Renovascular hypertension using a modified two-kidney, one-clip approach in mice is not dependent on the α1 or α2 Na-K-ATPase ouabain-binding site

American Journal of Physiology - Renal Physiology

Volumn 301, Issue 3, 2011, Pages

  Lorenz, John N ^a   Lasko, Valerie M ^a   Nieman, Michelle L ^a   Damhoff, Thomas ^a   Prasad, Vikram ^a   Beierwaltes, William H ^b   Lingre, Jerry B ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b HENRY FORD HOSPITAL   (United States)

Author keywords

Blood pressure; Cardiotonic steroids; NKA; Telemetry

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); MESSENGER RNA; OUABAIN; RENIN;

ALPHA CHAIN; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; BLOOD PRESSURE; CONTROLLED STUDY; DISEASE RESISTANCE; FEMALE; GENOTYPE; KIDNEY ARTERY STENOSIS; KIDNEY ISCHEMIA; MALE; MOUSE; NONHUMAN; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; RENOVASCULAR HYPERTENSION; SENSITIVITY ANALYSIS; SHAM PROCEDURE; TELEMETRY; WILD TYPE;

EID: 80052404631     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00158.2011     Document Type: Article

References (39)

1. Bagrov AY, Shapiro JI, Fedorova OV. Endogenous cardiotonic steroids: physiology, pharmacology, and novel therapeutic targets. Pharmacol Rev 61: 9-38, 2009.
2. Blaustein MP. Endogenous ouabain: role in the pathogenesis of hypertension. Kidney Int 49: 1748-1753, 1996.
3. Burgelova M, Vanourkova Z, Thumova M, Dvorak P, Opocensky M, Kramer HJ, Zelizko M, Maly J, Bader M, Cervenka L. Impairment of the angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas axis contributes to the acceleration of two-kidney, one-clip Goldblatt hypertension. J Hypertens 27: 1988-2000, 2009.
4. Cervenka L, Horacek V, Vaneckova I, Hubacek JA, Oliverio MI, Coffman TM, Navar LG. Essential role of AT1A receptor in thedevelopment of 2K1C hypertension. Hypertension 40: 735-741, 2002.
5. Cervenka L, Vaneckova I, Huskova Z, Vanourkova Z, Erbanova M, Thumova M, Skaroupkova P, Opocensky M, Maly J, Chabova VC, Tesar V, Burgelova M, Viklicky O, Teplan V, Zelizko M, Kramer HJ, Navar LG. Pivotal role of angiotensin II receptor subtype 1A in the development of two-kidney, one-clip hypertension: study in angiotensin II receptor subtype 1A knockout mice. J Hypertens 26: 1379-1389, 2008.
6. Cheng J, Zhou W, Warner GM, Knudsen BE, Garovic VD, Gray CE, Lerman LO, Platt JL, Romero JC, Textor SC, Nath KA, Grande JP. Temporal analysis of signaling pathways activated in a murine model of two-kidney, one-clip hypertension. Am J Physiol Renal Physiol 297: F1055-F1068, 2009.
7. Collis MG, Vanhoutte PM. Increased renal vascular reactivity to angiotensin II but not to nerve stimulation or exogenous norepinephrine in renal hypertensive rats. Circ Res 43: 544-552, 1978.
8. Dostanic I, Lorenz JN, Schultz Jel J, Grupp IL, Neumann JC, Wani A, Lingrel JB. The α2 isoform of Na,K-ATPase mediates ouabaininduced cardiac inotropy in mice. J Biol Chem 278: 53026-53034, 2003.
9. Dostanic I, Schultz Jel J, Lorenz JN, Lingrel JB. The α1 isoform of Na,K-ATPase regulates cardiac contractility and functionally interacts and co-localizes with the Na/Ca exchanger in heart. J Biol Chem 279: 54053- 54061, 2004.
10. Dostanic-Larson I, Van Huysse JW, Lorenz JN, Lingrel JB. The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation. Proc Natl Acad Sci USA 102: 15845-15850, 2005.
11. Farman N. Na,K-pump expression and distribution in the nephron. Miner Electrolyte Metab 22: 272-278, 1996.
12. Graves SW, Lincoln K, Cook SL, Seely EW. Digitalis-like factor and digoxin-like immunoreactive factor in diabetic women with preeclampsia, transient hypertension of pregnancy, and normotensive pregnancy. Am J Hypertens 8: 5-11, 1995.
13. Griol-Charhbili V, Sabbah L, Colucci J, Vincent MP, Baudrie V, Laude D, Elghozi JL, Bruneval P, Picard N, Meneton P, Alhenc-Gelas F, Richer C. Tissue kallikrein deficiency and renovascular hypertension in the mouse. Am J Physiol Regul Integr Comp Physiol 296: R1385-R1391, 2009.
14. Hamlyn JM. Increased levels of a humoral digitalis-like factor in deoxycorticosterone acetate-induced hypertension in the pig. J Endocrinol 122: 409-420, 1989.
15. +)ATPase associated with essential hypertension. Nature 300: 650-652, 1982.
