Haploinsufficiency of Pkd2 is associated with increased tubular cell proliferation and interstitial fibrosis in two murine Pkd2 models

Nephrology Dialysis Transplantation

Volumn 21, Issue 8, 2006, Pages 2078-2084

  Chang, Ming Yang ^a   Parker, Emma ^a   Ibrahim, Salwa ^c   Shortland, John R ^b   El Nahas, Meguid ^a   Haylor, John L ^a   Ong, Albert C M ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b SHEFFIELD TEACHING HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^c CAIRO UNIVERSITY   (Egypt)

Author keywords

ADPKD; Haploinsufficiency; Kidney fibrosis; PKD2; Proliferation; Renal tubule

Indexed keywords

CYCLINE; KI 67 ANTIGEN; POLYCYSTIN 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE DOSAGE; GENE MUTATION; HAPLOIDY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; KIDNEY FIBROSIS; KIDNEY PARENCHYMA; KIDNEY POLYCYSTIC DISEASE; KIDNEY TUBULE CELL; MALE; MOUSE; MOUSE MUTANT; NEPHRECTOMY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADULT; ALLELES; ANIMALS; CELL DIVISION; DISEASE PROGRESSION; FEMALE; HETEROZYGOTE; HUMANS; KI-67 ANTIGEN; KIDNEY TUBULES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MIDDLE AGED; MITOTIC INDEX; NEPHRITIS, INTERSTITIAL; POLYCYSTIC KIDNEY, AUTOSOMAL DOMINANT; PROLIFERATING CELL NUCLEAR ANTIGEN; SEVERITY OF ILLNESS INDEX; TRPP CATION CHANNELS;

EID: 33748085676     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfl150     Document Type: Article

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