Increasing specimen coverage using digital whole-mount breast pathology: Implementation, clinical feasibility and application in research

Computerized Medical Imaging and Graphics

Volumn 35, Issue 7-8, 2011, Pages 531-541

  Clarke, Gina M ^a   Peressotti, Chris ^a   Constantinou, Paul ^b   Hosseinzadeh, Danoush ^a   Martel, Anne ^a,c   Yaffe, Martin J ^a,c  

^a SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^b Quorum Technologies   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Biomarker distribution; Breast cancer; Histological sampling; Radiologic pathologic correlation; Serial sections; Virtual microscopy; Whole mount sections

Indexed keywords

BIOMARKER DISTRIBUTIONS; BREAST CANCER; HISTOLOGICAL SAMPLING; RADIOLOGIC-PATHOLOGIC CORRELATION; SERIAL SECTION; VIRTUAL MICROSCOPY; WHOLE-MOUNT SECTIONS;

DISEASES; PATHOLOGY; THREE DIMENSIONAL; TISSUE; VISUALIZATION;

MOUNTINGS;

BIOLOGICAL MARKER;

ARTICLE; BREAST CANCER; CAMERA; CLINICAL RESEARCH; COMPUTER; COMPUTER PROGRAM; CONFOCAL LASER MICROSCOPY; HISTOPATHOLOGY; HUMAN; IMAGE ANALYSIS; IMAGE RECONSTRUCTION; INTRADUCTAL CARCINOMA; MAJOR CLINICAL STUDY; MASTECTOMY; MICROSCOPY; PARTIAL MASTECTOMY; PATHOLOGY; PRIORITY JOURNAL; RADIOLOGY; THREE DIMENSIONAL IMAGING; TUMOR VOLUME; VALIDATION STUDY; VIRTUAL MICROSCOPY; VIRTUAL REALITY;

BREAST NEOPLASMS; COMPUTERS; DIAGNOSTIC IMAGING; FEASIBILITY STUDIES; FEMALE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IMAGING, THREE-DIMENSIONAL; MICROSCOPY; RESEARCH; SOFTWARE; SPECIMEN HANDLING; USER-COMPUTER INTERFACE;

EID: 80052324719     PISSN: 08956111     EISSN: 18790771     Source Type: Journal    
DOI: 10.1016/j.compmedimag.2011.05.002     Document Type: Article

References (68)

