Transpulmonary pyruvate kinetics

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 301, Issue 3, 2011, Pages

  Johnson, Matthew L ^a   Hussien, Rajaa ^a   Horning, Michael A ^a   Brooks, George A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Exercise; Isotope tracers; Lactate; Metabolism

Indexed keywords

ADRENALIN; LACTIC ACID; MONOCARBOXYLATE TRANSPORTER 1; MONOCARBOXYLATE TRANSPORTER 2; MONOCARBOXYLATE TRANSPORTER 4; PYRUVIC ACID;

ANIMAL TISSUE; ARTICLE; CARBOHYDRATE METABOLISM; CLAMP; CONTROLLED STUDY; FEMALE; KINETICS; LUNG; LUNG CAPILLARY; LUNG HOMOGENATE; LUNG PARENCHYMA; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY VEIN; RAT; STIMULATION; WESTERN BLOTTING;

ADRENERGIC AGONISTS; ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; CAPILLARIES; CARBON ISOTOPES; CARDIAC OUTPUT; ENERGY METABOLISM; EPINEPHRINE; FEMALE; INDICATOR DILUTION TECHNIQUES; INFUSIONS, INTRAVENOUS; KINETICS; LACTIC ACID; LUNG; MONOCARBOXYLIC ACID TRANSPORTERS; MUSCLE PROTEINS; PULMONARY CIRCULATION; PYRUVIC ACID; RATS; RATS, WISTAR; SYMPORTERS;

EID: 80052511567     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00206.2011     Document Type: Article

References (34)

1. Ahlborg G, Felig P. Lactate and glucose exchange across the forearm, legs, and splanchnic bed during and after prolonged leg exercise. J Clin Invest 69: 45-54, 1982
2. Bassett DJ, Bowen-Kelly E. Pyruvate metabolism of perfused rat lungs after exposure to 100% oxygen. J Appl Physiol 60: 1605-1609, 1986
3. Bassett DJ, Bowen-Kelly E. Rat lung metabolism after 3 days of continuous exposure to 0.6 ppm ozone. Am J Physiol Endocrinol Metab 250: E131-E136, 1986
4. Bassett DJ, Bowen-Kelly E, Reichenbaugh SS. Rat lung glucose metabolism after 24 h of exposure to 100% oxygen. J Appl Physiol 66: 989-996, 1989
5. Bassett DJ, Fisher AB. Glucose metabolism in rat lung during exposure to hyperbaric O2. J Appl Physiol 46: 943-949, 1979
6. Bassett DJ, Fisher AB. Alterations of glucose metabolism during perfusion of rat lung with paraquat. Am J Physiol Endocrinol Metab Gastrointest Physiol 234: E653-E659, 1978
7. Bassett DJ, Fisher AB. Pentose cycle activity of the isolated perfused rat lung. Am J Physiol 231: 1527-1532, 1976
8. Butz CE, McClelland GB, Brooks GA. MCT1 confirmed in rat striated muscle mitochondria. J Appl Physiol 97: 1059-1066, 2004
9. Chinkes DL, Zhang XJ, Romijn JA, Sakurai Y, Wolfe RR. Measurement of pyruvate and lactate kinetics across the hindlimb and gut of anesthetized dogs. Am J Physiol Endocrinol Metab 267: E174-E182, 1994
10. Donovan CM, Brooks GA. Endurance training affects lactate clearance, not lactate production. Am J Physiol Endocrinol Metab 244: E83-E92, 1983
11. Fisher AB. Intermediary metabolism of the lung. Environ Health Perspect 55: 149-158, 1984
12. Fisher AB. Energy status of the rat lung after exposure to elevated PO2. J Appl Physiol 45: 56-59, 1978
13. Fisher AB, Dodiuation of critical intracellular PO2 and PCO. Am J Physiol Endocrinol Metab 241: E47-E50, 1981
14. Garcia CK, Brown MS, Pathak RK, Goldstein JL. cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1. J Biol Chem 270: 1843-1849, 1995
15. Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS. Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle. Cell 76: 865-873, 1994
16. Halestrap AP, Meredith D. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflügers Arch 447: 619-628, 2004
17. Harris P, Bailey T, Bateman M, Fitzgerald MG, Gloster J, Harris EA, Donald KW. Lactate, pyruvate, glucose, and free fatty acid in mixed venous and arterial blood. J Appl Physiol 18: 933-936, 1963
18. Henderson GC, Horning MA, Wallis GA, Brooks GA. Pyruvate metabolism in working human skeletal muscle. Am J Physiol Endocrinol Metab 292: E366, 2007
19. Hussien R, Brooks GA. Mitochondrial and plasma membrane lactate transporter and lactate dehydrogenase isoform expression in breast cancer cell lines. Physiol Genomics 43: 255-264, 2011
20. Iscra F, Gullo A, Biolo G. Bench-to-bedside review: lactate and the lung. Crit Care 6: 327-329, 2002.
21. Izumi H, Takahashi M, Uramoto H, Nakayama Y, Oyama T, Wang KY, Sasaguri Y, Nishizawa S, Kohno K. Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells. Cancer Sci 102: 1007-1013, 2011
22. Kellum JA, Kramer DJ, Lee K, Mankad S, Bellomo R, Pinsky MR. Release of lactate by the lung in acute lung injury. Chest 111: 1301-1305, 1997
23. Levy B. Lactate and shock state: the metabolic view. Curr Opin Crit Care 12: 315-321, 2006
24. Lin M, Marshall CT, Qi Y, Johnston SM, Badea CT, Piantadosi CA, Johnson GA. Quantitative blood flow measurements in the small animal cardiopulmonary system using digital subtraction angiography. Med Phys 36: 5347-5358, 2009
25. Longmore WJ, Mourning JT. Lactate production in isolated perfused rat lung. Am J Physiol 231: 351-354, 1976
26. Lundgren F, Bennegard K, Elander A, Lundholm K, Schersten T, Bylund-Fellenius AC. Substrate exchange in human limb muscle during exercise at reduced blood flow. Am J Physiol Heart Circ Physiol 255: H1156-H1164, 1988
27. Mendez JL, Hubmayr RD. New insights into the pathology of acute respiratory failure. Curr Opin Crit Care 11: 29-36, 2005
28. Rhoades RA, Shaw ME, Eskew ML. Influence of altered O2 tension on substrate metabolism in perfused rat lung. Am J Physiol 229: 1476-1479, 1975
29. Rochester DF, Wichern WA Jr, Fritts HW Jr, Caldwell PR, Lewis ML, Giuntini C, Garfield JW. Arteriovenous differences of lactate and pyruvate across healthy and diseased human lung. Am Rev Respir Dis 107: 442-448, 1973
30. Roth DA, Brooks GA. Lactate and pyruvate transport is dominated by a pH gradient-sensitive carrier in rat skeletal muscle sarcolemmal vesicles. Arch Biochem Biophys 279: 386-394, 1990
31. Roth DA, Brooks GA. Lactate transport is mediated by a membranebound carrier in rat skeletal muscle sarcolemmal vesicles. Arch Biochem Biophys 279: 377-385, 1990
32. Scholz RW, Evans RM. Pyruvate metabolism by rat lung in vitro. Lipids 8: 360-365, 1973
33. Tappy L, Chiolero R. Substrate utilization in sepsis and multiple organ failure. Crit Care Med 35 Suppl: S531-S534, 2007
34. Wolfe RR, Jahoor F, Miyoshi H. Evaluation of the isotopic equilibration between lactate and pyruvate. Am J Physiol Endocrinol Metab 254: E532-E535, 1988