Peritubular capillary basement membrane changes in chronic renal allograft rejection: Comparison of light microscopic and ultrastructural observations

Virchows Archiv

Volumn 459, Issue 3, 2011, Pages 321-330

  Ivanyi, Bela ^a   Kemeny, Eva ^a   Rago, Peter ^a   Lazar, Norbert ^b   Boda, Krisztina ^a   Morvay, Zita ^a   Szenohradszky, Pal ^a   Szederkenyi, Edit ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Chronic antibody mediated rejection; Electron microscopy; Histology; Kidney allograft; Peritubular capillary

Indexed keywords

CALCINEURIN INHIBITOR;

ARTICLE; BIOPSY; DIABETIC NEPHROPATHY; ELECTRON MICROSCOPY; GLOMERULOPATHY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; KIDNEY ALLOGRAFT REJECTION; KIDNEY TUBULE BASEMENT MEMBRANE; PRIORITY JOURNAL; PYELONEPHRITIS; SENSITIVITY AND SPECIFICITY;

BASEMENT MEMBRANE; BIOPSY; CAPILLARIES; CHRONIC DISEASE; COMPLEMENT C4B; DIABETIC NEPHROPATHIES; GRAFT REJECTION; HUMANS; KIDNEY; KIDNEY TRANSPLANTATION; KIDNEY TUBULES; MICROSCOPY, ELECTRON; SENSITIVITY AND SPECIFICITY; STAINING AND LABELING; TRANSPLANTATION, HOMOLOGOUS;

EID: 80052398560     PISSN: 09456317     EISSN: 14322307     Source Type: Journal    
DOI: 10.1007/s00428-011-1114-x     Document Type: Article

References (20)

