Effects of Naokang Erhao decoction on cognitive ability and hippocampal apoptosis-related proteins in diabetic rats

Zhongguo Zhongyao Zazhi

Volumn 36, Issue 11, 2011, Pages 1519-1523

  Chen, Yujing ^a   Li, Lin ^a   Li, Zongxin ^a   Huang, Xiaobo ^a   Zhang, Li ^a   Chen, Wenqiang ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cognitive disorder; Naokang Erhao decoction; Type 2 diabetes

Indexed keywords

CASPASE 3; NAOKANG ERHAO DECOCTION; PLANT MEDICINAL PRODUCT; PROTEIN BAX; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LEARNING; MAZE TEST; MEMORY; MORRIS WATER MAZE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN EXPRESSION; RAT;

ACETOPHENONES; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BENZOIC ACIDS; BRIDGED COMPOUNDS; CA1 REGION, HIPPOCAMPAL; CASPASE 3; COGNITION DISORDERS; DIABETIC NEUROPATHIES; DITERPENES, ABIETANE; DRUG COMBINATIONS; DRUGS, CHINESE HERBAL; GLUCOSIDES; MALE; MAZE LEARNING; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRAZINES; RATS;

EID: 80052606826     PISSN: 10015302     EISSN: None     Source Type: Journal    
DOI: 10.4268/cjcmm20111125     Document Type: Article

References (16)

1. Gregg E W, Yaffe K, Cauley J A, et al. Is diabetes associated with cognitive impairment and cognitive decline among older women[J] Arch Intern Med, 2000, 160: 174.
2. Logroscino G, Kang J H, Grodstein F. Prospective study of type 2 diabetes and cognitive decline in women aged 70-81 years[J]. BMJ, 2004, 328: 548.
3. Knopman D, Boland L L, Mosley T, et al. Cardiovascular risk factors and cognitive decline in middle-aged adults[J]. Neurology, 2001, 56: 42.
4. Peila R, Rodriguez B L, Launer L J, et al. Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: the honolulu-asia aging study[J]. Diabetes, 2002, 51: 1256.
5. Savitz S I, Rosenbaum D M. Apoptosis in neurological disease[J]. Neurosurgery, 1998, 42: 555.
6. Elias D, Prigozin H, Polak N, et al. Autoimmune diabetes induced by theft cell toxin STZ[J]. Diabetes, 1994, 43: 992.
7. Morris R. Developments of a water maze procedure for studying spatial learning in the rat[J]. J Neurosci Methods, 1984, 11: 47.
8. Yuan J Y, Yankner B A. Apoptosis in the nervous system[J]. Nature, 2000, 407: 802.
9. Zhan Y, Water B, Wang Y, et al. The roles of caspase-3 and bcl-2 in chemically-induced apoptosis but not necrosis of renal epithelial cells[J]. Oncogene, 1999, 18: 6505.
10. Srinivasula S M, Saleh A, Ahmad M, et al. Isolation and assay of caspases[J]. Methods Cell Biol, 2001, 66: 1.
11. Cheng E H, Krisch D G, Clem R J, et al. Conversion of Bcl-2 to a Bax-like death effector by caspases[J]. Science, 1997, 278; 1966.
12. Steiler H. Mechanisms and genes of cellular suicide[J]. Science, 1995, 267: 1445.
13. 2-adrenaoceptor agonist clenbuterol modulates Bcl-2, Bcl-xl and Bax protein expression following transient forebrain ischemia[J]. Neuroscience, 1999, 90: 1255.