Haemoglobin A 1c levels and subsequent cardiovascular disease in persons without diabetes: A meta-analysis of prospective cohorts

Diabetologia

Volumn 54, Issue 6, 2011, Pages 1327-1334

  Santos Oliveira, R ^a   Purdy, C ^b   Da Silva, M Pereira ^c   Dos Anjos Carneiro Leao A M ^c   Machado, M ^d   Einarson, T R ^e  

^a INSTITUTO DE ENGENHARIA NUCLEAR   (Brazil)

^b AHRM   (United States)

^c UNIVERSIDADE FEDERAL RURAL DE PERNAMBUCO   (Brazil)

^d Estrada dos Bandeirantes   (Brazil)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cardiovascular death; Cardiovascular events; Glycated haemoglobin; Haemoglobin HbA 1c; Meta analysis; Prospective studies

Indexed keywords

HEMOGLOBIN A1C; BIOLOGICAL MARKER; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN;

ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; COHORT ANALYSIS; DISEASE ASSOCIATION; FOLLOW UP; HEART DEATH; HEMOGLOBIN BLOOD LEVEL; HUMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUALITY CONTROL; RISK ASSESSMENT; STATISTICAL ANALYSIS; SYSTEMATIC REVIEW; ADOLESCENT; ADULT; AGED; BLOOD; FEMALE; MALE; META ANALYSIS; METABOLISM; MIDDLE AGED; PROGNOSIS; REGRESSION ANALYSIS; RISK FACTOR;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; COHORT STUDIES; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; MALE; MIDDLE AGED; PROGNOSIS; REGRESSION ANALYSIS; RISK FACTORS; YOUNG ADULT;

EID: 80052531960     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2078-8     Document Type: Article

References (49)

