Soluble fms-like tyrosine kinase-1 (sFlt-1) and serum placental growth factor (PlGF) as biomarkers for ectopic pregnancy and missed abortion

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 9, 2011, Pages

  Daponte, Alexandros ^a   Pournaras, Spyros ^a   Polyzos, Nikolaos P ^a   Tsezou, Aspasia ^a   Skentou, Hara ^a   Anastasiadou, Foteini ^a   Lialios, Georgios ^a   Messinis, Ioannis E ^a  

^a University of Thessaly School of Medicine   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

PLACENTAL GROWTH FACTOR; VASCULOTROPIN RECEPTOR 1;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIFFERENTIAL DIAGNOSIS; ECTOPIC PREGNANCY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; HUMAN; MAJOR CLINICAL STUDY; MISSED ABORTION; PREGNANCY; PREGNANCY DISORDER; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SENSITIVITY AND SPECIFICITY; TERTIARY HEALTH CARE; TROPHOBLAST;

ABORTION, MISSED; ADULT; BIOLOGICAL MARKERS; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; PREGNANCY; PREGNANCY PROTEINS; PREGNANCY, ECTOPIC; PROSPECTIVE STUDIES; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 80052532802     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-0037     Document Type: Article

References (30)

1. Plaisier M., Rodrigues S., Willems F., Koolwijk P., Van Hinsbergh V.W., Helmerhorst F.M. 2007 Different degrees of vascularization and their relationship to the expression of vascular endothelial growth factor, placental growth factor, angiopoietins, and their receptors in first-trimester decidual tissues. Fertil Steril 88:176-187 (Pubitemid 47001384)
2. Plaisier M., Dennert I., Rost E., Koolwijk P., Van Hinsbergh V.W., Helmerhorst F.M. 2009 Decidual vascularization and the expression of angiogenic growth factors and proteases in first trimester spontaneous abortions. Hum Reprod 24:185-197
3. Jauniaux E., Poston L., Burton G.J. 2006 Placental-related diseases of pregnancy: Involvement of oxidative stress and implications in human evolution. Hum Reprod Update 12:747-755 (Pubitemid 44605512)
4. Jauniaux E., Van Oppenraaij R.H., Burton G.J. 2010 Obstetric outcome after early placental complications. Curr Opin Obstet Gynecol 22:452-457
5. Gastrich M.D., Faro R., Rosen T. 2010 Markers of preeclampsia and the relationship to cardiovascular disease: Review of the twenty-first century literature. J Matern Fetal Neonatal Med 23:751-769
6. Clark D.E., Smith S.K., Licence D., Evans A.L., Charnock-Jones D.S. 1998 Comparison of expression patterns for placenta growth factor, vascular endothelial growth factor (VEGF), VEGF-B and VEGF-C in the human placenta throughout gestation. J Endocrinol 159:459-467 (Pubitemid 29003021)
7. Nagamatsu T., Fujii T., Kusumi M., Zou L., Yamashita T., Osuga Y., Momoeda M., Kozuma S., Taketani Y. 2004 Cytotrophoblasts upregulate soluble fms-like tyrosine kinase-1 expression under reduced oxygen: An implication for the placental vascular development and the pathophysiology of preeclampsia. Endocrinology 145:4838-4845 (Pubitemid 39551100)
8. Muttukrishna S., Suri S., Groome N., Jauniaux E. 2008 Relationships between TGFβ proteins and oxygen concentrations inside the first trimester human gestational sac. PLoS One 3:e2302
9. Muttukrishna S., Swer M., Suri S., Jamil A., Calleja-Agius J., Gangooly S., Ludlow H., Jurkovic D., Jauniaux E. 2011 Soluble Flt-1 and PlGF: New markers of early pregnancy loss? PLoS One 6:e18041
10. Rossant J., Cross J.C. 2001 Placental development: Lessons from mouse mutants. Nat Rev Genet 2:538-548 (Pubitemid 33674027)
11. Kingdom J.C., Kaufmann P. 1999 Oxygen and placental vascular development. Adv Exp Med Biol 474:259-275 (Pubitemid 32206776)
12. Damsky C.H., Fisher S.J. 1998 Trophoblast pseudo-vasculogenesis: Faking it with endothelial adhesion receptors. Curr Opin Cell Biol 10:660-666 (Pubitemid 28477026)
13. Kendall R.L., Thomas K.A. 1993 Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc Natl Acad Sci USA 90:10705-10709 (Pubitemid 23347111)
