Consanguineous marriages, pearls and perils: Geneva International Consanguinity Workshop Report

Genetics in Medicine

Volumn 13, Issue 9, 2011, Pages 841-847

  Hamamy, Hanan ^a   Antonarakis, Stylianos E ^a   Cavalli Sforza, Luigi Luca ^b   Temtamy, Samia ^c   Romeo, Giovanni ^d   Kate, Leo P Ten ^e   Bennett, Robin L ^f   Shaw, Alison ^g   Megarbane, Andre ^h   Van Duijn, Cornelia ⁱ   Bathija, Heli ^j   Fokstuen, Siv ^a   Engel, Eric ^a   Zlotogora, Joel ^k   Dermitzakis, Emmanouil ^a   Bottani, Armand ^a   Dahoun, Sophie ^a   Morris, Michael A ^l   Arsenault, Steve ^m   Aglan, Mona S ^c   Ajaz, Mubasshir ⁿ   Alkalamchi, Ayad ^o   Alnaqeb, Dhekra ^p   Alwasiyah, Mohamed K ^q   Anwer, Nawfal ^r   Awwad, Rawan ^s   Bonnefin, Melissa ^t   Corry, Peter ^u   Gwanmesia, Lorraine ^a   Karbani, Gulshan A ^v   Mostafavi, Maryam ^a   Pippucci, Tommaso ^d   Ranza Boscardin, Emmanuelle ^a   Reversade, Bruno ^w   Sharif, Saghira M ^x   Teeuw, Marieke E ^e   Bittles, Alan H ^y   more..

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL RESEARCH CENTRE   (Egypt)

^d UNIVERSITY OF BOLOGNA   (Italy)

^e VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^f UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

^g UNIVERSITY OF OXFORD   (United Kingdom)

^h SAINT JOSEPH UNIVERSITY   (Lebanon)

ⁱ ERASMUS MEDICAL CENTER   (Netherlands)

^j WORLD HEALTH ORGANIZATION   (Switzerland)

^k HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^l GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^m Génome Québec and Ecogene 21 Biobank   (Canada)

ⁿ UNIVERSITY OF BEDFORDSHIRE   (United Kingdom)

^o MINISTRY OF HEALTH   (Iraq)

^p KING SAUD UNIVERSITY   (Saudi Arabia)

^q MINISTRY OF HEALTH   (Saudi Arabia)

^r Hadassah University Medical Center ^*  (Iraq)

^s HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^t KING'S COLLEGE LONDON   (United Kingdom)

^u BRADFORD TEACHING HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^v LEEDS TEACHING HOSPITALS NHS TRUST   (United Kingdom)

^w INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

^x CHAPEL ALLERTON HOSPITAL   (United Kingdom)

^y MURDOCH UNIVERSITY   (Australia)

more..

Author keywords

congenital disorders; consanguineous marriage; consanguinity; endogamy; fertility; genetic counseling; inbreeding; infant mortality; stillbirths

Indexed keywords

COMPARATIVE GENOMIC HYBRIDIZATION; CONFERENCE PAPER; CONSANGUINEOUS MARRIAGE; CONSANGUINITY; COPY NUMBER VARIATION; GENE SEQUENCE; GENETICS; GENOTYPE; HEALTH HAZARD; HUMAN; MARITAL THERAPY; PHENOTYPE; SOCIAL ASPECT; SOCIAL STRUCTURE; TECHNOLOGY;

CONSANGUINITY; DISEASE; DNA COPY NUMBER VARIATIONS; FEMALE; GENETIC RESEARCH; HUMANS; MALE; MARRIAGE; QUANTITATIVE TRAIT, HERITABLE;

EID: 80052606841     PISSN: 10983600     EISSN: 15300366     Source Type: Journal    
DOI: 10.1097/GIM.0b013e318217477f     Document Type: Conference Paper

References (52)

