Evaluation of the therapeutic and preventive efficacy of 2.5 % moxidectin /10 % imidacloprid (Advocate®, Bayer animal health) in dogs naturally infected or at risk of natural infection by Dirofilaria repens

Parasitology Research

Volumn 109, Issue SUPPL. 1, 2011, Pages

  Hellmann, Klaus ^a   Heine, Josef ^b   Braun, Gabriele ^a   Paran Dobesova, Radmila ^c   Svobodova, Vlasta ^c  

^a Klifovet AG   (Germany)

^b BAYER AG   (Germany)

^c UNIVERSITY OF VETERINARY AND PHARMACEUTICAL SCIENCES   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ADVOCATE; ANTIFILARIAL AGENT; IMIDACLOPRID PLUS MOXIDECTIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CZECH REPUBLIC; DIROFILARIA REPENS; DIROFILARIASIS; DOG; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; INFECTION PREVENTION; INFECTION RATE; INFECTION RISK; NONHUMAN; PARASITE IDENTIFICATION; PARASITE PREVALENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION;

ANIMALS; DIROFILARIA; DIROFILARIASIS; DOG DISEASES; DOGS; DRUG COMBINATIONS; DRUG EVALUATION; FILARICIDES; IMIDAZOLES; MACROLIDES; NITRO COMPOUNDS;

ANIMALIA; CANIS FAMILIARIS; DIROFILARIA REPENS;

EID: 80052386556     PISSN: 09320113     EISSN: 14321955     Source Type: Journal    
DOI: 10.1007/s00436-011-2404-6     Document Type: Article

References (30)

