Treatment-induced manic switch in the course of unipolar depression can predict bipolarity: Cluster analysis based evidence

Journal of Affective Disorders

Volumn 134, Issue 1-3, 2011, Pages 91-101

  Dumlu, Kemal ^a,d   Orhon, Zahide ^a,e   Özerdem, Ayşegül ^a,b   Tural, Ümit ^c   Ulaş, Halis ^a   Tunca, Zeliha ^a  

^a DOKUZ EYLUL UNIVERSITY   (Turkey)

^b ISTANBUL KULTUR UNIVERSITY   (Turkey)

^c KOCAELI UNIVERSITY   (Turkey)

^d Training and Research Hospital   (Turkey)

^e State Mental Hospital   (Turkey)

Author keywords

Bipolar disorder; Cluster analysis; Recurrent depression; Severity; Treatment induced mania

Indexed keywords

CITALOPRAM; CLOMIPRAMINE; ESCITALOPRAM; FLUOXETINE; IMIPRAMINE; MAPROTILINE; MOCLOBEMIDE; MOOD STABILIZER; NEFAZODONE; NEUROLEPTIC AGENT; PAROXETINE; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; VENLAFAXINE;

ADULT; ARTICLE; BIPOLAR DISORDER; CLINICAL FEATURE; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE COURSE; DISEASE DURATION; DISEASE SEVERITY; ELECTROCONVULSIVE THERAPY; FEMALE; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MANIA; MELANCHOLIA; MOOD DISORDER; ONSET AGE; PRIORITY JOURNAL; PSYCHOSIS; RECURRENT DISEASE; SUICIDE ATTEMPT;

ADULT; ANTIDEPRESSIVE AGENTS; BIPOLAR DISORDER; CLUSTER ANALYSIS; DEPRESSION; DEPRESSIVE DISORDER; DEPRESSIVE DISORDER, MAJOR; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; HUMANS; MALE; MIDDLE AGED; MOOD DISORDERS; RETROSPECTIVE STUDIES;

EID: 80052515582     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2011.06.019     Document Type: Article

References (122)

