Do sex hormones influence features of the metabolic syndrome in middle-aged women? A population-based study of Swedish women: The Women's Health in the Lund Area (WHILA) Study

Fertility and Sterility

Volumn 88, Issue 1, 2007, Pages 163-171

  Shakir, Yasameen A ^a   Samsioe, Göran ^a   Nyberg, Per ^b   Lidfeldt, Jonas ^b   Nerbrand, Christina ^b   Agardh, Carl David ^b  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

cortisol; Metabolic syndrome; middle aged women; sex hormones; SHBG

Indexed keywords

ANDROSTENEDIONE; CHOLESTEROL; ESTRADIOL; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SEX HORMONE; TESTOSTERONE; TRIACYLGLYCEROL;

ADULT; AGE DISTRIBUTION; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ESTRADIOL BLOOD LEVEL; FEMALE; GLUCOSE BLOOD LEVEL; HEALTH SURVEY; HORMONAL THERAPY; HORMONE DETERMINATION; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPERLIPIDEMIA; HYPERTENSION; INSULIN RESISTANCE; LABORATORY TEST; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; METABOLIC SYNDROME X; OUTCOME ASSESSMENT; PHYSICAL EXAMINATION; PREMENOPAUSE; PRIORITY JOURNAL; PROTEIN DETERMINATION; QUESTIONNAIRE; SMOKING; SWEDEN; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL;

COHORT STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; GONADAL STEROID HORMONES; HUMANS; METABOLIC SYNDROME X; MIDDLE AGED; RISK FACTORS; SWEDEN; WOMEN'S HEALTH;

EID: 34347227105     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2006.11.111     Document Type: Article

References (40)

