coronary syndrome and nonobstructive coronary artery disease. Clin Cardiol 2010; 33:36-41.
9. Minha S, Behar S, Krakover R, Boyko V, Vered Z, Blatt A. Characteristics and outcome of patients with acute coronary syndrome and normal or nearnormal coronary angiography. Coron Artery Dis 2010; 21:212-216.
10. Anderson JL, Adams CD, Antman EM, et al. ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction-executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction): developed in collaboration with the American College of Emergency Physicians, American College of Physicians, Society for Academic Emergency Medicine, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol 2007; 50:652-726.
11. Thygesen K, Alpert JS, White HD, et al. On behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the redefinition of myocardial infarction. Universal definition of myocardial infarction. Circulation 2007; 116:2634-2653.
12. Bybee KA, Kara T, Prasad A, et al. Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction. Ann Intern Med 2004; 141:858-865. (Pubitemid 39601180)
13. Assomull RG, Lyne JC, Keenan N, et al. The role of cardiovascular magnetic resonance in patients presenting with chest pain, raised troponin, and unobstructed coronary arteries. Eur Heart J 2007; 28:1242-1249. (Pubitemid 47343853)
14. Dey S, Flather MD, Devlin G, et al. Global Registry of Acute Coronary Events investigators. Sex-related differences in the presentation, treatment and outcomes among patients with acute coronary syndromes: the Global Registry of Acute Coronary Events. Heart 2009; 95:20-26.
15. Gianni M, Dentali F, Grandi AM, Sumner G, Hiralal R, Lonn E. Apical ballooning syndrome or takotsubo cardiomyopathy: a systematic review. Eur Heart J 2006; 27:1523-1529. (Pubitemid 43954909)
16. Prasad A. Apical ballooning syndrome. An important differential diagnosis of acute myocardial infarction. Circulation 2007; 115:e56-e59. (Pubitemid 46226154)
17. Wenger NK. Clinical characteristics of coronary heart disease in women: emphasis on gender differences. Cardiovasc Res 2002; 53:558-567. (Pubitemid 34175248)
18. Andreotti F, Marchese N. Women and coronary disease. Heart 2008; 94:108-116.
19. Naghavi M, Libby P, Falk E, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation 2003; 108:1664-1672. (Pubitemid 37243650)
20. Ambrose JA, Tannenbaum MA, Alexopoulos D, et al. Angiographic progression of coronary artery disease and the development of myocardial infarction. J Am Coll Cardiol 1988; 12:56-62.
21. Topol EJ, Nissen SE. Our preoccupation with coronary luminology. The dissociation between clinical and angiographic findings in ischemic heart disease. Circulation 1995; 92:2333-2342.
22. Lefer AM, Scalia R, Lefer DJ. Vascular effects of HMG CoA-reductase inhibitors (statins) unrelated to cholesterol lowering: new concepts for cardiovascular disease. Cardiovasc Res 2001; 49:281-287. (Pubitemid 32119545)
23. Shaw LJ, Bugiardini R, Merz CN. Women and ischemic heart disease: evolving knowledge. J Am Coll Cardiol 2009; 54:1561-1575.