Acute antibody-mediated rejection in paediatric renal transplant recipients

Pediatric Nephrology

Volumn 26, Issue 7, 2011, Pages 1149-1156

  Kranz, Birgitta ^a   Kelsch, Reinhard ^a   Kuwertz Bröking, Eberhard ^a   Bröcker, Verena ^b   Wolters, Heiner H ^a   Konrad, Martin ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Acute antibody mediated rejection; AT1 receptor antibodies; Immunoglobulin; Pediatric renal transplantation; Plasmapheresis; Rituximab

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTIBODY; COMPLEMENT COMPONENT C4D; CREATININE; CYCLOSPORIN A; HEPARIN; HLA ANTIBODY; HLA DR ANTIGEN; HLA DR1 ANTIBODY; HLA DR11 ANTIBODY; IMMUNOGLOBULIN; IRBESARTAN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NITROPRUSSIDE SODIUM; RAMIPRIL; RECEPTOR ANTIBODY; RITUXIMAB; STEROID; TACROLIMUS; UNCLASSIFIED DRUG;

ACUE ANTIBODY MEDIATED REJECTION; ACUTE ANTIBODY MEDIATED REJECTION; ACUTE GRAFT REJECTION; ACUTE KIDNEY FAILURE; ANTIBODY DETECTION; ANTIBODY SPECIFICITY; ANTIBODY TITER; ANTICOAGULANT THERAPY; ANTIHYPERTENSIVE THERAPY; ARTICLE; BLADDER BLEEDING; CASE REPORT; CHILD; COMPLEMENT DEPENDENT CYTOTOXICITY; CREATININE BLOOD LEVEL; DRUG BLOOD LEVEL; DRUG PULSE THERAPY; DRUG SUBSTITUTION; FEMALE; FOCAL GLOMERULOSCLEROSIS; FOLLOW UP; GLOMERULUS FILTRATION RATE; GRAFT FAILURE; HEMODIALYSIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPERTENSION; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY BIOPSY; KIDNEY DYSPLASIA; KIDNEY FUNCTION; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; MALE; PEDIATRIC SURGERY; PLASMAPHERESIS; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; SCHOOL CHILD; SINGLE DRUG DOSE;

ACUTE KIDNEY INJURY; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; BIOPSY; CHILD; DRUG THERAPY, COMBINATION; FEMALE; GRAFT REJECTION; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; IMMUNOSUPPRESSIVE AGENTS; ISOANTIBODIES; KIDNEY TRANSPLANTATION; LIVING DONORS; PLASMAPHERESIS; RENAL DIALYSIS; TIME FACTORS; TREATMENT OUTCOME;

EID: 80052436396     PISSN: 0931041X     EISSN: 1432198X     Source Type: Journal    
DOI: 10.1007/s00467-011-1864-3     Document Type: Article

References (22)