1. K Solez RB Colvin LC Racusen, et al. 2007 Banff'05 meeting report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN') Am J Transplant 7 518 552 17352710 10.1111/j.1600-6143.2006.01688.x 1:STN:280:DC%2BD2s7lt1ygsA%3D%3D (Pubitemid 46376465)
2. K Solez RB Colvin LC Racusen, et al. 2008 Banff 07 Classification of renal allograft pathology: updates and future directions Am J Transplant 8 753 760 18294345 10.1111/j.1600-6143.2008.02159.x 1:STN:280:DC%2BD1c7msFWruw%3D%3D (Pubitemid 351347767)
3. A Hvala D Ferluga T Rott T Kobenter 2005 Peritubular capillary changes in Alport syndrome, diabetic glomerulopathy, Balkan endemic nephropathy and hemorrhagic fever with renal syndrome Ultrastruct Pathol 29 451 459 16316945 10.1080/01913120500323282 (Pubitemid 41769932)
4. A Hvala D Ferluga T Rott T Kobenter M Koselj-Kajtna S Kaplan-Pavlovcic A Bren 2001 Interstitial capillary in normal and in transplanted kidneys: an ultrastructural study Ultrastruct Pathol 25 295 299 11577774 10.1080/019131201753136313 1:STN:280:DC%2BD3MrjtFGluw%3D%3D (Pubitemid 32881080)
5. K Aita Y Yamaguchi S Horita M Ohno K Tanabe S Fuchinoue S Teraoka H Toma M Nagata 2007 Thickening of the peritubular capillary basement membrane is a useful diagnostic marker of chronic rejection in renal allografts Am J Transplant 7 923 929 17391134 10.1111/j.1600-6143.2006.01708.x 1:STN:280:DC%2BD2s7ptVanug%3D%3D (Pubitemid 46481191)
6. S Mauiyyedi P Della Pelle S Saidman AB Collins M Pascual NE Tolkoff-Rubin WW Williams AB Cosimi EE Schneeberger RB Colvin 2001 Chronic humoral rejection: identification of antibody-mediated chronic renal allograft rejection by C4d deposits in peritubular capillaries J Am Soc Nephrol 12 574 582 11181806 1:STN:280:DC%2BD3M3mvFSjsg%3D%3D (Pubitemid 32180027)
7. A Wilkinson J Davidson F Dotta, et al. 2005 Guidelines for the treatment and management of new-onset diabetes after transplantation Clin Transplant 9 291 298 10.1111/j.1399-0012.2005.00359.x (Pubitemid 40711959)
8. LC Racusen K Solez RB Colvin, et al. 1999 The Banff 97 working classification of renal allograft pathology Kidney Int 55 713 723 9987096 10.1046/j.1523-1755.1999.00299.x 1:STN:280:DyaK1M7ktFGluw%3D%3D (Pubitemid 29082898)
9. B Ivanyi E Kemeny E Szederkenyi F Marofka P Szenohradszky 2001 The value of electron microscopy in the diagnosis of chronic renal allograft rejection Mod Pathol 14 1200 1208 11743041 10.1038/modpathol.3880461 1:STN:280: DC%2BD3MnpsFaitQ%3D%3D (Pubitemid 33151161)
10. B Ivanyi H Fahmy H Brown P Szenohradszky PF Halloran K Solez 2000 Peritubular capillaries in chronic renal allograft rejection: a quantitative ultrastructural study Hum Pathol 31 1129 1138 11014582 10.1053/hupa.2000.16677 1:STN:280:DC%2BD3cvmt1Ggsw%3D%3D
11. B Ivanyi 2003 Transplant capillaropathy and transplant glomerulopathy: ultrastructural markers of chronic renal allograft rejection Nephrol Dial Transplant 18 655 660 12637631 10.1093/ndt/gfg139 1:CAS:528:DC%2BD3sXit1yru74%3D (Pubitemid 36432244)
12. V Nickeleit M Zeiler F Gudat G Thiel MJ Mihatsch 1998 Histological characteristics of interstitial renal allograft rejection Kidney Blood Press Res 21 230 232 9762841 10.1159/000025862 1:STN:280:DyaK1cvjtlyjtw%3D%3D (Pubitemid 28438635)
13. Fleiss JL (2003) Statistical methods for rates and proportions, 3rd edn. Wiley, New York
14. V Bhalla CC Nast N Stollenwerk S Tran L Barba ES Kamil G Danovitch SG Adler 2003 Recurrent and de novo diabetic nephropathy in renal allografts Transplantation 75 66 71 12544873 10.1097/00007890-200301150-00012 1:STN:280:DC%2BD3s%2Fjslequg%3D%3D (Pubitemid 36139697)
15. H Regele GA Böhmig A Habicht D Gollowitzer M Schillinger S Rockenschaub B Watschinger D Kerjaschki 2002 Capillary deposition of complement split product C4d in renal allografts is associated with basement membrane injury in peritubular and glomerular capillaries: a contribution of humoral immunity to chronic allograft rejection J Am Soc Nephrol 13 2371 2380 12191982 10.1097/01.ASN.0000025780.03790.0F (Pubitemid 34925248)
16. B Sis PM Campbell T Mueller C Hunter SM Cockfield J Cruz C Meng D Wishart K Solez PF Halloran 2007 Transplant glomerulopathy, late antibody-mediated rejection and the ABCD tetrad in kidney allograft biopsies for cause Am J Transplant 7 1743 1752 17564636 10.1111/j.1600-6143.2007.01836.x 1:STN:280:DC%2BD2szltFaksA%3D%3D (Pubitemid 46905427)
17. G Einecke B Sis J Reeve M Mengel PM Campbell LG Hidalgo B Kaplan PF Halloran 2009 Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure Am J Transplant 9 2520 2531 19843030 10.1111/j.1600-6143.2009.02799.x 1:STN:280:DC%2BD1MjgsVymtA%3D%3D
18. B Sis GS Jhangri S Bunnag B Allanach B Kaplan PF Halloran 2009 Endothelial gene expression in kidney transplants with alloantibody indicates antibody-mediated damage despite lack of C4d staining Am J Transplant 9 2312 2323 19681822 10.1111/j.1600-6143.2009.02761.x 1:CAS:528:DC%2BD1MXhtlWlurrM
19. B Sis PF Halloran 2010 Endothelial transcripts uncover a previously unknown phenotype: C4d-negative antibody-mediated rejection Curr Opin Organ Transplant 15 42 48 20009933 10.1097/MOT.0b013e3283352a50
20. MD Wavamunno PJ O'Conell M Vitalone CL-S Fung RDM Allen JR Chapman BJ Nankivell 2007 Transplant glomerulopathy: ultrastructural abnormalities occur early in longitudinal analysis of protocol biopsies Am J Transplant 7 2757 2768 17924997 10.1111/j.1600-6143.2007.01995.x 1:CAS:528:DC%2BD2sXhsVGis7rL (Pubitemid 350045771)