Role of extracellular protease in nitrogen substrate management during antibiotic fermentation: A process model and experimental validation

Applied Microbiology and Biotechnology

Volumn 91, Issue 4, 2011, Pages 1019-1028

  Bapat, Prashant M ^a,b   Sinha, Avinash ^a   Wangikar, Pramod P ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY BOMBAY   (India)

^b NOVOZYMES A S   (Denmark)

Author keywords

Complex media; Nitrogen catabolite repression; Preculture conditions; Protease regulation; Structured model

Indexed keywords

COMPLEX MEDIA; NITROGEN CATABOLITE REPRESSION; PRECULTURE; PROTEASE REGULATION; STRUCTURED MODEL;

AMINO ACIDS; ANTIBIOTICS; FERMENTATION; GROWTH KINETICS; HYDROLYSIS; KINETICS; PHYSIOLOGY; PRODUCTIVITY; SUBSTRATES;

NITROGEN;

AMINO ACID; AMMONIA; EXTRACELLULAR PROTEASE; NITROGEN; PROTEINASE; RIFAMYCIN B; UNCLASSIFIED DRUG;

AMINO ACID; AMMONIA; ANTIBIOTICS; BACTERIUM; BIOTECHNOLOGY; CATABOLISM; ENZYME ACTIVITY; FERMENTATION; HYDROLYSIS; INDUSTRIAL PRODUCTION; MICROBIAL ACTIVITY; MODEL VALIDATION; NITROGEN; PROTEIN; REACTION KINETICS; SECRETION; SUBSTRATE;

AMYCOLATOPSIS MEDITTERRANEI; AMYCOLATOPSIS MEDITTERRANEI S699; ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BACTERIAL STRAIN; BATCH FERMENTATION; BIOAVAILABILITY; BIOREACTOR; CULTURE MEDIUM; DRUG MANUFACTURE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME REGULATION; ENZYME REPRESSION; ENZYME SUBSTRATE; ENZYME SYNTHESIS; GROWTH RATE; NONHUMAN; PREDICTIVE VALUE; PROCESS MODEL; PROTEIN HYDROLYSIS; VALIDATION PROCESS;

ACTINOMYCETALES; AMMONIA; ANTI-BACTERIAL AGENTS; BIOTECHNOLOGY; FERMENTATION; GENE EXPRESSION REGULATION, BACTERIAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; NITROGEN; PEPTIDE HYDROLASES; RIFAMYCINS; TIME FACTORS;

AMYCOLATOPSIS;

EID: 80052613395     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-011-3318-z     Document Type: Article

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