1. Solez K, Colvin RB, Racusen LC, Haas M, Sis B, Mengel M, Halloran PF, Baldwin W, Banfi G, Collins AB, Cosio F, David DS, Drachenberg C, Einecke G, Fogo AB, Gibson IW, Glotz D, Iskandar SS, Kraus E, Lerut E, Mannon RB, Mihatsch M, Nankivell BJ, Nickeleit V, Papadimitriou JC, Randhawa P, Regele H, Renaudin K, Roberts I, Seron D, Smith RN, Valente M (2008) Banff 07 Classification of renal allograft pathology: updates and future directions. Am J Transplant 8:753-760. (Pubitemid 351347767)
2. Colvin RB (2007) Antibody mediated renal allograft rejection: diagnosis and pathogenesis. J Am Soc Nephrol 18:1046-1056. (Pubitemid 46536891)
3. Jordan SC, Reinsmoen N, Peng A, Lai CH, Cao K, Villicana R, Toyoda M, Kahwaji J, Vo AA (2010) Advances in diagnosing and managing antibody-mediated rejection. Pediatr Nephrol 25:2035- 2045.
4. Ji SM, Liu ZH, Chen JS, Sha GZ, Ji DX, Li LS (2006) Rescue therapy by immunoadsorption in combination with tacrolimus and mycophenolate mofetil for C4d-positive acute humoral renal allograft rejection. Transplant Proc 38:3459-3463.
5. Gomes AM, Pedroso S, Martins LS, Malheiro J, Viscayno JR, Santos J, Dias L, Henriques AC, Sarmento AM, Cabrita A (2009) Diagnosis and treatment of acute humoral kidney allograft rejection. Transplant Proc 41:855-858.
6. Kaposztas Z, Podder H, Mauiyyedi S, Illoh O, Kerman R, Reyes M, Pollard V, Kahan MD (2009) Impact of rituximab therapy for treatment of acute humoral rejection. Clin Transplant 23:63-73.
7. Faguer S, Kamar N, Guilbeaud-Frugier C, Fort M, Modesto A, Mari A, Ribes D, Cointault O, Lavayssière L, Guitard J, Durand D, Rostaing L (2007) Rituximab therapy for acute humoral rejection after kidney transplantation. Transplantation 83:1277- 1280. (Pubitemid 46743692)
8. Becker YT, Becker BN, Pirsch JD, Sollinger HW (2004) Rituximab as treatment for refractory kidney transplant rejection. Am J Transpl 4:996-1001. (Pubitemid 38745599)
9. Mulley WR, Hudson FJ, Tait BD, Skene AM, Dowling JP, Kerr PG, Kanellis J (2009) A single low-fixed dose of rituximab to salvage renal transplants from refractory antibody-mediated rejection. Transplantation 87:286-289.
10. Schwartz GJ, Haycock GB, Edelmann CM, Spitzer A (1976) A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 58:259-263.
11. Dragun D, Hegner B (2009) Non-HLA antibodies posttransplantation: clinical relevance and treatment in solid organ transplantation. Contrib Nephrol 162:129-139.
12. Bundesärztekammer D (2010) Richtlinie zur medizinischen Beurteilung von Organspendern und zur Konservierung Spenderorganen. Dtsch Arztebl 107:A1532-A1541.
13. Lefaucheur C, Suberbielle-Boissel C, Hill GS, Nochy D, Andrade J, Antoine C, Gautreau C, Charron D, Glotz D (2009) Clinical relevance of preformed HLA donor-specific antibodies in kidney transplantation. Contrib Nephrol 162:1-12.
14. Riethmüller S, Ferrari-Lacraz S, Müller MK, Raptis DA, Hadaya K, Rüsi B, Laube G, Schneiter G, Fehr T, Villard J (2010) Donorspecific antibody levels and three generations of crossmatches to predict antibody-mediated rejection in kidney transplantation. Transplantation 90:160-167.
15. Ibernon M, Gil-Vernet S, Carrera M, Seron F, Moreso F, Bestard O, Cruzado JM, Grinyo JM (2005) Therapy with plasmapheresis and intravenous immunoglobulin for acute humoral rejection in kidney transplantation. Transplant Proc 37:3743-3745. (Pubitemid 43015152)
16. Jordan SC, Quartel AW, Czer LS, Admon D, Chen G, Fishbein MC, Schwieger J, Steiner RW, Davis C, Tyan DB (1998) Posttransplant therapy using high-dose immunoglobulin (intravenous gammaglobulin) to control acute humoral rejection in renal and cardiac allograft recipients and potential mechanism of action. Transplantation 66:800-805.
17. Luke PP, Scantlebury VP, Jordan ML, Vivas CA, Hakala TR, Jain A, Somani A, Fedorek S, Randhawa P, Shapiro R (2001) Reversal of steroid- and antilymphocyte antibody-resistant rejection using intravenous immunoglobulin (IVIG) in renal transplant recipients. Transplantation 72:419-422. (Pubitemid 32769625)
18. Casadei DH, del C Rial M, Opelz G, Golberg JC, Argento JA, Greco G, Guardia OE, Haas E, Raimondi EH (2001) A randomized and prospective study comparing treatment with high-dose intravenous immunoglobulin with monoclonal anti-bodies for rescue of kidney grafts with steroid-resistant rejection. Transplantation 71:53-58. (Pubitemid 32105778)
19. Nafar M, Farrokhi F, Pour-Reza-Gholi F, Firoozan A, Einollahi B (2006) Plasmapheresis in the treatment of early acute kidney allograft dysfunction. Exp Clin Transplant 4:506-509. (Pubitemid 46443877)
20. Guilbeau-Frugier C, Kamar N (2009) Rituximab for humoral rejection after kidney transplantation: an update. Transplantation 87:1261.
21. Billing H, Rieger S, Ovens J, Süsal C, Melk A, Waldherr R, Opelz G, Tönshoff B (2008) Successful treatment of chronic antibodymediated rejection with IVIG and rituximab in pediatric renal transplant recipients. Transplantation 86:1214-1221.
22. Zarkhin V, Li L, Kambham N, Sigdel T, Salvatierra O, Sarwal MM (2008) A randomized, prospective trial of rituximab for acute rejection in pediatric renal transplantation. Am J Transplant 8:2607-2617.