1. Scarth H., Cantin J., Levine M. Clinical practice guidelines for the care and treatment of breast cancer: mastectomy or lumpectomy? The choice of operation for clinical stages I and II breast cancer (summary of the 2002 update). Can Med Assoc J 2002, 167(2):154-155.
2. Whitman G.J., Sheppard D.G., Phelps M.J., Gonzales B.N. Breast cancer staging. Semin Roentgenol 2006, 41(2):91-104.
3. D' Arrigo C., Fentiman I. Pathology of breast carcinoma (series on management of breast cancer). J Clin Pract 2004, 58(1):29-34.
4. Rosen P. Pathological assessment of nonpalpable breast lesions. Semin Surg Oncol 1991, 7(5):257-260.
5. Lagios M., Bennington J. Protocol for the pathologic examination and tissue processing of the mammographically directed breast biopsy. Pathology (Phila) 1992, 1(1):23-45.
6. Egan R. Multicentric breast carcinomas: clinical-radiographic-pathologic whole organ studies and 10-year survival. Cancer 1982, 49(6):1123-1130.
7. Theory and practice of histological techniques 2002, Churchill Livingstone, London, UK. 5th ed. J. Bancroft, M. Gamble (Eds.).
8. Kiernan J. Histological and histochemical methods: theory and practice 2000, Butterworth Heinemann, Oxford.
9. Anderson G., Bancroft J. Tissue processing and microtomy. Theory and practice of histological techniques 2002, Churchill Livingstone, London, UK. J. Bancroft, M. Gamble (Eds.).
10. Horobin R. Theory of staining and its practical implications. Theory and practice of histological techniques 2002, Churchill Livingstone, London, UK. J. Bancroft, M. Gamble (Eds.).
11. Wilson I., Gamble M. The hematoxylins and eosin. Theory and practice of histological techniques 2002, Churchill Livingstone, London, UK. 5th ed. J. Bancroft, M. Gamble (Eds.).
12. Silverstein M., Gierson E., Colburn W., Cope L., Furmanski M., Senofsky G., et al. Can intraductal breast carcinoma be excised completely by local excision?. Cancer 1994, 73:2985-2989.
13. Schnitt S., Abner A., Gelman R., Connolly J., Recht A., Duda R., et al. The relationship between microscopic margins of resection and the risk of local recurrence in patients with breast cancer treated with breast-conserving surgery and radiation therapy. Cancer 1994, 74:1746-1751.
14. Holland R., Connolly J., Gelman R., Mravunac M., Hendriks J., Verbeek A., et al. The presence of an extensive intraductal component following a limited excision correlates with prominent residual disease in the remainder of the breast. J Clin Oncol 1990, 8:113-118.
15. Holland R., Veling S.H., Mravunac M., Hendriks J.H. Histologic multifocality of Tis T1-2 breast carcinomas. Implications for clinical trials of breast-conserving surgery. Cancer 1985, 56(5):979-990.
16. Gallager H.S., Martin J.E. The study of mammary carcinoma by mammography and whole organ sectioning. Early observations. Cancer 1969, 23(4):855-873.
17. Fredriksson I., Liljegren G., Palm-Sjovall M., Arnesson L., Emdin S., Fornander T., et al. Risk factors for local recurrence after breast-conserving surgery. Br J Surg 2003, 90:1093-1102.
18. Pedersen L., Gunnarsdottir K., Rasmussen B., Moeller S., Lanng C. The prognostic influence of multifocality in breast cancer patients. Breast 2004, 13:188-193.
19. Kricker A., Goumas C., Armstrong B. Ductal carcinoma in situ of the breast, a population-based study of epidemiology and pathology. Br J Cancer 2004, 90:1382-1385.
20. Faverly D., Hendriks J., Holland R. Breast carcinomas of limited extent: frequency, radiologic-pathologic characteristics, and surgical margin requirements. Cancer 2001, 91(4):647-659.
21. Holland R., Hendriks J., Verbeek A., Mravunac M., Schuurmans Stekhoven J. Extent, distribution, and mammographic/histological correlations of breast ductal carcinoma in situ. Lancet 1990, 335:519-522.
22. Tot T. D.C.I.S. cytokeratins, and the theory of the sick lobe. Virchows Arch 2005, 447(1):1-8.
23. AJCC cancer staging handbook 2002, Springer-Verlag, New York. 6th ed. F.L. Greene, A.G. Fritz, C.M. Balch, D.G. Haller, D.L. Page, I.A. Fleming (Eds.).
24. Mullenix P.S., Cuadrado D.G., Steele S.R., Martin M.J., See C.S., Beitler A.L., et al. Secondary operations are frequently required to complete the surgical phase of therapy in the era of breast conservation and sentinel lymph node biopsy. Am J Surg 2004, 187(5):643-646.
25. Anscher M.S., Jones P., Prosnitz L.R., Blackstock W., Hebert M., Reddick R., et al. Local failure and margin status in early-stage breast carcinoma treated with conservation surgery and radiation therapy. Ann Surg 1993, 218(1):22-28.