1. Geneva International Consanguinity Workshop, 2010. Available at: http://www.medecine.unige.ch/consanguinity/. Accessed December 1, 2010.
2. Biemont C. Inbreeding effects in the epigenetic era. Nat Rev Genet 2010; 11:234.
3. Cavalli-Sforza LL, Moroni A, Zei G. Consanguinity, inbreeding and genetic drift in Italy. Monographs in population biology 39. New Jersey: Princeton University Press, 2004.
4. Nebert DW, Galvez-Peralta M, Shi Z, Dragin N. Inbreeding and epigenetics: beneficial as well as deleterious effects. Nat Rev Genet 2010;11:662.
5. Ozcelik T, Kanaan M, Avraham KB, et al. Collaborative genomics for human health and cooperation in the Mediterranean region. Nat Genet 2010;42:641-645.
6. Bittles AH. The global prevalence of consanguinity, 2010. Available at: http://www.consang.net. Accessed December 1, 2010.
7. Bittles AH, Black ML. Evolution in health and medicine Sackler colloquium: consanguinity, human evolution, and complex diseases. Proc Natl Acad Sci USA 2010;107(suppl 1):1779-1786.
8. Tadmouri GO, Nair P, Obeid T, Al Ali MT, Al Khaja N, Hamamy HA. Consanguinity and reproductive health among Arabs. Reprod Health 2009; 6:17.
9. Hamamy H, Jamhawi L, Al-Darawsheh J, Ajlouni K. Consanguineous marriages in Jordan: why is the rate changing with time? Clin Genet 2005;67:511-516. (Pubitemid 40637449)
10. Khoury SA, Massad D. Consanguineous marriage in Jordan. Am J Med Genet 1992;43:769-775.
11. Bittles A. Consanguinity and its relevance to clinical genetics. Clin Genet 2001;60:89-98. (Pubitemid 32791662)
12. Bittles AH. Consanguinity, genetic drift and genetic diseases in populations with reduced numbers of founders. In: Speicher M, Antonarakis SE, Mot-ulsky AG, editors. Human genetics-principles and approaches, 4th ed. Heidelberg: Springer, 2009:507-528.
13. Zlotogora J. The molecular basis of autosomal recessive diseases among the Arabs and Druze in Israel. Hum Genet 2010;128:473-479.
14. Aldahmesh MA, Abu-Safieh L, Khan AO, et al. Allelic heterogeneity in inbred populations: the Saudi experience with Alstrom syndrome as an illustrative example. Am J Med Genet A 2009;149A:662-665.
15. Khlat M. Consanguineous marriages in Beirut: time trends, spatial distribution. Soc Biol 1988;35:324-330.
16. Vardi-Saliternik R, Friedlander Y, Cohen T. Consanguinity in a population sample of Israeli Muslim Arabs, Christian Arabs and Druze. Ann Hum Biol 2002;29:422-431. (Pubitemid 34842116)
17. Bittles AH, Mason WM, Greene J, Rao NA. Reproductive behavior and health in consanguineous marriages. Science 1991;252:789-794. (Pubitemid 121000514)
18. Sandridge AL, Takeddin J, Al-Kaabi E, Frances Y. Consanguinity in Qatar: knowledge, attitude and practice in a population born between 1946 and 1991. J Biosoc Sci 2010;42:59-82.
19. Assaf S, Khawaja M. Consanguinity trends and correlates in the Palestinian Territories. J Biosoc Sci 2009;41:107-124.
20. Shaw A. 2009. Negotiating risk: British Pakistani experiences of genetics. New York: Berghahn books, 2010.
21. Liu F, Elefante S, van Duijn CM, Aulchenko YS. Ignoring distant genea-logic loops leads to false-positives in homozygosity mapping. Ann Hum Genet 2006;70:965-970. (Pubitemid 44530659)
22. Barbour B, Salameh P. Consanguinity in Lebanon: prevalence, distribution and determinants 4. J Biosoc Sci 2009;41:505-517.
23. Othman H, Saadat M. Prevalence of consanguineous marriages in Syria. J Biosoc Sci 2009;41:685-692.
24. Bener A, Alali KA. Consanguineous marriage in a newly developed country: the Qatari population. J Biosoc Sci 2006;38:239-246. (Pubitemid 44367112)
25. Jurdi R, Saxena PC. The prevalence and correlates of consanguineous marriages in Yemen: similarities and contrasts with other Arab countries. J Biosoc Sci 2003;35:1-13. (Pubitemid 36068140)
26. Bras H, Van Poppel F, Mandemakers K. Relatives as spouses: preferences and opportunities for kin marriage in a Western society. Am J Hum Biol 2009;21:793-804.
27. Imaizumi Y. A recent survey of consanguineous marriages in Japan. Clin Genet 1986;30:230-233. (Pubitemid 16004756)
28. Grjibovski AM, Magnus P, Stoltenberg C. Decrease in consanguinity among parents of children born in Norway to women of Pakistani origin: a registry-based study. Scand J Public Health 2009;37:232-238.
