Increased tau protein differentiates mild cognitive impairment from geriatric depression and predicts conversion to dementia

Neuroscience Letters

Volumn 416, Issue 1, 2007, Pages 39-42

  Schönknecht, Peter ^a   Pantel, Johannes ^b   Kaiser, Elmar ^a   Thomann, Philipp ^a   Schröder, Johannes ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

Aging associated cognitive decline; Alzheimer's disease; Depression; Mild cognitive impairment; Phospho tau; Total tau

Indexed keywords

TAU PROTEIN; THREONINE;

ADULT; AGED; AGING; ARTICLE; CLINICAL ASSESSMENT; COGNITIVE DEFECT; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED STUDY; DEMENTIA; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN CEREBROSPINAL FLUID LEVEL; UPREGULATION;

AGED; AGING; COGNITION DISORDERS; DEMENTIA; DEPRESSIVE DISORDER; DIAGNOSIS, DIFFERENTIAL; DISEASE PROGRESSION; EARLY DIAGNOSIS; FEMALE; FOLLOW-UP STUDIES; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; PROGNOSIS; SENSITIVITY AND SPECIFICITY; TAU PROTEINS;

EID: 33947206696     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2007.01.070     Document Type: Article

References (20)

1. American Psychiatric Association. Diagnostic and Statistical Manual. fourth ed. (1994), American Psychiatric Association, Washington DC
2. Blennow K. Cerebrospinal fluid protein biomarkers for Alzheimer's disease. NeuroRx 1 (2004) 213-225
3. Blennow K., de Leon M.L., and Zetterberg H. Alzheimer's disease. Lancet 368 (2006) 387-403
4. Buerger K., Zinkowski R., Teipel S.J., Arai H., DeBernardis J., Kerkman D., McCulloch C., Padberg S., Faltraco F., Goernitz A., Tapiola T., Rapoport S.I., Pirttila T., Möller H.J., and Hampel H. Differentiation of geriatric major depression from Alzheimer's disease with CSF tau protein phosphorylated at threonine 231. Am. J. Psychiatry 160 (2003) 376-379
5. Busse A., Angermeyer M.C., and Riedel-Heller S.G. Progression of mild cognitive impairment to dementia: a challenge to current thinking. Br. J. Psychiatry 189 (2006) 399-404
6. DeLeon M.J., Segal S., Tarshish C.Y., DeSanti S., Zinkowski R., Mehta P.D., Convit A., Caraos C., Rusinek H., Tsui W., Saint Louis L.A., DeBernardis J., Kerkman D., Qadri F., Gary A., Lesbre P., Wisniewski T., Poirier J., and Davies P. Longitudinal cerebrospinal fluid tau load increases in mild cognitive impairment. Neurosci. Lett. 333 (2002) 183-186
7. Düring M., Grimm H.O., Grimm H.S., Schröder J., and Hartmann T. Mean age of onset in familial Alzheimer's disease is determined by amyloid beta 42. Neurobiol. Aging 26 (2005) 785-788
8. Folstein M.F., Folstein S.E., and McHugh P.R. 'Mini Mental State'. A practical method for grading the cognitive state of patients for the clinicians. J. Psychiatric Res. 12 (1975) 189-198
9. D.R. Gustafson, I. Skoog, L. Rosengren, H. Zetterberg, K. Blennow, Cerebrospinal fluid Aß42 concentration may predict cognitive decline in elderly women. J. Neurol. Neurosurg. Psychiatry, (in press).
10. Herukka S.K., Hallikainen M., Soininen H., and Pirtilla T. CSF Aβ42 and tau or phosphorylated tau and prediction of progressive mild cognitive impairment. Neurology 64 (2005) 1294-1297
11. Hansson O., Zetterberg H., Buchhave P., Londos E., Blennow K., and Minthon L. Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study. Lancet Neurol. 5 (2006) 228-234
12. Levy R. Aging-associated cognitive decline. Int. Psychogeriatr. 6 (1994) 63-68
13. Loeb C., and Gandolfo C. Diagnostic evaluation of degenerative and vascular dementia. Stroke 14 (1983) 399-401
14. Öst M., Nylen K., Csajbok L., Öhrfelt O., Tullberg M., Wikkelsö C., Nellgard P., Rosengren L., Blennow K., and Nellgard B. Initial CSF total tau correlates with 1-year outcome in patients with traumatic brain injury. Neurology 67 (2006) 1600-1604
15. Pantel J., Kratz B., Essig M., and Schröder J. Parahippocampal volume deficits in subjects with aging associated cognitive decline. Am. J. Psychiatry 160 (2003) 379-382
16. Schönknecht P., Pantel J., Hartmann T., Werle E., Volkmann M., Essig M., Amann M., Zanabili N., Bardenheuer H., Hunt A., and Schröder J. Cerebrospinal fluid tau levels in Alzheimer's disease are elevated when compared to vascular dementia but do not correlate with measures of cerebral atrophy. Psychiatry Res. 120 (2003) 231-238
17. Schönknecht P., Pantel J., Hunt A., Volkmann M., Buerger K., Hampel H., and Schröder J. Tau protein phosphorylated at threonine 181 is increased in incipient and manifest Alzheimeŕs disease but not in vascular dementia. Neurosci. Lett. 339 (2003) 172-174
18. Schönknecht P., Pantel J., Kruse A., and Schröder J. Prevalence and natural course of aging-associated cognitive decline in a population based sample of "young-old" subjects. Am. J. Psychiatry 11 (2005) 2071-2077
19. J. Schröder, P. Schönknecht, M. Essig, J. Pantel, Die leichte kognitive Beeinträchtigung: Symptomatik, Epidemiologie und Verlauf. In: Wahl & Mollenkopf (Hrsg.) Alternsforschung am Beginn des 21. Jahrhunderts. Alterns- und Lebenslaufkonzeptionen im deutschsprachigen Raum, Steinkopff, Darmstadt, (in press).
20. Winblad B., Palmer K., Kivipelto M., Jelic V., Fratiglioni L., Wahlund L.O., Nordberg A., Backman L., Albert M., Almkvist O., Arai H., Basun H., Blennow K., de Leon M., DeCarli C., Erkinjuntti T., Giacobini E., Graff C., Hardy J., Jack C., Jorm A., Ritchie K., van Duijn C., Visser P., and Petersen R.C. Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J. Intern. Med. 3 (2004) 240-246