Transplant glomerulopathy: Ultrastructural abnormalities occur early in longitudinal analysis of protocol biopsies

American Journal of Transplantation

Volumn 7, Issue 12, 2007, Pages 2757-2768

  Wavamunno, M D ^a   O'Connell, P J ^a   Vitalone, M ^a   Fung, C L S ^a   Allen, R D M ^a   Chapman, J R ^a   Nankivell, B J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

C4d; Chronic allograft nephropathy; Donor specific antibody; Kidney transplantation; Transplant glomerulopathy

Indexed keywords

COMPLEMENT COMPONENT C4D;

ADULT; ARTICLE; CELL ULTRASTRUCTURE; CLINICAL FEATURE; COHORT ANALYSIS; COMPLEMENT DEPOSITION; CYTOPATHOLOGY; EARLY DIAGNOSIS; FEMALE; GLOMERULOPATHY; GLOMERULUS BASEMENT MEMBRANE; GLOMERULUS CAPILLARY; GOLGI COMPLEX; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOPEROXIDASE STAINING; KIDNEY BIOPSY; KIDNEY TRANSPLANT GLOMERULOPATHY; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MESANGIUM CELL; MORPHOMETRICS; PHENOTYPE; PRIORITY JOURNAL; RIBOSOME; TISSUE SECTION;

ADULT; BIOPSY; CAPILLARIES; CASE-CONTROL STUDIES; COMPLEMENT C4B; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; KAPLAN-MEIERS ESTIMATE; KIDNEY GLOMERULUS; KIDNEY TRANSPLANTATION; LONGITUDINAL STUDIES; MALE; MESANGIAL CELLS; MIDDLE AGED; PEPTIDE FRAGMENTS; PODOCYTES; TIME FACTORS;

EID: 35748959613     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2007.01995.x     Document Type: Article

References (34)

