Exercise training increases adipose tissue GLUT4 expression in patients with type 2 diabetes

Diabetes, Obesity and Metabolism

Volumn 13, Issue 10, 2011, Pages 959-962

  Hussey, S E ^a   McGee, S L ^b   Garnham, A ^b   Wentworth, J M ^c   Jeukendrup, A E ^d   Hargreaves, Mark ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b DEAKIN UNIVERSITY   (Australia)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Adipocyte; Glucose uptake; Insulin resistance; Skeletal muscle

Indexed keywords

GLUCOSE TRANSPORTER 4;

ADIPOSE TISSUE; ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; EXERCISE; FEMALE; HUMAN; HUMAN TISSUE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN EXPRESSION; SKELETAL MUSCLE;

EID: 80052523638     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2011.01426.x     Document Type: Article

References (12)

1. Garvey WT, Maianu L, Huecksteadt TP, Birnbaum MJ, Molina JM, Ciaraldi TP. Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity. J Clin Invest 1991; 87: 1072-1081.
2. Pedersen O, Bak JF, Andersen PH et al. Evidence against altered expression of GLUT 1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM. Diabetes 1990; 39: 865-870.
3. Dela F, Larsen JJ, Mikines KJ, Ploug T, Petersen LN, Galbo H. Insulin-stimulated muscle glucose clearance in patients with NIDDM. Effects of one-legged physical training. Diabetes 1995; 44: 1010-1020.
4. Rodnick KJ, Haskell WL, Swislocki AL, Foley JE, Reaven GM. Improved insulin action in muscle, liver, and adipose tissue in physically trained human subjects. Am J Physiol 1987; 253(5 Pt 1): E489-495.
5. Hirshman MF, Goodyear LJ, Horton ED, Wardzala LJ, Horton ES. Exercise training increases GLUT-4 protein in rat adipose cells. Am J Physiol 1993; 264(6 Pt 1): E882-889.
6. Shepherd PR, Gnudi L, Tozzo E, Yang H, Leach F, Kahn BB. Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue. J Biol Chem 1993; 268: 22243-22246.
7. Kraniou GN, Cameron-Smith D, Hargreaves M. Effect of short-term training on GLUT-4 mRNA and protein expression in human skeletal muscle. Exp Physiol 2004; 89: 559-563.
8. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 1999; 22: 1462-1470.
9. Retnakaran R, Shen S, Hanley AJ, Vuksan V, Hamilton JK, Zinman B. Hyperbolic relationship between insulin secretion and sensitivity on oral glucose tolerance test. Obesity (Silver Spring) 2008; 16: 1901-1907.
10. O'Gorman DJ, Karlsson HK, McQuaid S et al. Exercise training increases insulin-stimulated glucose disposal and GLUT4 (SLC2A4) protein content in patients with type 2 diabetes. Diabetologia 2006; 49: 2983-2992.
11. Dela F, von Linstow ME, Mikines KJ, Galbo H. Physical training may enhance beta-cell function in type 2 diabetes. Am J Physiol Endocrinol Metab 2004; 287: E1024-1031.
12. Rogers MA, Yamamoto C, King DS, Hagberg JM, Ehsani AA, Holloszy JO. Improvement in glucose tolerance after 1 wk of exercise in patients with mild NIDDM. Diabetes Care 1988; 11: 613-618.