Negative argument for debate with V. O. Emery for J Neural Transmission : Alzheimer's disease: Are we intervening too late? No we are not

Journal of Neural Transmission

Volumn 118, Issue 9, 2011, Pages 1379-1381

  Ames, David ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Alzheimer's disease; Cholinesterase inhibitors; Early intervention; Evidence; Novel therapies; Treatment

Indexed keywords

ALPHA TOCOPHEROL; AMYLOID PROTEIN; ANTIINFLAMMATORY AGENT; APOLIPOPROTEIN E4; CHOLINESTERASE INHIBITOR; DONEPEZIL; GALANTAMINE; GAMMA SECRETASE INHIBITOR; HERBACEOUS AGENT; HOMOCYSTEINE; HORMONE; MEMANTINE; PLACEBO; TAU PROTEIN;

ALZHEIMER DISEASE; ARTICLE; BRAIN ATROPHY; CARDIOVASCULAR RISK; CLINICAL TRIAL (TOPIC); COGNITION; DIAGNOSTIC ACCURACY; DISEASE PREDISPOSITION; DRUG EFFICACY; DRUG ERUPTION; DRUG MEGADOSE; DRUG SAFETY; EXERCISE; GINKGO BILOBA; HIPPOCAMPUS; HUMAN; IMMUNOTHERAPY; MILD COGNITIVE IMPAIRMENT; NEUROTRANSMISSION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SOCIAL INTERACTION; UNSPECIFIED SIDE EFFECT;

ALZHEIMER DISEASE; HUMANS; MILD COGNITIVE IMPAIRMENT; NOOTROPIC AGENTS;

EID: 80052507323     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-011-0678-6     Document Type: Article

References (19)

1. Alzheimer's Disease International (2009) World Alzheimer report. Alzheimer's Disease International, London
2. Barber R, O'Brien JT (2010) Structural brain imaging. In: Ames D, Burns A, O'Brien JT (eds) Dementia, 4th edn. Hodder Arnold, London, pp 97-108
3. Cummings JL, Benson DF (1992) Dementia: definition, prevalence, classification and approach to diagnosis. In: Cummings JL, Benson DF (eds) Dementia: a clinical approach. Butterworth-Heineman, Boston
4. ST DeKosky JD Williamson AL Fitzpatrick, et al. 2008 Ginkgo biloba for prevention of dementia: a randomized controlled trial JAMA 300 2253 2262 19017911 10.1001/jama.2008.683 1:CAS:528:DC%2BD1cXhtl2jsr%2FF
5. K Ellis A Bush D Darby, et al. 2009 The Australian Imaging, Biomarkers and Lifestyle (AIBL) flagship study of ageing: methodology and characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease Int Psychogeriatr 21 672 687 19470201 10.1017/S1041610209009405
6. CP Ferri M Prince C Brayne, et al. 2005 Global prevalence of dementia: a Delphi consensus study Lancet 366 2112 2117 16360788 10.1016/S0140-6736(05) 67889-0 (Pubitemid 41797645)
7. Ferri CP, Jackson J, Prince M (2010) The global challenge of dementia: what can be done. In: Ames D, Burns A, O'Brien JT (eds) Dementia, 4th edn. Hodder Arnold, London, pp 341-348
8. B Frank S Gupta 2005 A review of antioxidants and Alzheimer's disease Ann Clin Psychiatry 17 269 286 16402761 10.1080/10401230500296428 (Pubitemid 41780250)
9. Kurz A, Lautenschlager N (2010) Established treatments for Alzheimer's disease: cholinesterase inhibitors and memantine. In: Ames D, Burns A, O'Brien JT (eds) Dementia, 4th edn. Hodder Arnold, London, pp 471-483
10. L Lannfelt K Blennow H Zetterberg, et al. 2008 Safety, efficacy and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa double blind randomised placebo controlled trial Lancet Neurol 7 779 786 18672400 10.1016/S1474-4422(08)70167-4 1:CAS:528:DC%2BD1cXhtFWmsL3F
11. Lautenschlager N, Kurz A (2010) Managing the patient with mild cognitive impairment. In: Ames D, Burns A, O'Brien JT (eds) Dementia, 4th edn. Hodder Arnold, London, pp 379-387
12. Masters C (2010) The neuropathology of Alzheimer's disease. In: Ames D, Burns A, O'Brien JT (eds) Dementia, 4th edn. Hodder Arnold, London, pp 417-431
13. G McKhann D Drachman M Folstein, et al. 1984 Clinical diagnosis of Alzheimer's disease Neurology 34 939 944 6610841 1:STN:280:DyaL2c3ks1altQ%3D%3D
14. Pantel J, Hampel H (2010) Blood and CSF markers for Alzheimer's disease. In: Ames D, Burns A, O'Brien JT (eds) Dementia, 4th edn. Hodder Arnold, London, pp 459-470
15. RC Petersen GE Smith SC Waring, et al. 1999 Mild cognitive impairment: clinical characterization and outcome Arch Neurol 56 303 308 10190820 10.1001/archneur.56.3.303 1:STN:280:DyaK1M3gsFSqtw%3D%3D (Pubitemid 29120227)
16. RC Petersen R Doody A Kurz, et al. 2001 Current concepts in mild cognitive impairment Arch Neurol 58 1985 1992 11735772 10.1001/archneur.58.12. 1985 1:STN:280:DC%2BD38%2FivVyrsw%3D%3D (Pubitemid 33143977)
17. Ritchie C, McLean C, Beyreuther K, Masters C (2010) The central role of Aβ amyloid in the pathogenesis of Alzheimer's disease. In: Ames D, Burns A, O'Brien JT (eds) Dementia, 4th edn. Hodder Arnold, London, pp 438-451
18. Villemagne VL, Rowe C (2010) Molecular brain imaging in dementia. In: Ames D, Burns A, O'Brien JT (eds) Dementia, 4th edn. Hodder Arnold, London, pp 120-127
19. Woodward M (2010) Drug treatments in development for Alzheimer's disease. In: Ames D, Burns A, O'Brien JT (eds) Dementia, 4th edn. Hodder Arnold, London, pp 484-497