29. Awwad R, Veach PM, Bartels DM, LeRoy BS. Culture and acculturation influences on Palestinian perceptions of prenatal genetic counseling. J Genet Couns 2008;17:101-116. (Pubitemid 351230514)
30. Bittles AH, Black ML. The impact of consanguinity on neonatal and infant health. Early Hum Dev 2010;86:737-741.
31. Bennett R, Motulsky A, Bittles A, et al. Genetic counseling and screening of consanguineous couples and their offspring: recommendations of the National Society of Genetic Counselors. J Genet Counsel 2002;11:97-119. (Pubitemid 41450839)
32. Bennett RL, Hudgins L, Smith CO, Motulsky AG. Inconsistencies in genetic counseling and screening for consanguineous couples and their offspring: the need for practice guidelines. Genet Med 1999;1:286-292. (Pubitemid 129736031)
33. Zlotogora J, Shalev SA. The consequences of consanguinity on the rates of malformations and major medical conditions at birth and in early childhood in inbred populations. Am J Med Genet A 2010;152A:2023-2028.
34. Teeuw ME, Henneman L, Bochdanovits Z, et al. Do consanguineous parents of a child affected by an autosomal recessive disease have more DNA identical-by-descent than similarly-related parents with healthy offspring? Design of a case-control study. BMC Med Genet 2010;11:113.
35. Center for Arab Genomic Studies, 2010. Available at: http://www.cags.org. ae/ctga-search.html. Accessed December 1, 2010.
36. Temtamy SA, Aglan MS, Valencia M, et al. Long interspersed nuclear element-1 (LINE1)-mediated deletion of EVC, EVC2, C4orf6, and STK32B in Ellis-van Creveld syndrome with borderline intelligence. Hum Mutat 2008;29:931-938. (Pubitemid 351951287)
37. Teebi A. Genetic disorders among Arab populations, 2nd ed. New York: Springer, 2010.
38. Al-Gazali L, Ali BR. Mutations of a country: a mutation review of single gene disorders in the United Arab Emirates (UAE). Hum Mutat 2010;31: 505-520.
39. Hamamy H, Al-Hait S, Alwan A, Ajlouni K. Jordan: communities and community genetics. Community Genet 2007;10:52-60. (Pubitemid 46005803)
40. Megarbane A, Dorison N, Rodriguez D, Tamraz J. Multiple cranial nerve neuropathies, microcephaly, neurological degeneration, and "fork and bracket sign" in the MRI: a distinct syndrome. Am J Med Genet A 2010;152A:2297-2300.
41. Temtamy SA, Aglan MS. Brachydactyly Orphanet J Rare Dis 2008;3:15.
42. Reversade B, Escande-Beillard N, Dimopoulou A, et al. Mutations in PYCR1 cause cutis laxa with progeroid features. Nat Genet 2009;41:1016-1021.
43. Yunis K, Mumtaz G, Bitar F, et al. Consanguineous marriage and congenital heart defects: a case-control study in the neonatal period. Am J Med Genet A 2006;140:1524-1530.
44. McGregor TL, Misri A, Bartlett J, et al. Consanguinity mapping of congenital heart disease in a South Indian population. PLoS One 2010;5:e10286.
45. Farrer LA, Bowirrat A, Friedland RP, Waraska K, Korczyn AD, Baldwin CT. Identification of multiple loci for Alzheimer disease in a consanguineous Israeli-Arab community. Hum Mol Genet 2003;12:415-422. (Pubitemid 36285133)
46. Liede A, Malik IA, Aziz Z, de los Rios P, Kwan E, Narod SA. Contribution of BRCA1 and BRCA2 mutations to breast and ovarian cancer in Pakistan. Am J Hum Genet 2002;71:595-606. (Pubitemid 34970130)
47. Bener A, Ayoubi HR, Ali AI, Al-Kubaisi A, Al-Sulaiti H. Does consanguinity lead to decreased incidence of breast cancer? Cancer Epidemiol 2010;34:413-418.
48. Dobrusin M, Weitzman D, Levine J, et al. The rate of consanguineous marriages among parents of schizophrenic patients in the Arab Bedouin population in Southern Israel 1. World J Biol Psychiatry 2009;10:334-336.
49. van Rijn MJ, Slooter AJ, Schut AF, et al. Familial aggregation, the PDE4D gene, and ischemic stroke in a genetically isolated population 1. Neurology 2005;65:1203-1209. (Pubitemid 41508212)
50. Ten Kate LP, Teeuw ME, Henneman L, Cornel MC. Autosomal recessive disease in children of consanguineous parents: inferences from the proportion of compound heterozygotes. J Community Genet 2010;1:37-40.
51. Romeo G. LSDBs: promise and challenges. Hum Mutat 2010;31:V.
52. Antonarakis SE, Chakravarti A, Cohen JC, Hardy J. Mendelian disorders and multifactorial traits: the big divide or one for all? Nat Rev Genet 2010;11:380-384.