1. V. Agosti, and J.W. Stewart Atypical and non-atypical subtypes of depression: comparison of social functioning, symptoms, course of illness, co-morbidity, and demographic features J. Affect. Disord. 65 2001 75 79 (Pubitemid 32411575)
2. H.S. Akiskal The prevalent clinical spectrum of bipolar disorders: beyond DSM-IV J. Clin. Psychopharmacol. 16 1996 4S 14S (Pubitemid 26120571)
3. H.S. Akiskal, and F. Benazzi Atypical depression: a variant of bipolar II or a bridge between unipolar and bipolar II? J. Affect. Disord. 84 2005 209 217 (Pubitemid 40222502)
4. H.S. Akiskal, and O. Pinto The evolving bipolar spectrum. Prototypes I, II, III and IV Psychiatry Clin. North Am. 22 1999 517 534 (Pubitemid 29463705)
5. H.S. Akiskal, P. Walker, V.R. Puzantian, D. King, T. Rosenthal, and M. Dranon Bipolar outcome in the course of depressive illness: phenomenologic, familial, and pharmacologic predictors J. Affect. Disord. 5 1983 115 128 (Pubitemid 13120405)
6. H.S. Akiskal, J.D. Maser, and P.J. Zener Switching from unipolar to bipolar 2: an 11 year prospective study of clinical and temperamental predictors in 559 patients Arch. Gen. Psychiatry 52 1995 114 123
7. H.S. Akiskal, M.L. Bourgeois, J. Angst, R. Post, H. Moller, and R. Hirschfeld Re-evaluating the prevalence of and diagnostic composition within the broad clinical spectrum of bipolar disorders J. Affect. Disord. 59 Suppl. 1 2000 S5 S30 (Pubitemid 32164448)
8. H.S. Akiskal, E.G. Hantouche, and J.F. Allilaire Systematic comparison of major depression with spontaneous hypomania (bipolar 2) versus those with antidepressant-associated hypomania in the French national EPIDEP Study J. Affect. Disord. 73 2001 65 74
9. H.S. Akiskal, E.G. Hantouche, J.F. Allilaire, D. Sechter, M.L. Bourgeois, J.M. Azorin, L. Chatenêt-Duchêne, and S. Lancrenon Validating antidepressant-associated hypomania (bipolar III): a systematic comparison with spontaneous hypomania (bipolar II) J. Affect. Disord. 73 2003 65 74 (Pubitemid 36044634)
10. L.L. Altshuler, R.M. Post, G.S. Leverich, K. Mikalauskas, A. Rosoff, and L. Ackerman Antidepressant-induced manic and cyclic acceleration: a controversy revisited Am. J. Psychiatry 152 1995 1130 1138
11. L.L. Altshuler, T. Suppes, D.O. Black, W.A. Nolen, G. Leverich, P.E. Keck Jr., M.A. Frye, R. Kupka, S.L. McElroy, H. Grunze, C.M. Kitchen, and R. Post Lower switch rate in depressed patients with bipolar II than bipolar I disorder treated adjunctively with second-generation antidepressants Am. J. Psychiatry 163 2006 313 315 (Pubitemid 44480853)
12. L.L. Altshuler, R.W. Kupka, G. Hellemann, M.A. Frye, C.A. Sugar, S.L. McElroy, W.A. Nolen, Grunze H., G.S. Leverich, P.E. Keck, M. Zermeno, R.M. Post, and T. Suppes Gender and depressive symptoms in 711 patients with bipolar disorder evaluated prospectively in the Stanley Foundation bipolar treatment outcome network Am. J. Psychiatry 167 2010 708 715
13. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 4th ed., text rev. 2001 Washington, DC
14. J.D. Amsterdam, F. Garcia-España, J. Fawcett, F.M. Quitkin, F.W. Reimherr, J.F. Rosenbaum, Schweizer E., and C. Beasley Efficacy and safety of fluoxetine in treating bipolar II major depressive episode J. Clin. Psychopharmacol. 18 1998 435 440 (Pubitemid 28555325)
15. J. Angst Switch from depression to mania: a record study over decades between 1920 and 1982 Psychopathology 18 1985 140 154 (Pubitemid 16224274)
16. J. Angst Commentary on the paper of Smith, et al J. Psychopharmacol. 22 2008 404 408
