Comment on "Additive genetic breeding values correlate with the load of partially deleterious mutations"

Science

Volumn 333, Issue 6047, 2011, Pages

  Postma, Erik ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BREEDING LINE; GENE MUTATION; GENETIC CORRELATION; NONHUMAN; NOTE; NULL HYPOTHESIS; PHENOTYPE; PRIORITY JOURNAL; PROGENY; RANDOMIZATION; WEEVIL;

ANIMALS; BEETLES; BREEDING; DATA INTERPRETATION, STATISTICAL; FEMALE; GENES, INSECT; GENETIC FITNESS; GENETIC VARIATION; INBREEDING; MALE; MUTATION; PHENOTYPE; REPRODUCTION; SELECTION, GENETIC; STATISTICS AS TOPIC;

BRUCHUS PISORUM;

EID: 80052436338     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1200996     Document Type: Note

References (13)

1. M. Lynch, B. Walsh, Genetics and Analysis of Quantitative Traits (Sinauer, Sunderland, MA, 1998).
2. M. Lynch, L. Latta, J. Hicks, M. Giorgianni, Evolution 52, 727 (1998).
3. N. H. Barton, P. D. Keightley, Nat. Rev. Genet. 3, 11 (2002).
4. E. Postma, J. Evol. Biol. 19, 309 (2006).
5. M. O. Johnston, D. J. Schoen, Evolution 48, 1735 (1994).
6. C. W. Fox, Am. J. Bot. 92, 1929 (2005).
7. J. L. Tomkins, M. A. Penrose, J. Greeff, N. R. LeBas, Science 328, 892 (2010).
8. p = μ + â, where m is the population mean and â the predicted breeding value, given by the mean of the parental predicted breeding values.
9. o = μ + a + e - d, where a is the true breeding value, e the environmental deviation, and d the amount of inbreeding depression (i.e., mutational load).
10. If â is an unbiased prediction of a, then cov(â, a) = var(â) (see 4) and cov(â, e) = 0. From this, it follows that cov(p, o) = cov(â, a + e - d) = var(â) - cov(â, d). So if cov(â, d) = 0 (the null hypothesis), then cov(p, o) = var(â).
11. As cov(p, o) = var(â) - cov(â, d), cov(p, p - o) = var(p) - cov(p, o) = var(â) - [var(â) - cov(â, d)] = cov(â, d) . So if cov(â, d) = 0 (the null hypothesis), then cov(p, p - o) = 0.
12. randomized) = var(p).
13. I. Booksmythe, H. Kokko, M. D. Jennions, Curr. Biol. 20, R672 (2010).