1. Grodstein F., Stampfer M.J., Manson J.E., Colditz G.A., Willett W.C., Rosner B., et al. Postmenopausal estrogen and progestin use and the risk of cardiovascular disease. N Engl J Med 335 (1996) 453-461
2. Grady D., Herrington D., Bittner V., Blumenthal R., Davidson M., Hlatky M., et al., HERS Research Group. Cardiovascular disease outcomes during 6-8 years of hormone therapy: Heart and Estrogen/ progestin Replacement Study follow-up (HERS II). JAMA 288 (2002) 49-57
3. The Writing Group for the Women's Health Initiative investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women. JAMA 288 (2002) 321-333
4. Goldberg R.J., Larson M., and Levy D. Factors associated with survival to 75 years of age in middle aged men and women. The Framingham Study. Arch Intern Med 156 (1996) 505-509
5. Kannel W.B., and McGee D.L. Diabetes and cardiovascular disease. The Framingham Study. JAMA 241 (1979) 2035-2038
6. Alberti K.G., and Zimmet P.Z. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus: provisional report of a WHO consultation. Diabet Med 15 (1998) 539-553
7. Haffner S.M., Moss S.E., Klein B.E., and Klein R. Sex hormones and DHEA-SO4 in relation to ischemic heart disease mortality in diabetic subjects: the Wisconsin Epidemiologic Study of Diabetic Retinopathy. Diabetes Care 19 (1996) 1045-1050
8. Haffner S.M., Valdez R.A., Morales P.A., Hazuda H.P., and Stern M.P. Decreased sex hormone-binding globulin predicts noninsulin-dependent diabetes mellitus in women but not in men. J Clin Endocrinol Metab 77 (1993) 56-60
9. Goodman-Gruen D., and Barrett-Connor E. A prospective study of sex hormone-binding globulin and fatal cardiovascular disease in Rancho Bernardo men and women. J Clin Endocrinol Metab 81 (1996) 2999-3003
10. Rexrode K.M., Manson J.E., Lee I.M., Ridker P.M., Sluss P.M., Cook N.R., et al. Sex hormone levels and risk of cardiovascular events in postmenopausal women. Circulation 108 (2003) 1688-1693
11. Reinecke H., Bogdanski J., Woltering A., Breithardt G., Assmann G., Kerber S., et al. A Relation of serum levels of sex hormone binding globulin to coronary heart disease in postmenopausal women. Am J Cardiol 90 (2002) 364-368
12. Bernini G.P., Sgro' M., Moretti A., Argenio G.F., Barlascini C.O., Cristofani R., et al. Endogenous androgens and carotid intimal-medial thickness in women. J Clin Endocrinol Metab 84 (1999) 2008-2012
13. Hauner H., Bognar E., and Blum A. Body fat distribution and its association with metabolic and hormonal risk factors in women with angiographically assessed coronary artery disease: evidence for the presence of a metabolic syndrome. Atherosclerosis 105 (1994) 209-216
14. Liu Y., Ding J., Bush T.L., Longenecker J.C., Nieto F.J., Golden S.H., et al. Relative androgen excess and increased cardiovascular risk after menopause: a hypothesized relation. Am J Epidemiol 154 (2001) 489-494
15. Haffner S.M., Newcomb P.A., Marcus P.M., Klein B.E., and Klein R. Relation of sex hormones and dehydroepiandrosterone sulfate (DHEA-SO4) to cardiovascular risk factors in postmenopausal women. Am J Epidemiol 142 (1995) 925-934
16. Phillips G.B., Pinkernell B.H., and Jing T.Y. Relationship between serum sex hormones and coronary artery disease in postmenopausal women. Arterioscler Thromb Vasc Biol 17 (1997) 695-701
17. Lidfeldt J., Nerbrand C., and Samsioe G. The women's health in the Lund area (WHILA) study. In: Schneider H.F.G., and Naftolin F. (Eds). Climacteric medicine-where do we go? (2005), Taylor and Francis, London & New York 36-48
18. Lidfeldt J., Nerbrand C., Samsioe G., Schersten B., and Agardh C.-D. A screening procedure detecting high-yield candidates for OGTT. The Women's Health in the Lund Area (WHILA) study: a population based study of middle-aged Swedish women. Eur J Epidemiol 17 (2001) 943-951
19. Shakir Y.A., Samsioe G., Nerbrand C., and Lidfeldt J. Combined hormone therapy in postmenopausal women with features of metabolic syndrome. Results from a population-based study of Swedish women: Women's Health in the Lund Area study. Menopause 11 (2004) 549-555
20. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., and Turner R.C. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28 (1985) 412-419
21. Shelley J.M., Green A., Smith A.M., Dudley E., Dennerstein L., Hopper J., et al. Relationship of endogenous sex hormones to lipids and blood pressure in mid-aged women. Ann Epidemiol 8 (1998) 39-45
22. Acien P., Quereda F., Matallin P., Villarroya E., Lopez-Fernandez J.A., Acien M., et al. Insulin, androgens, and obesity in women with and without polycystic ovary syndrome: a heterogeneous group of disorders. Fertil Steril 72 (1999) 32-40
23. Björntorp P. Hyperandrogenicity in women-a prediabetic condition?. J Intern Med 234 (1993) 579-583
24. Noyan V., Yucel A., and Sagsoz N. The association of androgenic sex steroids with serum lipid levels in postmenopausal women. Acta Obstet Gynecol Scand 83 (2004) 487-490
25. Korhonen S., Hippelainen M., Vanhala M., Heinonen S., and Niskanen L. The androgenic sex hormone profile is an essential feature of metabolic syndrome in premenopausal women: a controlled community-based study. Fertil Steril 79 (2003) 1327-1334
26. Kumagai S., Kai Y., and Sasaki H. Relationship between insulin resistance, sex hormones and sex hormone-binding globulin in the serum lipid and lipoprotein profiles of Japanese postmenopausal women. J Atheroscler Thromb 8 (2001) 14-20
27. Oh J.Y., Barrett-Connor E., Wedick N.M., and Wingard D.L. Rancho Bernardo Study. Endogenous sex hormones and the development of type 2 diabetes in older men and women. Diabetes Care 25 (2002) 55-60
28. Rouru J., Anttila L., Koskinen P., Penttila T.A., Irjala K., Huupponen R., et al. Serum leptin concentrations in women with polycystic ovary syndrome. J Clin Endocrinol Metab 82 (1997) 1697-1700
29. Hergenc G., Schulte H., Assmann G., and von Eckardstein A. Associations of obesity markers, insulin, and sex hormones with HDL-cholesterol levels in Turkish and German individuals. Atherosclerosis 145 (1999) 147-156
30. Sherif K., Kushner H., and Falkner B.E. Sex hormone-binding globulin and insulin resistance in African-American women. Metabolism 47 (1998) 70-74
31. Ruigi J.B., Dekker J.M., Blum W.F., Stehouwer C.D., Nijpels G., Mooy J., et al. Leptin and variables of body adiposity, energy balance, and insulin resistance in a population-based study. The Hoorn Study. Diabetes Care 22 (1999) 1097-1104
32. Saladin R., De Vos P., Guerre-Millo M., Leturque A., Girard J., Staels B., et al. Transient increase in obese gene expression after food intake or insulin adminstration. Nature 377 (1995) 527-529
33. Flier J.S. Clinical review 94. What's in a name? In search of leptin's physiologic role. J Clin Endocrinol Metab 83 (1998) 1407-1413
34. Panarotto D., Ardilouze J.L., Tessier D., and Maheux P. The degree of hyperinsulinemia and impaired glucose tolerance predicts plasma leptin concentrations in women only: a new exploratory paradigm. Metabolism 49 (2000) 1055-1062
35. Golden S.H., Ding J., Szklo M., Schmidt M.I., Duncan B.B., and Dobs A. Glucose and insulin components of the metabolic syndrome are associated with hyperandrogenism in postmenopausal women: the atherosclerosis risk in communities study. Am J Epidemiol 160 (2004) 540-548
36. Lindstedt G., Lundberg P., Lapidus L., Lundgren H., Bengtsson C., and Björntorp P. Low sex hormone binding globulin concentration as an independent risk factor for development of NIDDM: 12 yr follow up of population study of women in Gothenburg. Diabetes 40 (1991) 123-128
37. Raikkonen K., Keltikangas-Jarvinen L., Adlercreutz H., and Hautanen A. Psychological stress and the insulin resistance syndrome. Metabolism 45 (1996) 1533-1538
38. Björntorp P. Behaviour and the metabolic disease. Int J Behav Med 3 (1996) 285-302
39. Björntorp P. Do stress reactions cause abdominal obesity and comorbidities?. Obes Rev 2 (2001) 73-86
40. Weber-Hamann B., Hentschel F., Kniest A., Deuschle M., Colla M., Lederbogen F., et al. Hypercortisolemic depression is associated with increased intra-abdominal fat. Psychosom Med 64 (2002) 274-277