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Volumn 12, Issue 5, 2011, Pages 383-387

Polymorphisms in the hypoxia-inducible factor-1α gene confer susceptibility to pancreatic cancer

Author keywords

CA19 9; Hypoxia inducible factor 1 (HIF 1 ); Pancreatic cancer; Pancreatic ductal adenocarcinoma (PDAC); Single nucleotide polymorphism (SNP)

Indexed keywords

CA 19-9 ANTIGEN; HYPOXIA INDUCIBLE FACTOR 1ALPHA;

EID: 80052354214     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.12.5.15982     Document Type: Article
Times cited : (48)

References (22)
  • 1
    • 0029051439 scopus 로고
    • Hypoxiainducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • PMID: 7539918; DOI: 10.1073/pnas.92.12.5510
    • Wang G.L., Jiang B.H., Rue E.A., Semenza GL. Hypoxiainducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 1995; 92:5510-4; PMID: 7539918; DOI: 10.1073/pnas.92.12.5510.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 2
    • 31044447666 scopus 로고    scopus 로고
    • Targeting the molecular basis for tumour hypoxia
    • PMID: 15831177; DOI: 10.1017/ S1462399405009117
    • Carroll V.A., Ashcroft M. Targeting the molecular basis for tumour hypoxia. Expert Rev Mol Med 2005; 7:1-16; PMID: 15831177; DOI: 10.1017/ S1462399405009117.
    • (2005) Expert Rev Mol Med , vol.7 , pp. 1-16
    • Carroll, V.A.1    Ashcroft, M.2
  • 3
    • 1642387020 scopus 로고    scopus 로고
    • Hypoxia-inducible factor (HIF-1)alpha: Its protein stability and biological functions
    • PMID: 15031665
    • Lee J.W., Bae S.H., Jeong J.W., Kim S.H., Kim K.W. Hypoxia-inducible factor (HIF-1)alpha: Its protein stability and biological functions. Exp Mol Med 2004; 36:1-12; PMID: 15031665.
    • (2004) Exp Mol Med , vol.36 , pp. 1-12
    • Lee, J.W.1    Bae, S.H.2    Jeong, J.W.3    Kim, S.H.4    Kim, K.W.5
  • 4
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxiainducible factor-1α in common human cancers and their metastases
    • PMID: 10582706
    • Zhong H., De Marzo A.M., Laughner E., Lim M., Hilton D.A., Zagzag D., et al. Overexpression of hypoxiainducible factor-1α in common human cancers and their metastases. Cancer Res 1999; 59:5830-5835; PMID: 10582706.
    • (1999) Cancer Res , vol.59 , pp. 5830-5835
    • Zhong, H.1    De Marzo, A.M.2    Laughner, E.3    Lim, M.4    Hilton, D.A.5    Zagzag, D.6
  • 6
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxiainducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol-3-kinase/PTEN/ AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • PMID: 10749120
    • Zhong H., Chiles K., Feldser D., Laughner E., Hanrahan C., Georgescu M.M., et al. Modulation of hypoxiainducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol-3-kinase/PTEN/ AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics. Cancer Res 2000; 60:1541-1545; PMID: 10749120.
    • (2000) Cancer Res , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3    Laughner, E.4    Hanrahan, C.5    Georgescu, M.M.6
  • 7
    • 45849149957 scopus 로고    scopus 로고
    • High expression of HIF1α is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF and bFGF
    • PMID: 18592007
