Synergy between the N-terminal and C-terminal domains of Mycobacterium tuberculosis HupB is essential for high-affinity binding, DNA supercoiling and inhibition of RecA-promoted strand exchange

FEBS Journal

Volumn 278, Issue 18, 2011, Pages 3447-3462

  Sharadamma, N ^a   Khan, Krishnendu ^a   Kumar, Sandeep ^b   Neelakanteshwar Patil, K ^a   Hasnain, Seyed E ^b,c,d,e   Muniyappa, K ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b CENTRE FOR DNA FINGERPRINTING AND DIAGNOSTICS   (India)

^c INSTITUTE OF LIFE SCIENCES   (India)

^d JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

^e INDIAN INSTITUTE OF TECHNOLOGY DELHI   (India)

Author keywords

DNA strand exchange; DNA supercoiling; HU protein; HupB protein; nucleoid

Indexed keywords

BACTERIAL PROTEIN; HUPB PROTEIN; PROTEIN DERIVATIVE; RECA PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA BINDING; DNA REPAIR; DNA STRAND; DNA SUPERCOILING; GENE CONTROL; GENETIC RECOMBINATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION;

BACTERIAL PROTEINS; CARRIER PROTEINS; CROSS-LINKING REAGENTS; DIMERIZATION; DNA, BACTERIAL; DNA, SUPERHELICAL; DNA-BINDING PROTEINS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HISTONES; KINETICS; MUTANT PROTEINS; MYCOBACTERIUM TUBERCULOSIS; PEPTIDE FRAGMENTS; POLYDEOXYRIBONUCLEOTIDES; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STABILITY; REC A RECOMBINASES; RECOMBINANT PROTEINS; RECOMBINATION, GENETIC; TRANSCRIPTION FACTORS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MYCOBACTERIUM TUBERCULOSIS;

EID: 80052485955     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2011.08267.x     Document Type: Article

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