A systematic approach to overcome the matrix effect during LC-ESI-MS/MS analysis by different sample extraction techniques

Journal of Bioequivalence and Bioavailability

Volumn 3, Issue 6, 2011, Pages 122-127

  Ghosh, Chinmoy ^a,b   Shashank, Gaur ^a   Shinde, Chandrakant P ^b   Chakraborty, Bhaswat ^a  

^a Cadila Pharmaceuticals Limited   (India)

^b JIWAJI UNIVERSITY   (India)

Author keywords

Extraction technique; LC ESI MS MS; Liquid liquid extraction; Matrix effect; Nevirapin; Plasma samples; Protein precipitation; Solid phase extraction

Indexed keywords

ACETONITRILE; METHANOL; NEVIRAPINE; PHOSPHOLIPID;

ANALYTICAL PARAMETERS; ARTICLE; BIOASSAY; BLOOD SAMPLING; CONTROLLED STUDY; DRUG ISOLATION; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; HUMAN; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MATRIX EFFECT; PRECIPITATION; PRECURSOR; RELIABILITY; REPRODUCIBILITY; SENSITIVITY ANALYSIS; SOLID PHASE EXTRACTION; STANDARDIZATION; TABLET MATRIX;

EID: 80052353992     PISSN: None     EISSN: 09750851     Source Type: Journal    
DOI: 10.4172/jbb.1000072     Document Type: Article

References (33)

