Oral bisphosphonates are associated with reduced mortality in frail older people: A prospective five-year study

Osteoporosis International

Volumn 22, Issue 9, 2011, Pages 2551-2556

  Sambrook, P N ^a   Cameron, I D ^a   Chen, J S ^a   March, L M ^a   Simpson, J M ^b   Cumming, R G ^a   Seibel, M J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Aged care facility; Elderly; Hip fracture; Mortality; Osteoporosis

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; CALCIUM; ETIDRONIC ACID; PARATHYROID HORMONE; RISEDRONIC ACID; VITAMIN D;

AGED; AGING; BODY MASS; BONE TURNOVER; DEATH; DIET SUPPLEMENTATION; FEMALE; FOLLOW UP; FRAIL ELDERLY; GERIATRIC PATIENT; HIP FRACTURE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; NURSING HOME PATIENT; OUTCOME ASSESSMENT; PARATHYROID HORMONE BLOOD LEVEL; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; REVIEW; RISK REDUCTION; SEX DIFFERENCE;

AGED; AGED, 80 AND OVER; AUSTRALIA; BONE DENSITY CONSERVATION AGENTS; DIPHOSPHONATES; FEMALE; FOLLOW-UP STUDIES; FRAIL ELDERLY; HIP FRACTURES; HOMES FOR THE AGED; HUMANS; IMIDAZOLES; MALE; NURSING HOMES; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 80052332532     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-010-1444-6     Document Type: Review

References (17)

1. D Bliuc ND Nguyen VE Milch TV Nguyen JA Eisman JR Center 2009 Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women JAMA 301 513 521 19190316 10.1001/jama.2009.50 1:CAS:528:DC%2BD1MXhtlyqs7Y%3D
2. J Magaziner EM Simonsick TM Kashner JR Hebel JE Kenzora 1989 Survival experience of aged hip fracture patients Am J Public Health 79 274 278 2916711 10.2105/AJPH.79.3.274 1:STN:280:DyaL1M7jt1yrtg%3D%3D (Pubitemid 19077861)
3. KW Lyles CS Colon-Emeric JS Magaziner JD Adachi CF Pieper C Mautalen L Hyldstrup C Recknor L Nordsletten KA Moore C Lavecchia J Zhang P Mesenbrink PK Hodgson K Abrams JJ Orloff Z Horowitz EF Eriksen S Boonen 2007 Zoledronic acid and clinical fractures and mortality after hip fracture N Engl J Med 357 1799 1809 17878149 10.1056/NEJMoa074941 1:CAS:528:DC%2BD2sXht1Kit7nN (Pubitemid 350044800)
4. CS Colon-Emeric P Mesenbrink KW Lyles CF Pieper S Boonen P Delmas EF Eriksen J Magaziner 2010 Potential mediators of the mortality reduction with zoledronic acid after hip fracture J Bone Miner Res 25 91 97 19580467 10.1359/jbmr.090704 1:CAS:528:DC%2BC3cXksl2ksr8%3D
5. MJ Bolland AB Grey GD Gamble IR Reid 2010 Effect of osteoporosis treatment on mortality: a meta-analysis J Clin Endocrinol Metab 95 1174 1181 20080842 10.1210/jc.2009-0852 1:CAS:528:DC%2BC3cXjs1Kqtrg%3D
6. PN Sambrook CJ Chen L March ID Cameron RG Cumming SR Lord JM Simpson MJ Seibel 2006 High bone turnover is an independent predictor of mortality in the frail elderly J Bone Miner Res 21 549 555 16598375 10.1359/jbmr.060104
7. ID Cameron JS Chen LM March JM Simpson RG Cumming MJ Seibel PN Sambrook 2010 Hip fracture causes excess mortality owing to cardiovascular and infectious disease in institutionalized older people: a prospective 5-year study J Bone Miner Res 25 866 872 19839771
8. PN Sambrook JS Chen LM March ID Cameron RG Cumming SR Lord J Zochling YY Sitoh TC Lau J Schwarz MJ Seibel 2004 Serum parathyroid hormone predicts time to fall independent of vitamin D status in a frail elderly population J Clin Endocrinol Metab 89 1572 1576 15070914 10.1210/jc.2003-031782 1:CAS:528:DC%2BD2cXjt1els7Y%3D (Pubitemid 38507904)
9. J Zochling YY Sitoh TC Lau ID Cameron RG Cumming SR Lord J Schwarz A Trube LM March PN Sambrook 2002 Quantitative ultrasound of the calcaneus and falls risk in the institutionalized elderly: sex differences and relationship to vitamin D status Osteoporos Int 13 882 887 12415435 10.1007/s001980200121 1:STN:280:DC%2BD38nlsFWlug%3D%3D (Pubitemid 35364789)
10. J Holtzman N Lurie 1996 Causes of increasing mortality in a nursing home population J Am Geriatr Soc 44 258 264 8600193 1:STN:280:DyaK287osVKrsw%3D%3D (Pubitemid 26081091)
11. MF Folstein SE Folstein PR McHugh 1975 Mini-mental state. A practical method for grading the cognitive state of patients for the clinician J Psychiatr Res 12 189 198 1202204 10.1016/0022-3956(75)90026-6 1:STN:280: DyaE28%2FntFKjtw%3D%3D
12. Bliuc D, Nguyen N, Nguyen T, Eisman JA, Center J (2009) Relationship Between Low BMD And Fracture In Mortality Risk: An 18-Year Prospective Study From Dubbo Osteoporosis Epidemiology Study. 31st Annual Meeting of American Society for Bone and Mineral Research Abst FR0329
13. D Santini F Martini ME Fratto S Galluzzo B Vincenzi C Agrati F Turchi P Piacentini L Rocci JS Manavalan G Tonini F Poccia 2009 In vivo effects of zoledronic acid on peripheral gammadelta T lymphocytes in early breast cancer patients Cancer Immunol Immunother 58 31 38 18458903 10.1007/s00262-008-0521-6 1:CAS:528:DC%2BD1cXht1yqs7jF
14. LD Carbone KJ Warrington KD Barrow M Pugazhenthi MA Watsky G Somes J Ingels AE Postlethwaite 2006 Pamidronate infusion in patients with systemic sclerosis results in changes in blood mononuclear cell cytokine profiles Clin Exp Immunol 146 371 380 17100755 10.1111/j.1365-2249.2006.03216.x 1:CAS:528:DC%2BD2sXmslKgtw%3D%3D (Pubitemid 44722154)
15. DM Black PD Delmas R Eastell IR Reid S Boonen JA Cauley F Cosman P Lakatos PC Leung Z Man C Mautalen P Mesenbrink H Hu J Caminis K Tong T Rosario-Jansen J Krasnow TF Hue D Sellmeyer EF Eriksen SR Cummings 2007 Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis N Engl J Med 356 1809 1822 17476007 10.1056/NEJMoa067312 1:CAS:528:DC%2BD2sXltVSktLc%3D (Pubitemid 46698462)
16. P Szulc C Maurice F Marchand PD Delmas 2009 Increased bone resorption is associated with higher mortality in community-dwelling men > or = 50 years of age: the MINOS study J Bone Miner Res 24 1116 1124 19113925 10.1359/jbmr.081251 1:CAS:528:DC%2BD1MXmvFyjt7w%3D
17. P Szulc EJ Samelson DP Kiel PD Delmas 2009 Increased bone resorption is associated with increased risk of cardiovascular events in men: the MINOS study J Bone Miner Res 24 2023 2031 19453264 10.1359/jbmr.090531 1:CAS:528: DC%2BC3cXht1Wns74%3D