Hormonally defined pancreatic and duodenal neuroendocrine tumors differ in their transcription factor signatures: Expression of ISL1, PDX1, NGN3, and CDX2

Virchows Archiv

Volumn 459, Issue 2, 2011, Pages 147-154

  Hermann, Gratiana ^a,b   Konukiewitz, Björn ^b   Schmitt, Anja ^c   Perren, Aurel ^c   Klöppel, Günter ^b,d  

^a TEL AVIV UNIVERSITY   (Israel)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF BERN   (Switzerland)

^d UNIVERSITY OF KIEL   (Germany)

Author keywords

CDX2; Duodenum; Gastrinoma; Glucagonoma; Insulinoma; ISL1; Neuroendocrine tumors; NGN3; Pancreas; PDX1; Transcription factors

Indexed keywords

CALCITONIN; GASTRIN; GLUCAGON; INSULIN; NEUROGENIN 3; PANCREAS POLYPEPTIDE; SEROTONIN; SOMATOSTATIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR ISL1; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER GRADING; DUODENUM NEUROENDOCRINE TUMOR; DUODENUM TUMOR; FEMALE; HUMAN; HUMAN TISSUE; MALE; METASTASIS; NEUROENDOCRINE TUMOR; PANCREAS TUMOR; PANCREATIC NEUROENDOCRINE TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR LOCALIZATION; TUMOR VOLUME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CALCITONIN; DUODENAL NEOPLASMS; FEMALE; GASTRINS; GLUCAGON; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; NEUROENDOCRINE TUMORS; PANCREATIC NEOPLASMS; PANCREATIC POLYPEPTIDE; SOMATOSTATIN; TRANS-ACTIVATORS; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 80052412083     PISSN: 09456317     EISSN: 14322307     Source Type: Journal    
DOI: 10.1007/s00428-011-1118-6     Document Type: Article

References (24)