17. J. Angst, K. Angst, I. Baruffol, and R. Meinherz-Surbeck ECT-induced and drug-induced hypomania Convuls. Ther. 8 1992 179 185
18. J. Angst, A. Gamma, R. Sellaro, P.W. Lavori, and H. Zhang Recurrence of bipolar disorders and major depression. A life-long perspective Eur. Arch. Psychiatry Clin. Neurosci. 253 2003 236 240 (Pubitemid 37203960)
19. A. Ansari, and D.N. Osser The psychopharmacology algorithm project at the Harvard South Shore Program: an update on bipolar depression Harv. Rev. Psychiatry 18 2010 36 55
20. R.J. Baldessarini, L. Bolzani, N. Cruz, P.B. Jones, M. Lai, B. Lepri, J. Perez, P. Salvatore, M. Tohen, L. Tondo, and E. Vieta Onset-age of bipolar disorders at six international sites J. Affect. Disord. 121 2010 143 146
21. T. Ben Abla, F. Ellouze, H. Amri, G. Krid, A. Zouari, and M. Fi M'Rad Unipolar versus bipolar depression: clues toward predicting bipolarity disorder Encephale 32 2006 962 965
22. F. Benazzi Antidepressant-associated hypomania in outpatient depression: a 203-case study in private practice J. Affect. Disord. 46 1997 73 77 (Pubitemid 27471056)
23. F. Benazzi Bipolar versus unipolar psychotic outpatient depression J. Affect. Disord. 55 1999 63 66 (Pubitemid 29412917)
24. B. Benazzi Depression with DSM-IV atypical features: a marker for bipolar II disorder Eur. Arch. Psychiatry Clin. Neurosci. 250 2000 53 55
25. F. Benazzi Symptoms of depression as possible markers of bipolar II disorder Prog. Neuropsychopharmacol. Biol. Psychiatry 30 2006 471 477
26. F. Benazzi Classifying mood disorders by age-at-onset instead of polarity Prog. Neuropsychopharmacol. Biol. Psychiatry. 33 2009 86 93
27. F. Benazzi, and H.S. Akiskal How best to identify a bipolar-related subtype among major depressive patients without spontaneous hypomania: superiority of age at onset criterion over recurrence and polarity? J. Affect. Disord. 107 2008 77 88 (Pubitemid 351288919)
28. F. Benazzi, and Z. Rihmer Sensitivity and specificity of DSM-IV atypical features for bipolar II disorder diagnosis Psychiatry Res. 93 2000 257 262 (Pubitemid 30175956)
29. H.L. Boerlin, M.J. Gitlin, L.A. Zoellner, and C.L. Hammen Bipolar depression and antidepressant-induced mania: a naturalistic study J. Clin. Psychiatry 59 1998 374 379 (Pubitemid 28373104)
30. D.J. Bond, M.M. Noronha, M. Kauer-Sant'Anna, R.W. Lam, and L.N. Yatham Antidepressant-associated mood elevations in bipolar II disorder compared with bipolar I disorder and major depressive disorder: a systematic review and meta-analysis J. Clin. Psychiatry 69 2008 1589 1601
31. C.L. Bowden Strategies to reduce misdiagnosis of bipolar depression Psychiatr. Serv. 52 2001 51 55 (Pubitemid 32039805)
32. C.L. Bowden A different depression; clinical distinctions between bipolar and unipolar depression J. Affect. Disord. 84 2005 117 123
33. I.F. Brockington, E. Altman, V. Hillier, H.Y. Meltzer, and S. Nand The clinical picture of bipolar affective disorder in its depressed phase. A report from London and Chicago Br. J. Psychiatry 141 1982 558 562 (Pubitemid 13196921)
34. E. Brugue, F. Colom, J. Sanchez-Moreno, N. Cruz, and E. Vieta Depression subtypes in bipolar I and II disorders Psychopathology 41 2008 111 114 (Pubitemid 350308311)
35. J.R. Calabrese, D.J. Muzina, D.E. Kemp, G.S. Sachs, M.A. Frye, T.R. Thompson, D. Klingman, M.L. Reed, and R.M. Hirschfeld Predictors of bipolar disorder risk among patients currently treated for major depression Med. Gen. Med. 8 2006 38