1. Nankivell BJ, Borrows RJ, Fung CL, O'Connell PJ, Allen RD, Chapman JR. The natural history of chronic allograft nephropathy. N Engl J Med 2003 349 : 2326 2333.
2. Suri DL, Tomlanovich SJ, Olson JL, Meyer TW. Transplant glomerulopathy as a cause of late graft loss. Am J Kidney Dis 2000 35 : 674 680.
3. Mauiyyedi S, Colvin RB. Humoral rejection in kidney transplantation: New concepts in diagnosis and treatment. Curr Opin Nephrol Hypertens 2002 11 : 609 618.
4. Briner J. Transplant glomerulopathy. Appl Pathol 1987 5 : 82 87.
5. Zollinger HU, Moppert J, Thiel G, Rohr HP. Morphology and pathogenesis of glomerulopathy in cadaver kidney allografts treated with antilymphocyte globulin. Curr Top Pathol 1973 57 : 1 48.
6. Ivanyi B. Transplant capillaropathy and transplant glomerulopathy: Ultrastructural markers of chronic renal allograft rejection. Nephrol Dial Transplant 2003 18 : 655 660.
7. Mauiyyedi S, Pelle PD, Saidman S et al. Chronic humoral rejection: Identification of antibody-mediated chronic renal allograft rejection by C4d deposits in peritubular capillaries. J Am Soc Nephrol 2001 12 : 574 582.
8. Feucht HE. Complement C4d in graft capillaries - the missing link in the recognition of humoral alloreactivity. Am J Transplant 2003 3 : 646 652.
9. Regele H, Bohmig GA, Habicht A et al. Capillary deposition of complement split product C4d in renal allografts is associated with basement membrane injury in peritubular and glomerular capillaries: A contribution of humoral immunity to chronic allograft rejection. J Am Soc Nephrol 2002 13 : 2371 2380.
10. Bohmig GA, Exner M, Habicht A et al. Capillary C4d deposition in kidney allografts: A specific marker of alloantibody-dependent graft injury. J Am Soc Nephrol 2002 13 : 1091 1099.
11. Regele H, Exner M, Watschinger B et al. Endothelial C4d deposition is associated with inferior kidney allograft outcome independently of cellular rejection. Nephrol Dial Transplant 2001 16 : 2058 2066.
12. Sijpkens YW, Joosten SA, Wong MC et al. Immunologic risk factors and glomerular C4d deposits in chronic transplant glomerulopathy. Kidney Int 2004 65 : 2409 2418.
13. Smith RN, Kawai T, Boskovic S et al. Chronic antibody mediated rejection of renal allografts: Pathological, serological and immunologic features in nonhuman primates. Am J Transplant 2006 6 : 1790 1798.
14. Solez K. International standardization of criteria for histologic diagnosis of chronic rejection in renal allografts. Clin Transplant 1994 8 (3 Pt 2 345 350.
15. Racusen LC, Colvin RB, Solez K et al. Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejection. Am J Transplant 2003 3 : 708 714.
16. Worthington JE, McEwen A, McWilliam LJ, Picton ML, Martin S. Association between C4d staining in renal transplant biopsies, production of donor-specific HLA antibodies, and graft outcome. Transplantation 2007 83 : 398 403.
17. Dische FE. Measurement of glomerular basement membrane thickness and its application to the diagnosis of thin-membrane nephropathy. Arch Pathol Lab Med 1992 116 : 43 49.
18. Jensen EB, Gundersen HJ, Osterby R. Determination of membrane thickness distribution from orthogonal intercepts. J Microsc 1979 115 : 19 33.
19. Caramori ML, Basgen JM, Mauer M. Glomerular structure in the normal human kidney: Differences between living and cadaver donors. J Am Soc Nephrol 2003 14 : 1901 1903.
20. Weibe ER. Stereological methods. Practical methods for biological morphometry : New York Academic, 1979 : 101 161.
21. Fioretto P, Steffes MW, Mauer M. Glomerular structure in nonproteinuric IDDM patients with various levels of albuminuria. Diabetes 1994 43 : 1358 1364.
22. Osterby R, Gundersen HJ, Nyberg G, Aurell M. Advanced diabetic glomerulopathy. Quantitative structural characterization of nonoccluded glomeruli. Diabetes 1987 36 : 612 619.
23. Maryniak RK, First MR, Weiss MA. Transplant glomerulopathy: Evolution of morphologically distinct changes. Kidney Int 1985 27 : 799 806.
24. Habib R, Zurowska A, Hinglais N et al. A specific glomerular lesion of the graft: Allograft glomerulopathy. Kidney Int Suppl 1993 42 : S104 111.
25. Vongwiwatana A, Gourishankar S, Campbell PM, Solez K, Halloran PF. Peritubular capillary changes and C4d deposits are associated with transplant glomerulopathy but not IgA nephropathy. Am J Transplant 2004 4 : 124 129.
26. Monga G, Mazzucco G, Messina M, Motta M, Quaranta S, Novara R. Intertubular capillary changes in kidney allografts: A morphologic investigation on 61 renal specimens. Mod Pathol 1992 5 : 125 130.
27. Monga G, Mazzucco G, Novara R, Reale L. Intertubular capillary changes in kidney allografts: An ultrastructural study in patients with transplant glomerulopathy. Ultrastruct Pathol 1990 14 : 201 209.
28. Drachenberg CB, Steinberger E, Hoehn-Saric E et al. Specificity of intertubular capillary changes: Comparative ultrastructural studies in renal allografts and native kidneys. Ultrastruct Pathol 1997 21 : 227 233.
29. Ivanyi B, Fahmy H, Brown H, Szenohradszky P, Halloran PF, Solez K. Peritubular capillaries in chronic renal allograft rejection: A quantitative ultrastructural study. Hum Pathol 2000 31 : 1129 1138.
30. Gough J, Yilmaz A, Miskulin D et al. Peritubular capillary basement membrane reduplication in allografts and native kidney disease: A clinicopathologic study of 278 consecutive renal specimens. Transplantation 2001 71 : 1390 1393.
31. Glotz D, Lucchiari N, Pegaz-Fiornet B, Suberbielle-Boissel C. Endothelial cells as targets of allograft rejection. Transplantation 2006 82 (1 Suppl S19 21.
32. Rifle G, Mousson C, Herve P. Endothelial cells in organ transplantation: Friends or foes? Transplantation 2006 82 (1 Suppl S4 5.
33. Colvin RB, Smith RN. Antibody-mediated organ-allograft rejection. Nat Rev Immunol 2005 5 : 807 817.
34. Halloran PF, Schlaut J, Solez K, Srinivasa NS. The significance of the anti-class I response. II. Clinical and pathologic features of renal transplants with anti-class I-like antibody. Transplantation 1992 53 : 550 555.