Development of cellular therapy for the treatment of stress urinary incontinence

International Urogynecology Journal

Volumn 22, Issue 9, 2011, Pages 1075-1083

  Wang, Hung Jen ^a   Chuang, Yao Chi ^a   Chancellor, Michael B ^b  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b OAKLAND UNIVERSITY WILLIAM BEAUMONT SCHOOL OF MEDICINE   (United States)

Author keywords

Mesenchymal stem cells; Muscle derived stem cells; Stem cell therapy; Stress urinary incontinence

Indexed keywords

NERVE GROWTH FACTOR; POLYGLACTIN;

ADIPOSE DERIVED STEM CELL; ADIPOSE DERIVED STEM CELL TRANSPLANTATION; ADULT STEM CELL; AUTOLOGOUS STEM CELL TRANSPLANTATION; BLADDER PRESSURE; BLADDER SPHINCTER; BONE MARROW DERIVED STEM CELL; CELL DIFFERENTIATION; CELL SURVIVAL; COLPOSUSPENSION; EMBRYONIC STEM CELL; HUMAN; INNERVATION; MESENCHYMAL STEM CELL TRANSPLANTATION; MULTIPOTENT STEM CELL; MUSCLE DERIVED STEM CELL; MYOBLAST; NONHUMAN; ONUF NUCLEUS; PERFUSION PRESSURE; PRIORITY JOURNAL; RETROGRADE URETHRAL PERFUSION PRESSURE; REVIEW; SACRAL SPINAL CORD; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE FIBER; SNEEZING; STEM CELL; STEM CELL TRANSPLANTATION; STRESS INCONTINENCE; SUBURETHRAL SLING; TRANSVAGINAL TAPE; URETHRA; URETHRAL MUSCLE;

EID: 80052489811     PISSN: 09373462     EISSN: 14333023     Source Type: Journal    
DOI: 10.1007/s00192-011-1432-1     Document Type: Review

References (77)