26. Swanson G., Rynearson K., Symmonds R. Significance of margins of excision on breast cancer recurrence. Am J Clin Oncol 2002, 25:438-441.
27. Tartter P.I., Bleiweiss I.J., Levchenko S. Factors associated with clear biopsy margins and clear reexcision margins in breast cancer specimens from candidates for breast conservation. J Am Coll Surg 1997, 185(3):268-273.
28. Feder J.M., de Paredes E.S., Hogge J.P., Wilken J.J. Unusual breast lesions: radiologic-pathologic correlation. Radiographics 1999, [19 Spec No:S11-26; quiz S260].
29. Oude Munnink T.H., Nagengast W.B., Brouwers A.H., Schroder C.P., Hospers G.A., Lub-de Hooge M.N., et al. Molecular imaging of breast cancer. Breast 2009, 18(Suppl 3):S66-73.
30. Nofech-Mozes S., Spayne J., Rakovitch E., Hanna W. Prognostic and predictive molecular markers in DCIS: a review. Adv Anat Pathol 2005, 12(5):256-264.
31. Gupta D., Nath M., Layfield L. Utility of four-quadrant random sections in mastectomy specimens. Breast J 2003, 9(4):307-311.
32. Wiley E., Keh P. Diagnostic discrepancies in breast specimens subjected to gross reexamination. Am J Surg Pathol 1999, 23(8):876-891.
33. Tang P., Hajdu S.I., Conte C.C., Filardi D.A. Incidental finding of mammary carcinoma in lumpectomy specimens. Ann Clin Lab Sci 2003, 33(1):23-31.
34. Owings D.V., Hann L., Schnitt S.J. How thoroughly should needle localization breast biopsies be sampled for microscopic examination? A prospective mammographic/pathologic correlative study. Am J Surg Pathol 1990, 14(6):578-583.
35. Tot T. Clinical relevance of the distribution of the lesions in 500 consecutive breast cancer cases documented in large-format histologic sections. Cancer 2007, 110(11):2551-2560.
36. Clarke G., Peressotti C., Mawdsley G., Eidt S., Ge M., Morgan T., et al. Three-dimensional breast histopathology imaging. P Soc Photo-Opt Inst 2005, 5744:555-565.
37. Sun L., Wang D., Zubovits J.T., Yaffe M.J., Clarke G.M. An improved processing method for breast whole-mount serial sections for three-dimensional histopathology imaging. Am J Clin Pathol 2009, 131(3):383-392.
38. Weinstein R.S., Graham A.R., Richter L.C., Barker G.P., Krupinski E.A., Lopez A.M., et al. Overview of telepathology, virtual microscopy, and whole slide imaging: prospects for the future. Hum Pathol 2009, 40(8):1057-1069.
39. Zwonitzer R., Hofmann H., Roessner A., Kalinski T. Virtual 3D microscopy in pathology education. Hum Pathol 2010, 41(3):457-458.
40. Gabril M.Y., Yousef G.M. Informatics for practicing anatomical pathologists: marking a new era in pathology practice. Mod Pathol 2010, 23(3):349-358.
41. Clarke G., Peressotti C., Mawdsley G., Yaffe M. Design and characterization of a digital image acquisition system for whole-specimen breast histopathology. Phys Med Biol 2006, 51(20):5089-5103.
42. http://www.awaresystems.be/imaging/tiff/bigtiff.html.
43. Changing the Way You Look at Tissue (Technical Report). In: Biomedical Photometrics Inc. 2008 [accessed 25.5.2010]. http://www.confocal.com/PDFS/TissuescopeSpecs.pdf.
44. Confocal Fluorescence Imaging of Tissue Using the TISSUEscope (Technical Report). In: Biomedical Photometrics Inc. 2008 [accessed 25.5.2010]. http://www.confocal.com/PDFS/TISSUEscopeBackgrounder.pdf.
45. BPIs MACROscope Technology (Technical Report). In: Biomedical Photometrics Inc. 2008 [accessed 25.5.2010]. http://www.confocal.com/PDFS/MACROscope2008.pdf.
46. Clarke G.M., Zubovits J.T., Katic M., Peressotti C., Yaffe M.J. Spatial resolution requirements for acquisition of the virtual screening slide for digital whole-specimen breast histopathology. Hum Pathol 2007, 38(12):1764-1771.
47. Zubovits J., Clarke G.M., Sun L., Wang D., Moskaluk A.-M., Peressotti C., et al. Three-dimensional breast pathology imaging for reducing sampling errors: a case study. United States and Canadian Academy of Pathology 98th Annual Meeting; 2010 2010.
48. Jenkinson A.D., Al-Mufti R.A., Mohsen Y., Berry M.J., Wells C., Carpenter R. Does intraductal breast cancer spread in a segmental distribution? An analysis of residual tumour burden following segmental mastectomy using tumour bed biopsies. Eur J Surg Oncol 2001, 27(1):21-25.
49. Cheng L., Al-Kaisi N.K., Gordon N.H., Liu A.Y., Gebrail F., Shenk R.R. Relationship between the size and margin status of ductal carcinoma in situ of the breast and residual disease. J Natl Cancer Inst 1997, 89(18):1356-1360.
