Liver injury induced by high-dose methylprednisolone therapy: A case report and brief review of the literature

Hepatitis Monthly

Volumn 11, Issue 8, 2011, Pages 656-661

  Gutkowski, Krzysztof ^a   Chwist, Alina ^a   Hartleb, Marek ^a  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

Author keywords

Adverse drug reactions; Hepatotoxicity; Methylprednisolone; Multiple sclerosis

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ALPHA FETOPROTEIN; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; GAMMA GLUTAMYLTRANSFERASE; INTERFERON BETA SERINE; METHYLPREDNISOLONE; PROTHROMBIN; SMOOTH MUSCLE ANTIBODY;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CASE REPORT; DISEASE ASSOCIATION; DISEASE EXACERBATION; DRUG EXPOSURE; DRUG MEGADOSE; DRUG PULSE THERAPY; DRUG RECHALLENGE; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HUMAN; JAUNDICE; LIVER FUNCTION; MULTIPLE SCLEROSIS; REVIEW; SIDE EFFECT; TOXIC HEPATITIS;

EID: 80052597317     PISSN: 1735143X     EISSN: 17353408     Source Type: Journal    
DOI: 10.5812/kowsar.1735143X.713     Document Type: Review

References (19)

1. Nanki T, Koike R, Miyasaka N. Subacute severe steatohepatitis during prednisolone therapy for systemic lupus erythematosis. Am J Gastroenterol. 1999;94(11):3379.
2. Dourakis SP, Sevastianos VA, Kaliopi P. Acute severe steatohepatitis related to prednisolone therapy. Am J Gastroenterol. 2002;97(4):1074-1075.
3. Weissel M, Hauff W. Fatal liver failure after high-dose glucocorticoid pulse therapy in a patient with severe thyroid eye disease. Thyroid. 2000;10(6):521.
4. Rivero Fernandez M, Riesco JM, Moreira VF, Moreno A, Lopez San Roman A, Arranz G, et al. Recurrent acute liver toxicity from intravenous methylprednisolone. Rev Esp Enferm Dig. 2008;100(11):720-3.
5. Loraschi A, Banfi P, Mauri M, Sessa F, Bono G, Cosentino M. Hepatotoxicity after high-dose methylprednisolone for demyelinating disease. Clin Neuropharmacol. 2010;33(1):52-54.
6. Das D, Graham I, Rose J. Recurrent acute hepatitis in patient receiving pulsed methylprednisolone for multiple sclerosis. Indian J Gastroenterol. 2006;25(6):314-316.
7. Takahashi A, Kanno Y, Takahashi Y, Sakamoto N, Monoe K, Saito H, et al. Development of autoimmune hepatitis type 1 after pulsed methylprednisolone therapy for multiple sclerosis: a case report. World J Gastroenterol. 2008;14(35):5474-5477.
8. Gerolami R, Mambrini P, Barthet M, Jean-Pastor MJ, Salducci J, Grimaud JC. Acute hepatitis caused by Solupred in a patient with Crohn disease. Gastroenterol Clin Biol. 1997;21(3):236-7.
9. Hammond A, Ramersdorfer C, Palitzsch KD, Scholmerich J, Lock G. Fatal liver failure after corticosteroid treatment of a hepatitis B virus carrier. Dtsch Med Wochenschr. 1999;124(22):687-690.
10. Stravitz RT, Sanyal AJ. Drug-induced steatohepatitis. Clin Liver Dis. 2003;7(2):435-451.
11. Gunawan BK, Kaplowitz N. Mechanisms of drug-induced liver disease. Clin Liver Dis. 2007;11(3):459-475
12. Kaplowitz N. Idiosyncratic drug hepatotoxicity. Nat Rev Drug Discov. 2005;4(6):489-499.
13. Andrade RJ, Lucena MI, Fernandez MC, Vega JL, Camargo R. Hepatotoxicity in patients with cirrhosis, an often unrecognized problem: lessons from a fatal case related to amoxicillin/clavulanic acid. Dig Dis Sci. 2001;46(7):1416-1419.
14. Perez Moreno JM, Saldana Gonzalez FJ, Puertas Montenegro M, Baez Perea J. Cholestatic hepatitis caused by midecamycin. Gastroenterol Hepatol. 1996;19(9):459-461.
15. Lucena MI, Andrade RJ, Rodrigo L, Salmeron J, Alvarez A, Lopez-Garrido MJ, et al. Trovafloxacin-induced acute hepatitis. Clin Infect Dis. 2000;30(2):400-401.
16. Olsson R, Wiholm BE, Sand C, Zettergren L, Hultcrantz R, Myrhed M. Liver damage from flucloxacillin, cloxacillin and dicloxacillin. J hepatol. 1992;15(1-2):154-161.
17. Salvi M, Vannucchi G, Sbrozzi F, Del Castello AB, Carnevali A, Fargion S, et al. Onset of autoimmune hepatitis during intravenous steroid therapy for thyroid-associated ophthalmopathy in a patient with Hashimoto's thyroiditis: case report. Thyroid. 2004;14(8):631-634.
18. Hofstee HM, Nanayakkara PW, Stehouwer CD. Acute hepatitis related to prednisolone. Eur J Intern Med. 2005;16(3):209-210.
19. Topal F, Ozaslan E, Akbulut S, Kucukazman M, Yuksel O, Altiparmak E. Methylprednisolone-induced toxic hepatitis. Ann Pharmacother. 2006;40(10):1868-1871.