1. A Atala 2004 Tissue engineering and regenerative medicine: concepts for clinical application Rejuvenation Res 7 15 31 15256042 10.1089/ 154916804323105053 (Pubitemid 39619805)
2. A Atala 2009 Regenerative medicine and tissue engineering in urology Urol Clin North Am 36 199 209 19406321 10.1016/j.ucl.2009.02.009 viii-ix
3. JR Beauchamp JE Morgan CN Pagel TA Partridge 1999 Dynamics of myoblast transplantation reveal a discrete minority of precursors with stem cell-like properties as the myogenic source J Cell Biol 144 1113 1122 10087257 10.1083/jcb.144.6.1113 1:CAS:528:DyaK1MXitVKjtLs%3D (Pubitemid 29157292)
4. AE Bent RT Tutrone MT McLennan LK Lloyd MJ Kennelly G Badlani 2001 Treatment of intrinsic sphincter deficiency using autologous ear chondrocytes as a bulking agent Neurourol Urodyn 20 157 165 11170190 10.1002/1520-6777(2001)20: 2<157::AID-NAU18>3.0.CO;2-A 1:STN:280:DC%2BD3MzjvVWhug%3D%3D (Pubitemid 32180198)
5. AH Brivanlou FH Gage R Jaenisch T Jessell D Melton J Rossant 2003 Stem cells. Setting standards for human embryonic stem cells Science 300 913 916 12738841 10.1126/science.1082940 1:CAS:528:DC%2BD3sXksFWjsLw%3D
6. TW Cannon JY Lee G Somogyi R Pruchnic CP Smith J Huard MB Chancellor 2003 Improved sphincter contractility after allogenic muscle-derived progenitor cell injection into the denervated rat urethra Urology 62 958 963 14624934 10.1016/S0090-4295(03)00679-4 (Pubitemid 37421257)
7. LK Carr D Steele S Steele D Wagner R Pruchnic R Jankowski J Erickson J Huard MB Chancellor 2008 1-year follow-up of autologous muscle-derived stem cell injection pilot study to treat stress urinary incontinence Int Urogynecol J Pelvic Floor Dysfunct 19 881 883 18204978 10.1007/s00192-007-0553-z 1:STN:280:DC%2BD1crpslWiuw%3D%3D (Pubitemid 351597572)
8. MB Chancellor H Perkin N Yoshimura 2005 Recent advances in the neurophysiology of stress urinary incontinence Scand J Urol Nephrol 39 21 24 15764266 10.1080/00365590410002474 (Pubitemid 40380438)
9. MB Chancellor T Yokoyama S Tirney CE Mattes H Ozawa N Yoshimura WC de Groat J Huard 2000 Preliminary results of myoblast injection into the urethra and bladder wall: a possible method for the treatment of stress urinary incontinence and impaired detrusor contractility Neurourol Urodyn 19 279 287 10797585 10.1002/(SICI)1520-6777(2000)19:3<279::AID-NAU9>3.0.CO;2-M 1:STN:280:DC%2BD3c3lvFyltQ%3D%3D (Pubitemid 30253985)
10. CJ Chermansky T Tarin DD Kwon RJ Jankowski TW Cannon WC de Groat J Huard MB Chancellor 2004 Intraurethral muscle-derived cell injections increase leak point pressure in a rat model of intrinsic sphincter deficiency Urology 63 780 785 15072911 10.1016/j.urology.2003.10.035 (Pubitemid 38479439)
11. KL Chrouser F Fick A Goel NB Itano SD Sweat DJ Lightner 2004 Carbon coated zirconium beads in beta-glucan gel and bovine glutaraldehyde cross-linked collagen injections for intrinsic sphincter deficiency: continence and satisfaction after extended follow-up J Urol 171 1152 1155 14767290 10.1097/01.ju.0000103688.83606.06 1:CAS:528:DC%2BD2cXhtV2rt7o%3D (Pubitemid 38327547)
12. J Corcos S Beaulieu J Donovan M Naughton M Gotoh 2002 Quality of life assessment in men and women with urinary incontinence J Urol 168 896 905 12187188 10.1016/S0022-5347(05)64540-5
13. J Corcos O Loutochin L Campeau N Eliopoulos M Bouchentouf B Blok J Galipeau 2010 Bone marrow mesenchymal stromal cell therapy for external urethral sphincter restoration in a rat model of stress urinary incontinence Neurourol Urodyn 30 447 455 21412824 10.1002/nau.20998
14. WC de Groat 1998 Anatomy of the central neural pathways controlling the lower urinary tract Eur Urol 34 Suppl 1 2 5 9705544 10.1159/000052265 (Pubitemid 28418609)
15. WC de Groat 2006 Integrative control of the lower urinary tract: preclinical perspective Br J Pharmacol 147 Suppl 2 S25 S40 16465182 10.1038/sj.bjp.0706604 (Pubitemid 43237573)