36. G.A. Carlson, S.J. Finch, L.J. Fochtmann, Q. Ye, Q. Wang, B. Naz, and E.J. Bromet Antidepressant-associated switches from depression to mania in severe bipolar disorder Bipolar Disord. 9 2007 851 859 (Pubitemid 350215110)
37. B.J. Chun, and D.L. Dunner A review of antidepressant-induced hypomania in major depression: suggestions for DSM-V Bipolar Disord. 6 2004 32 42 (Pubitemid 38256502)
38. D.M. Clarke, K. Cook, G.C. Smith, and L. Piterman What do general practitioners think depression is? A taxonomy of distress and depression for general practice Med. J. Australia 188 12 Suppl. 2008 110 113
39. F. Colom, and E. Vieta The road to DSM-V. Bipolar disorder episode and course specifiers Psychopathology 42 2009 209 218
40. F. Colom, E. Vieta, C. Daban, I. Pacchiarotti, and J. Sánchez-Moreno Clinical and therapeutic implications of predominant polarity in bipolar disorder J. Affect. Disord. 93 2006 13 17 (Pubitemid 43816068)
41. A.K. Cueller, S.L. Johnson, and R. Winters Distinctions between bipolar and unipolar depression Clin. Psychol. Rev. 25 2005 307 339 (Pubitemid 40404050)
42. T. Detre, J. Himmelhoch, M. Swartzburg, C.M. Anderson, R. Byck, and D.J. Kupfer Hypersomnia and manic-depressive disease Am. J. Psychiatry. 128 1972 1303 1305
43. J.M. Duax, E.A. Youngstrom, J.R. Calabrese, and R.L. Findling Sex differences in pediatric bipolar disorder J. Clin. Psychiatry. 68 2007 1565 1573 (Pubitemid 350073407)
44. R.S. El-Mallakh, S.N. Ghaemi, K. Sagduyu, M.E. Thase, S.R. Wisniewski, A.A. Nierenberg, H.W. Zhang, T.A. Pardo, and G. Sachs STEP-BD Investigators. Antidepressant-associated chronic irritable dysphoria (ACID) in STEP-BD patients J. Affect. Disord. 111 2008 372 377
45. R.S. El-Mallakh, A.Z. Elmaadawi, M. Loganathan, K. Lohano, and Y. Gao Bipolar disorder: an update Postgrad. Med. 122 2010 24 31
46. G.L. Faedda, L. Tondo, M.H. Teicher, R.J. Baldessarini, H.A. Gelbard, and G.F. Floris Seasonal mood disorders. Patterns of seasonal recurrence in mania and depression Arch. Gen. Psychiatry 50 1993 17 23 (Pubitemid 23026984)
47. M.B. First, R.I. Spitzer, M. Gibbon, and J.B.W. Williams Structurel Clinical Interview for DSM-IV Axis I Disorders (SCID I) Clinical Version. (SCID-CV) 1997 American Psychiatric Press Inc Washington DC
48. M.P. Freeman, and A.J. Gelenberg Bipolar disorder in women: reproductive events and treatment considerations Acta Psychiatr. Scand. 112 2005 88 96 (Pubitemid 41003186)
49. M.P. Freeman, and P.E. Keck Postpartum depression with bipolar disorder Am. J. Psychiatry. 158 2001 652 660
50. S.N. Ghaemi, G.S. Sachs, A.M. Chiou, A.K. Pandurangi, and K. Goodwin Is bipolar disorder still underdiagnosed? Are antidepressants overutilized? J. Affect. Disord. 52 1999 135 144 (Pubitemid 29232042)
51. S.N. Ghaemi, J.Y. Ko, and F.K. Goodwin The bipolar spectrum and the antidepressant view of the world J. Psychiatr. Pract. 7 2001 287 297
52. S.N. Ghaemi, K.J. Rosenquist, J.Y. Ko, C.F. Baldassano, N.J. Kontos, and R.J. Baldessarini Antidepressant treatment in bipolar versus unipolar depression Am. J. Psychiatry. 161 2004 163 165 (Pubitemid 38419324)
53. S.N. Ghaemi, A.P. Wingo, M.A. Filkowski, and R.J. Baldessarini Long-term antidepressant treatment in bipolar disorder: meta-analyses of benefits and risks Acta Psychiatr. Scand. 118 2008 347 356
54. J.F. Goldberg, and M. Harrow Risk for bipolar illness in patients initially hospitalized for unipolar depression Am. J. Psychiatry. 158 2001 1265 1270 (Pubitemid 32717701)
55. J.F. Goldberg, and C.J. Truman Antidepressant-induced mania: an overview of current controversies Bipolar Disord. 5 2003 407 420 (Pubitemid 38072243)