1. Arther RG, Bowman DD, Slone RL, Travis LE (2005) Imidacloprid plus moxidectin topical solution for the prevention of heartworm disease (Dirofilaria immitis) in dogs. Parasitol Res. 2005, Oct; Res 97(Suppl 1):76-80.
2. Baneth G, Volansky Z, Anug Y, Favia G, Bain O, Goldstein RE, Harrus S (2002) Dirofilaria repens infection in a dog: diagnosis and treatment with melarsomine and doramectin. Vet Parasitol 105:173-178. (Pubitemid 34252931)
3. Bowman DD, Johnson RC, Ulrich ME et al. (1992) Effects of long-term administration of ivermectin and milbemycin oxime on circulating microfilariae and parasite antigenemia in dogs with patent heartworm infections. In: Proceedings of the Heartworm Symposium, Austin, TX, 1992, pp 151-158.
4. Dobešová R, Svobodova V (2009) Progressive spread of Dirofilaria infections in dogs along rivers in the Southeastern Czech Republic. Second European Dirofilaria Days, Salamanca, Spain, p 190.
5. Dobson RJ, Sangster NC, Besier RB, Woodgate RG (2009) Geometric means provide a biased efficacy result when conducting faecal egg count reduction test (FECRT). Vet Parasitol 161:162-167.
6. Duscher G, Feiler A, Wille-Plazzai W, Bakonyi T, Leschnik M, Miterpáková M, Kolodziejek J, Nowotny N, Joachim A (2009) Nachweis von Dirofilarien in österreichischen Hunden. Berl Münch Tierärztl Wochenschr 122:199-203.
7. EMEA/CVMP/816/00-Final: Guideline on statistical principles for veterinary clinical trials.
8. Fok É, Szabo Z, Farkas R (1998) The first autochthonous case of a dog infected with Dirofilaria repens in hungary. Kisal Latorvoslás 4:218-219.
9. Fok É, Jascó O, Szebeni Z, Györffy A, Südkösd l, Lukács Z, Schaper R (2010) Elimination of Dirofilaria (syn. Nochtiella) repens microfilariae in dogs with monthly treatments of moxidectin 2.5 %/imidacloprid 10 % (Advocate®, Bayer) spoton. Parasitol Res 106(5):1141-1149.
10. Genchi C, Poglayen G, Kramer L, Casiraghi M, Venco L, Brianti E (2002) Efficacy of selamectin in the prophylaxis of Dirofilaria repens infestations in dogs. Veterinaria 16(1):69-71.
11. Genchi M, Pengo G, Genchi C (2010) Efficacy of moxidectin microsphere sustained release formulation for the prevention of subcutaneous filarial (Dirofilaria repens) infection in dogs. Vet Parasitol 170:167-169.
12. Hermosilla C, Pantchev N, Dyachenko V, Gutmann M, Bauer C (2006) First autochthonus case of canine ocular Dirofilaria repens in Germany. Vet Rec 158:134-135. (Pubitemid 43230651)
13. Kershaw O, Dyachenko V, Gruber AD (2009) Kutane Dirofilariose beim Hund in Deutschland. Dtsch Tierärztl Wochenschr 116(7):273.
14. Marconcini A, Magi M, Hecht Contin B (1993) The value of ivermectin in the prophylaxis of Dirofilaria repens infestation in naturally infected dogs. Parassitologia 35:67-71.
15. McCall J (2005) The safety-net story about macrocyclic lactone heartworm preventives: a review, an update, and recommendations. Vet Parasitol 133:197-206. (Pubitemid 41405852)
16. Rishniw M, Barr SC, Simpson KW, Frongillo MF, Franz M, Domingues-Alpizar JL (2006) Discrimination between six species of canine microfilaria by a single polymerase chain reaction. Vet Parasitol 135:303-313.
17. Rossi L, Ferroglio E, Agostini A (2002) Use of moxidectin tablets in the control of canine subcutaneous dirofilariosis. Vet Rec 150:383. (Pubitemid 34262768)
18. Rossi L, Ferroglio E, Agostini A (2004) Use of an injectable sustained-release formulation of moxidectin to prevent canine subcutaneous dirofilariosis. Vet Rec 154:26-27. (Pubitemid 38072832)
19. Sassnau R, Dyachenko V, Pantchev N, Stöckel F, Dittmar K, Daugschies A (2009) Dirofilari repens Befall in einem Schlittenhunde- Rudel im Land Brandenburg. Tierärztl Prax Ausg K Kleintiere Heimtiere 37: 95-101.
20. Sasaki Y and Kitagawa, H (1993) Effects of milbemycin D on microfilarial number and reproduction of Dirofilaria immitis in dogs. J Vet Med Sci 55:763-769
21. Svobodova V, Svobodova Z, Beladicova V, Valentova D (2005) First cases of canine dirofilariosis in Slovakia, a case report. Vet Med Czech 50(11):510-512. (Pubitemid 43127992)
22. Svobodova Z, Svobodova V, Genchi C, Forejtek P (2006) The first report of authochthonous dirofilariosis in dogs in the Czech Republic. Helminthologica 43(4):242-245. (Pubitemid 46360155)
23. Svobodova Z, Svobodova V, Genchi C (2007) Dirofilaria repens infection in dogs in the Czech Republic. In: Genchi C, Rinaldi L, Cringoli G (eds), Mappe Parasitologie 8-Dirofilaria immitis and Dirofilaria repens in dog and cat and human infection. Rolando Editore, Neapel, Italy, pp 199-200.
24. Traversa D, Aste G, Di Cesare A, Paoletti B, Di Tommaso M, Di Giulio M, Pampurini F, Tunesi C, Boar A (2011) Efficacy of a single administration of a spot-on solution containing imidacloprid 10 %/moxidectin 2.5 % in eliminating Dirofilaria repens microfilariae in naturally infected dogs. Vet Parasitol. doi:10.1016/j.vetpar.2011.02.018.
25. Trotz-Williams LA, Trees AJ (2003) Systematic review of the distribution of the major vector-borne parasitic infections in dogs and cats in Europe. Vet Rec 152:97-105. (Pubitemid 36305182)
26. Vasylyk NS (2004) Morhological and functional changes and adaptations and compensatory reactions in dog's organism at dirofilariosis. Dissertation, National Agrarian University, Kiew, pp 1-22.
27. VICH guideline 7: Efficacy requirements for anthelmintics, overall requirements (Step 7, CVMP/VICH/832/99-corr) 1999.
28. VICH guideline 9: Good clinical practice (CVMP/VICH/595/98 - Final) 2000.
29. VICH guideline 19: Efficacy of anthelmintics: specific recommendations for canines (Step 7, CVMP/VICH/835/99-Final) 1999.
30. WAAVP (World Association for the Advancement of Veterinary Parasitology): Guidelines for evaluating the efficacy of anthelmintics for dogs and cats (Accepted August 31, 1993).