    • Hoffmann A.C., Mori R., Vallbohmer D., Brabender J., Klein E., Drebber U., et al. High expression of HIF1α is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF and bFGF. Neoplasia 2008; 10:674-679; PMID: 18592007.
    • (2008) Neoplasia , vol.10 , pp. 674-679
    • Hoffmann, A.C.1    Mori, R.2    Vallbohmer, D.3    Brabender, J.4    Klein, E.5    Drebber, U.6
  • 8
    • 0347478156 scopus 로고    scopus 로고
    • Clinicopathological significance of hypoxiainducible factor-1α expression in human pancreatic carcinoma
    • PMID: 14636255; DOI: 10.1111/j.1365-2559.2003.01733.x
    • Kitada T., Seki S., Sakaguchi H., Sawada T., Hirakawa K., Wakasa K. Clinicopathological significance of hypoxiainducible factor-1α expression in human pancreatic carcinoma. Histopathology 2003; 43:550-5; PMID: 14636255; DOI: 10.1111/j.1365-2559.2003.01733.x.
    • (2003) Histopathology , vol.43 , pp. 550-555
    • Kitada, T.1    Seki, S.2    Sakaguchi, H.3    Sawada, T.4    Hirakawa, K.5    Wakasa, K.6
  • 9
    • 0842333201 scopus 로고    scopus 로고
    • Prognostic significance of HIF-1α overexpression in human pancreatic cancer
    • PMID: 14981919
    • Shibaji T, Nagao M, Ikeda N, Kanehiro H, Hisanaga M, Ko S, et al. Prognostic significance of HIF-1α overexpression in human pancreatic cancer. Anticancer Res 2003; 23:4721-4727; PMID: 14981919.
    • (2003) Anticancer Res , vol.23 , pp. 4721-4727
    • Shibaji, T.1    Nagao, M.2    Ikeda, N.3    Kanehiro, H.4    Hisanaga, M.5    Ko, S.6
  • 10
    • 20644470124 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factors is correlated with the presence of a fibrotic focus and angiogenesis in pancreatic ductal adenocarcinomas
    • PMID:15910598; DOI: 10.1111/j.1365-2559.2005.02160.x
    • Couvelard A., O'Toole D., Leek R., Turley H., Sauvanet A., Degott C., et al. Expression of hypoxia-inducible factors is correlated with the presence of a fibrotic focus and angiogenesis in pancreatic ductal adenocarcinomas. Histopathology 2005; 46:668-76; PMID:15910598; DOI: 10.1111/j.1365-2559.2005. 02160.x.
    • (2005) Histopathology , vol.46 , pp. 668-676
    • Couvelard, A.1    O'Toole, D.2    Leek, R.3    Turley, H.4    Sauvanet, A.5    Degott, C.6
  • 11
    • 34447266708 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1α and associated proteins in pancreatic ductal adenocarcinoma and their impact on prognosis
    • PMID: 17487356
    • Sun H.C., Qiu Z.J., Liu J., Sun J., Jiang T., Huang K.J., et al. Expression of hypoxia-inducible factor-1α and associated proteins in pancreatic ductal adenocarcinoma and their impact on prognosis. Int J Oncol 2007; 30:1359-1367; PMID: 17487356.
    • (2007) Int J Oncol , vol.30 , pp. 1359-1367
    • Sun, H.C.1    Qiu, Z.J.2    Liu, J.3    Sun, J.4    Jiang, T.5    Huang, K.J.6
  • 12
    • 77957309341 scopus 로고    scopus 로고
    • Pancreatic cancer cells expressing hypoxia-inducible factor-1α tend to be adjacent to intratumoral blood vessels
    • PMID: 20924188; DOI: 10.1159/000319876
    • Cheng B.Q., Segersvärd R., Permert J., Wang F. Pancreatic cancer cells expressing hypoxia-inducible factor-1α tend to be adjacent to intratumoral blood vessels. Eur Surg Res 2010; 45:134-7; PMID: 20924188; DOI: 10.1159/000319876.
    • (2010) Eur Surg Res , vol.45 , pp. 134-137