56. F. Goodwin, and K. Jamison Manic Depressive Illness 1990 Oxford University Press New York
57. F. Goodwin, and K. Jamison Manic Depressive Illness: Bipolar Disorder and Recurrent Depression Second Ed 2007 Oxford University Press New York
58. S.B. Guze, R.A. Woodruff, and P.J. Clayton The significance of psychotic affective disorders Arch. Gen. Psychiatry 32 1975 1147 1150
59. M.L. Hamshere, K. Gordon-Smith, L. Forty, L. Jones, S. Caesar, C. Fraser, S. Hyde, J. Tredget, G. Kirov, I. Jones, N. Craddock, and D.J. Smith Age-at-onset in bipolar-I disorder: mixture analysis of 1369 cases identifies three distinct clinical sub-groups J. Affect. Disord. 116 2009 23 29
60. C. Henry, F. Sorbara, J. Lacoste, C. Gindre, and M. Leboyer Antidepressant-induced mania in bipolar patients: identification of risk factors J. Clin. Psychiatry 62 2001 249 255 (Pubitemid 32428763)
61. R.M. Hirschfeld, A.R. Cass, D.C. Holt, and C.A. Carlson Screening for bipolar disorder in patients treated for depression in a family medicine clinic J. Am. Board Fam. Pract. 18 2005 233 239 (Pubitemid 41663994)
62. International Classification of Disease World Health Organisation 10th ed 1993 (Geneva)
63. K.R. Jamison Suicide and bipolar disorder J. Clin. Psychiatry. 61 2000 47 51 (Pubitemid 30453887)
64. M. Joseph, E.A. Youngstrom, and J.C. Soares Antidepressant-coincident mania in children and adolescents treated with selective serotonin reuptake inhibitors Futur. Neurol. 4 2009 87 102
65. L.L. Judd, P.J. Schettler, H.S. Akiskal, J. Maser, W. Coryell, D. Solomon, J. Endicott, and M. Keller Long-term symptomatic status of bipolar I vs. bipolar II disorders Int. J. Neuropsychopharmacol. 6 2003 127 137 (Pubitemid 36850965)
66. E. Kelly, and V. Sharma Diagnosis and treatment of postpartum bipolar depression Expert. Rev. Neurother. 10 2010 1045 1051
67. L.V. Kessing, H.M. Jensen, and E.M. Christensen Differences in the ICD-10 diagnostic subtype of depression in bipolar disorder compared to recurrent depressive disorder Psychopathology 41 2008 141 146 (Pubitemid 351555827)
68. I. Koszewska, and J.K. Rybakowski Antidepressant-induced mood conversions in bipolar disorder: a retrospective study of tricyclic versus non-tricyclic antidepressant drugs Neuropsychobiology 59 2009 12 16
69. A. Koukopoulos, and A. Koukopoulos Agitated depression as a mixed state and the problem of melancholia Psychiatr. Clin. North. Am. 22 1999 547 564 (Pubitemid 29463707)
70. E. Leibenluft Women and bipolar disorder: an update Bull. Menn. Clin. 64 2000 5 17 (Pubitemid 30091580)
71. G.S. Leverich, L.L. Altshuler, M.A. Frye, T. Suppes, S.L. McElroy, P.E. Keck Jr., R.W. Kupka, K.D. Denicoff, W.A. Nolen, H. Grunze, M.I. Martinez, and R.M. Post Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers Am. J. Psychiatry. 163 2006 232 239 (Pubitemid 44480842)
72. R.W. Licht, H. Gijsman, W.A. Nolen, and J. Angst Are antidepressants safe in the treatment of bipolar depression? A critical evaluation of their potential risk to induce switch into mania or cycle acceleration Acta Psychiatr. Scand. 118 2008 337 346
73. J.S. Manning, and S. Ahmed Mood disorders in family practice: beyond unipolarity to bipolararity J. Clin. Psychiatry. 4 2002 142 150
74. O. Mantere, K. Suominen, H.M. Valtonen, P. Arvilommi, S. Leppämäki, T. Melartin, and E. Isometsä Differences in outcome of DSM-IV bipolar I and II disorders Bipolar Disord. 10 2008 413 425 (Pubitemid 351517375)