16. JO DeLancey 1994 Structural support of the urethra as it relates to stress urinary incontinence: the hammock hypothesis Am J Obstet Gynecol 170 1713 20 8203431 1:STN:280:DyaK2c3mt1Klug%3D%3D discussion 1720-3
17. M Dezawa H Ishikawa Y Itokazu T Yoshihara M Hoshino S Takeda C Ide Y Nabeshima 2005 Bone marrow stromal cells generate muscle cells and repair muscle degeneration Science 309 314 317 16002622 10.1126/science.1110364 1:CAS:528:DC%2BD2MXlsl2jtLs%3D (Pubitemid 40967871)
18. AC Drost S Weng G Feil J Schafer S Baumann L Kanz KD Sievert A Stenzl R Mohle 2009 In vitro myogenic differentiation of human bone marrow-derived mesenchymal stem cells as a potential treatment for urethral sphincter muscle repair Ann NY Acad Sci 1176 135 143 19796241 10.1111/j.1749-6632.2009.04610.x 1:CAS:528:DC%2BD1MXhtlKqt7bF
19. RG Edwards 2007 A burgeoning science of embryological genetics demands a modern ethics Reprod Biomed Online 15 Suppl 1 34 40 17822615 10.1016/S1472-6483(10)60356-2 (Pubitemid 47430360)
20. G Ferrari G Cusella-De Angelis M Coletta E Paolucci A Stornaiuolo G Cossu F Mavilio 1998 Muscle regeneration by bone marrow-derived myogenic progenitors Science 279 1528 1530 9488650 10.1126/science.279.5356.1528 1:CAS:528: DyaK1cXhs1Kmtbs%3D (Pubitemid 28217075)
21. A Furuta RJ Jankowski R Pruchnic N Yoshimura MB Chancellor 2007 The promise of stem cell therapy to restore urethral sphincter function Curr Urol Rep 8 373 378 17880836 10.1007/s11934-007-0034-4 (Pubitemid 47493036)
22. C Hampel D Wienhold N Benken C Eggersmann JW Thuroff 1997 Prevalence and natural history of female incontinence Eur Urol 32 Suppl 2 3 12 9248806 (Pubitemid 27299957)
23. S Herschorn LK Carr C Birch 2010 Autologous muscle-derived cells as therapy for stress urinary incontinence: a randomized blinded trial Neurourol Urodyn 29 243 326 10.1002/nau.20844
24. S Herschorn AA Glazer 2000 Early experience with small volume periurethral polytetrafluoroethylene for female stress urinary incontinence J Urol 163 1838 1842 10799194 10.1016/S0022-5347(05)67555-6 1:STN:280: DC%2BD3c3lvFKntw%3D%3D (Pubitemid 30366748)
25. JM Holroyd-Leduc SE Straus 2004 Management of urinary incontinence in women: scientific review JAMA, J Am Med Assoc 291 986 995 10.1001/jama.291.8.986 1:CAS:528:DC%2BD2cXhs1eisrs%3D (Pubitemid 38543757)
26. A Hoshi T Tamaki K Tono Y Okada A Akatsuka Y Usui T Terachi 2008 Reconstruction of radical prostatectomy-induced urethral damage using skeletal muscle-derived multipotent stem cells Transplantation 85 1617 1624 18551069 10.1097/TP.0b013e318170572b
27. GS Jack FG Almeida R Zhang ZC Alfonso PA Zuk LV Rodriguez 2005 Processed lipoaspirate cells for tissue engineering of the lower urinary tract: implications for the treatment of stress urinary incontinence and bladder reconstruction J Urol 174 2041 2045 16217390 10.1097/01.ju.0000176489.96993.84 1:CAS:528:DC%2BD2MXhtV2rt7jP (Pubitemid 41547020)
28. RJ Jankowski BM Deasy J Huard 2002 Muscle-derived stem cells Gene Ther 9 642 647 12032710 10.1038/sj.gt.3301719 1:CAS:528:DC%2BD38XjslSht7g%3D (Pubitemid 34575318)
29. L Jeffry B Deval A Birsan D Soriano E Darai 2001 Objective and subjective cure rates after tension-free vaginal tape for treatment of urinary incontinence Urology 58 702 706 11711344 10.1016/S0090-4295(01)01340-1 1:STN:280:DC%2BD3Mnms1agtw%3D%3D (Pubitemid 33065699)
30. Y Kaiho I Kamo MB Chancellor Y Arai WC de Groat N Yoshimura 2007 Role of noradrenergic pathways in sneeze-induced urethral continence reflex in rats Am J Physiol Ren Physiol 292 F639 F646 10.1152/ajprenal.00226.2006 1:CAS:528:DC%2BD2sXjt1Gmsbc%3D (Pubitemid 46220531)
31. AM Kajbafzadeh A Elmi S Payabvash AH Salmasi P Saeedi A Mohamadkhani Z Sadeghi L Nikfarjam 2008 Transurethral autologous myoblast injection for treatment of urinary incontinence in children with classic bladder exstrophy J Urol 180 1098 1105 18639289 10.1016/j.juro.2008.05.057
