High Throughput Automated LC-MS/MS Analysis of Endogenous Small Molecule Biomarkers

Clinics in Laboratory Medicine

Volumn 31, Issue 3, 2011, Pages 429-441

  Grant, Russell P ^a  

^a LABORATORY CORPORATION OF AMERICA   (United States)

Author keywords

Automation; Endogenous biomarkers; High throughput; LC MS MS

Indexed keywords

BIOGENIC AMINE; BIOLOGICAL MARKER; STEROID HORMONE; VITAMIN D;

ACCURACY; AUTOANALYSIS; DATA ANALYSIS; HIGH THROUGHPUT SCREENING; HUMAN; INSTRUMENTATION; LABORATORY AUTOMATION; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MOLECULAR LIBRARY; PRIORITY JOURNAL; REVIEW; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; STANDARDIZATION; TANDEM MASS SPECTROMETRY; ULTRAFILTRATION;

ANALYTIC SAMPLE PREPARATION METHODS; BIOLOGICAL MARKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; TANDEM MASS SPECTROMETRY;

EID: 80052542674     PISSN: 02722712     EISSN: 15579832     Source Type: Journal    
DOI: 10.1016/j.cll.2011.07.008     Document Type: Review

References (46)

1. Proctor C.J., Todd J.F.J. Atmospheric pressure ionization mass spectrometry. Org Mass Spec 1983, 18:509-516.
2. Niwa T. Metabolic profiling with gas chromatography-mass spectrometry and its application to clinical medicine. J Chromatogr 1986, 370:313-345.
3. Van Bocxlaer J.F., Clauwaert K.M., Lambert W.E., et al. Liquid chromatography-mass spectrometry in forensic toxicology. Mass Spectrom Rev 2000, 19:165-214.
4. Chace D. Mass spectrometry in newborn and metabolic screening: historical perspective and future directions. J Mass Spectrom 2009, 44:163-170.
5. Shackleton C.H. Mass spectrometry in the diagnosis of steroid related disorders and in hypertension research. J Steroid Biochem Mol Biol 1993, 45:127-140.
6. Soldin O.P., Soldin S.J. Thyroid hormone testing by tandem mass spectrometry. Clin Biochem 2011, 44:89-94.
7. de Jong W.H., de Vries E.G., Kema I.P. Current status and future developments of LC-MS/MS in clinical chemistry for quantification of biogenic amines. Clin Biochem 2011, 44:95-103.
8. Schmedes A., Brandslund I. Analysis of methylmalonic acid in plasma by liquid chromatography-tandem mass spectrometry. Clin Chem 2006, 52:754-757.
9. Chace D.H. Mass spectrometry in the clinical laboratory. Chem Rev 2001, 101:445-478.
10. Yue B., Rockwood A.L., Sandrock T., et al. Free thyroid hormones in serum by direct equilibrium dialysis and online solid-phase extraction-liquid chromatography/tandem mass spectrometry. Clin Chem 2008, 54:642-651.
11. Bhasin S., Zhang A., Coviello A., et al. The impact of assay quality and reference ranges on clinical decision making in the diagnosis of androgen disorders. Steroids 2008, 73:1311-1317.
12. Thienpont L.M., Van Uytfanghe K., Blincko S., et al. State-of-the-art of serum testosterone measurement by isotope dilution-liquid chromatography-tandem mass spectrometry. Clin Chem 2008, 54:1290-1297.
13. Singh R.J., Grebe S.K., Yue B., et al. Precisely wrong?. Urinary fractionated metanephrines and peer-based laboratory proficiency testing. Clin Chem 2005, 51:472-473. discussion 473-4.
14. Rappold B., Grant R.P., Holland P. Quantitative underivatized amino acid analysis - development, dimensionality, data reduction and diagnostic utility 2010, MOB 176.
15. Minkler P., Stoll M.S.K., Ingalls S., et al. Selective, Accurate, and Precise Quantification of Acylcarnitines in Human Urine, Plasma, and Skeletal Muscle by HPLC-MS/MS 2011, MP349.
16. Guo T., Taylor R.L., Singh R.J., et al. Simultaneous determination of 12 steroids by isotope dilution liquid chromatography-photospray ionization tandem mass spectrometry. Clin Chim Acta 2006, 372:76-82.
17. Grebe S.K., Singh R.J. LC-MS/MS in the Clinical Laboratory - Where to From Here?. Clin Biochem Rev 2011, 32:5-31.
18. Vogeser M., Seger C. Pitfalls associated with the use of liquid chromatography-tandem mass spectrometry in the clinical laboratory. Clin Chem 2010, 56:1234-1244.
19. Taylor P.J. Therapeutic drug monitoring of immunosuppressant drugs by high performance liquid chromatography-mass spectrometry. Ther Drug Monit 2004, 26:215-219.
20. Santen R.J., Lee J.S., Wang S., et al. Potential role of ultra-sensitive estradiol assays in estimating the risk of breast cancer and fractures. Steroids 2008, 73:1318-1321.
21. Stanczyk F.Z., Clarke N.J. Advantages and challenges of mass spectrometry assays for steroid hormones. J Steroid Biochem Mol Biol 2010, 121:491-495.
22. Kushnir M.M., Rockwood A.L., Roberts W.L., et al. Liquid chromatography tandem mass spectrometry for analysis of steroids in clinical laboratories. Clin Biochem 2011, 44:77-88.