75. A. Martin, C. Young, J.F. Leckman, C. Mukonoweshuro, R. Rosenheck, and D. Leslie Age effects on antidepressant-induced manic conversion Arch. Pediatr. Adolesc. Med. 158 2004 773 780 (Pubitemid 39025076)
76. A. Martinez-Aran, E. Vieta, K.N. Chengappa, S. Gershon, J. Mullen, and B. Bjorn Reporting outcomes in clinical trials for bipolar disorder - a commentary and suggestions for change Bipolar Disord. 10 2008 566 579 (Pubitemid 352003825)
77. V. Maskill, M. Crowe, S. Luty, and P. Joyce Two sides of the same coin: caring for a person with bipolar disorder J. Psychiatr. Ment. Health Nurs. 17 2010 535 542
78. L. Mazzarini, F. Colom, I. Pacchiarotti, A.M. Nivoli, A. Murru, C.M. Bonnin, N. Cruz, J. Sanchez-Moreno, G.D. Kotzalidis, P. Girardi, R. Tatarelli, and E. Vieta Psychotic versus non-psychotic bipolar II disorder J. Affect. Disord. 126 2010 55 60
79. P. Mitchell, and G. Malhi Bipolar depression: phenomenological overview and clinical characteristics Bipolar Disord. 6 2004 530 539 (Pubitemid 39562421)
80. P.B. Mitchell, K. Wilhelm, and G. Parker The clinical features of bipolar depression: a comparison with matched major depressive disorder patients J. Clin. Psychiatry. 62 2001 212 216 (Pubitemid 32270103)
81. P.B. Mitchell, G.M. Goodwin, G.F. Johnson, and R.M. Hirschfeld Diagnostic guidelines for bipolar depression: a probabilistic approach Bipolar Disord. 10 2008 144 152
82. D.E. Moreno, and L.H. Andrade Latent class analysis of manic and depressive symptoms in a population-based sample in Sao Paulo, Brazil J. Affect. Disord. 123 2010 208 213
83. D.J. Muzina, D.E. Kemp, and R.S. McIntyre Differentiating bipolar disorders from major depressive disorders: treatment implications Ann. Clin. Psychiatry 19 2007 305 312 (Pubitemid 350208801)
84. C.B. Nemeroff, R. Entsuah, I. Benattia, M. Demitrack, D.M. Sloan, and M.E. Thase Comprehensive analysis of remission (COMPARE) with venlafaxine versus SSRIs Biol. Psychiatry 63 2008 424 434
85. D.M. Novick, H.A. Swartz, and E. Frank Suicide attempts in bipolar I and bipolar II disorder: a review and meta-analysis of the evidence Bipolar Disord. 12 2010 1 9
86. C. O'Donovan, J.S. Garnham, T. Hajek, and M. Alda Antidepressant monotherapy in pre-bipolar depression; predictive value and inherent risk J. Affect. Disord. 107 2008 293 298 (Pubitemid 351297780)
87. M. Olfson, A.K. Das, M.J. Gameroff, D. Pilowsky, A. Feder, and R. Gross Bipolar depression in a low-income primary care clinic Am. J. Psychiatry. 162 2005 2146 2151 (Pubitemid 41598270)
88. G. Parker, K. Roy, and K. Wilhelm The nature of bipolar depression: implications for the definition of melancholia J. Affect. Disord. 59 2000 217 224 (Pubitemid 30347544)
89. M. Peet Induction of mania with selective serotonin re-uptake inhibitors and tricyclic antidepressants Br. J. Psychiatry 164 1994 549 550 (Pubitemid 24141686)
90. R.H. Perlis, S. Miyahara, L.B. Marangell, S.R. Wisniewski, M. Ostacher, M.P. Delbello, C.L. Bowden, G.S. Sachs, and A.A. Nierenberg Long-term implications of early onset in bipolar disorder: data from the first 1,000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD) Biol. Psychiatry 55 2004 875 881 (Pubitemid 38526299)
91. R.H. Perlis, E. Brown, R.W. Baker, and A.A. Nierenberg Clinical features of bipolar depression versus major depressive disorder in large multicenter trials Am. J. Psychiatry. 163 2006 225 231 (Pubitemid 44480841)
92. R.H. Perlis, M.J. Ostacher, J.F. Goldberg, D.J. Miklowitz, E. Friedman, J. Calabrese, M.E. Thase, and G.S. Sachs Transition to mania during treatment of bipolar depression Neuropsychopharmacology 35 2010 2545 2552