1. Juutilainen A, Lehto S, Rönnemaa T, Pyörälä K, Laakso M (2008) Similarity of the impact of type 1 and type 2 diabetes on cardiovascular mortality in middle-aged subjects. Diab Care 31:714-719
2. Hanefeld M, Temelkova-Kurktschiev T (2002) Control of postprandial hyperglycemia-an essential part of good diabetes treatment and prevention of cardiovascular complications. Nutr Metab Cardiovasc Dis 12:98-107 (Pubitemid 135712752)
3. Ceriello A, Hanefeld M, Leiter L et al (2004) Postprandial glucose regulation and diabetic complications. Arch Intern Med 164:2090-2095 (Pubitemid 39410797)
4. Ceriello A (2005) Postprandial hyperglycemia and diabetes complications: is it time to treat? Diabetes 54:1-7
5. O'Keefe J, Bell D (2007) Postprandial hyperglycemia/hyperlipidemia (postprandial dysmetabolism) is a cardiovascular risk factor. Am J Cardiol 100:899-904 (Pubitemid 47268287)
6. Stettler C, Allemann S, Jüni P et al (2006) Glycemic control and macrovascular disease in types 1 and 2 diabetes mellitus: metaanalysis of randomized trials. Am Heart J 152:27-38 (Pubitemid 43974725)
7. Turnbull FM, Abraira C, Anderson RJ et al (2009) Intensive glucose control and macrovascular outcomes in type 2 diabetes. Diabetologia 52:2288-2298, Erratum 52: 2470
8. Coutinho M, Wong Y, Gerstein H, Yusuf S (1999) The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years. Diab Care 22:233-240 (Pubitemid 29056916)
9. Cochran W (1954) The combination of estimates from different experiments. Biometrics 10:101-129
10. Higgins J, Thompson S (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21:1539-1558 (Pubitemid 34746062)
11. Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629-634 (Pubitemid 27387172)
12. Downs S, Black N (1998) The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health 52:377-384 (Pubitemid 28438523)
13. Blake D, Meigs J, Muller D, Najjar S, Andres R, Nathan D (2004) Impaired glucose tolerance, but not impaired fasting glucose, is associated with increased levels of coronary heart disease risk factors: results from the Baltimore longitudinal study on aging. Diabetes 53:2095-2100 (Pubitemid 38970760)
14. Gerstein H, Pogue J, Mann J et al (2005) The relationship between dysglycaemia and cardiovascular and renal risk in diabetic and non-diabetic participants in the HOPE study: a prospective epidemiological analysis. Diabetologia 48:1749-1755 (Pubitemid 41317828)
15. Ko G, Chan J, Woo J et al (1998) Glycated haemoglobin and cardiovascular risk factors in Chinese subjects with normal glucose tolerance. Diabet Med 15:573-578 (Pubitemid 28319939)
16. Lawlor D, Fraser A, Ebrahim S, Davey Smith G (2007) Independent associations of fasting insulin, glucose, and glycated haemoglobin with stroke and coronary heart disease in older women. PLoS Med 8:1396-1404 (Pubitemid 47358175)
17. Liao D, Leonetti D, Shofer J et al (2001) Abnormal glucose tolerance and increased risk for cardiovascular disease in Japanese-Americans with normal fasting glucose. Diab Care 24:39-44 (Pubitemid 32104217)
18. Meigs J, D'Agostino R, Nathan D, Wilson P (2002) Fasting and postchallenge glycemia and cardiovascular disease risk: the Framingham Offspring Study. Diab Care 25:1845-1850 (Pubitemid 41071098)
19. Park S, Barrett-Connor E, Wingard D, Shan J, Edelstein S (1996) GHb is a better predictor of cardiovascular disease than fasting or postchallenge plasma glucose in women without diabetes: the Rancho Bernardo Study. Diab Care 19:450-456
20. Selvin E, Coresh J, Golden S, Boland L, Brancati F, Steffes M (2005) Glycemic control, atherosclerosis, and risk factors for cardiovascular disease in individuals with diabetes. Diab Care 28:1965-1973 (Pubitemid 41060971)
21. Selvin E, Coresh J, Golden S, Brancati F, Folsom A, Steffes M (2005) Glycemic control and coronary heart disease risk in persons with and without diabetes: The Atherosclerosis Risk in Communities Study. Arch Intern Med 165:1910-1916 (Pubitemid 41352087)
22. Simmons R, Sharp S, Boekholdt M et al (2008) Evaluation of the Framingham risk score in the European Prospective Investigation of Cancer-Norfolk Cohort: does adding glycated hemoglobin improve the prediction of coronary heart disease events? Arch Intern Med 168:1209-1216 (Pubitemid 351831404)
23. Stephens J, Humphries S, Cooper J, Hurel S (2004) What are the clinical manifestations of cardiovascular disease in diabetes? Ten year analysis from a clinic based population. Br J Diab Vasc Dis 4:190-194 (Pubitemid 38967713)
24. Stevens R, Kothari V, Adler A, Stratton I, Holman R (2001) The UKPDS risk engine: a model for the risk of coronary heart disease in Type II diabetes (UKPDS 56). Clin Sci 101:671-679 (Pubitemid 33135349)
25. Stratton I, Adler A, Neil A et al (2000) Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 321:405-412 (Pubitemid 30609442)