1. Guidance for Industry and FDA (2007) Staff - Assayed and Unassayed Quality Control Material, Food and Drug Administration, CDRH 01-13
2. Savoie N, Garofolo F, Van Amsterdam P, Bansal S, Beaver C, et al. (2010) White Paper on Recent Issues in Regulated Bioanalysis & Global Harmonization of Bioanalytical Guidance. Bioanalysis 2: 1945-1960.
3. Taylor PJ (2005) Matrix effects: The Achilles heel of quantitative high-performance liquid chromatography-electrospray-tandem mass spectrometry. Clin Biochem 38: 328-334.
4. Smeraglia J, Baldrey SF, Watson D (2002) Matrix Effects and Selectivity Issues in LC-MS-MS. Chromatographia 55: S95-S99.
5. Annesley TM (2003) Ion Suppression in Mass Spectrometry. Clin Chem 49: 1041-1044.
6. Fu I, Woolf EJ, Matuszewski BK (1998) Effect of the Sample Matrix on the Determination of Indinavir in Human Urine by HPLC with Turbo Ion Spray Tandem Mass Spectrometric Detection. J Pharmaceut Biomed Anal 18: 347- 357.
7. Jemal M, Ouyang Z, Yuan-Qing X (2010) Systematic LC-MS/MS Bioanalytical method development that incorporates plasma phospholipids risk avoidance, usage of incurred sample and well thought-out chromatography. Biomed Chromatogr 24: 2-19.
8. Du L, White RL (2008) Reducing glycerophosphocholine lipid matrix interference effects in biological fluid assays by using high-turbulance liquid chromatography. Rapid Commun Mass Sppectrom 22: 3362-3370.
9. Steene JCVD, Lambert WE (2008) Comparison of Matrix Effects in HPLCMS/ MS and UPLC-MS/MS Analysis of Nine Basic Pharmaceuticals in Surface Waters. J Am Soc Mass Spectrom 19: 713-718.
10. Chambers E, Wagrowski-Diehl DM, Lu Z, Mazzeo JR (2007) Syetematic and comprehensive strategy for reducing matrix effects in LC/MS/MS analysis. J Chromatogr B Analyt Technol Biomed Life Sci 852: 22-34.
11. Annesley TM (2007) Methanol-Associated Matrix Effects in Electrospray Ionization Tandem Mass Spectrometry. Clin Chem 53: 1827-1834.
12. Gosetti F, Mazzucco E, Zampieri D, Gennaro MC (2010) Signalsuppression/ enhancement in high-performance liquid chromatography tandem mass spectrometry. J Chromatogr A 1217: 3929-3937.
13. Omnia I, Halquist MS, Elmamly MY, Shalaby A, Kames HT (2007) Monitoring phospholipids for assessment of matrix effects in a liquid chromatographytandem mass spectrometry method for hydrocodon and pseudoephedrine in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci 859: 84-93.
14. Ismaiel OA, Halquist MS, Elmamly MY, Shalaby A, Thomas Karnes H (2008) Monitoring phospholipids for assessment of ion enhancement and ion suppression in ESI and APCI LC/MS/MS for chlorpheniramine in human plasma and the importance of multiple source matrix effect evaluations. J Chromatogr B Analyt Technol Biomed Life Sci 875: 333-343
15. Mei H, Hsieh Y, Nardo C, Xu X, Wang S, et al. (2003) Investigation of Matrix Effects in Bioanalytical High-Performance Liquid Chromatography/Tandem Mass Spectrometric Assays: Application to Drug Discovery. Rapid Commun Mass Spectrom 17: 97-103.
16. Mallet CR, Ziling L, Mazzeo JR (2004) A study of ion suppression effects in electrospray ionization from mobile phase additives and solid-phase extracts. Rapid Commun Mass Spectrom 18: 49-58.
17. Matuszewski BK, Constanzer ML, Chavez-Eng CM (2003) A Systematic Approach to Reducing Matrix Effects in LC/MS/MS Analyses. Anal Chem 75: 3019-3030.
18. Dams R, Huestis MA, Lambert WE, Murphy CM (2003) Matrix Effect in Bio- Analysis of Illicit Drugs with LC-MS/MS: Influence of Ionization Type, Sample Preparation, and Biofluid. J Am Soc Mass Spectrom 14: 1290-1294.
19. Mei H, Korfmacher W (Ed.) (2005) Using Mass Spectrometry for Drug Metabolism Studies. CRC Press, Boca Raton, FL, 103-150.
20. Liang HR, Foltz RL, Meng M, Bennett P (2003) Ionization enhancement in atmospheric pressure chemical ionization and suppression in electrospray ionization between target drugs and stable-isotope-labeled internal standards in quantitative liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom 17: 2815-2821.
21. Souverain S, Rudaz S, Veuthey JL (2004) Matrix effect in LC-ESI-MS and LC-APCI-MS with off-line and on-line extraction procedures. J Chromatogr A 1058: 61-66.
22. Ghosh C, Shinde CP, Chakraborty BS (2010) Ionization Polarity as a Cause of Matrix Effects, its Removal and Estimation in ESI-LC-MS/ MS Bio-analysis. J Anal Bioanal Techniques 1: 106
23. Buhrman DL, Price PI, Rudewicz PJ (1996) Quantitation of SR27417 in Human Plasma Using Electrospray Liquid Chromatography Tandem Mass Spectrometry: A Study of Ion Suppression. J Am Soc Mass Spectrom 7: 1099-1105.
24. Pucci V, Palma SD, Alfieri A, Bonelli F, Monteagudo E (2009) A novel strategy for reducing phospholipids-based matrix effect in LC-ESI-MS bioanalysis by means of Hybrid SPE. J. Pharmaceut. Biomed Anal 50: 867-871.
25. Shena JX, Motykab RJ, Roachb JP, Hayesa RN (2005) Minimization of ion suppression in LC-MS/MS analysis through the application of strong cation exchange solid-phase extraction (SCX-SPE). J Pharmaceut Biomed Anal 37: 359-367.
26. Chin C, Zhang ZP, Karnes HT (2004) A study of matrix effects on an LC/MS/ MS assay for olanzapine and desmethyl olanzapine. J Pharmaceut Biomed Anal 35: 1149-1167.
27. Avery M (2003) Quantitative characterization of differential ion suppression on liquid chromatography/atmospheric pressure ionization mass spectrometric bioanalytical methods. Rapid Commun Mass Spectrom 17: 197-201.
28. Marchese A, McHugh C, Kehler J, Bi H (1998) Determination of Pranlukast and its metabolites in human plasma by LC/MS/MS with PROSPEKT on-line solid-phase extraction. J Mass Spectrom 33: 1071-1079.
29. Bennett P, Hairui (2004) Overcoming Matrix Effects Resulting From Biological Phospholipids Through Selective Extraction in Quantitative LC/ MS/MS. Presented at the ASMS Conference.
30. Bonfiglio R, King R, Olah T, Merkle K (1999) The effects of sample preparation methods on variability of the electrospray ionization response for model drug compounds. Rapid Commun Mass Spectrom 13: 1175-1185.
31. Capka V, Carter SJ (2006) Non-intuitive Strategies for Minimizing Matrix Effects in Development of Ultrasensitive Bioanalytical LC/MS/MS Methods. Presented at the ASMS Conference.
32. Brugger B, Erben G, Sandhoff R, Wieland FT, Lehmann WD (1997) Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry. Proc Natl Acad Sci USA 94: 2339-2344.
33. Ghosh C, Gaur S, Singh A, Shinde CP, Chakraborty BS (2011) Estimation of Nevirapine from Human Plasma by LC-ESI-MS/MS: a Pharmacokinetic Application. J Bioequiv Availab 3: 020-025.