50. Ratanawichitrasin A., Rybicki L.A., Steiger E., Grundfest-Broniatowski S., Hermann R.E., Crowe J.P. Predicting the likelihood of residual disease in women treated for ductal carcinoma in situ. J Am Coll Surg 1999, 188(1):17-21.
51. Mai K.T., Yazdi H.M., Burns B.F., Perkins D.G. Pattern of distribution of intraductal and infiltrating ductal carcinoma: a three-dimensional study using serial coronal giant sections of the breast. Hum Pathol 2000, 31(4):464-474.
52. Breast Irradiation in Women with Early Stage Invasive Breast Cancer Following Breast Conserving Surgery; 2002.
53. Boyages J., Delaney G., Taylor R. Predictors of local recurrence after treatment of ductal carcinoma in situ. Cancer 1999, 85:616-628.
54. Recht A, Rutgers EJ, Fentiman IS, kurtz JM, Mansel RE, Sloane JP. The fourth EORTC DCIS Consensus meeting (Chateau Marquette, Heemskerk, The Netherlands, 23-24 January 1998): Conference report. Eur J Cancer 1998;34:1664-79.
55. Winchester D., Strom E. Standards for diagnosis and management of ductal carcinoma in situ (DCIS) of the breast American College of Radiology. American College of Surgeons. American College of Pathologists. American College of Surgical Oncology. CA Cancer J Clin 1998, 48:108-128.
56. Silverstein M., Lagios M., Groshen S., Waisman J., Lewinsky B., Martino S., et al. The influence of margin width on local control of ductal carcinoma in situ of the breast. N Engl J Med 1999, 340:1455-1461.
57. Fisher E., Costantino J., Fisher B., Palekar A., Redmond C., Mamounas E. Pathologic findings from the National Surgical Adjuvant Breast Project (NSABP) Protocol B-17: intraductal carcinoma (ductal carcinoma in situ) The National Surgical Adjuvant Breast and Bowel Project Collaborating Investigators. Cancer 1995, 75:1310-1319.
58. Ginestier C., Hur M.H., Charafe-Jauffret E., Monville F., Dutcher J., Brown M., et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 2007, 1(5):555-567.
59. Ponti D., Costa A., Zaffaroni N., Pratesi G., Petrangolini G., Coradini D., et al. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res 2005, 65(13):5506-5511.
60. Al-Hajj M., Wicha M.S., Benito-Hernandez A., Morrison S.J., Clarke M.F. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A 2003, 100(7):3983-3988.
61. Soliman H., Gunasekara A., Rycroft M., Zubovits J., Dent R., Spayne J., et al. Functional imaging using diffuse optical spectroscopy of neoadjuvant chemotherapy response in women with locally advanced breast cancer. Clin Cancer Res 2010, 16(9):2605-2614.
62. Mainprize J., Okhai S., Clarke G., Kempston M., Eidt S., Yaffe M. Correlating cone-beam CT and large-section histology image sets: initial results using a surgical lumpectomy specimen. IWDM 2006, 8th International Workshop; 2006 2006, 299-306. Springer, Manchester, UK. S. Astley (Ed.).
63. Clarke G.M., Mainprize J., Peressotti C., Sun L., Wang D., Zubovits J., et al. Validation of cone-beam CT measurements of tumour burden using three-dimensional histopathology: initial results for a lumpectomy. International Workshop in Digitial Mammography; 2008 July 20-23, 2008 2008, 440-446. Springer, Tucson, AZ. E. Krupinski (Ed.).
64. Dahele M., Hwang D., Peressotti C., Sun L., Kusano M., Okhai S., et al. Developing a methodology for three-dimensional correlation of PET-CT images and whole-mount histopathology in non-small-cell lung cancer. Curr Oncol 2008, 15(5):62-69.
65. Campbell S., Markel D., Vena D., Raphael S., Higgins K., Enepekides D., et al. Evaluation of microscopic disease in oral tongue cancer using whole-mount histopathological techniques: Implications for the treatment of head and neck cancers. American Society for Therapeutic Radiology and Oncology (ASTRO) Multidisciplinary Head and Neck Cancer Symposium; 2010 February 25-27 2010 2010, Chandler, Arizona.
66. Langer D.L., van der Kwast T.H., Evans A.J., Sun L., Yaffe M.J., Trachtenberg J., et al. Intermixed normal tissue within prostate cancer: effect on MR imaging measurements of apparent diffusion coefficient and T2 - sparse versus dense cancers. Radiology 2008, 249(3):900-908.
67. Boyes A., Tang K., Yaffe M., Sugar L., Chopra R., Bronskill M. Prostate tissue analysis immediately following magnetic resonance imaging guided transurethral ultrasound thermal therapy. J Urol 2007, 178(3 Pt 1):1080-1085.
68. Chopra R., Tang K., Burtnyk M., Boyes A., Sugar L., Appu S., et al. Analysis of the spatial and temporal accuracy of heating in the prostate gland using transurethral ultrasound therapy and active MR temperature feedback. Phys Med Biol 2009, 54(9):2615-2633.