Synthesis and evaluation of C-ring aromatized analogues of phenanthridone alkaloids

Archives of Pharmacal Research

Volumn 34, Issue 7, 2011, Pages 1065-1070

  Lee, Seokwoo ^a   Hwang, Soonho ^a   Yu, Shuai ^a   Jang, Wonyoung ^a   Lee, Yun Mi ^a   Kim, Sanghee ^a  

^a Seoul National University   (South Korea)

Author keywords

Anticancer activity; Aromatization; Heck coupling; Phenanthridone alkaloids; Structure activity relationship

Indexed keywords

2,3 BIS(BENZYLOXY) 5 [[2 (TRIMETHYLSILYL)ETHOXY]METHYL][1,3]DIOXOLO[4,5 J]PHENAN THRIDIN 6(5H) ONE; 2,3 DIHYDROXY [1,3]DIOXOLO[4,5 J]PHENANTHRIDIN 6(5H) ONE; 2,3,4 TRIHYDROXY [1,3]DIOXOLO[4,5 J]PHENANTHRIDIN 6(5H) ONE; 2,3,4 TRIS(BENZYLOXY) 5 [[2 (TRIMETHYLSILYL)ETHOXY]METHYL][1,3]DIOXOLO[4,5 J]PHENANTHRIDIN 6(5H) ONE; 2,4 BIS(BENZYLOXY) 5 [[2 (TRIMETHYLSILYL)ETHOXY]METHYL][1,3]DIOXOLO[4,5 J]PHENAN THRIDIN 6(5H) ONE; 2,4 DIHYDROXY [1,3]DIOXOLO[4,5 J]PHENANTHRIDIN 6(5H) ONE; 3,4 BIS(BENZYLOXY) 5 [[2 (TRIMETHYLSILYL)ETHOXY]METHYL][1,3]DIOXOLO[4,5 J]PHENAN THRIDIN 6(5H) ONE; 3,4 DIHYDROXY [1,3]DIOXOLO[4,5 J]PHENANTHRIDIN 6(5H) ONE; ALKALOID DERIVATIVE; ANTINEOPLASTIC AGENT; HYDROXYL GROUP; PHENANTHRIDONE ALKALOID DERIVATIVE; UNCLASSIFIED DRUG;

AROMATIZATION; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOLECULAR MODEL; STEREOCHEMISTRY;

ALKALOIDS; AMARYLLIDACEAE ALKALOIDS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG DESIGN; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; ELECTROPHYSIOLOGICAL PHENOMENA; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; PHENANTHRENES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80052310874     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-011-0703-1     Document Type: Article

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