Effect of chronic high altitude hypoxia on foetal and maternal juxta-alveolar distal pulmonary smooth muscle cells actin and calponin organisation and growth profiles;Effets de l'hypoxie chronique liee a la haute altitude sur les cellules musculaires lisses pulmonaires distales juxta-alveolaires, organisation des filaments d'actine et de calponine et leur profil de croissance

West African Journal of Medicine

Volumn 29, Issue 6, 2010, Pages 388-392

  John, T A ^a  

^a LAGOS STATE UNIVERSITY   (Nigeria)

Author keywords

Chronic high altitude hypoxia; Foetus; Lung; Pulmonary smooth muscle cells

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CALPONIN; ACTIN; ACTIN BINDING PROTEIN; BIOLOGICAL MARKER; CALCIUM BINDING PROTEIN; OXYGEN;

ALTITUDE; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL GROWTH; CELL STRUCTURE; FEMALE; HYPOXIA; IMMUNOHISTOCHEMISTRY; LUNG PARENCHYMA; NONHUMAN; PULMONARY VEIN; SHEEP; SMOOTH MUSCLE FIBER; ALTITUDE DISEASE; ANIMAL; ANOXIA; COMPARATIVE STUDY; FETUS; METABOLISM; PATHOPHYSIOLOGY; PHENOTYPE; PREGNANCY; VASCULAR SMOOTH MUSCLE;

ACTINS; ALTITUDE SICKNESS; ANIMALS; ANOXIA; BIOLOGICAL MARKERS; CALCIUM-BINDING PROTEINS; FEMALE; FETUS; IMMUNOHISTOCHEMISTRY; MICROFILAMENT PROTEINS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; OXYGEN; PHENOTYPE; PREGNANCY; PULMONARY VEINS; SHEEP;

EID: 80052342003     PISSN: 0189160X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Murata T, Yamawaki H, Hori M, Sato K, Ozaki H, Karaki H. Hypoxia impairs endothelium-dependent relaxation in organ cultured pulmonary artery. Eur J Pharmacol. 2001; 421: 45-53.
2. Tuder RM, Yun JH, Bhunia A, Fijalkowska I. Hypoxia and chronic lung disease. J Mol Med. 2007; 85: 1317-24.
3. John TA, Ibe BO, Usha Raj J. Oxygen alters caveolin-1 and nitric oxide synthase-3 functions in ovine foetal and neonatal lung microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2006; 291: L1079-93.
4. John TA, Ibe BO, Raj JU. Regulation of endothelial nitric oxide synthase: involvement of protein kinase G 1 beta, serine 116 phosphorylation and lipid structures. Clin Exp Pharmacol Physiol. 2008; 35: 148-58.
5. Dull RO, Yuan J, Chang YS, Tarbell J, Jain RK, Munn LL. Kinetics of placenta growth factor/vascular endothelial growth factor synergy in endothelial hydraulic conductivity and proliferation. Microvasc Res. 2001; 61: 203-10.
6. Ibe BO, Abdallah MF, Portugal AM, Raj JU. Platelet-activating factor stimulates ovine foetal pulmonary vascular smooth muscle cell proliferation: role of nuclear factor-kappa B and cyclin-dependent kinases. Cell Prolif. 2008; 41: 208-29.
7. Nair PM, Bataclan MF. Persistent pulmonary hypertension of the new- born. Saudi Med J. 2004; 25: 693-9.
8. Hermansen CL, Lorah KN. Respiratory distress in the newborn. Am Fam Physician. 2007; 76: 987-94.
9. Gao Y, Portugal AD, Liu J, Negash S, Zhou W, Tian J, Xiang R, Longo LD, Raj JU. Preservation of cGMP-induced relaxation of pulmonary veins of foetal lambs exposed to chronic high altitude hypoxia: role of PKG and Rho kinase. Am J Physiol Lung Cell Mol Physiol. 2008; 295: L889-96.
10. Gao Y, Dhanakoti S, Trevino EM, Sander FC, Portugal AM, Raj JU. Effect of oxygen on cyclic GMP- dependent protein kinase-mediated relaxation in ovine foetal pulmonary arteries and veins. Am J Physiol Lung Cell Mol Physiol. 2003; 285: L611-8.
11. Sander F, Gao Y, Raj JU. Hypoxia down-regulates cyclic guanidine monophosphate-dependent protein kinase in foetal pulmonary vascular smooth muscle cell through generation of reactive oxygen species and promotes development of pulmonary hypertension. Chest. 2005; 128: 577S-578S.
12. Zhou W, Dasgupta C, Negash S, Raj JU. Modulation of pulmonary vascular smooth muscle cell phenotype in hypoxia: role of cGMP-dependent protein kinase. Am J Physiol Lung Cell Mol Physiol. 2007; 292: L1459-66.
13. Bixby CE, Ibe BO, Abdallah MF, Zhou W, Hislop AA, Longo LD, Raj JU. Role of platelet-activating factor in pulmonary vascular remodeling associated with chronic high altitude hypoxia in ovine foetal lambs. Am J Physiol Lung Cell Mol Physiol. 2007; 293: L1475-82.