93. C. Perris A study of bipolar (manic-depressive) and unipolar recurrent depressive psychoses: introduction Acta Psychiatr. Scand. 194 1966 9 14
94. G. Perugi, H.S. Akiskal, L. Lattanzi, D. Cecconi, C. Mastrocinque, A. Patronelli, S. Vignoli, and E. Bemi The high prevalence of "soft" bipolar (II) features in atypical depression Compr. Psychiatry 39 1998 63 71 (Pubitemid 28093926)
95. C.M. Perugi, H.S. Akiskal, D. Madaro, C. Socci, C. Quilici, and L. Musetti Polarity of the first episode, clinical characteristics, and course of manic depressive illness: a systematic retrospective investigation of 320 bipolar I patients Compr. Psychiatry 41 2000 13 18 (Pubitemid 30051762)
96. A. Pfennig, P. Schlattmann, M. Alda, P. Grof, T. Glenn, B. Muller-Oerlinghausen, A. Suwalska, J. Rybakowski, S.N. Willich, M. Bauer, and A. Berghofer Influence of atypical features on the quality of prophylactic effectiveness of long-term lithium treatment in bipolar disorders Bipolar Disord. 12 2010 390 396
97. R.M. Post, K.D. Denicoff, G.S. Leverich, L.L. Altshuler, M.A. Frye, T.M. Suppes, P.E. Keck Jr., S.L. McElroy, R. Kupka, W.A. Nolen, H. Grunze, and J. Walden Presentations of depression in bipolar illness Clin. Neurosci. Res. 2 2002 142 157 (Pubitemid 35375329)
98. R.M. Post, L.L. Altshuler, M.A. Frye, T. Suppes, S. McElroy, P.E. Keck Jr., G.S. Leverich, R. Kupka, W.A. Nolen, and H. Grunze New findings from the Bipolar Collaborative Network: clinical implications for therapeutics Curr. Psychiatry Rep. 8 2006 489 497 (Pubitemid 46017239)
99. M. Raja, and A. Azzoni Suicide attempts: differences between unipolar and bipolar patients and among groups with different lethality risk J. Affect. Disord. 82 2004 437 442 (Pubitemid 39536176)
100. K.A. Roecklein, K.J. Rohan, and T.T. Postolache Is seasonal affective disorder a bipolar variant? Curr. Psychiatr. Rep. 9 2010 42 54
101. A.R. Rosa, C.M. Bonnín, G.H. Vázquez, M. Reinares, B. Solé, R. Tabarés-Seisdedos, V. Balanzá-Martínez, A. González-Pinto, J. Sánchez-Moreno, and E. Vieta Functional impairment in bipolar II disorder: is it as disabling as bipolar I? J. Affect. Disord. 127 2010 71 76
102. G. Salvadore, J.A. Quiroz, R. Machado-Vieira, I.D. Henter, H.K. Manji, and C.A. Zarate Jr. The neurobiology of the switch process in bipolar disorder: a review J. Clin. Psychiatry. 71 2010 1488 1501
103. A. Schaffer, P. Zuker, and A. Levitt Randomized, double-blind pilot trial comparing lamotrigine versus citalopram for the treatment of bipolar depression J. Affect. Disord. 96 2006 95 99 (Pubitemid 44548053)
104. A. Schaffer, J. Cairney, S. Veldhuizen, P. Kurdyak, A. Cheung, and A. Levitt A population-based analysis of distinguishers of bipolar disorder from major depressive disorder J. Affect. Disord. 125 2010 103 110
105. C.D. Schneck, D.J. Miklowitz, J.R. Calabrese, M.H. Allen, M.R. Thomas, S.R. Wisniewski, S. Miyahara, M.D. Shelton, T.A. Ketter, J.F. Goldberg, C.L. Bowden, and G.S. Sachs Phenomenology of rapid-cycling bipolar disorder: data from the first 500 participants in the Systematic Treatment Enhancement Program Am. J. Psychiatry 161 2004 1902 1908 (Pubitemid 39314686)
106. T.G. Schulze, D.J. Muller, H. Krauss, M. Gross, H. Fangerau-Lefevre, F. Illes, S. Ohlraun, S. Cichon, T. Held, P. Propping, M.M. Nothen, W. Maier, and M. Rietschel Further evidence for age of onset being an indicator for severity in bipolar disorder J. Affect. Disord. 68 2002 343 345 (Pubitemid 34628340)
