Analysis of toxicokinetic data using NONMEM: Impact of quantification limit and replacement strategies for censored data

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 28, Issue 5, 2001, Pages 465-479

  Hing, Jeremy P ^a   Woolfrey, Steven G ^b   Greenslade, Dennis ^b   Wright, Peter M C ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b Alnwick Research Centre   (United Kingdom)

Author keywords

Computer simulations; Destructive sampling; Mixed effects model; Research study design; Toxicokinetics

Indexed keywords

ANTIARRHYTHMIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPUTER SIMULATION; DRUG CLEARANCE; DRUG DETERMINATION; FEMALE; MALE; MODEL; NONHUMAN; PARAMETER; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RAT; RELIABILITY; TOXICOKINETICS;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; DRUG EVALUATION, PRECLINICAL; FEMALE; MALE; MODELS, THEORETICAL; PHARMACOKINETICS; RATS; SAMPLE SIZE;

EID: 0035217983     PISSN: 1567567X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012247131190     Document Type: Article

References (4)

1. Analysis and design issues for studies using censored biomarker measurements with an example of viral load measurements in HIV clinical trials
2. Analysis of animal pharmacokinetic data: Performance of the one point per animal design
3. Is mixed effects modeling or naive pooled data analysis preferred for the interpretation of singel sample per subject toxicokinetic data
4. The Bayesian analysis of a pivotal pharmacokinetic study