32. I Kamo TW Cannon DA Conway K Torimoto MB Chancellor WC de Groat N Yoshimura 2004 The role of bladder-to-urethral reflexes in urinary continence mechanisms in rats Am J Physiol Ren Physiol 287 F434 F441 10.1152/ajprenal. 00038.2004 1:CAS:528:DC%2BD2cXnvVaqu7w%3D (Pubitemid 39095957)
33. I Kamo Y Kaiho TW Canon MB Chancellor WC de Groat RL Prantil DA Vorp N Yoshimura 2006 Functional analysis of active urethral closure mechanisms under sneeze induced stress condition in a rat model of birth trauma J Urol 176 2711 2715 17085201 10.1016/j.juro.2006.07.139 (Pubitemid 44665970)
34. I Kamo K Torimoto MB Chancellor WC de Groat N Yoshimura 2003 Urethral closure mechanisms under sneeze-induced stress condition in rats: a new animal model for evaluation of stress urinary incontinence Am J Physiol Regul Integr Comp Physiol 285 R356 65 12750148 1:CAS:528:DC%2BD3sXmsVagtL8%3D
35. SB Kang HN Lee JY Lee JS Park HS Lee 2008 Sphincter contractility after muscle-derived stem cells autograft into the cryoinjured anal sphincters of rats Dis Colon Rectum 51 1367 1373 18536965 10.1007/s10350-008-9360-y
36. O Kayigil S Iftekhar Ahmed A Metin 1999 The coexistence of intrinsic sphincter deficiency with type II stress incontinence J Urol 162 1365 1366 10492198 10.1016/S0022-5347(05)68289-4 1:STN:280:DyaK1MvhvF2ntQ%3D%3D (Pubitemid 29428581)
37. S Kern H Eichler J Stoeve H Kluter K Bieback 2006 Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue Stem Cells 24 1294 1301 16410387 10.1634/stemcells.2005-0342 1:CAS:528:DC%2BD28XhtFGhu7fJ (Pubitemid 44464698)
38. SO Kim HS Na D Kwon SY Joo HS Kim Y Ahn 2011 Bone-marrow-derived mesenchymal stem cell transplantation enhances closing pressure and leak point pressure in a female urinary incontinence rat model Urol Int 86 110 116 20689260 10.1159/000317322
39. Y Kinebuchi N Aizawa T Imamura O Ishizuka Y Igawa O Nishizawa 2010 Autologous bone-marrow-derived mesenchymal stem cell transplantation into injured rat urethral sphincter Int J Urol, official journal of the Japanese Urological Association 17 359 368
40. S Kleinert R Horton 2008 Retraction-autologous myoblasts and fibroblasts versus collagen [corrected] for treatment of stress urinary incontinence in women: a [corrected] randomised controlled trial Lancet 372 789 790 18774408 10.1016/S0140-6736(08)61320-3
41. D Kwon Y Kim R Pruchnic R Jankowski I Usiene F de Miguel J Huard MB Chancellor 2006 Periurethral cellular injection: comparison of muscle-derived progenitor cells and fibroblasts with regard to efficacy and tissue contractility in an animal model of stress urinary incontinence Urology 68 449 454 16904482 10.1016/j.urology.2006.03.040 (Pubitemid 44175517)
42. JY Lee TW Cannon R Pruchnic MO Fraser J Huard MB Chancellor 2003 The effects of periurethral muscle-derived stem cell injection on leak point pressure in a rat model of stress urinary incontinence Int Urogynecol J Pelvic Floor Dysfunct 14 31 7 12601514 10.1007/s00192-002-1004-5 1:STN:280: DC%2BD3s%2FovFChsQ%3D%3D discussion 37 (Pubitemid 41510428)
43. JY Lee SY Paik SH Yuk JH Lee SH Ghil SS Lee 2004 Long term effects of muscle-derived stem cells on leak point pressure and closing pressure in rats with transected pudendal nerves Mol Cells 18 309 313 15650326 1:CAS:528:DC%2BD2MXpsFartg%3D%3D (Pubitemid 40298025)
44. R Levy N Muller 2006 Urinary incontinence: economic burden and new choices in pharmaceutical treatment Adv Ther 23 556 573 17050499 10.1007/BF02850045 (Pubitemid 44747437)
45. Y Lin Z Yan L Liu J Qiao W Jing L Wu X Chen Z Li W Tang X Zheng W Tian 2006 Proliferation and pluripotency potential of ectomesenchymal cells derived from first branchial arch Cell Prolif 39 79 92 16542344 10.1111/j.1365-2184. 2006.00374.x 1:CAS:528:DC%2BD28XksFCmtLw%3D
