Role of platelet-activating factor in pulmonary vascular remodeling associated with chronic high altitude hypoxia in ovine fetal lambs

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 293, Issue 6, 2007, Pages

  Bixby, Christine E ^a   Ibe, Basil O ^a   Abdallah, May F ^a   Zhou, Weilin ^a   Hislop, Alison A ^b   Longo, Lawrence D ^c   Usha Raj, J ^a  

^a HARBOR UCLA MEDICAL CENTER   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell proliferation; Platelet activating factor receptor binding; Pulmonary arteries; Smooth muscle

Indexed keywords

THROMBOCYTE ACTIVATING FACTOR;

ALTITUDE DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL ISOLATION; CONTROLLED STUDY; FEMALE; GESTATION PERIOD; IMMUNOCYTOCHEMISTRY; LAMB; LUNG BLOOD VESSEL; LUNG PARENCHYMA; MORPHOMETRICS; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; SMOOTH MUSCLE FIBER; WESTERN BLOTTING;

ALTITUDE SICKNESS; ANIMALS; ANOXIA; BIRTH WEIGHT; CELL ADHESION; CELL MEMBRANE; CELL PROLIFERATION; CHRONIC DISEASE; FEMALE; FETUS; MUSCLE, SMOOTH, VASCULAR; PLATELET ACTIVATING FACTOR; PLATELET MEMBRANE GLYCOPROTEINS; PREGNANCY; PULMONARY ARTERY; RECEPTORS, G-PROTEIN-COUPLED; SHEEP, DOMESTIC;

EID: 37149037805     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00089.2007     Document Type: Article

References (39)