107. F. Schurhoff, F. Bellivier, R. Jouvent, M.C. Mouren-Simeoni, M. Bouvard, J.F. Allilaire, and M. Leboyer Early and late onset bipolar disorders: two different forms of manic-depressive illness? J. Affect. Disord. 58 2000 215 221 (Pubitemid 30232777)
108. A. Serretti, L. Mandelli, E. Lattuada, C. Cusin, and E. Smeraldi Clinical and demographic features of mood disorder subtypes Psychiatry Res. 112 2002 195 210 (Pubitemid 35351721)
109. A. Serretti, P. Artioli, R. Zanardi, and D. Rossini Clinical features of antidepressant associated manic and hypomanic switches in bipolar disorder Prog. Neuropsychopharmacol. Biol. Psychiatry 27 2003 751 757 (Pubitemid 36966755)
110. K. Shin, A. Schaffer, A.J. Levitt, and M.H. Boyle Seasonality in a community sample of bipolar, unipolar and control subjects J. Affect. Disord. 86 2005 19 25 (Pubitemid 40487956)
111. G.E. Simon, E. Hunkeler, B. Fireman, J.Y. Lee, and J. Savarino Risk of suicide attempt and suicide death in patients treated for bipolar disorder Bipolar Disord. 9 2007 526 530 (Pubitemid 47202516)
112. B. Solé, A. Martínez-Arán, C. Torrent, C.M. Bonnin, M. Reinares, D. Popovic, J. Sánchez-Moreno, and E. Vieta Are bipolar II patients cognitively impaired? A systematic review Psychol. Med. 28 2011 1 13
113. T. Suppes, G.S. Leverich, P.E. Keck, W.A. Nolen, K.D. Denicoff, L.L. Altshuler, S.L. McElroy, A.J. Rush, R. Kupka, M.A. Frye, M. Bickel, and R.M. Post The Stanley Foundation Bipolar Treatment Outcome Network. II. Demographics and illness characteristics of the first 261 patients J. Affect. Disord. 67 2001 45 59 (Pubitemid 34183336)
114. R.S. Tamada, C.K. Issler, J.A. Amaral, G.S. Sachs, and B. Lafer Treatment emergent affective switch: a controlled study Bipolar Disord. 6 2004 333 337 (Pubitemid 39077096)
115. M.E. Thase, and G.S. Sachs Bipolar depression: pharmacotherapy and related therapeutic strategies Biol. Psychiatry 48 2000 558 572
116. L. Tondo, G. Vazquez, and R.J. Baldessarini Mania associated with antidepressant treatment: comprehensive meta-analytic review Acta Psychiatr. Scand. 121 2010 404 414
117. C.J. Truman, J.F. Goldberg, S.N. Ghaemi, C.F. Baldassano, S.R. Wisniewski, E.B. Dennehy, M.E. Thase, and G.S. Sachs Self-reported history of manic/hypomanic switch associated with antidepressant use: data from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) J. Clin. Psychiatry 68 2007 1472 1479 (Pubitemid 350073393)
118. E. Vieta, C. Gasto, A. Otero, E. Nieto, and J. Vallejo Differential features between bipolar I and bipolar II disorder Compr. Psychiatry 38 1997 98 101 (Pubitemid 27097697)
119. E. Vieta, A. Martinez-Arán, J.M. Goikolea, C. Torrent, F. Colom, A. Benabarre, and M. Reinares A randomized trial comparing paroxetine and venlafaxine in the treatment of bipolar depressed patients taking mood stabilizers J. Clin. Psychiatry. 63 2002 508 512 (Pubitemid 34680359)
120. T.A. Wehr, and F.K. Goodwin Can antidepressants cause mania and worsen the course of affective illness? Am. J. Psychiatry. 144 1987 1403 1411 (Pubitemid 18009530)
121. M.M. Weissman, R.C. Bland, G.J. Canino, C. Faravelli, S. Greenwald, H.G. Hwu, P.R. Joyce, E.G. Karam, C.K. Lee, J. Lellouch, J.P. Lépine, S.C. Newman, M. Rubio-Stipec, J.E. Wells, P.J. Wickramaratne, H. Wittchen, and E.K. Yeh Cross-national epidemiology of major depression and bipolar disorder JAMA 276 1996 293 299 (Pubitemid 26249533)
122. E.A. Youngstrom Definitional issues in bipolar disorder across the life cycle Clin. Psychol. Sci. Pract. 16 2009 140 160