Calcium does not inhibit the absorption of 5 milligrams of nonheme or heme iron at doses less than 800 milligrams in nonpregnant women

Journal of Nutrition

Volumn 141, Issue 9, 2011, Pages 1652-1656

  Gaitán, Diego ^a   Flores, Sebastián ^a   Saavedra, Pía ^a   Miranda, Constanza ^a   Olivares, Manuel ^a   Arredondo, Miguel ^a   de Romaña, Daniel López ^a   Lönnerdal, Bo ^b   Pizarro, Fernando ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHLORIDE; ERYTHROCYTE PROTOPORPHYRIN; FERRITIN; FERROUS SULFATE; HEMOGLOBIN; IRON; TRACER; TRANSFERRIN;

ADULT; ARTICLE; BODY MASS; DOSE RESPONSE; ERYTHROCYTE; FEMALE; FERRITIN BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; IRON ABSORPTION; MEAL; MEAN CORPUSCULAR VOLUME; MINERAL INTAKE; NORMAL HUMAN;

ADULT; ANEMIA, IRON-DEFICIENCY; CALCIUM; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FEMALE; HEME; HUMANS; IRON; MIDDLE AGED;

EID: 80052572910     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.111.138651     Document Type: Article

References (30)

1. Sharp P, Srai SK. Molecular mechanisms involved in intestinal iron absorption. World J Gastroenterol. 2007;13:4716-24.
2. Disler PB, Lynch SR, Charlton RW, Torrance JD, Bothwell TH, Walker RB,Mayet F. The effect of tea on iron absorption. Gut. 1975;16:193-200.
3. Hurrell RF, Juillerat MA, Reddy MB, Lynch SR, Dassenko SA, Cook JD. Soy protein, phytate, and iron absorption in humans. Am J Clin Nutr. 1992;56:573-8.
4. Layrisse M, Martinez-Torres C. Model for measuring dietary absorption of heme iron: test with a complete meal. Am J Clin Nutr. 1972; 25:401-11.
5. Lynch SR, Dassenko SA, Cook JD, Juillerat MA, Hurrell RF. Inhibitory effect of a soybean-protein-related moiety on iron absorption in humans. Am J Clin Nutr. 1994;60:567-72.
6. Gibson RS, Yeudall F, Drost N, Mtitimuni BM, Cullinan TR. Experiences of a community-based dietary intervention to enhance micronutrient adequacy of diets low in animal source foods and high in phytate: a case study in rural Malawian children. J Nutr. 2003;133:S3992-9.
7. Hallberg L, Brune M, Erlandsson M, Sandberg AS, Rossander-Hulten L. Calcium: effect of different amounts on nonheme- and heme-iron absorption in humans. Am J Clin Nutr. 1991;53:112-9.
8. Hallberg L, Rossander-Hulthen L, Brune M, Gleerup A. Inhibition of haem-iron absorption in man by calcium. Br J Nutr. 1993;69:533-40.
9. Dawson-Hughes B, Seligson FH, Hughes VA. Effects of calcium carbonate and hydroxyapatite on zinc and iron retention in postmenopausal women. Am J Clin Nutr. 1986;44:83-8.
10. Cook JD, Dassenko SA, Whittaker P. Calcium supplementation: effect on iron absorption. Am J Clin Nutr. 1991;53:106-11.
11. Looker A. Dietary calcium. In: Weaver C, Heaney R, editors. Calcium in human health. Totawa, NJ: Humana Press; 2006. p. 105-27.
12. Weaver CM. Closing the gap between calcium intake and requirements. J Am Diet Assoc. 2009;109:812-3.
13. INACG. Guidelines for the use of iron supplements to prevent and treat iron deficiency anemia. Stoltzfus R, Dreyfuss M, editors. Washington, DC: International Life Sciences Institute; 1998. p. 18-21.
14. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, Hediger MA. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature. 1997;388:482-8.
15. Rouault TA. The intestinal heme transporter revealed. Cell. 2005;122: 649-51.
16. Asenjo J, Amar M, Cartagena N, King J, Hiche E, Stekel A. Use of a bovine heme iron concentrate in the fortification of biscuits. J Food Sci. 1985;50:795-9.
17. Flowers CA, Kuizon M, Beard JL, Skikne BS, Covell AM, Cook JD. A serum ferritin assay for prevalence studies of iron deficiency. Am J Hematol. 1986;23:141-51.
18. WHO. CDC. Report of a joint WHO/CDC and prevention technical consultation on the assessment of iron status at the population level. Geneva: WHO Press; 2004. p. 2-18.
19. WHO. Iron deficiency anaemia assessment, prevention, and control: a guide for programme managers. Geneva: WHO Press; 2001. p. 47-70.
20. Eakins JD, Brown DA. An improved method for the simultaneous determination of iron-55 and iron-59 in blood by liquid scintillation counting. Int J Appl Radiat Isot. 1966;17:391-7.
21. Nadler S, Hidalgo I, Block T. Prediction of blood volume in normal human adults. Surgery. 1962;51:224-32.
22. Bothwell TH, Charlton RW, Cook JD, Finch CA. Iron metabolism in man. Oxford: Blackwell Scientific Publications; 1979.
23. Yanatori I, Tabuchi M, Kawai Y, Yasui Y, Akagi R, Kishi F. Heme and nonheme iron transporters in non-polarized and polarized cells. BMC Cell Biol. 2010;11:39.
24. McKie AT,Marciani P, Rolfs A, Brennan K,Wehr K, Barrow D, Miret S, Bomford A, Peters TJ, Farzaneh F, et al. A novel duodenal ironregulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell. 2000;5:299-309.
25. Thompson BA, Sharp PA, Elliott R, Fairweather-Tait SJ. Inhibitory effect of calcium on nonheme iron absorption may be related to translocation of DMT-1 at the apical membrane of enterocytes. J Agric Food Chem. 2010;58:8414-7.
26. Monsen ER, Cook JD. Food iron absorption in human subjects. IV. The effects of calcium and phosphate salts on the absorption of nonheme iron. Am J Clin Nutr. 1976;29:1142-8.
27. Roughead ZK, Zito CA, Hunt JR. Inhibitory effects of dietary calcium on the initial uptake and subsequent retention of heme and nonheme iron in humans: comparisons using an intestinal lavage method. Am J Clin Nutr. 2005;82:589-97.
28. Kalkwarf HJ, Harrast SD. Effects of calcium supplementation and lactation on iron status. Am J Clin Nutr. 1998;67:1244-9.
29. Molgaard C, Kaestel P, Michaelsen KF. Long-term calcium supplementation does not affect the iron status of 12-14-y-old girls. Am J Clin Nutr. 2005;82:98-102.
30. Minihane AM, Fairweather-Tait SJ. Effect of calcium supplementation on daily nonheme-iron absorption and long-term iron status. Am J Clin Nutr. 1998;68:96-102.