    • Cheng, B.Q.1    Segersvärd, R.2    Permert, J.3    Wang, F.4
  • 13
    • 0242559086 scopus 로고    scopus 로고
    • Hypoxia-inducible factor- 1alpha polymorphisms associated with enhanced transactivation capacity, implying clinical significance
    • PMID: 12919954; DOI: 10.1093/carcin/bgg132
    • Tanimoto K., Yoshiga K., Eguchi H., Kaneyasu M., Ukon K., Kumazaki T., et al. Hypoxia-inducible factor- 1alpha polymorphisms associated with enhanced transactivation capacity, implying clinical significance. Carcinogenesis 2003; 24:1779-83; PMID: 12919954; DOI: 10.1093/carcin/bgg132.
    • (2003) Carcinogenesis , vol.24 , pp. 1779-1783
    • Tanimoto, K.1    Yoshiga, K.2    Eguchi, H.3    Kaneyasu, M.4    Ukon, K.5    Kumazaki, T.6
  • 14
    • 0030787469 scopus 로고    scopus 로고
    • Transactivation and inhibitory domains of hypoxiainducible factor 1alpha. Modulation of transcriptional activity by oxygen tension
    • PMID: 9235919; DOI: 10.1074/ jbc.272.31.19253
    • Jiang B.H., Zheng J.Z., Leung S.W., Roe R., Semenza GL. Transactivation and inhibitory domains of hypoxiainducible factor 1alpha. Modulation of transcriptional activity by oxygen tension. J Biol Chem 1997; 272:19253-60; PMID: 9235919; DOI: 10.1074/ jbc.272.31.19253.
    • (1997) J Biol Chem , vol.272 , pp. 19253-19260
    • Jiang, B.H.1    Zheng, J.Z.2    Leung, S.W.3    Roe, R.4    Semenza, G.L.5
  • 15
    • 17644397056 scopus 로고    scopus 로고
    • Identification of hypoxia-inducible factor-1alpha (HIF-1alpha) polymorphism as a mutation in prostate cancer that prevents normoxia-induced degradation
    • PMID: 15538748; DOI: 10.1002/ pros.20190
    • Fu X.S., Choi E., Bubley G.J., Balk SP. Identification of hypoxia-inducible factor-1alpha (HIF-1alpha) polymorphism as a mutation in prostate cancer that prevents normoxia-induced degradation. Prostate 2005; 63:215-21; PMID: 15538748; DOI: 10.1002/ pros.20190.
    • (2005) Prostate , vol.63 , pp. 215-221
    • Fu, X.S.1    Choi, E.2    Bubley, G.J.3    Balk, S.P.4
  • 16
    • 70449569293 scopus 로고    scopus 로고
    • The association between hypoxia inducible factor-1alpha gene polymorphisms and increased susceptibility to oral cancer
    • PMID: 19717330; DOI: 10.1016/j.oraloncology. 2009.07.015
    • Chen M.K., Chiou H.L., Su S.C., Chung T.T., Tseng H.C., Tsai H.T., et al. The association between hypoxia inducible factor-1alpha gene polymorphisms and increased susceptibility to oral cancer. Oral Oncol 2009; 45:222- 6; PMID: 19717330; DOI: 10.1016/j.oraloncology. 2009.07.015.
    • (2009) Oral Oncol , vol.45 , pp. 222-226
    • Chen, M.K.1    Chiou, H.L.2    Su, S.C.3    Chung, T.T.4    Tseng, H.C.5    Tsai, H.T.6
  • 17
    • 77955116731 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1alpha gene polymorphism G1790A and its interaction with tobacco and alcohol consumptions increase susceptibility to hepatocellular carcinoma
    • PMID: 20648588; DOI: 10.1002/jso.21539
    • Hsiao P.C., Chen M.K., Su S.C., Ueng K.C., Chen Y.C., Hsieh Y.H., et al. Hypoxia inducible factor-1alpha gene polymorphism G1790A and its interaction with tobacco and alcohol consumptions increase susceptibility to hepatocellular carcinoma. J Surg Oncol 2010; 102:163- 9; PMID: 20648588; DOI: 10.1002/jso.21539.
