Methylphenidate side effects in advanced cancer: A retrospective analysis

American Journal of Hospice and Palliative Medicine

Volumn 27, Issue 1, 2010, Pages 16-23

  Lasheen, Wael ^a   Walsh, Declan ^a   Mahmoud, Fade ^a   Davis, Mellar P ^a   Rivera, Nilo ^a   Khoshknabi, Dilara Seyidova ^a  

^a TAUSSIG CANCER INSTITUTE   (United States)

Author keywords

Cancer; Depression; Fatigue; Methylphenidate; Symptoms

Indexed keywords

EID: 75949100809     PISSN: 10499091     EISSN: None     Source Type: Journal    
DOI: 10.1177/1049909109345145     Document Type: Article

References (26)

1. Challman TD, Lipsky JJ Methylphenidate: its pharmacology and uses. Mayo Clin Proc. 2000;75(7):711-721.
2. Volkow MD, Fowler JS, Wang G., Ding Y., Gatley SJ Mechanism of action of methylphenidate: insights from PET imaging studies. J Atten Disord. 2002;6(suppl 1): S31-S43.
3. Rozans M., Dreisbach A., Lertora JJ, Kahn MJ Palliative uses of methylphenidate in patients with cancer: a review. J Clin Oncol. 2001;20(1):335-339.
4. Homsi J., Walsh D., Nelson KA, LeGrand S., Davis M. Methylphenidate for depression in hospice practice: a case series. Am J Hosp Palliat Care. 2000; 17(6):393-398.
5. Sarhill N., Walsh D., Nelson K., Homsi J., LeGrand S., Davis M. Methylphenidate for fatigue in advanced cancer: a prospective open-label pilot study. Am J Hosp Palliat Care. 2001;18(3):187-192.
6. Homsi J., Nelson KA, Sarhill N.,et al.A phase II study of methylphenidate for depression in advanced cancer. Am J Hosp Palliat Care. 2001;18(6):403-407.
7. Homsi J., Walsh D., Nelson KA Psychostimulants in supportive care. Support Care Cancer. 2000;8(5):385-397.
8. Walsh D., Doona M., Molnar M., Lipnickey V. Symptom control in advanced cancer: important drugs and routes of administration. Semin Oncol. 2000;27(1):69-83.
9. Miaskowski C., Portenoy RK Assessment and management of cancer related fatigue. In: Berger A, Portenoy RK, Weissman DE, eds. Principles and Practice of Supportive Oncology. Philadelphia, PA: Lippincott-Raven; 1998: 109-118.
10. Bruera E., Chadwick S., Breeneis C., Hanson J., MacDonald RN Methylphenidate associated with narcotics for the treatment of cancer pain. Cancer Treat Rep. 1987;71(1):67-70.
11. Bruera E., Fainsinger R., MacEachern T., Hanson J. The use of methylphenidate in patients with incident cancer pain receiving regular opiates. A preliminary report. Pain. 1992;50(1):75-77.
12. Bruera E., Miller MJ, Macmillan K., Kuehn N. Neuropsychological effects of methylphenidate in patients receiving a continuous infusion of narcotics for cancer pain. Pain. 1992;48(2):163-166.
13. Bruera E., Driver L., Barnes EA,et al.Patient-controlled methylphenidate for the management of fatigue in patients with advanced cancer: a preliminary report. J Clin Oncol. 2003;21(23):4439-4443.
14. Bruera E., Valero V., Driver L.,et al.Patient-controlled methylphenidate for cancer fatigue: a double-blind, randomized, placebo-controlled trial. J Clin Oncol. 2006; 24(13):2073-2078.
15. Butler JM Jr, Case LD, Atkins J.,et al.A phase III, double-blind, placebo-controlled prospective randomized clinical trial of d-threo-methylphenidate HCl in brain tumor patients receiving radiation therapy. Int J Radiat Oncol Biol Phys. 2007;69(5): 1496-1501.
16. Fernandez F., Adams F., Holmes VF, Levy JK, Neidhart M. Methylphenidate for depressive disorders in cancer patients. An alternative to standard antidepressants. Psychosomatics. 1987;28(9):455-461.
17. Gagnon B., Low G., Schreier G. Methylphenidate hydrochloride improves cognitive function in patients with advanced cancer and hypoactive delirium: a prospective clinical study. J Psychiatry Neurosci. 2005;30(2): 100-107.
18. Hanna A., Sledge G., Mayer ML,et al.A phase II study of methylphenidate for the treatment of fatigue. Support Care Cancer. 2006;14(3):210-215.
19. Macleod AD Methylphenidate in terminal depression. J Pain Symptom Manage. 1998;16(3):193-198.
20. Mar Fan HG, Clemons M., Xu W.,et al.A randomised, placebo-controlled, double-blind trial of the effects of d-methylphenidate on fatigue and cognitive dysfunction in women undergoing adjuvant chemotherapy for breast cancer. Support Care Cancer. 2008;16(6): 577-583.
21. Meyers CA, Weitzner MA, Valentine AD, Levin VA Methylphenidate therapy improves cognition, mood, and function of brain tumor patients. J Clin Oncol. 1998; 16(7):2522-2527.
22. Sugawara Y., Akechi T., Shima Y.,et al.Efficacy of methylphenidate for fatigue in advanced cancer patients: a preliminary study. Palliat Med. 2002;16(3): 261-263.
23. Wilwerding MB, Loprinzi CL, Mailliard JA,et al.A randomized, crossover evaluation of methylphenidate in cancer patients receiving strong narcotics. Support Care Cancer. 1995;3(2):135-138.
24. Swanson J., Gupta S., Lam A.,et al.Development of a new once-a-day formulation of methylphenidate for the treatment of attention-deficit/hyperactivity disorder: proof-of-concept and proof-of-product studies. Arch Gen Psychiatry. 2003;60(2):204-211.
25. Ayache DC, Junior RF Methylphenidate in a patient with depression and respiratory insufficiency. Int J Psychiatry Med. 2001;31(4):443-449.
26. Levy F., Hobbes G. Does haloperidol block methylphenidate? Motivation or attention? Psychopharmacology (Berl). 1996;126(1):70-74.