1. Abman SH, Shanley PF, Accurso FJ. Failure of postnatal adaptation of the pulmonary circulation after chronic intrauterine pulmonary hypertension in fetal lambs. J Clin Invest 83: 1849-1858, 1989.
2. Ballew C, Haas JD. Hematologic evidence of fetal hypoxia among newborn infants at high altitude in Bolivia. Am J Obstet Gynecol 155: 166-169, 1986.
3. Belknap JK, Orton EC, Ensley B, Tucker A, Stenmark KR. Hypoxia increases bromodeoxyuridine labeling indices in bovine neonatal pulmonary arteries. Am J Respir Cell Mol Biol 16: 366-371, 1997.
4. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
5. Browne VA, Stiffel VM, Pearce WJ, Longo LD, Gilbert RD. Cardiac β-adrenergic receptor function in fetal sheep exposed to long-term high-altitude hypoxemia. Am J Physiol Regul Integr Comp Physiol 273: R2022-R2031, 1997.
6. Caplan MS, Hsueh W, Sun XM, Gidding SS, Hegeman JR. Circulating plasma platelet activating factor in persistent pulmonary hypertension of the newborn. Am Rev Respir Dis 142: 1258-1262, 1990.
7. Chen D, Chen W. Changes of distribution of platelet activating factor in the lung of rats with hypoxic pulmonary hypertension. Chin Med J (Engl) 109: 776-779, 1996.
8. Cooper AL, Beasley D. Hypoxia stimulates proliferation and interleukin-1α production in human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 277: H1326-H1337, 1999.
9. Geggel RL, Aronovitz MJ, Reid LM. Effects of chronic in utero hypoxemia on rat neonatal pulmonary arterial structure. J Pediatr 108: 756-759, 1986.
10. Goldberg SJ, Levy RA, Siassi B, Betten AB. The effects of maternal hypoxia and hyperoxia upon the neonatal pulmonary vasculature. Pediatrics 48: 528-533, 1971.
11. Growcott EJ, Banner KH, Wharton J. Hypoxia amplifies the proliferative capacity of distal human pulmonary artery smooth muscle cells. Chest 128: 600S-601S, 2005.
12. Haworth SG, Reid LM. Persistent fetal circulation: newly recognized structural features. J Pediatr 88: 614-620, 1976.
13. Ibe BO, Hibler S, Raj JU. Platelet-activating factor modulates vasomotor tone in the perinatal lamb. J Appl Physiol 85: 1079-1085, 1998.
14. Ibe BO, Pham P, Kaapa P, Raj JU. Maturational changes in ovine pulmonary metabolism of platelet activating factor: implications for postnatal adaptation. Mol Genet Metab 74: 385-395, 2001.
15. Ibe BO, Portugal A, Chaturvedi S, Raj JU. Oxygen-dependent platelet activating factor-receptor binding and intracellular signaling in ovine fetal pulmonary vascular smooth muscle. Am J Physiol Lung Cell Mol Physiol 288: L879-L886, 2005.
16. Ibe BO, Portugal AM, Raj JU. Metabolism of platelet activating factor by intrapulmonary vascular smooth muscle cells. Effect of oxygen on phospholipase A2 protein expression, activities of acetyl CoA acetyltransferase and cholinephosphotransferase. Mol Genet Metab 77: 237-248, 2002.
17. Ibe BO, Portugal A, Raj JU. Platelet activating factor (PAF) and ovine fetal pulmonary vascular smooth muscle cell proliferation (Abstract). FASEB J 19: A1089, 2005.
18. Ibe BO, Raj JU. Leukotriene metabolism by intrapulmonary vessels of newborn lambs. Effect of platelet activating factor. Exp Lung Res 27: 331-348, 2001.
19. Ibe BO, Sander FC, Raj JU. Platelet-activating factor receptors in lamb lungs are downregulated immediately after birth. Am J Physiol Heart Circ Physiol 278: H1168-H1176, 2000.
20. Ihida K, Predescu D, Czekay RP, Palade GE. PAF-R is found in a large endosomal compartment in human umbilical vein endothelial cells. J Cell Sci 112: 285-295, 1999.
21. Ishii S, Shimizu T. Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice. Prog Lipid Res 39: 41-82, 2001.
22. Kamitomo M, Alonso JG, Okai T, Longo LD, Gilbert RD. Effects of long-term, high-altitude hypoxemia on ovine fetal cardiac output and blood flow distribution. Am J Obstet Gynecol 169: 701-707, 1993.
23. Kamitomo M, Longo LD, Gilbert RD. Right and left ventricular function in fetal sheep exposed to long-term high-altitude hypoxemia. Am J Physiol Heart Circ Physiol 262: H399-H405, 1992.
24. Korth RM, Hirafuji M, Benveniste J, Russo-Marie F. Human umbilical vein endothelial cells: specific binding of platelet-activating factor and cytosolic calcium flux. Biochem Pharmacol 49: 1703-1799, 1995.
25. Lewis AM, Mathieu-Costello O, McMillan PJ, Gilbert RD. Effects of long-term, high-altitude hypoxia on the capillarity of the ovine fetal heart. Am J Physiol Heart Circ Physiol 277: H756-H762, 1999.
26. Meyrick B, Reid L. Hypoxia-induced structural changes in the media and adventitia of the rat hilar pulmonary artery and their regression. Am J Pathol 100: 151-178, 1980.
27. Miller AA, Hislop AA, Vallance PJ, Haworth SG. Deletion of eNOS gene has a greater impact on the pulmonary circulation of male than female mice. Am J Physiol Lung Cell Mol Physiol 289: L299-L306, 2005.
28. Murphy JD, Rabinovitch M, Goldstein JD, Reid LM. The structural basis of persistent pulmonary hypertension of the newborn infant. J Pediatr 98: 962-967, 1981.
29. Nakamura M, Honda Z, Izumi T, Sakanaka C, Mutoh H, Minami M, Bito H, Seyama Y, Matsumoto T, Noma M, Shimizu T. Molecular cloning and expression of platelet-activating factor receptor from human leukocytes. J Biol Chem 266: 20400-20405, 1991.
30. Niermeyer S. Cardiopulmonary transition in the high altitude infant. High Alt Med Biol 4: 225-239, 2003.
31. Niermeyer S, Shaffer E, Moore LG. Impaired cardiopulmonary transition at high altitude (Abstract). Pediatr Res 43: 292, 1998.
32. Niermeyer S, Yang P, Shanmina, Drolkar, Zhuang J, Moore LG. Arterial oxygen saturation in Tibetan and Han infants born in Lhasa, Tibet. N Engl J Med 333: 1248-1252, 1995.
33. Niermeyer S, Shaffer EM, Thilo E, Corbin C, Moore LG. Arterial oxygenation and pulmonary arterial pressure in healthy neonates and infants at high altitude. J Pediatr 123: 767-772, 1993.
34. Ono S, Westcott JY, Voelkel NF. PAF antagonists inhibit pulmonary vascular remodeling induced by hypobaric hypoxia in rats. J Appl Physiol 73: 1084-1092, 1992.
35. Pauly RR, Bilato C, Cheng L, Monticone R, Crow MT. Vascular smooth muscle cell culture. Methods Cell Biol 52: 133-154, 1998.
36. Parent JL, Le Gouill C, Escher E, Rola-Pleszcynski M, Stankova J. Identification of transmembrane domain residues determinant in the structure-function relationship of human platelet-activating factor receptor by site directed mutagenesis. J Biol Chem 271: 23298 -23303, 1996.
37. Salva A, Ibe BO, Cliborn E, Reyes G, Raj JU. Hypoxia attenuates metabolism of platelet activating factor by fetal and newborn lamb lungs. J Lipid Res 37: 783-789, 1996.
38. Siassi B, Goldberg SJ, Emmanouilides GC, Higashino SM, Lewis E. Persistent pulmonary vascular obstruction in newborn infants. J Pediatr 78: 610-615, 1971.
39. Stenmark KR, Fasules J, Hyde DM, Voelkel NF, Henson J, Tucker A, Wilson H, Reeves JT. Severe pulmonary hypertension and arterial adventitial changes in newborn calves at 4,300 m. J Appl Physiol 62: 821-830, 1987.