    • (2010) J Surg Oncol , vol.102 , pp. 163-169
    • Hsiao, P.C.1    Chen, M.K.2    Su, S.C.3    Ueng, K.C.4    Chen, Y.C.5    Hsieh, Y.H.6
  • 18
    • 69849088105 scopus 로고    scopus 로고
    • Associations between hypoxia-inducible factor-1alpha (HIF-1alpha) gene polymorphisms and risk of developing breast cancer
    • PMID: 19580347; DOI: 10.4149/neo-2009-05-441
    • Naidu R., Har Y.C., Taib NA. Associations between hypoxia-inducible factor-1alpha (HIF-1alpha) gene polymorphisms and risk of developing breast cancer. Neoplasma 2009; 56:441-7; PMID: 19580347; DOI: 10.4149/neo-2009-05-441.
    • (2009) Neoplasma , vol.56 , pp. 441-447
    • Naidu, R.1    Har, Y.C.2    Taib, N.A.3
  • 19
    • 77956198446 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in the hypoxia-inducible factor-1 gene and colorectal cancer risk
    • PMID: 20572162
    • Knechtel G., Szkandera J., Stotz M., Hofmann G., Langsenlehner U., Krippl P., et al. Single nucleotide polymorphisms in the hypoxia-inducible factor-1 gene and colorectal cancer risk. Mol Carcinog 2010; 49:805-809; PMID: 20572162.
    • (2010) Mol Carcinog , vol.49 , pp. 805-809
    • Knechtel, G.1    Szkandera, J.2    Stotz, M.3    Hofmann, G.4    Langsenlehner, U.5    Krippl, P.6
  • 20
    • 33750489434 scopus 로고    scopus 로고
    • Association between ulcerative growth and hypoxia inducible factor-1alpha polymorphisms in colorectal cancer patients
    • PMID: 16865676; DOI: 10.1002/mc.20209
    • Fransén K., Fenech M., Fredrikson M., Dabrosin C., Söderkvist P. Association between ulcerative growth and hypoxia inducible factor-1alpha polymorphisms in colorectal cancer patients. Mol Carcinog 2006; 45:833- 40; PMID: 16865676; DOI: 10.1002/mc.20209.
    • (2006) Mol Carcinog , vol.45 , pp. 833-840
    • Fransén, K.1    Fenech, M.2    Fredrikson, M.3    Dabrosin, C.4    Söderkvist, P.5
  • 21
    • 77952973346 scopus 로고    scopus 로고
    • Predictive and prognostic value of CA 19-9 in resected pancreatic adenocarcinoma
    • PMID: 19756875; DOI: 10.1007/s11605-009-0849-z
    • Barton J.G., Bois J.P., Sarr M.G., Wood C.M., Qin R., Thomsen K.M., et al. Predictive and prognostic value of CA 19-9 in resected pancreatic adenocarcinoma. J Gastrointest Surg 2009; 13:2050-8; PMID: 19756875; DOI: 10.1007/s11605-009-0849-z.
    • (2009) J Gastrointest Surg , vol.13 , pp. 2050-2058
    • Barton, J.G.1    Bois, J.P.2    Sarr, M.G.3    Wood, C.M.4    Qin, R.5    Thomsen, K.M.6
  • 22
    • 67651005032 scopus 로고    scopus 로고
    • Polymorphisms in the hypoxia inducible factor-1alpha and the impact on the prognosis of early stages of oral cancer
    • PMID: 19449077; DOI: 10.1245/s10434-009-0503-8
    • Muñoz-Guerra M.F., Fernández-Contreras M.E., Moreno A.L., Martín I.D., Herráez B., Gamallo C. Polymorphisms in the hypoxia inducible factor-1alpha and the impact on the prognosis of early stages of oral cancer. Ann Surg Oncol 2009; 16:2351-8; PMID: 19449077; DOI: 10.1245/s10434-009-0503-8.
    • (2009) Ann Surg Oncol , vol.16 , pp. 2351-2358
    • Muñoz-Guerra, M.F.1    Fernández-Contreras, M.E.2    Moreno, A.L.3    Martín, I.D.4    Herráez, B.5    Gamallo, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.