Inhibition of phospholipase A2 in rat brain decreases the levels of total Tau protein

Journal of Neural Transmission

Volumn 118, Issue 9, 2011, Pages 1273-1279

  Schaeffer, Evelin L ^a   De Paula, Vanessa J ^a   Da Silva, Emanuelle R ^a   De A Novaes, Barbara ^a   Skaf, Heni D ^a   Forlenza, Orestes V ^a   Gattaz, Wagner F ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Alzheimer disease; Frontal cortex; Hippocampus; Phospholipase A2; Rat; Tau protein

Indexed keywords

METHYL ARACHIDONYL FLUOROPHOSPHONATE; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; TAU PROTEIN; UNCLASSIFIED DRUG; ARACHIDONIC ACID DERIVATIVE; MAPT PROTEIN, RAT; METHYL ARACHIDONYLFLUOROPHOSPHONATE; PHOSPHONIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; CONTROLLED STUDY; FRONTAL CORTEX; HIPPOCAMPUS; MALE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; RADIOENZYMATIC ASSAY; RAT; WESTERN BLOTTING; ALZHEIMER DISEASE; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; ENZYMOLOGY; FRONTAL LOBE; HUMAN; METABOLISM; METHODOLOGY; NERVE CELL; WISTAR RAT;

ALZHEIMER DISEASE; ANIMALS; ARACHIDONIC ACIDS; DRUG EVALUATION, PRECLINICAL; FRONTAL LOBE; HIPPOCAMPUS; HUMANS; MALE; NEURONS; PHOSPHOLIPASES A2; PHOSPHONIC ACIDS; RATS; RATS, WISTAR; TAU PROTEINS;

EID: 80052477281     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-011-0619-4     Document Type: Article

References (53)

