Synthesis and biological activities of (R)- and (S)- N -(4-Methoxyphenyl)- N,2,6-trimethyl-6,7-dihydro-5 H -cyclopenta[ d ]pyrimidin-4-aminium chloride as potent cytotoxic antitubulin agents

Journal of Medicinal Chemistry

Volumn 54, Issue 17, 2011, Pages 6151-6155

  Gangjee, Aleem ^a   Zhao, Ying ^a   Hamel, Ernest ^b   Westbrook, Cara ^c   Mooberry, Susan L ^c  

^a DUQUESNE UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMITOTIC AGENT; COLCHICINE; COMBRETASTATIN; COMBRETASTATIN A4; CYTOTOXIC AGENT; HYDROGEN; N (4 METHOXYPHENYL) N,2,6 TRIMETHYL 6,7 DIHYDRO 5H CYCLOPENTA[D]PYRIMIDIN 4 AMINIUM; PACLITAXEL; TUBULIN; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CELL PROLIFERATION; CHEMICAL BINDING; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; ENANTIOMER; MICROTUBULE; MICROTUBULE ASSEMBLY; MITOSIS INHIBITION; TUMOR CELL LINE;

ANILINE COMPOUNDS; ANTIMITOTIC AGENTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOTOXINS; HUMANS; MICROTUBULES; MITOSIS; NEOPLASMS; PYRIMIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN MODULATORS; TUMOR CELLS, CULTURED;

EID: 80052380398     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2007722     Document Type: Article

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