14. Makrydimas G., Sotiriadis A., Savvidou M.D., Spencer K., Nicolaides K.H. 2008 Physiological distribution of placental growth factor and soluble Flt-1 in early pregnancy. Prenat Diagn 28:175-179 (Pubitemid 351427933)
15. Jauniaux E., Gulbis B. 2000 Fluid compartments of the embryonic environment. Hum Reprod Update 6:268-278 (Pubitemid 30348896)
16. Daponte A., Pournaras S., Zintzaras E., Kallitsaris A., Lialios G., Maniatis A.N., Messinis I.E. 2005 The value of a single combined measurement of VEGF, glycodelin, progesterone, PAPP-A, HPL and LIF for differentiating between ectopic and abnormal intrauterine pregnancy. Hum Reprod 20:3163-3166 (Pubitemid 41662672)
17. Lam P.M., Briton-Jones C., Cheung C.K., Leung S.W., Cheung L.P., Haines C. 2004 Increased messenger RNA expression of vascular endothelial growth factor and its receptors in the implantation site of the human oviduct with ectopic gestation. Fertil Steril 82:686-690 (Pubitemid 39243193)
18. Maynard S.E., Moore Simas T.A., Bur L., Crawford S.L., Solitro M.J., Meyer B.A. 2010 Soluble endoglin for the prediction of preeclampsia in a high risk cohort. Hypertens Pregnancy 29:330-341
19. Levine R.J., Lam C., Qian C., Yu K.F., Maynard S.E., Sachs B.P., Sibai B.M., Epstein F.H., Romero R., Thadhani R., Karumanchi S.A. 2006 Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med 355:992-1005 (Pubitemid 44343543)
20. Horne A.W., Shaw J.L., Murdoch A., McDonald S.E., Williams A.R., Jabbour H.N., Duncan W.C., Critchley H.O. 2011 Placental growth factor: A promising diagnostic biomarker for tubal ectopic pregnancy. J Clin Endocrinol Metab 96:E104-E108
21. Smith G.C., Crossley J.A., Aitken D.A., Jenkins N., Lyall F., Cameron A.D., Connor J.M., Dobbie R. 2007 Circulating angiogenic factors in early pregnancy and the risk of preeclampsia, intrauterine growth restriction, spontaneous preterm birth, and stillbirth. Obstet Gynecol 109:1316-1324 (Pubitemid 46869870)
22. Reddy A., Suri S., Sargent I.L., Redman C.W., Muttukrishna S. 2009 Maternal circulating levels of activin A, inhibin A, sFlt-1 and endoglin at parturition in normal pregnancy and pre-eclampsia. PLoS One 4:e4453
23. Wathén K.A., Sarvela J., Stenman F., Stenman U.H., Vuorela P. 2011 Changes in serum concentrations of soluble vascular endothelial growth factor receptor-1 after pregnancy. Hum Reprod 26:221-226
24. Levine R.J., Maynard S.E., Qian C., Lim K.H., England L.J., Yu K.F., Schisterman E.F., Thadhani R., Sachs B.P., Epstein F.H., Sibai B.M., Sukhatme V.P., Karumanchi S.A. 2004 Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 350:672-683 (Pubitemid 38364626)
25. Levine R.J., Karumanchi S.A. 2005 Circulating angiogenic factors in preeclampsia. Clin Obstet Gynecol 48:372-386 (Pubitemid 40605141)
26. Carmeliet P., Moons L., Luttun A., Vincenti V., Compernolle V., De Mol M., Wu Y., Bono F., Devy L., Beck H., Scholz D., Acker T., DiPalma T., Dewerchin M., Noel A., Stalmans I., Barra A., Blacher S., Vandendriessche T., Ponten A., Eriksson U., Plate K.H., Foidart J.M., Schaper W., Charnock-Jones D.S., Hicklin D.J., Herbert J.M., Collen D., Persico M.G. 2001 Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat Med 7:575-583 (Pubitemid 32448325)
27. Taylor R.N., Grimwood J., Taylor R.S., McMaster M.T., Fisher S.J., North R.A. 2003 Longitudinal serum concentrations of placental growth factor: Evidence for abnormal placental angiogenesis in pathologic pregnancies. Am J Obstet Gynecol 188:177-182 (Pubitemid 36135616)
28. Romero R., Nien J.K., Espinoza J., Todem D., Fu W., Chung H., Kusanovic J.P., Gotsch F., Erez O., Mazaki-Tovi S., Gomez R., Edwin S., Chaiworapongsa T., Levine R.J., Karumanchi S.A. 2008 A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate. J Matern Fetal Neonatal Med 21:9-23
29. Marill K.A., Ingmire T.E., Nelson B.K. 1999 Utility of a single β HCG measurement to evaluate for absence of ectopic pregnancy. J Emerg Med 17:419-426 (Pubitemid 29226530)
30. Kirk E., Papageorghiou A.T., Condous G., Tan L., Bora S., Bourne T. 2007 The diagnostic effectiveness of an initial transvaginal scan in detecting ectopic pregnancy. Hum Reprod 22:2824-2828