1. G Arunachalam H Yao IK Sundar S Caito I Rahman 2010 SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: role of resveratrol Biochem Biophys Res Commun 393 66 72 20102704 10.1016/j.bbrc.2010.01.080 1:CAS:528:DC%2BC3cXis1arsr8%3D
2. J Balsinde EA Dennis 1996 Distinct roles in signal transduction for each of the phospholipase A2 enzymes present in P388D1 macrophages J Biol Chem 271 6758 6765 8636097 10.1074/jbc.271.50.32381 1:CAS:528:DyaK28XhvVyisL0%3D (Pubitemid 26422280)
3. S Bezzine JG Bollinger AG Singer SL Veatch SL Keller MH Gelb 2002 On the binding preference of human groups IIA and X phospholipases A2 for membranes with anionic phospholipids J Biol Chem 277 48523 48534 12244093 10.1074/jbc.M203137200 1:CAS:528:DC%2BD38Xptlegt7o%3D (Pubitemid 35470813)
4. SK Billa N Sinha SR Rudrabhatla JÁ Morón 2009 Extinction of morphine-dependent conditioned behavior is associated with increased phosphorylation of the GluR1 subunit of AMPA receptors at hippocampal synapses Eur J Neurosci 29 55 64 19077125 10.1111/j.1460-9568.2008.06560.x
5. JE Burke EA Dennis 2009 Phospholipase A2 structure/function, mechanism, and signaling J Lipid Res 50 Supp1 S237 S242 19011112
6. S Chalbot H Zetterberg K Blennow T Fladby I Grundke-Iqbal K Iqbal 2009 Cerebrospinal fluid secretory Ca(2+)-dependent phospholipase A2 activity is increased in Alzheimer disease Clin Chem 55 2171 2179 19850632 10.1373/clinchem.2009.130286 1:CAS:528:DC%2BD1MXhsFaqs7bL
7. V Colangelo J Schurr MJ Ball RP Pelaez NG Bazan WJ Lukiw 2002 Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down regulation and up-regulation of apoptotic and pro-inflammatory signaling J Neurosci Res 70 462 473 12391607 10.1002/jnr.10351 1:CAS:528:DC%2BD38XosVejsr8%3D (Pubitemid 35222383)
8. EA Dennis 1994 Diversity of group types, regulation, and function of phospholipase A2 J Biol Chem 269 13057 13060 8175726 1:CAS:528: DyaK2cXkt12lsrk%3D (Pubitemid 24206060)
9. EA Dennis 1997 The growing phospholipase A2 superfamily of signal transduction enzymes Trends Biochem Sci 22 1 2 9020581 10.1016/S0968-0004(96) 20031-3 1:CAS:528:DyaK2sXhtVOrtLg%3D (Pubitemid 27056087)
10. VJ De-Paula EL Schaeffer LL Talib WF Gattaz OV Forlenza 2010 Inhibition of phospholipase A2 increases tau phosphorylation at Ser214 in embryonic rat hippocampal neurons Prostaglandins Leukot Essent Fatty Acids 82 57 60 19726172 10.1016/j.plefa.2009.07.006 1:CAS:528:DC%2BC3cXotV2ntw%3D%3D
11. B Esmaeli-Azad JH McCarty SC Feinstein 1994 Sense and antisense transfection analysis of tau function: tau influences net microtubule assembly, neurite outgrowth and neuritic stability J Cell Sci 107 869 879 8056843 1:CAS:528:DyaK2cXltVGhsr0%3D (Pubitemid 24119346)
12. A Ferreira J Busciglio A Cáceres 1989 Microtubule formation and neurite growth in cerebellar macroneurons which develop in vitro: evidence for the involvement of the microtubule-associated proteins, MAP-1a, HMW-MAP2 and Tau Brain Res Dev Brain Res 49 215 228 2509111 10.1016/0165-3806(89)90023-0 1:CAS:528:DyaL1MXmt12kt7s%3D (Pubitemid 19250373)
13. WF Gattaz A Maras NJ Cairns R Levy H Förstl 1995 Decreased phospholipase A2 activity in Alzheimer brains Biol Psychiatry 37 13 17 7893853 10.1016/0006-3223(94)00123-K 1:STN:280:DyaK2M3gtFSlug%3D%3D
14. M Goedert MG Spillantini R Jakes D Rutherford RA Crowther 1989 Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease Neuron 3 519 526 2484340 10.1016/0896-6273(89)90210-9 1:CAS:528:DyaK38XjvFSmsQ%3D%3D
15. M Goedert MG Spillantini MC Potier J Ulrich RA Crowther 1989 Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain EMBO J 8 393 399 2498079 1:CAS:528:DyaL1MXmtV2qsLY%3D (Pubitemid 19274956)
16. M Goedert MG Spillantini NJ Cairns RA Crowther 1992 Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms Neuron 8 159 168 1530909 10.1016/0896-6273(92)90117-V 1:CAS:528:DyaK38XhsV2nsb0%3D
17. I Grundke-Iqbal K Iqbal YC Tung M Quinlan HM Wisniewski LI Binder 1986 Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology Proc Natl Acad Sci USA 83 4913 4917 3088567 10.1073/pnas.83.13.4913 1:CAS:528:DyaL28XksFyqtrg%3D
18. O Hansson H Zetterberg P Buchhave E Londos K Blennow L Minthon 2006 Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study Lancet Neurol 5 228 234 16488378 10.1016/S1474-4422(06)70355-6 1:CAS:528:DC%2BD28XisF2qsbg%3D (Pubitemid 43238346)