46. B Lo P Zettler MI Cedars E Gates AR Kriegstein M Oberman R Reijo Pera RM Wagner MT Wuerth LE Wolf KR Yamamoto 2005 A new era in the ethics of human embryonic stem cell research Stem Cells 23 1454 1459 16293581 10.1634/stemcells.2005-0324 (Pubitemid 41740994)
47. CF Maher BA O'Reilly PL Dwyer MP Carey A Cornish P Schluter 2005 Pubovaginal sling versus transurethral Macroplastique for stress urinary incontinence and intrinsic sphincter deficiency: a prospective randomised controlled trial BJOG 112 797 801 15924540 10.1111/j.1471-0528.2005.00547.x (Pubitemid 40852852)
48. EJ McGuire B Lytton V Pepe EI Kohorn 1976 Stress urinary incontinence Obstet Gynecol 47 255 264 943076 1:STN:280:DyaE287is1yhsA%3D%3D
49. I Milsom P Ekelund U Molander L Arvidsson B Areskoug 1993 The influence of age, parity, oral contraception, hysterectomy and menopause on the prevalence of urinary incontinence in women J Urol 149 1459 1462 8501788 1:STN:280:DyaK3s3nsVOgsg%3D%3D (Pubitemid 23164544)
50. CG Nilsson N Kuuva C Falconer M Rezapour U Ulmsten 2001 Long-term results of the tension-free vaginal tape (TVT) procedure for surgical treatment of female stress urinary incontinence Int Urogynecol J Pelvic Floor Dysfunct 12 Suppl 2 S5 S8 11450979 10.1007/s001920170003 (Pubitemid 32605816)
51. P Norton L Brubaker 2006 Urinary incontinence in women Lancet 367 57 67 16399154 10.1016/S0140-6736(06)67925-7 (Pubitemid 43038671)
52. H Oshima TR Payne KL Urish T Sakai Y Ling B Gharaibeh K Tobita BB Keller JH Cummins J Huard 2005 Differential myocardial infarct repair with muscle stem cells compared to myoblasts Mol Ther 12 1130 1141 16125468 10.1016/j.ymthe.2005. 07.686 1:CAS:528:DC%2BD2MXht1GhsbzK (Pubitemid 41723047)
53. J Pannek FH Brands T Senge 2001 Particle migration after transurethral injection of carbon coated beads for stress urinary incontinence J Urol 166 1350 1353 11547072 10.1016/S0022-5347(05)65767-9 1:STN:280:DC%2BD3MvpvVaqtA%3D%3D (Pubitemid 32862174)
54. PE Papa Petros 1994 Tissue reaction to implanted foreign materials for cure of stress incontinence Am J Obstet Gynecol 171 1159 7943090 1:STN:280:DyaK2M%2FivFKhtg%3D%3D
55. D Peroni I Scambi A Pasini V Lisi F Bifari M Krampera G Rigotti A Sbarbati M Galie 2008 Stem molecular signature of adipose-derived stromal cells Exp Cell Res 314 603 615 18022619 10.1016/j.yexcr.2007.10.007 1:CAS:528:DC%2BD1cXpsFyjsg%3D%3D
56. MF Pittenger AM Mackay SC Beck RK Jaiswal R Douglas JD Mosca MA Moorman DW Simonetti S Craig DR Marshak 1999 Multilineage potential of adult human mesenchymal stem cells Science 284 143 147 10102814 10.1126/science.284.5411.143 1:CAS:528:DyaK1MXitlCnu7o%3D (Pubitemid 29282067)
57. Z Qu L Balkir JC van Deutekom PD Robbins R Pruchnic J Huard 1998 Development of approaches to improve cell survival in myoblast transfer therapy J Cell Biol 142 1257 1267 9732286 10.1083/jcb.142.5.1257 1:CAS:528: DyaK1cXlvFejur0%3D (Pubitemid 28429107)
58. M Rezapour U Ulmsten 2001 Tension-free vaginal tape (TVT) in women with mixed urinary incontinence-a long-term follow-up Int Urogynecol J Pelvic Floor Dysfunct 12 Suppl 2 S15 S18 11450974 10.1007/s001920170006 (Pubitemid 32605819)
59. LV Rodriguez Z Alfonso R Zhang J Leung B Wu LJ Ignarro 2006 Clonogenic multipotent stem cells in human adipose tissue differentiate into functional smooth muscle cells Proc Natl Acad Sci USA 103 12167 12172 16880387 10.1073/pnas.0604850103 1:CAS:528:DC%2BD28XotlymtLw%3D (Pubitemid 44215829)
60. K Sakamoto S Sharma JS Wheeler 2007 Long-term subjective continence status and use of alternative treatments by women with stress urinary incontinence after collagen injection therapy World J Urol 25 431 433 17593370 10.1007/s00345-007-0193-4 1:CAS:528:DC%2BD2sXptlKhtb4%3D
61. CM Sampselle JM Miller BL Mims JO Delancey JA Ashton-Miller CL Antonakos 1998 Effect of pelvic muscle exercise on transient incontinence during pregnancy and after birth Obstet Gynecol 91 406 412 9491869 10.1016/S0029-7844(97)00672-8 1:STN:280:DyaK1c7ltVygsQ%3D%3D (Pubitemid 28119844)
