A study to evaluate factors associated with seizure in tramadol poisoning in Iran

Indian Journal of Forensic Medicine and Toxicology

Volumn 5, Issue 2, 2011, Pages 66-69

  Goodarzi, Fazel ^a   Mehrpour, Omid ^b,c   Eizadi Mood, Nastaran ^d  

^a SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b BIRJAND UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c BIRJAND UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Poisoning; Seizure; Tramadol

Indexed keywords

DIAZEPAM; NALOXONE; PHENOBARBITAL; THIOPENTAL; TRAMADOL;

ADOLESCENT; ADULT; ARTICLE; COMA; DISEASE ASSOCIATION; DRUG ABUSE; DRUG DEPENDENCE; DRUG INTOXICATION; FEMALE; HUMAN; INTENSIVE CARE; IRAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; SEIZURE;

EID: 80052389191     PISSN: 09739122     EISSN: 09739130     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Clarot, F, Goulle, JP, Vaz, E, Proust, B. Fatal overdoses of tramadol: is benzodiazepine a risk factor of lethality.Forensic Sci Int 2003; 134: 57-61.
2. Musshoff M, Madea B. Fatality due to ingestion of tramadol alone. Forensic Science International 116 2001;197-199
3. Loughrey, MB, Loughrey, CM, Johnston, S, O'Rourke, D. Fatal hepatic failure following accidental tramadol overdose. Forensic Sci Int 2003; 134: 232-233.
4. Michaud, K, Augsburger, M, Romain, N, Giroud, C, Mangin, P. Fatal overdose of tramadol and alprazolam.Forensic Sci Int 1999; 105: 185-189.
5. Shadnia S, Soltaninejad K, Heydari K, Sasanian G, Abdollahi M.Tramadol intoxication: a review of 114 cases. Hum Exp Toxicol 2008; 27; 201.
6. Hennies, HH, Friderichs, B, Schneider, J. Receptor binding, analgesic and antitussive potency of tramadol and other selected opioids. Arzneimittelforschung 1988; 38: 877-880
7. Talaie H, Panahandeh R, Fayaznouri M, Asadi Z, Abdollahi M. Dose-independent occurrence of seizure with tramadol. J Med Toxicol. 2009; 5(2):63-7.
8. Kahn LH, Alderfer RJ, Graham DJ. Seizures reported with tramadol. JAMA 1997;278:1661.
9. Mehrpour O, Abdollahi M. Poison treatment centers in Iran. Hum Exp Toxicol. 2010. [Epub ahead of print]
10. Chadha IA. Poisoning. Ind J Anaesth.2003;47 (5): 402-411
11. Spiller, HA, Gorman, SE, Villalobos, D, Benson, BE, Ruskosky, DR, Stancavage, MM, et al. Prospective multicenter evaluation of tramadol exposure. J Toxicol Clin Toxicol 1997; 35: 361-364.
12. Gholami, K, Shalviri, G, Zarbakhsh, A, Daryabari, N, Yousefian, S. New guideline for tramadol usage following adverse drug reactions reported to the Iranian pharmacovigilance center. Pharmacoepidemiol Drug Saf 2007; 16: 229-237
13. Afshari R, Ghooshkhanehee H.Tramadol overdose induced seizure, dramatic rise of CPK and acute renal failure. 2009; 59(3):178.
14. Severe tramadol addiction in a 61 year-old woman without a history of substance abuse.Pollice R, Casacchia M, Bianchini V, Mazza M, Conti CM, Roncone R.Int J Immunopathol Pharmacol. 2008; 21(2):475-6.
15. Raffa RB, Stone DJ Jr. Unexceptional seizure potential of tramadol or its enantiomers or metabolites in mice. J Pharmacol Exp Ther. 2008; 325(2):500-6
16. Taghaddosinejad F, Mehrpour O, Afshari R, Seghatoleslami AR, Abdollahi M, Dart RC. Factors related to seizure in Tramadol poisoning and its blood concentration. Journal of medical toxicology (Accepted).
17. Marquardt, KA, Alsop, JA, Albertson, TE. Tramadol exposures reported to statewide poison control system. Ann Pharmacother 2005; 39: 1039-1044.
18. Potschka H, Friderichs E, Löscher W. Anticonvulsant and metabolite in the rat kindling model of epilepsy.Br J Pharmacol 2000; 131:203-12
19. Gardner JS, Blough D, Drinkard CR, Shatin D, Anderson G, Graham D, Alderfer R. Tramadol and seizures: a surveillance study in a managed care population. Pharmacotherapy. 2000; 20(12):1423-31
20. Jovanoviæ-Cupiæ V, Martinoviæ Z, Nesiæ N.Seizures associated with intoxication and abuse of tramadol. Clin Toxicol (Phila) 2006; 44(2):143-6.
21. Mehrpour M. Intravenous Tramadol-Induced Seizure: Two Case Reports. Iranian Journal of Pharmacology & Therapeutics. 2005; 4(2):146-147.
22. De Decker K, Cordonnier J, Jacobs W, Coucke V, Schepens P, Jorens PG. Fatal intoxication due to tramadol alone: case report and review of the literature. Forensic Sci Int. 2008 Feb 25;175(1):79-82.