19. A Himmler D Drechsel MW Kirschner DW Martin Jr 1989 Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains Mol Cell Biol 9 1381 1388 2498649 1:CAS:528: DyaK3cXkvFKlsw%3D%3D (Pubitemid 19095177)
20. F Hulstaert K Blennow A Ivanoiu HC Schoonderwaldt M Riemenschneider PP De Deyn C Bancher P Cras J Wiltfang PD Mehta K Iqbal H Pottel E Vanmechelen H Vanderstichele 1999 Improved discrimination of AD patients using beta-amyloid (1-42) and tau levels in CSF Neurology 52 1555 1562 10331678 1:STN:280:DyaK1M3mtVGhsw%3D%3D (Pubitemid 29220627)
21. K Iqbal I Grundke-Iqbal AJ Smith L George YC Tung T Zaidi 1989 Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease Proc Natl Acad Sci USA 86 5646 5650 2501795 10.1073/pnas.86.14.5646 1:CAS:528:DyaL1MXlslWqs7g%3D (Pubitemid 19185601)
22. S Khatoon I Grundke-Iqbal K Iqbal 1992 Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein J Neurochem 59 750 753 1629745 10.1111/j.1471-4159.1992.tb09432.x 1:CAS:528:DyaK38Xlt12ht70%3D
23. S Khatoon I Grundke-Iqbal K Iqbal 1994 Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains FEBS Lett 351 80 84 8076698 10.1016/0014-5793(94) 00829-9 1:CAS:528:DyaK2cXlslKktbY%3D (Pubitemid 24268070)
24. ME King V Ahuja LI Binder J Kuret 1999 Ligand-dependent tau filament formation: implications for Alzheimer's disease progression Biochemistry 38 14851 14859 10555967 10.1021/bi9911839 1:CAS:528:DyaK1MXmslCltL0%3D (Pubitemid 29536545)
25. ME King TC Gamblin J Kuret LI Binder 2000 Differential assembly of human tau isoforms in the presence of arachidonic acid J Neurochem 74 1749 1757 10737634 10.1046/j.1471-4159.2000.0741749.x 1:CAS:528:DC%2BD3cXitVens78%3D (Pubitemid 30163998)
26. A Kurz M Riemenschneider K Buch F Willoch P Bartenstein U Müller W Guder 1998 Tau protein in cerebrospinal fluid is significantly increased at the earliest clinical stage of Alzheimer disease Alzheimer Dis Assoc Disord 12 372 377 9876968 10.1097/00002093-199812000-00020 1:STN:280:DyaK1M%2Fpt1Oqtw%3D%3D (Pubitemid 29050754)
27. A Lanari L Parnetti 2009 Cerebrospinal fluid biomarkers and prediction of conversion in patients with mild cognitive impairment: 4-year follow-up in a routine clinical setting Sci World J 9 961 966 1:CAS:528:DC%2BC3cXhsVSjs78%3D
28. PK Larsson Forsell BP Kennedy HE Claesson 1999 The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene Eur J Biochem 262 575 585 10336645 10.1046/j.1432-1327.1999.00418.x 1:STN:280:DyaK1M3mvFSgsQ%3D%3D (Pubitemid 29266072)
29. PK Larsson HE Claesson BP Kennedy 1998 Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity J Biol Chem 273 207 214 9417066 10.1074/jbc.273.1.207 1:CAS:528: DyaK1cXjvFSgsw%3D%3D (Pubitemid 28042195)
30. YC Lio LJ Reynolds J Balsinde EA Dennis 1996 Irreversible inhibition of Ca(2+)-independent phospholipase A2 by methyl arachidonyl fluorophosphonate Biochim Biophys Acta 1302 55 60 8695655 10.1016/0167-4838(95)00262-6 (Pubitemid 26160291)
31. OH Lowry NJ Rowebrough LA Farr RJ Randall 1951 Protein measurement with the Folin phenol reagent J Biol Chem 193 265 275 14907713 1:CAS:528: DyaG38XhsVyrsw%3D%3D
32. DJ Mancuso CM Jenkins RW Gross 2000 The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium-independent phospholipase A(2) J Biol Chem 275 9937 9945 10744668 10.1074/jbc.275.14.9937 1:CAS:528:DC%2BD3cXisFSqu7w%3D (Pubitemid 30202039)
33. GS Moses MD Jensen LF Lue DG Walker AY Sun A Simonyi GY Sun 2006 Secretory PLA2-IIA: a new inflammatory factor for Alzheimer's disease J Neuroinflamm 3 28 10.1186/1742-2094-3-28 (Pubitemid 44680746)
34. M Murakami RS Koduri A Enomoto S Shimbara M Seki K Yoshihara A Singer E Valentin F Ghomashchi G Lambeau MH Gelb I Kudo 2001 Distinct arachidonate-releasing functions of mammalian secreted phospholipase A2 s in human embryonic kidney 293 and rat mastocytoma RBL-2H3 cells through heparan sulfate shuttling and external plasma membrane mechanisms J Biol Chem 276 10083 10096 11106649 10.1074/jbc.M007877200 1:CAS:528:DC%2BD3MXis1Oksbw%3D
35. EA Nalefski JJ Falke 1996 The C2 domain calcium-binding motif: structural and functional diversity Protein Sci 5 2375 2390 8976547 10.1002/pro.5560051201 1:CAS:528:DyaK2sXisFyi (Pubitemid 26424851)
36. EA Nalefski T McDonagh W Somers J Seehra JJ Falke JD Clark 1998 Independent folding and ligand specificity of the C2 calcium-dependent lipid binding domain of cytosolic phospholipase A2 J Biol Chem 273 1365 1372 9430670 10.1074/jbc.273.3.1365 1:CAS:528:DyaK1cXktFGjsw%3D%3D (Pubitemid 28133654)