62. HD Schroder E Reske-Nielsen 1983 Fiber types in the striated urethral and anal sphincters Acta Neuropathol 60 278 282 6613535 10.1007/BF00691877 1:STN:280:DyaL3szgsVyntQ%3D%3D (Pubitemid 13025686)
63. P Seale A Asakura MA Rudnicki 2001 The potential of muscle stem cells Dev Cell 1 333 342 11702945 10.1016/S1534-5807(01)00049-1 1:CAS:528: DC%2BD3MXntlamtbw%3D (Pubitemid 33586083)
64. F Sharifi-Aghdas 2005 Surgical management of stress urinary incontinence Urol J 2 175 182 17602425
65. H Strasser R Marksteiner E Margreiter M Mitterberger GM Pinggera F Frauscher M Fussenegger K Kofler G Bartsch 2007 Transurethral ultrasonography-guided injection of adult autologous stem cells versus transurethral endoscopic injection of collagen in treatment of urinary incontinence World J Urol 25 385 392 17701044 10.1007/s00345-007-0190-7 1:STN:280:DC%2BD2svovFentg%3D%3D
66. SD Sweat DJ Lightner 1999 Complications of sterile abscess formation and pulmonary embolism following periurethral bulking agents J Urol 161 93 96 10037377 10.1016/S0022-5347(01)62074-3 1:STN:280:DyaK1M7lsV2rsw%3D%3D (Pubitemid 29422299)
67. DD Sweeney MB Chancellor 2005 Treatment of stress urinary incontinence with duloxetine hydrochloride Rev urol 7 81 86 16985814
68. T Tamaki Y Uchiyama Y Okada T Ishikawa M Sato A Akatsuka T Asahara 2005 Functional recovery of damaged skeletal muscle through synchronized vasculogenesis, myogenesis, and neurogenesis by muscle-derived stem cells Circulation 112 2857 2866 16246946 10.1161/CIRCULATIONAHA.105.554832 (Pubitemid 41641681)
69. KL Ward P Hilton 2004 A prospective multicenter randomized trial of tension-free vaginal tape and colposuspension for primary urodynamic stress incontinence: two-year follow-up Am J Obstet Gynecol 190 324 331 14981369 10.1016/j.ajog.2003.07.029 (Pubitemid 38249224)
70. Y Wu L Chen PG Scott EE Tredget 2007 Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis Stem Cells 25 2648 2659 17615264 10.1634/stemcells.2007-0226 1:CAS:528:DC%2BD2sXht1CltLzF (Pubitemid 47582758)
71. R Yiou JJ Yoo A Atala 2003 Restoration of functional motor units in a rat model of sphincter injury by muscle precursor cell autografts Transplantation 76 1053 1060 14557752 10.1097/01.TP.0000090396.71097.C2 (Pubitemid 37280833)
72. T Yokoyama R Pruchnic JY Lee YC Chuang H Jumon N Yoshimura WC de Groat J Huard MB Chancellor 2001 Autologous primary muscle-derived cells transfer into the lower urinary tract Tissue Eng 7 395 404 11506729 10.1089/10763270152436454 1:STN:280:DC%2BD3Mvmt1Shug%3D%3D (Pubitemid 32734772)
73. T Yokoyama N Yoshimura R Dhir Z Qu MO Fraser H Kumon WC de Groat J Huard MB Chancellor 2001 Persistence and survival of autologous muscle derived cells versus bovine collagen as potential treatment of stress urinary incontinence J Urol 165 271 276 11125423 10.1097/00005392-200101000-00077 1:STN:280: DC%2BD3M%2FovFajsg%3D%3D
74. X Zeng GS Jack R Zhang 2006 Treatment of SUI using adipose derived stem cells: restoration of urethral function J Urol 175 291
75. W Zhao C Zhang C Jin Z Zhang D Kong W Xu Y Xiu 2010 Periurethral injection of autologous adipose-derived stem cells with controlled-release nerve growth factor for the treatment of stress urinary incontinence in a rat model Eur Urol 59 e1 e4
76. PA Zuk M Zhu P Ashjian DA De Ugarte JI Huang H Mizuno ZC Alfonso JK Fraser P Benhaim MH Hedrick 2002 Human adipose tissue is a source of multipotent stem cells Mol Biol Cell 13 4279 4295 12475952 10.1091/mbc.E02-02-0105 1:CAS:528:DC%2BD38XpsFOqsrw%3D (Pubitemid 35471185)
77. PA Zuk M Zhu H Mizuno J Huang JW Futrell AJ Katz P Benhaim HP Lorenz MH Hedrick 2001 Multilineage cells from human adipose tissue: implications for cell-based therapies Tissue Eng 7 211 228 11304456 10.1089/107632701300062859 1:CAS:528:DC%2BD3MXjsFShtro%3D (Pubitemid 32295155)