23. Rappold B., Grant R.P., Crawford M., et al. An Empirical Marriage of HILIC and Clinical Diagnostics: Exploration and Expansion of Development, Utility and Doctrine 2011, TOG125.
24. Kushnir M.M., Rockwood A.L., Nelson G.J. Assessing analytical specificity in quantitative analysis using tandem mass spectrometry. Clin Biochem 2005, 38;:319-327.
25. Kushnir M.M., Urry F.M., Frank E.L., et al. Analysis of catecholamines in urine by positive-ion electrospray tandem mass spectrometry. Clin Chem 2002, 48:323-331.
26. Kushnir M.M., Rockwood A.L., Bergquist J. High-sensitivity tandem mass spectrometry assay for serum estrone and estradiol. Am J Clin Pathol 2008, 129:530-539.
27. Vogeser M., Kirchoff F. Progress in automation of LC-MS in laboratory medicine. Clin Biochem 2011, 44:4-13.
28. Blomberg L.G. Two new techniques for sample preparation in bioanalysis: microextraction in packed sorbent (MEPS) and use of a bonded monolith as sorbent for sample preparation in polypropylene tips for 96-well plates. Anal Bioanal Chem 2009, 393:797-807.
29. De Jong W.H.A., Graham K.S., van der Molen J.C. Plasma free metanephrine measurement using automated online solid phase extraction HPLC-tandem mass spectrometry. Clin Chem 2007, 53:1684-1693.
30. Grant R.P., Rappold B., Holland P. Ultra High-Throughput Quantitative LC-MS/MS in a Clinical Diagnostics Laboratory - Breaking the 2000 samples/system/day barrier 2009, MOB.
31. Rauh M., Groschl M., Rascher W., et al. Automated, fast and sensitive quantification of 17alpha-hydroxyprogesterone, androstenedione, and testosterone by tandem mass spectrometry with online extraction. Steroids 2006, 71:450-458.
32. Henriksen T., Hellestrom P.R., Poulsen H.E., et al. Automated method for the direct analysis of 8-oxo-guanosine and 8-oxo-2'-deoxyguanosine in human urine using ultraperformance liquid chromatography and tandem mass spectrometry. Free Radic Biol Med 2009, 47:629-635.
33. Blom H.J., van Rooij A., Hogeveen M. A simple high-throughput method for the determination of plasma methylmalonic acid by liquid chromatography-tandem mass spectrometry. Clin Chem Lab Med 2007, 45:645-650.
34. Alvarez Sánchez B., Capote F.P., Jiménez J.R., et al. Automated solid-phase extraction for concentration and clean-up of female steroid hormones prior to liquid chromatography-electrospray ionization-tandem mass spectrometry: an approach to lipidomics. J Chromatogr A 2008, 1207:46-54.
35. Bonfiglio R., King R.C., Olah T.V., et al. The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds. Rapid Commun Mass Spectrom 1999, 13:1175-1185.
36. Grant R.P., Rappold B., Holland P. Steroid Analysis in Clinical Diagnostics: Selectivity, Sensitivity and Speed 2011.
37. Hoofnagle A.N., Laha T.J., Donaldson T.F. A rubber transfer gasket to improve the throughput of liquid-liquid extraction in 96 well plates: application to vitamin D testing. J Chromogr B Analyt Technol Biomed Life Sci 2010, 878:1639-1642.
38. Crawford M., Rappold R., Grant R.P. Clinical Testosterone Analysis for the Masses: Taking Testosterone Testing to the Next Level 2011.
39. Singh R.J. Quantitation of 17-OH-progesterone (OHPG) for diagnosis of congenital adrenal hyperplasia (CAH). Methods Mol Biol 2010, 603:271-277.
40. Kushnir M.M., Rockwood A.L., Bergquist J. Liquid chromatography-tandem mass spectrometry applications in endocrinology. Mass Spectrom Rev 2010, 29:480-502.
41. Lacey J., Casetta B., Daniels S.B., et al. Amino Acid Quantitation in Plasma, Urine and CSF by iTRAQ™ Reagent Amino Acid Analysis Kit and MS/MS 2008, 205.
42. Evans A.M., DeHaven C.D., Barrett T., et al. Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems. Anal Chem 2009, 81:6656-6667.
43. Singh R.J. Validation of a high throughput method for serum/plasma testosterone using liquid chromatography tandem mass spectrometry (LC-MS/MS). Steroids 2008, 73:1339-1344.
44. MacNair J.E., Lewis K.C., Jorgenson J.W. Ultrahigh-pressure reversed-phase liquid chromatography in packed capillary columns. Anal Chem 1997, 69:983-989.
45. Pieters S., Dejaegher B., Vander Heyden Y. Emerging analytical separation techniques with high throughput potential for pharmaceutical analysis, part I: Stationary phase and instrumental developments in LC. Comb Chem High Throughput Screen 2010, 13:510-529. Review.
46. Netzel B.C., Cradic K.W., Bro E.T., et al. Increasing liquid chromatography-tandem mass spectrometry throughput by mass tagging: a sample-multiplexed high-throughput assay for 25-hydroxyvitamin D2 and D3. Clin Chem 2011, 57:431-440.