26. Danaei G, Lawes C, Vander Hoorn S, Murray C, Ezzati M (2006) Global and regional mortality from ischaemic heart disease and stroke attributable to higher-than-optimum blood glucose concentration: comparative risk assessment. Lancet 368:1651-1659 (Pubitemid 46048553)
27. Dilley J, Ganesan A, Deepa R et al (2007) Association of A1C with cardiovascular disease and metabolic syndrome in Asian Indians with normal glucose tolerance. Diab Care 30:1527-1532 (Pubitemid 46871165)
28. O'Sullivan C, Hynes N, Mahendran B et al (2006) Haemoglobin A1c (HbA1C) in non-diabetic and diabetic vascular patients. Is HbA1C an independent risk factor and predictor of adverse outcome? Eur J Vasc Endovasc Surg 32:188-197 (Pubitemid 44403446)
29. Stakos D, Schuster D, Sparks E et al (2007) Association between glycosylated hemoglobin, left ventricular mass and aortic function in nondiabetic individuals with insulin resistance. Eur J Endocrinol 157:63-68 (Pubitemid 47162567)
30. Chowdhury T, Lasker S (1998) Elevated glycated haemoglobin in non-diabetic patients is associated with an increased mortality. Postgrad Med J 74:480-481 (Pubitemid 28408542)
31. Gray C, Taylor R, French J et al (1987) The prognostic value of stress hyperglycaemia and previously unrecognized diabetes in acute stroke. Diabet Med 4:237-240 (Pubitemid 17075916)
32. Shankar A, Klein R, Klein B, Moss S (2007) Association between glycosylated hemoglobin level and cardiovascular and all-cause mortality in type 1 diabetes. Am J Epidemiol 166:393-402 (Pubitemid 47216790)
33. Khaw K-T, Wareham N, Luben R et al (2001) Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of European Prospective Investigation of Cancer and Nutrition (EPICNorfolk). BMJ 22:15-18 (Pubitemid 32066250)
34. Myint P, Sinha S, Wareham N et al (2007) Glycated hemoglobin and risk of stroke in people without known diabetes in the European Prospective Investigation Into Cancer (EPIC)-Norfolk Prospective Population Study: a threshold relationship? Stroke 38:271-275 (Pubitemid 46184293)
35. Sigal R (2005) Hemoglobin A1c levels were associated with increased cardiovascular disease and all-cause mortality in persons with and without diabetes. ACP J Club 142:52
36. Gerstein H, Yusuf S (1996) Dysglycaemia and risk of cardiovascular disease. Lancet 347:949-950 (Pubitemid 26102554)
37. Sigal RJ (2005) Haemoglobin A1c concentrations were associated with increased cardiovascular disease and all cause mortality. Evid Based Med 10:57
38. Adams R, Appleton S, Hill C et al (2009) Independent association of HbA1c and incident cardiovascular disease in people without diabetes. Obesity 17:559-563
39. Corpus R, O'Neill W, Dixon S, Timmis G, Devlin W (2003) Relation of hemoglobin A1c to rate of major adverse cardiac events in nondiabetic patients undergoing percutaneous coronary revascularization. Am J Cardiol 92:1282-1286 (Pubitemid 37431135)
40. de Vegt F, Dekker J, Ruhe H et al (1999) Hyperglycaemia is associated with all-cause and cardiovascular mortality in the Hoorn population: the Hoorn Study. Diabetologia 42:926-931 (Pubitemid 29369599)
41. Gao L, Matthews F, Sargeant L, Brayne C (2008) An investigation of the population impact of variation in HbA1c levels in older people in England and Wales: from a population based multicentre longitudinal study. BMC Public Health 5:54
42. Khaw K-T, Wareham N, Bingham S, Luben R, Welch A, Day N (2004) Association of hemoglobin A1c with cardiovascular disease and mortality in adults: The European Prospective Investigation into Cancer in Norfolk. Ann Intern Med 141:413-420
43. Pradhan A, Rifai N, Buring J, Ridker P (2007) HbA1c predicts diabetes but not cardiovascular disease in non-diabetic women. Am J Med 120:720-727 (Pubitemid 47176521)
44. Singer D, Nathan D, Anderson K, Wilson P, Evans J (1992) Association of HbA1c with prevalent cardiovascular disease in the original cohort of the Framingham Heart Study. Diabetes 41:202-208
45. The Diabetes Control and Complications Trial Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complication in insulin-dependent diabetes mellitus. N Engl J Med 329:977-986
46. Turner RC, Millns H, Neil HA et al (1998) Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS: 23). BMJ 316:823-828
47. Muntner P, He J, Chen J, Fonseca V, Whelton PK (2004) Prevalence of non-traditional cardiovascular disease risk factors among persons with impaired fasting glucose, impaired glucose tolerance, diabetes, and the metabolic syndrome: analysis of the Third National Health and Nutrition Examination Survey (NHANES III). Ann Epidemiol 14:686-695 (Pubitemid 39233630)
48. The DECODE Study Group on behalf of the European Diabetes Epidemiology Group (2004) Prediction of cardiovascular mortality using a score that includes glucose as a risk factor. The DECODE Study. Diabetologia 47:2118-2128
49. Selvin E, Steffes MW, Zhu H et al (2010) Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults. N Engl J Med 362:800-811