1. S La Rosa E Rigoli S Uccella AM Chiaravalli C Capella 2004 CDX2 as a marker of intestinal EC-cells and related well-differentiated endocrine tumors Virchows Arch 445 248 254 15517368 10.1007/s00428-004-1080-7 1:CAS:528:DC%2BD2cXptVejsLk%3D (Pubitemid 39286892)
2. M Barbareschi C Roldo G Zamboni P Capelli A Cavazza E Macri MG Cangi M Chilosi C Doglioni 2004 CDX-2 homeobox gene product expression in neuroendocrine tumors: its role as a marker of intestinal neuroendocrine tumors Am J Surg Pathol 28 1169 1176 15316316 10.1097/01.pas.0000131531.75602.b9 (Pubitemid 39121611)
3. A Srivastava JL Hornick 2009 Immunohistochemical staining for CDX-2, PDX-1, NESP-55, and TTF-1 can help distinguish gastrointestinal carcinoid tumors from pancreatic endocrine and pulmonary carcinoid tumors Am J Surg Pathol 33 626 632 19065104 10.1097/PAS.0b013e31818d7d8b
4. JF Habener DM Kemp MK Thomas 2005 Minireview: transcriptional regulation in pancreatic development Endocrinology 146 1025 1034 15604203 10.1210/en.2004-1576 1:CAS:528:DC%2BD2MXitlehsL0%3D (Pubitemid 40289291)
5. SE Schonhoff M Giel-Moloney AB Leiter 2004 Minireview: development and differentiation of gut endocrine cells Endocrinology 145 2639 2644 15044355 10.1210/en.2004-0051 1:CAS:528:DC%2BD2cXkt12gtLw%3D (Pubitemid 38686209)
6. Park JY, Hong SM, Klimstra DS, Goggins MG, Maitra A, Hruban RH (2011) Pdx1 expression in pancreatic precursor lesions and neoplasms. Appl Immunohistochem Mol Morphol (in press)
7. DA Cano M Hebrok M Zenker 2007 Pancreatic development and disease Gastroenterology 132 745 762 17258745 10.1053/j.gastro.2006.12.054 1:CAS:528:DC%2BD2sXjtlKis70%3D (Pubitemid 46274681)
8. AS Bernardo CW Hay K Docherty 2008 Pancreatic transcription factors and their role in the birth, life and survival of the pancreatic beta cell Mol Cell Endocrinol 294 1 9 18687378 10.1016/j.mce.2008.07.006 1:CAS:528: DC%2BD1cXht1KnsL%2FP
9. JM Rukstalis JF Habener 2009 Neurogenin3: a master regulator of pancreatic islet differentiation and regeneration Islets 1 177 184 21099270 10.4161/isl.1.3.9877
10. U Ahlgren SL Pfaff TM Jessell T Edlund H Edlund 1997 Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells Nature 385 257 260 9000074 10.1038/385257a0 1:CAS:528:DyaK2sXlslCitg%3D%3D (Pubitemid 27043725)
11. J Jensen 2004 Gene regulatory factors in pancreatic development Dev Dyn 229 176 200 14699589 10.1002/dvdy.10460 1:CAS:528:DC%2BD2cXht1egsLw%3D (Pubitemid 38036833)
12. O Karlsson S Thor T Norberg H Ohlsson T Edlund 1990 Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain Nature 344 879 882 1691825 10.1038/344879a0 1:CAS:528:DyaK3cXkvFent7c%3D (Pubitemid 20178888)
13. C Abate-Shen 2002 Deregulated homeobox gene expression in cancer: cause or consequence? Nat Rev Cancer 2 777 785 12360280 10.1038/nrc907 1:CAS:528:DC%2BD38XnsVGrtbs%3D (Pubitemid 37328912)
14. CA Moskaluk H Zhang SM Powell LA Cerilli GM Hampton HF Frierson Jr 2003 Cdx2 protein expression in normal and malignant human tissues: an immunohistochemical survey using tissue microarrays Mod Pathol 16 913 919 13679455 10.1097/01.MP.0000086073.92773.55 (Pubitemid 37152021)
15. AM Schmitt F Riniker M Anlauf S Schmid A Soltermann H Moch PU Heitz G Klöppel P Komminoth A Perren 2008 Islet 1 (Isl1) expression is a reliable marker for pancreatic endocrine tumors and their metastases Am J Surg Pathol 32 420 425 18300808 10.1097/PAS.0b013e318158a397 (Pubitemid 351398934)
16. V Fendrich R Ramerth J Waldmann K Maschuw P Langer DK Bartsch EP Slater A Ramaswamy M Rothmund 2009 Sonic hedgehog and pancreatic-duodenal homeobox 1 expression distinguish between duodenal and pancreatic gastrinomas Endocr Relat Cancer 16 613 622 19240184 10.1677/ERC-08-0204 1:CAS:528:DC%2BD1MXptlOhu74%3D
17. MH Lejonklou K Edfeldt TA Johansson P Stalberg B Skogseid 2009 Neurogenin 3 and neurogenic differentiation 1 are retained in the cytoplasm of multiple endocrine neoplasia type 1 islet and pancreatic endocrine tumor cells Pancreas 38 259 266 19307926 10.1097/MPA.0b013e3181930818 1:CAS:528:DC%2BD1MXjsVyqsLc%3D
18. G Klöppel G Rindi M Anlauf A Perren P Komminoth 2007 Site-specific biology and pathology of gastroenteropancreatic neuroendocrine tumors Virchows Arch 451 SUPPL. 1 S9 S27 17684761 10.1007/s00428-007-0461-0 (Pubitemid 47283382)
19. Rindi G, Klöppel G (2010) WHO classification of tumours of the digestive system. IARC, Lyon
20. Solcia E, Sobin LH, Klöppel G (2000) WHO classification of tumours of the digestive system. IARC, Lyon
21. Heitz PU, Komminoth P, Perren A (2004) WHO classification of tumours of the endocrine pancreas. IARC, Lyon
22. WW de Herder B Niederle JY Scoazec S Pauwels G Klöppel M Falconi DJ Kwekkeboom K Öberg B Eriksson B Wiedenmann G Rindi D O'Toole D Ferone all other Frascati Consensus Conference participants 2006 Well-differentiated pancreatic tumor/carcinoma: insulinoma Neuroendocrinology 84 183 188 17312378 10.1159/000098010 (Pubitemid 46361052)
23. E Ruttman G Klöppel G Bommer M Kiehn PU Heitz 1980 Pancreatic glucagonoma with and without syndrome. Immunocytochemical study of 5 tumour cases and review of the literature Virchows Arch A Pathol Anat 388 51 67 10.1007/BF00430676 1:STN:280:DyaL3M7isl2mtg%3D%3D (Pubitemid 10032412)
24. B Konukiewitz T Enosawa G Kloppel 2011 Glucagon expression in cystic pancreatic neuroendocrine neoplasms: an immunohistochemical analysis Virchows Arch 458 47 53 20922407 10.1007/s00428-010-0985-6 1:CAS:528: DC%2BC3MXjtVartw%3D%3D