16. 2+ exchanger type-1 in vascular smooth muscle. Nat Med 10: 1193-1199, 2004.
17. Johns C, Gavras I, Handy DE, Salomao A, Gavras H. Models of experimental hypertension in mice. Hypertension 28: 1064-1069, 1996.
18. Kost CK Jr, Li P, Pfeifer CA, Jackson EK. Telemetric blood pressure monitoring in benign 2-kidney, 1-clip renovascular hypertension: effect of chronic caffeine ingestion. J Pharmacol Exp Ther 270: 1063-1070, 1994.
19. Krep H, Price DA, Soszynski P, Tao QF, Graves SW, Hollenberg NK. Volume sensitive hypertension and the digoxin-like factor reversal by a fab directed against digoxin in DOCA-salt hypertensive rats. Am J Hypertens 8: 921-927, 1995.
20. Lazartigues E, Lawrence AJ, Lamb FS, Davisson RL. Renovascular hypertension in mice with brain-selective overexpression of AT1a receptors is buffered by increased nitric oxide production in the periphery. Circ Res 95: 523-531, 2004.
21. Leenen FHH. The central role of the brain aldosterone-"ouabain" pathway in salt-sensitive hypertension. Biochim Biophys Acta 1802: 1132- 1139, 2010.
22. Lingrel JB. The physiological significance of the cardiotonic steroid/ ouabain-binding site of the Na,K-ATPase. Annu Rev Physiol 72: 395-412, 2010.
23. Loreaux EL, Oshiro N, Lingrel JB, Lorenz JN. DOCA-salt hypertension persists in mice with ouabain-resistant α1 and α2 Na,K-ATPase (NKA) (Abstract). FASEB J 22: 1210A, 2008.
24. +-ATPase subunit. Am J Physiol Heart Circ Physiol 295: H273-H280, 2008.
25. Lucking K, Nielsen JM, Pedersen PA, Jorgensen PL. Na-K-ATPase isoform α3, α2, α1) abundance in rat kidney estimated by competitive RT-PCR and ouabain binding Am J Physiol Renal Fluid lectrolyte Physiol 271: F253-F260, 1996.
26. Lum C, Shesely EG, Potter DL, Beierwaltes WH. Cardiovascular and renal phenotype in mice with one or two renin genes. Hypertension 43: 79-86, 2004.
27. Manunta P, Stella P, Rivera R, Ciurlino D, Cusi D, Ferrandi M, Hamlyn JM, Bianchi G. Left ventricular mass, stroke volume, and ouabain-like factor in essential hypertension. Hypertension 34: 450-456, 1999.
28. Salguero G, Akin E, Templin C, Kotlarz D, Doerries C, Landmesser U, Grote K, Schieffer B. Renovascular hypertension by two-kidney one-clip enhances endothelial progenitor cell mobilization in a p47phoxdependent manner. J Hypertens 26: 257-268, 2008.
29. + pump α2-isoform specifically couples to contractility in vascular smooth muscle: evidence from gene-targeted neonatal mice. Am J Physiol Cell Physiol 286: C813-C820, 2004.
30. Sigmon DH, Beierwaltes WH. Degree of renal artery stenosis alters nitric oxide regulation of renal hemodynamics. J Am Soc Nephrol 5: 1369-1377, 1994.
31. Spandidos A, Wang X, Wang H, Seed B. Primer Bank: a resource of human and mouse PCR primer pairs for gene expression detection and quantification. Nucleic Acids Res 38: D792-D799, 2010.
32. Van Huysse JW. Endogenous brain Na pumps, brain ouabain-like substance and the α2 isoform in salt-dependent hypertension. Pathophysiology 14: 213-220, 2007.
33. Vu HV, Ianosi-Irimie MR, Pridjian CA, Whitbred JM, Durst JM, Bagrov AY, Fedorova OV, Pridjian G, Puschett JB. Involvement of marinobufagenin in a rat model of human preeclampsia. Am J Nephrol 25: 520-528, 2005.
34. Wang X, Seed B. A PCR primer bank for quantitative gene expression analysis. Nucleic Acids Res 31: e154, 2003.
35. Wansapura AN, Lasko VM, Lingrel JB, Lorenz JN. Mice expressing ouabain-sensitive α1-Na,K-ATPase have increased susceptibility to pressure overload-induced cardiac hypertrophy. Am J Physiol Heart Circ Physiol 300: H347-H355, 2011.
36. Watkins BE, Davis JO, Hanson RC, Lohmeier TE, Freeman RH. Incidence and pathophysiological changes in chronic two-kidney hypertension in the dog. Am J Physiol 231: 954-960, 1976.
37. Whitworth JA, Zhang Y, Mangos G, Kelly JJ. Species variability in cardiovascular research: the example of adrenocorticotrophin-induced hypertension. Clin Exp Pharmacol Physiol 33: 887-891, 2006.
38. Wiesel P, Mazzolai L, Nussberger J, Pedrazzini T. Two-kidney, one clip and one-kidney, one clip hypertension in mice. Hypertension 29: 1025-1030, 1997.
39. Yamada K, Goto A, Omata M. Adrenocorticotropin-induced hypertension in rats: role of ouabain-like compound. Am J Hypertens 10: 403-408, 1997.