37. T Ohto N Uozumi T Hirabayashi T Shimizu 2005 Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta} J Biol Chem 280 24576 24583 15866882 10.1074/jbc.M413711200 1:CAS:528:DC%2BD2MXlsFyru70%3D (Pubitemid 40934545)
38. Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates. Academic, San Diego
39. BM Ross A Moszczynska J Erlich SJ Kish 1998 Phospholipid-metabolizing enzymes in Alzheimer's disease: increased lysophospholipid acyltransferase activity and decreased phospholipase A2 activity J Neurochem 70 786 793 9453575 10.1046/j.1471-4159.1998.70020786.x 1:CAS:528:DyaK1cXmtFaqug%3D%3D (Pubitemid 28079370)
40. 2 activity in rat hippocampus impairs acquisition of short- and long-term memory. Psychopharmacology (Berl) 181:392-400 (Pubitemid 41492209)
41. EL Schaeffer WF Gattaz 2008 Cholinergic and glutamatergic alterations beginning at the early stages of Alzheimer disease: participation of the phospholipase A2 enzyme Psychopharmacology (Berl) 198 1 27 10.1007/s00213-008- 1092-0 1:CAS:528:DC%2BD1cXlt1CrtLs%3D
42. P Schönknecht J Pantel E Kaiser P Thomann J Schröder 2007 Increased tau protein differentiates mild cognitive impairment from geriatric depression and predicts conversion to dementia Neurosci Lett 416 39 42 17331644 10.1016/j.neulet.2007.01.070 (Pubitemid 46428014)
43. M Sjögren P Davidsson M Tullberg L Minthon A Wallin C Wikkelso AK Granérus H Vanderstichele E Vanmechelen K Blennow 2001 Both total and phosphorylated tau are increased in Alzheimer's disease J Neurol Neurosurg Psychiatry 70 624 630 11309456 10.1136/jnnp.70.5.624 (Pubitemid 32397998)
44. S Smesny S Stein I Willhardt J Lasch H Sauer 2008 Decreased phospholipase A2 activity in cerebrospinal fluid of patients with dementia J Neural Transm 115 1173 1179 18584113 10.1007/s00702-008-0081-0 1:CAS:528:DC%2BD1cXht1ShurnM
45. C Song XJ Chang KM Bean MS Proia JL Knopf RW Kriz 1999 Molecular characterization of cytosolic phospholipase A2-beta J Biol Chem 274 17063 17067 10358058 10.1074/jbc.274.24.17063 1:CAS:528:DyaK1MXjvVGktbk%3D (Pubitemid 29275164)
46. DT Stephenson CA Lemere DJ Selkoe JA Clemens 1996 Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer's disease brain Neurobiol Dis 3 51 63 9173912 10.1006/nbdi.1996.0005 1:CAS:528:DyaK28Xis1Kqt7c%3D (Pubitemid 26145405)
47. D Stephenson K Rash B Smalstig E Roberts E Johnstone J Sharp J Panetta S Little R Kramer J Clemens 1999 Cytosolic phospholipase A2 is induced in reactive glia following different forms of neurodegeneration Glia 27 110 128 10417811 10.1002/(SICI)1098-1136(199908)27:2<110::AID-GLIA2>3.0.CO;2-C 1:STN:280:DyaK1MzkvVagtg%3D%3D (Pubitemid 29365748)
48. K Talbot RA Young C Jolly-Tornetta VM Lee JQ Trojanowski BA Wolf 2000 A frontal variant of Alzheimer's disease exhibits decreased calcium-independent phospholipase A2 activity in the prefrontal cortex Neurochem Int 37 17 31 10781842 10.1016/S0197-0186(00)00006-1 1:CAS:528:DC%2BD3cXkt12nuro%3D (Pubitemid 30211603)
49. PA Thomann E Kaiser P Schönknecht J Pantel M Essig J Schröder 2009 Association of total tau and phosphorylated tau 181 protein levels in cerebrospinal fluid with cerebral atrophy in mild cognitive impairment and Alzheimer disease J Psychiatry Neurosci 34 136 142 19270764
50. KW Underwood C Song RW Kriz XJ Chang JL Knopf LL Lin 1998 A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2 J Biol Chem 273 21926 21932 9705332 10.1074/jbc.273.34.21926 1:CAS:528:DyaK1cXlsFOqsbc%3D (Pubitemid 28405371)
51. AK Wallin K Blennow N Andreasen L Minthon 2006 CSF biomarkers for Alzheimer's disease: levels of beta-amyloid, tau, phosphorylated tau relate to clinical symptoms and survival Dement Geriatr Cogn Disord 21 131 138 16391474 10.1159/000090631 1:CAS:528:DC%2BD28XhtFSntLY%3D (Pubitemid 43201321)
52. DM Wilson LI Binder 1997 Free fatty acids stimulate the polymerization of tau and amyloid beta peptides. In vitro evidence for a common effector of pathogenesis in Alzheimer's disease Am J Pathol 150 2181 2195 9176408 1:CAS:528:DyaK2sXktFaksrY%3D (Pubitemid 27233088)
53. HC Yang M Mosior B Ni EA Dennis 1999 Regional distribution, ontogeny, purification, and characterization of the Ca(2+)-independent phospholipase A2 from rat brain J Neurochem 73 1278 1287 10461922 10.1046/j.1471-4159.1999. 0731278.x 1:CAS:528:DyaK1MXlsVOitbY%3D (Pubitemid 29395489)